SE8901031L - NEW POLYPEPTIDES WITH ADDITION FACTOR ACTIVITY AND NUCLEIC ACID SEQUENCES CODING POLYPEPTIDES - Google Patents

NEW POLYPEPTIDES WITH ADDITION FACTOR ACTIVITY AND NUCLEIC ACID SEQUENCES CODING POLYPEPTIDES

Info

Publication number
SE8901031L
SE8901031L SE8901031A SE8901031A SE8901031L SE 8901031 L SE8901031 L SE 8901031L SE 8901031 A SE8901031 A SE 8901031A SE 8901031 A SE8901031 A SE 8901031A SE 8901031 L SE8901031 L SE 8901031L
Authority
SE
Sweden
Prior art keywords
polypeptides
nucleic acid
acid sequences
sequences coding
factor activity
Prior art date
Application number
SE8901031A
Other languages
Swedish (sv)
Other versions
SE8901031D0 (en
Inventor
J P Brown
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of SE8901031D0 publication Critical patent/SE8901031D0/en
Publication of SE8901031L publication Critical patent/SE8901031L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)

Abstract

Polypeptides capable of binding to an epidermal growth factor receptor are provided, as well as precursors thereof, where the polypeptides find analogy with polypeptides coded for by pox viruses. The compounds have a framework structure, particularly involving six cysteines which provide loops analogous to those found in naturally occurring growth factors which bind to an epidermal growth factor receptor. The compounds find use as mitogens, additives in nutrient media, in assays for EGF receptors, and as competitors for other growth factors. The components also find use in wound healing. <IMAGE>
SE8901031A 1988-03-24 1989-03-22 NEW POLYPEPTIDES WITH ADDITION FACTOR ACTIVITY AND NUCLEIC ACID SEQUENCES CODING POLYPEPTIDES SE8901031L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17265388A 1988-03-24 1988-03-24

Publications (2)

Publication Number Publication Date
SE8901031D0 SE8901031D0 (en) 1989-03-22
SE8901031L true SE8901031L (en) 1989-09-25

Family

ID=22628611

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8901031A SE8901031L (en) 1988-03-24 1989-03-22 NEW POLYPEPTIDES WITH ADDITION FACTOR ACTIVITY AND NUCLEIC ACID SEQUENCES CODING POLYPEPTIDES

Country Status (22)

Country Link
JP (1) JPH0279981A (en)
KR (1) KR890014743A (en)
AU (2) AU3169589A (en)
BE (1) BE1004202A5 (en)
CH (1) CH681081A5 (en)
DE (1) DE3910084A1 (en)
DK (1) DK146789A (en)
ES (1) ES2013408A6 (en)
FI (1) FI891308A (en)
FR (1) FR2632321A1 (en)
GB (1) GB2219799B (en)
GR (1) GR1000876B (en)
HU (1) HUT50501A (en)
IE (1) IE890950L (en)
IL (1) IL89673A0 (en)
IT (1) IT1234961B (en)
LU (1) LU87489A1 (en)
NL (1) NL8900724A (en)
NO (1) NO891273D0 (en)
NZ (1) NZ228427A (en)
PT (1) PT90118B (en)
SE (1) SE8901031L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293785A3 (en) * 1987-05-29 1990-05-02 Oncogen Limited Partnership Cloning and expression of simian transforming growth factor-ss1
CA2037440A1 (en) * 1990-03-02 1991-09-03 Gregory D. Plowman Her3: a novel egf receptor homolog
EP0739984A1 (en) * 1995-04-26 1996-10-30 San Tumorforschungs-Gmbh Bivalent polypeptides containing at least two domains
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein
JP2000508531A (en) * 1996-04-10 2000-07-11 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Extracellular / epidermal growth factor-like protein

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108132A1 (en) * 1982-05-06 1984-05-16 Applied Molecular Genetics Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
JPS6028994A (en) * 1983-07-08 1985-02-14 Wakunaga Seiyaku Kk (21-leucine) human urogastrone, corresponding gene, corresponding recombinant plasmid, transformed cell and their preparation
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
JP2554459B2 (en) * 1984-07-02 1996-11-13 アース製薬 株式会社 β-urogastron gene, corresponding plasmid recombinant and corresponding transformant
AU600433B2 (en) * 1984-10-30 1990-08-16 Oncogen Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
GB2210618B (en) * 1987-10-08 1991-10-16 British Bio Technology Synthetic egf gene
ES2081801T3 (en) * 1987-10-30 1996-03-16 Bristol Myers Squibb Co EXPRESSION PLASMIDS.
JP2970811B2 (en) * 1987-10-30 1999-11-02 オンコゲン ア リミテッド パートナーシップ Expression systems for preparing polypeptides in prokaryotic cells

