EP0493434A4 - Tsh receptor - Google Patents

Tsh receptor

Info

Publication number
EP0493434A4
EP0493434A4 EP19900913766 EP90913766A EP0493434A4 EP 0493434 A4 EP0493434 A4 EP 0493434A4 EP 19900913766 EP19900913766 EP 19900913766 EP 90913766 A EP90913766 A EP 90913766A EP 0493434 A4 EP0493434 A4 EP 0493434A4
Authority
EP
European Patent Office
Prior art keywords
tsh receptor
tsh
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900913766
Other versions
EP0493434A1 (en
Inventor
Roger Cone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New England Medical Center Hospitals Inc
Original Assignee
New England Medical Center Hospitals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Medical Center Hospitals Inc filed Critical New England Medical Center Hospitals Inc
Publication of EP0493434A1 publication Critical patent/EP0493434A1/en
Publication of EP0493434A4 publication Critical patent/EP0493434A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP19900913766 1989-09-08 1990-09-07 Tsh receptor Withdrawn EP0493434A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40489989A 1989-09-08 1989-09-08
US404899 1989-09-08
US56566990A 1990-08-10 1990-08-10
US565669 1990-08-10

Publications (2)

Publication Number Publication Date
EP0493434A1 EP0493434A1 (en) 1992-07-08
EP0493434A4 true EP0493434A4 (en) 1993-05-05

Family

ID=27018824

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900913766 Withdrawn EP0493434A4 (en) 1989-09-08 1990-09-07 Tsh receptor

Country Status (4)

Country Link
EP (1) EP0493434A4 (en)
JP (1) JP3181582B2 (en)
CA (1) CA2066263C (en)
WO (1) WO1991003483A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
EP0471030B1 (en) * 1989-05-05 1994-12-14 Genentech, Inc. Glycoprotein hormone receptor molecules
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
US5744348A (en) * 1989-09-08 1998-04-28 New England Medical Center Hospitals, Inc. TSH receptor
EP0433509B1 (en) * 1989-12-14 1996-11-13 B.R.A.H.M.S Diagnostica GmbH Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor
DE19645729C1 (en) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Receptor binding assay for detecting auto-antibodies to thyroid stimulating hormone receptor
DE19651093C2 (en) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Receptor binding assay for the detection of TSH receptor autoantibodies and set of reagents for performing such a receptor binding assay
WO1999015545A1 (en) * 1997-09-24 1999-04-01 Merck & Co., Inc. G-protein coupled glycoprotein hormone receptor aomf05
GB9823397D0 (en) 1998-10-27 1998-12-23 Rsr Ltd Assays for thyroid autoantibodies
JP4744147B2 (en) 2002-11-26 2011-08-10 ベー・エル・アー・ハー・エム・エス・ゲーエムベーハー Identification of thyroid-stimulating hormone receptor autoantibodies using affinity purified antibodies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013643A2 (en) * 1989-05-05 1990-11-15 Genentech, Inc. Glycoprotein hormone receptor molecules
WO1991009137A1 (en) * 1989-12-20 1991-06-27 Basil Rapoport Recombinant thyrotropin receptor
WO1991009121A2 (en) * 1989-12-14 1991-06-27 Henning Berlin Gmbh Chemie- Und Pharmawerk Polypeptides having thyrotropin-receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
WO1991010735A2 (en) * 1990-01-15 1991-07-25 Institut National De La Sante Et De La Recherche Medicale Human receptor of tsh. sequence coding for such receptor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013643A2 (en) * 1989-05-05 1990-11-15 Genentech, Inc. Glycoprotein hormone receptor molecules
WO1991009121A2 (en) * 1989-12-14 1991-06-27 Henning Berlin Gmbh Chemie- Und Pharmawerk Polypeptides having thyrotropin-receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
WO1991009137A1 (en) * 1989-12-20 1991-06-27 Basil Rapoport Recombinant thyrotropin receptor
WO1991010735A2 (en) * 1990-01-15 1991-07-25 Institut National De La Sante Et De La Recherche Medicale Human receptor of tsh. sequence coding for such receptor

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
64TH MEETING OF THE AMERICAN THYROID ASSOCIATION, 1989, abstract no. T-51; L. FRAZIER-SEABROOK et al.: "Isolation of a thyroid-specific cDNA with over 80% aminoacid homology with the luteinizing hormone receptor" *
ACTA ENDOCRINOLOGICA, vol. 115, suppl. 281, 1987, pages 166-172, Copenhagen, DK; J. CHAN et al.: "TSH receptor structure" *
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 165, no. 3, 29th December 1989, pages 1184-1190, Academic Press, New York, US; Y. NAGAYAMA et al.: "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor" *
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 165, no. 3, 29th December 1989, pages 1250-1255, Academic Press, New York, US; F. LIBERT et al.: "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies" *
CLINICAL RESEARCH, vol. 29, no. 2, April 1981, page 294A, Thorofare, NJ, US; M.N. ISLAM et al.: "Purification of the human thyrotropin receptor" *
ENDOCRINOLOGY, vol. 110, no. 4, April 1982, pages 1381-1391, The Endocrine Soc., Baltimore, US; Y. KOIZUMI et al.: "Solubilisation, purification, and partial characterization of thyrotropin receptor from bovine and human thyroid glands" *
SCIENCE, vol. 246, 22nd December 1989, pages 1620-1622, AAAS, Washington, DC, US; M. PARMENTIER et al.: "Molecular cloning of the thyroid receptor" *
See also references of WO9103483A1 *

Also Published As

Publication number Publication date
JP3181582B2 (en) 2001-07-03
JPH05501952A (en) 1993-04-15
WO1991003483A1 (en) 1991-03-21
CA2066263C (en) 1999-11-02
CA2066263A1 (en) 1991-03-09
EP0493434A1 (en) 1992-07-08

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Legal Events

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