EP0506890A4 - Recombinant thyrotropin receptor - Google Patents

Recombinant thyrotropin receptor

Info

Publication number
EP0506890A4
EP0506890A4 EP19910904350 EP91904350A EP0506890A4 EP 0506890 A4 EP0506890 A4 EP 0506890A4 EP 19910904350 EP19910904350 EP 19910904350 EP 91904350 A EP91904350 A EP 91904350A EP 0506890 A4 EP0506890 A4 EP 0506890A4
Authority
EP
European Patent Office
Prior art keywords
thyrotropin receptor
recombinant
recombinant thyrotropin
receptor
thyrotropin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910904350
Other versions
EP0506890A1 (en
Inventor
Basil Rapoport
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nichols Institute Diagnostics
Original Assignee
Nichols Institute Diagnostics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nichols Institute Diagnostics filed Critical Nichols Institute Diagnostics
Publication of EP0506890A1 publication Critical patent/EP0506890A1/en
Publication of EP0506890A4 publication Critical patent/EP0506890A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
EP19910904350 1989-12-20 1990-12-19 Recombinant thyrotropin receptor Withdrawn EP0506890A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45197389A 1989-12-20 1989-12-20
US57501890A 1990-08-30 1990-08-30
US575018 1990-08-30
US451973 2006-06-13

Publications (2)

Publication Number Publication Date
EP0506890A1 EP0506890A1 (en) 1992-10-07
EP0506890A4 true EP0506890A4 (en) 1993-06-30

Family

ID=27036589

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910904350 Withdrawn EP0506890A4 (en) 1989-12-20 1990-12-19 Recombinant thyrotropin receptor

Country Status (5)

Country Link
EP (1) EP0506890A4 (en)
JP (1) JPH05504683A (en)
AU (1) AU7257391A (en)
IE (1) IE904641A1 (en)
WO (1) WO1991009137A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69015175T2 (en) * 1989-05-05 1995-06-29 Genentech Inc GLYCOPROTEIN HORMONE RECEPTOR MOLECULES.
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
CA2066263C (en) * 1989-09-08 1999-11-02 New England Medical Center Hospitals, Inc. Tsh receptor
DE68927461T2 (en) * 1989-12-14 1997-03-20 B.R.A.H.M.S Diagnostica Gmbh, 12099 Berlin Polypeptides with thyrotropin receptor activity, coding nucleic acid sequences for such receptors and use of these polypeptides
EP0719858A3 (en) * 1994-12-27 1997-12-29 Tosoh Corporation Myeloma cell line expressing recombinant human thyroid stimulating hormone receptor
DE19645729C1 (en) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Receptor binding assay for detecting auto-antibodies to thyroid stimulating hormone receptor
DE19728991A1 (en) * 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Receptor binding assay, recombinant fusion receptor suitable for the receptor binding assay, vector for its production and set of reagents for carrying out the receptor binding assay
DE19651093C2 (en) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Receptor binding assay for the detection of TSH receptor autoantibodies and set of reagents for performing such a receptor binding assay
US6686171B2 (en) * 1999-05-10 2004-02-03 Tropix, Inc. Competitive chemiluminescent assay for cyclic nucleotide monophosphates
DE50010992D1 (en) * 1999-10-12 2005-09-22 Ulrich Loos METHOD FOR DETERMINING AUTOANTIC BODIES AGAINST THE TSH RECEPTOR
US6852546B1 (en) * 2000-03-30 2005-02-08 Diagnostic Hybrids, Inc. Diagnosis of autoimmune disease
US8293879B2 (en) 2000-03-30 2012-10-23 Diagnostic Hybrids, Inc. Methods of using chimeric receptors to identify autoimmune disease
ES2736165T3 (en) 2001-08-23 2019-12-26 Rsr Ltd Epitope regions of a thyrotropin receptor (TSH), its uses and antibodies to them
AU2003285540A1 (en) * 2002-11-29 2004-06-23 Rsr Limited Antibody for the thyrotropin receptor and uses thereof
CN102050875B (en) * 2010-12-10 2013-05-29 天津市协和医药科技有限公司 Extraction and purification method of TSHR (Thyroid Stimulating Hormone Receptor)
FR3126005A1 (en) * 2021-08-04 2023-02-10 Upec Pharmacological and/or genetic activator for use in preserving and regenerating muscle structure and function by blocking senescence
CN115925966A (en) * 2021-09-22 2023-04-07 厦门英博迈生物科技有限公司 Recombinant thyroid stimulating hormone receptor protein, preparation method and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002779A1 (en) * 1982-12-30 1984-07-19 Beth Israel Hospital A test for detecting and measuring the graves' disease-specific immunoglobulins
WO1990013643A2 (en) * 1989-05-05 1990-11-15 Genentech, Inc. Glycoprotein hormone receptor molecules
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
EP0433509A2 (en) * 1989-12-14 1991-06-26 B.R.A.H.M.S Diagnostica GmbH Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
WO1992008726A1 (en) * 1990-11-15 1992-05-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Rat thyrotropin receptor gene and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818684A (en) * 1985-09-10 1989-04-04 The Trustees Of Columbia University In The City Of New York Auto-anti-idiotypic monoclonal antibodies to steroid receptors and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002779A1 (en) * 1982-12-30 1984-07-19 Beth Israel Hospital A test for detecting and measuring the graves' disease-specific immunoglobulins
WO1990013643A2 (en) * 1989-05-05 1990-11-15 Genentech, Inc. Glycoprotein hormone receptor molecules
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
EP0433509A2 (en) * 1989-12-14 1991-06-26 B.R.A.H.M.S Diagnostica GmbH Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
WO1992008726A1 (en) * 1990-11-15 1992-05-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Rat thyrotropin receptor gene and uses thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
64th Meeting of the American Thyroid ass.; 1989; abstract T-51; Frazier-Seabrook et al.; "Isolation of a thyroid-specific cDNA with over 80% homology with the luteinizing hormone receptor." *
ACTA ENDOCRINOLOGICA vol. 115, 1987, pages 166 - 172 Chan, J. et al.; 'TSH receptor structure.' *
CLINICAL CHEMISTRY vol. 34, no. 8, 1988, NEW YORK, US page 1662 Tamaki, H. et al.; 'On standardization of the radioreceptor assay for anti-thyrotropin receptor antibody.' *
CLINICAL RESEARCH vol. 29, no. 2, April 1981, NEW YORK, US page 294A ISLAM, M.N. ET AL. 'Purification of the human thyrotropin receptor' *
CLINICAL RESEARCH vol. 29, no. 2, April 1981, NEW YORK, US page 491A ISLAM, M.N. ET AL. 'Purification of the human thyrotropin receptor' *
ENDOCRINOLOGY vol. 110, no. 4, 1982, THE ENDOCRINE SOC., US pages 1381 - 1391 Koizumi, Y.; Zakarija, M.; McKenzie, J. M. 'Solubilization, purification, and partial characterization of thyrotropin receptor from bovine and human thyroid glands' *
luteinizing hormone receptor." *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. vol. 79, November 1982, WASHINGTON US pages 6680 - 6684 Valente et al.; 'Monoclonal antibodies to the thyrotropin receptor : Stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease.' *
See also references of WO9109137A1 *

Also Published As

Publication number Publication date
IE904641A1 (en) 1991-07-17
JPH05504683A (en) 1993-07-22
AU7257391A (en) 1991-07-18
EP0506890A1 (en) 1992-10-07
WO1991009137A1 (en) 1991-06-27

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