Also Published As

Publication number Publication date
FI891308A0 (en) 1989-03-20
IT1234961B (en) 1992-06-09
IE890950L (en) 1989-09-24
GR1000876B (en) 1993-03-16
NZ228427A (en) 1993-03-26
KR890014743A (en) 1989-10-25
ES2013408A6 (en) 1990-05-01
IL89673A0 (en) 1989-09-28
PT90118B (en) 1994-07-29
GB2219799A (en) 1989-12-20
NL8900724A (en) 1989-10-16
PT90118A (en) 1989-11-10
FI891308A (en) 1989-09-25
GR890100185A (en) 1990-01-19
GB2219799B (en) 1992-10-14
DE3910084A1 (en) 1989-11-16
IT8919917A0 (en) 1989-03-24
DK146789A (en) 1989-09-25
BE1004202A5 (en) 1992-10-13
FR2632321A1 (en) 1989-12-08
CH681081A5 (en) 1993-01-15
DK146789D0 (en) 1989-03-22
LU87489A1 (en) 1989-10-26
NO891273D0 (en) 1989-03-22
HUT50501A (en) 1990-02-28
GB8906758D0 (en) 1989-05-10
AU2990492A (en) 1993-03-04
JPH0279981A (en) 1990-03-20
AU3169589A (en) 1989-09-28
SE8901031D0 (en) 1989-03-22

Similar Documents

Publication Publication Date Title
ATE194385T1 (en) HUMAN PF4A RECEPTORS AND THEIR USE
ES539678A0 (en) PROCEDURE FOR PREPARING A CYCLIC POLYPEPTIDE
ATE276034T1 (en) USE OF METAL OXIDE COMPOUNDS WITH PEROVSKITS STRUCTURE
ATE164884T1 (en) NEW SEVEN TRANSMEMBRANE RECEPTOR V28
ATE211947T1 (en) ACIDIC CATALYST IN SOLID FORM AND METHOD FOR PRODUCING THE SAME
DE69030579D1 (en) METHOD FOR PRODUCING FUSION PROTEINS
DE50015156D1 (en) Procalcitonin-targeted antibodies, their production and use
ATE196162T1 (en) TOXOPLASMA GONDII ANTIGENS, THEIR PRODUCTION AND THEIR USE
SE8901031L (en) NEW POLYPEPTIDES WITH ADDITION FACTOR ACTIVITY AND NUCLEIC ACID SEQUENCES CODING POLYPEPTIDES
DK0486572T3 (en) Improvements in granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof
ATE48835T1 (en) QUINOLYLGLYCINAMIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THERAPEUTIC USE AS PSYCHOTROPS.
DK39695A (en) Use of sulfonic acid esters for the preparation of ACE inhibitors and / or analogues
ATE88751T1 (en) MONOCLONAL ANTIBODIES SPECIFIC AGAINST NEUTROPHILS.
DE69802811D1 (en) METHOD FOR PRODUCING POLYBORACYLENE MESOPHASE, POLYBORAZYLENE MESOPHASE, THEIR USE AS BN PRECURSOR
ATE37534T1 (en) ARYLETHANOLHYDROXYLAMINE, PROCESS FOR THEIR PRODUCTION AND USE TO ENHANCE PERFORMANCE.
ES8802185A1 (en) Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
EP0237964A3 (en) 2-azolylmethyl-2-aryl-1,3-dioxolanes and their salts, processes for their preparation, compositions containing them and their use
DE69405928D1 (en) Synthesis of alkyl tert-alkyl ethers using alkyl sulfonic acid modified oxide catalysts
DE69007941D1 (en) Mesophase pitch for the production of carbon materials.
DE3671603D1 (en) METHOD FOR THE BREEDING OF BABESIA CANIS, USE FOR THE PRODUCTION OF ANTIGENS AND VACCINALS AND ANTIGENS AND VACCINATES AGAINST PIROPLASMOSIS.
ATE104266T1 (en) 1-BROMO-3-CHLORO-1,2-DIARYL-2-PROPANOLS, PROCESS FOR THE STEREOSELECTIVE PREPARATION OF ERYTHRO-1- BROMO-3-CHLORO-1,2-DIARYL-2-PROPANOLS AND THEIR CONVERSION TO AZOLYLMETHYLOXIRANES.
DE3677270D1 (en) CHINOLIN-8-CARBONIC ACID AZOLIDE, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS HERBICIDES.
ATE33837T1 (en) AZOLYLMETHYLCYCLOACETALS, PROCESSES FOR THEIR PRODUCTION AND USE AS MEDICINES.
RU94016916A (en) METHOD FOR PRODUCING 5- [3- (4) -R-1-ADAMANTYL] PYRIMIDINES
JPS642586A (en) Western subtype dna and rna molecule of fsme-virus, polypeptide coded by the molecule and its usage

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8901031-8

Effective date: 19941001