ES2095243T3 - Proteina de actividad urato oxidasa; gen recombinante codante para esta, vector de expresion, micro-organismos y celulas transformadas. - Google Patents
Proteina de actividad urato oxidasa; gen recombinante codante para esta, vector de expresion, micro-organismos y celulas transformadas.Info
- Publication number
- ES2095243T3 ES2095243T3 ES90402023T ES90402023T ES2095243T3 ES 2095243 T3 ES2095243 T3 ES 2095243T3 ES 90402023 T ES90402023 T ES 90402023T ES 90402023 T ES90402023 T ES 90402023T ES 2095243 T3 ES2095243 T3 ES 2095243T3
- Authority
- ES
- Spain
- Prior art keywords
- urato
- organisms
- vector
- micro
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Glass Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UNA NUEVA PROTEINA CON ACTIVIDAD URATO OXIDASA QUE TIENE LA SECUENCIA SIGUIENTE: SER ALA VAL LYS ALA ALA ARG TYR GLY LYS ASP ASN VAL ARG VAL TYR LYS VAL HIS LYS ASP GLU LYS THR GLY VAL GLN THR VAL TYR GLU MET THR VAL CYS VAL LEU LEU GLU GLY GLU ILE GLU THR SER TYR THR LYS ALA ASP ASN SER VAL ILE VAL ALA THR ASP SER ILE LYS ASN THR ILE TYR ILE THR ALA LYS GLN ASN PRO VAL THR PRO PRO GLU LEU PHE GLY SER ILE LEU GLY THR LYS PHE ILE GLU LYS TYR ASN HIS ILE HIS ALA ALA HIS VAL ASN ILE VAL CYS HIS ARG TRP THR ARG MET ASP ILE ASP GLY LYS PRO HIS PRO HIS SER PHE ILE ARG ASP SER GLU GLU LYS ARG ASN VAL GLN VAL ASP VAL VAL GLU GLY LYS ILE ASP ILE LYS SER SER LEU SER GLY LEU THR VAL LEU LYS SER THR ASN SER GLN PHE TRP GLY PHE LEU ARG ASP GLU TYR THR THR LEU LYS GLU THR TRP ASP ARG ILE LEU SER THR ASP VAL ASP ALA THR TRP GLN TRP LYS ASN PHE SER GLY LEU GLN GLU VAL ARG SER HIS VAL PRO LYS PHE ASP ALA THR TRP ALA THR ALA ARG GLU VAL THR LEU LYS THR PHE ALA GLU ASP ASN SER ALA SER VAL GLN ALA THR MET TYR LYS MET ALA GLU GLN ILE LEU ALA ARG GLN GLN LEU ILE GLU THR VAL GLU TYR SER LEU PRO ASN LYS HIS TYR PHE GLU ILE ASP LEU SER TRP HIS LYS GLY LEU GLN ASN THR GLY LYS ASN ALA GLU VAL PHE ALA PRO GLN SER ASP PRO ASN GLY LEU ILE LYS CYS THR VAL GLY ARG SER SER LEU LYS SER LYS LEU, PRECEDIDO EVENTUALMENTE DE UNA METIONINA, O EN QUE PRESENTA UN GRADO DE HOMOLOGIA SUSTANCIAL CON ESTA SECUENCIA. LA INVENCION TIENE POR OBJETO IGUALMENTE LOS MEDICAMENTOS QUE CONTIENEN ESTA PROTEINA ASI COMO LOS UTILES DE INGENIERIA GENETICA PARA OBTENERLA.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8909550A FR2649720A1 (en) | 1989-07-13 | 1989-07-13 | Recombinant gene which encodes a protein such as urate oxidase |
| FR8917466A FR2656530B1 (fr) | 1989-12-29 | 1989-12-29 | Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase. |
| FR9001368A FR2657785A2 (fr) | 1989-12-29 | 1990-02-06 | Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2095243T3 true ES2095243T3 (es) | 1997-02-16 |
Family
ID=27251947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90402023T Expired - Lifetime ES2095243T3 (es) | 1989-07-13 | 1990-07-13 | Proteina de actividad urato oxidasa; gen recombinante codante para esta, vector de expresion, micro-organismos y celulas transformadas. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0408461B1 (es) |
| JP (1) | JP2664804B2 (es) |
| AT (1) | ATE144282T1 (es) |
| AU (1) | AU636637B2 (es) |
| BR (1) | BR9006855A (es) |
| CA (1) | CA2035900C (es) |
| DE (2) | DE69028884T2 (es) |
| DK (1) | DK0408461T3 (es) |
| ES (1) | ES2095243T3 (es) |
| FI (1) | FI105047B (es) |
| GR (1) | GR3022085T3 (es) |
| HK (1) | HK1000099A1 (es) |
| HU (1) | HU215948B (es) |
| IE (1) | IE77158B1 (es) |
| IL (1) | IL95057A (es) |
| LU (1) | LU90781I2 (es) |
| LV (1) | LV12000B (es) |
| MC (1) | MC2145A1 (es) |
| NL (1) | NL300046I2 (es) |
| NO (1) | NO2001018I2 (es) |
| NZ (1) | NZ234453A (es) |
| PT (1) | PT94680B (es) |
| RU (1) | RU2105812C1 (es) |
| WO (1) | WO1991000909A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2971218B2 (ja) * | 1991-12-04 | 1999-11-02 | 協和醗酵工業株式会社 | ウリカーゼ遺伝子およびウリカーゼの製造法 |
| US5691188A (en) | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
| EP0935651B1 (en) * | 1996-09-13 | 2004-12-29 | Transkaryotic Therapies, Inc. | THERAPY FOR alpha-GALACTOSIDASE A DEFICIENCY |
| US6083725A (en) | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
| CN1896231B (zh) | 1998-08-06 | 2012-09-05 | 山景药品公司 | 分离四聚体尿酸氧化酶的方法 |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| CN1275980C (zh) | 2000-08-17 | 2006-09-20 | 味之素株式会社 | 来源于微生物的转谷氨酰胺酶的修饰方法 |
| ES2367257T3 (es) | 2002-04-25 | 2011-10-31 | Shire Human Genetic Therapies, Inc. | Tratamiento de deficit de alfa-galactosidasa a. |
| TWI418564B (zh) * | 2005-04-11 | 2013-12-11 | Savient Pharmaceuticals Inc | 利用陽離子界面活性劑之蛋白質純化 |
| BRPI0612942A2 (pt) | 2005-04-11 | 2012-10-09 | Savient Pharmaceuticals Inc | forma variante de oxidase de urato e uso do mesmo |
| CA2604399A1 (en) | 2005-04-11 | 2006-10-19 | Savient Pharmaceuticals, Inc. | Variant forms of urate oxidase and use thereof |
| US9534013B2 (en) | 2006-04-12 | 2017-01-03 | Horizon Pharma Rheumatology Llc | Purification of proteins with cationic surfactant |
| US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| RU2443426C2 (ru) * | 2008-11-07 | 2012-02-27 | Мунтэн Вью Фармасьютикэлз, Инк. | Конъюгаты уратоксидазы, фармацевтическая композиция для снижения уровней мочевой кислоты и способ получения вышеупомянутых конъюгатов |
| EP3482768A1 (en) | 2009-06-25 | 2019-05-15 | Horizon Pharma Rheumatology LLC | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| CN109223707B (zh) * | 2018-09-13 | 2020-12-08 | 中国药科大学 | 一种尿酸酶外用凝胶制剂、其制备方法及用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1529675A (fr) * | 1967-03-29 | 1968-06-21 | Applic Biochimiques Soc Et | Urate oxydase à haute activité et sa préparation |
| SU457723A1 (ru) * | 1973-04-09 | 1977-08-05 | Всесоюзный Научно-Исследовательский Витаминный Институт | Штамм 313-152 - продуцент уратоксидазы |
| EP0173378B1 (en) * | 1984-07-27 | 1991-06-12 | Unilever N.V. | Process for preparing a polypeptide by culturing a transformed microorganism, a transformed microorganism suitable therefor and dna sequences suitable for preparing such microorganism |
| WO1988008450A1 (en) * | 1987-05-01 | 1988-11-03 | Birdwell Finlayson | Gene therapy for metabolite disorders |
| JPH0671428B2 (ja) * | 1988-08-17 | 1994-09-14 | サッポロビール株式会社 | ウリカーゼのｄｎａ配列および製法 |
-
1990
- 1990-07-11 NZ NZ234453A patent/NZ234453A/xx unknown
- 1990-07-12 IL IL95057A patent/IL95057A/xx active IP Right Grant
- 1990-07-12 PT PT94680A patent/PT94680B/pt not_active IP Right Cessation
- 1990-07-13 AU AU60523/90A patent/AU636637B2/en not_active Expired
- 1990-07-13 BR BR909006855A patent/BR9006855A/pt not_active Application Discontinuation
- 1990-07-13 IE IE255990A patent/IE77158B1/en not_active IP Right Cessation
- 1990-07-13 WO PCT/FR1990/000532 patent/WO1991000909A1/fr active IP Right Grant
- 1990-07-13 DE DE69028884T patent/DE69028884T2/de not_active Expired - Lifetime
- 1990-07-13 RU SU4895030/13A patent/RU2105812C1/ru active
- 1990-07-13 CA CA002035900A patent/CA2035900C/fr not_active Expired - Lifetime
- 1990-07-13 ES ES90402023T patent/ES2095243T3/es not_active Expired - Lifetime
- 1990-07-13 HU HU906046A patent/HU215948B/hu active Protection Beyond IP Right Term
- 1990-07-13 DE DE2001199042 patent/DE10199042I2/de active Active
- 1990-07-13 JP JP2510514A patent/JP2664804B2/ja not_active Expired - Lifetime
- 1990-07-13 DK DK90402023.7T patent/DK0408461T3/da active
- 1990-07-13 AT AT90402023T patent/ATE144282T1/de active
- 1990-07-13 MC MC@@@@D patent/MC2145A1/xx unknown
- 1990-07-13 EP EP90402023A patent/EP0408461B1/fr not_active Expired - Lifetime
-
1991
- 1991-03-12 FI FI911212A patent/FI105047B/fi active Protection Beyond IP Right Term
-
1996
- 1996-12-18 GR GR960403531T patent/GR3022085T3/el unknown
-
1997
- 1997-07-08 HK HK97101519A patent/HK1000099A1/xx not_active IP Right Cessation
- 1997-10-15 LV LVP-97-200A patent/LV12000B/lv unknown
-
2001
- 2001-05-23 LU LU90781C patent/LU90781I2/fr unknown
- 2001-06-12 NL NL300046C patent/NL300046I2/nl unknown
- 2001-10-30 NO NO2001018C patent/NO2001018I2/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 408461 Country of ref document: ES |
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| SPCF | Request for supplementary protection certificate filed |
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| SPCG | Supplementary protection certificate granted |
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