ATE144282T1 - Protein mit urate-oxidase-aktivität, dafür kodierendes rekombinantes gen, expressionsvektor, mikroorganismen und transformanten - Google Patents

Protein mit urate-oxidase-aktivität, dafür kodierendes rekombinantes gen, expressionsvektor, mikroorganismen und transformanten

Info

Publication number
ATE144282T1
ATE144282T1 AT90402023T AT90402023T ATE144282T1 AT E144282 T1 ATE144282 T1 AT E144282T1 AT 90402023 T AT90402023 T AT 90402023T AT 90402023 T AT90402023 T AT 90402023T AT E144282 T1 ATE144282 T1 AT E144282T1
Authority
AT
Austria
Prior art keywords
protein
oxidase activity
transformants
microorganisms
expression vector
Prior art date
Application number
AT90402023T
Other languages
English (en)
Inventor
Daniel Caput
Pascual Ferrara
Jean Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elizabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/fr
Priority claimed from FR8917466A external-priority patent/FR2656530B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE144282T1 publication Critical patent/ATE144282T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Glass Compositions (AREA)
AT90402023T 1989-07-13 1990-07-13 Protein mit urate-oxidase-aktivität, dafür kodierendes rekombinantes gen, expressionsvektor, mikroorganismen und transformanten ATE144282T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (fr) 1989-12-29 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.
FR9001368A FR2657785A2 (fr) 1989-12-29 1990-02-06 Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage.

Publications (1)

Publication Number Publication Date
ATE144282T1 true ATE144282T1 (de) 1996-11-15

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90402023T ATE144282T1 (de) 1989-07-13 1990-07-13 Protein mit urate-oxidase-aktivität, dafür kodierendes rekombinantes gen, expressionsvektor, mikroorganismen und transformanten

Country Status (24)

Country Link
EP (1) EP0408461B1 (de)
JP (1) JP2664804B2 (de)
AT (1) ATE144282T1 (de)
AU (1) AU636637B2 (de)
BR (1) BR9006855A (de)
CA (1) CA2035900C (de)
DE (2) DE69028884T2 (de)
DK (1) DK0408461T3 (de)
ES (1) ES2095243T3 (de)
FI (1) FI105047B (de)
GR (1) GR3022085T3 (de)
HK (1) HK1000099A1 (de)
HU (1) HU215948B (de)
IE (1) IE77158B1 (de)
IL (1) IL95057A (de)
LU (1) LU90781I2 (de)
LV (1) LV12000B (de)
MC (1) MC2145A1 (de)
NL (1) NL300046I2 (de)
NO (1) NO2001018I2 (de)
NZ (1) NZ234453A (de)
PT (1) PT94680B (de)
RU (1) RU2105812C1 (de)
WO (1) WO1991000909A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (ja) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 ウリカーゼ遺伝子およびウリカーゼの製造法
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
KR100547402B1 (ko) * 1996-09-13 2006-02-01 트랜스케리오틱 쎄러피스, 인코포레이티드 α-갈락토시다아제 Ａ 결핍을 치료하는 방법
CN102161984B (zh) 1998-08-06 2016-06-01 山景药品公司 分离四聚体尿酸氧化酶的方法
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
CA2419453C (en) 2000-08-17 2010-03-09 Ajinomoto Co., Inc. Mutant transglutaminase from streptoverticillium having modified substrate specificity
WO2003090695A2 (en) 2002-04-25 2003-11-06 Transkaryotic Therapies, Inc. TREATMENT OF α-GALACTOSIDASE A DEFICIENCY
TWI418564B (zh) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc 利用陽離子界面活性劑之蛋白質純化
WO2006110761A2 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. A variant form of urate oxidase and use thereof
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
HUE052976T2 (hu) 2005-04-11 2021-06-28 Horizon Pharma Rheumatology Llc Urát-oxidáz variáns formái és azok alkalmazása
PL2013225T3 (pl) 2006-04-12 2015-06-30 Crealta Pharmaceuticals Llc Oczyszczanie białek z zastosowaniem kationowego środka powierzchniowo czynnego
RU2443426C2 (ru) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Конъюгаты уратоксидазы, фармацевтическая композиция для снижения уровней мочевой кислоты и способ получения вышеупомянутых конъюгатов
MX347903B (es) 2009-06-25 2017-05-18 Crealta Pharmaceuticals Llc Metodos y equipos para predecir el riesgo de reaccion a la infusion y perdida de respuesta mediada por anticuerpos al supervisar el acido urico en suero durante una terapia con uricasa conjugada con peg.
CN109223707B (zh) * 2018-09-13 2020-12-08 中国药科大学 一种尿酸酶外用凝胶制剂、其制备方法及用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529675A (fr) * 1967-03-29 1968-06-21 Applic Biochimiques Soc Et Urate oxydase à haute activité et sa préparation
SU457723A1 (ru) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Штамм 313-152 - продуцент уратоксидазы
EP0423890A3 (en) * 1984-07-27 1991-07-03 Unilever Nv Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (ja) * 1988-08-17 1994-09-14 サッポロビール株式会社 ウリカーゼのｄｎａ配列および製法

Also Published As

Publication number Publication date
AU6052390A (en) 1991-02-06
IE77158B1 (en) 1997-12-03
ES2095243T3 (es) 1997-02-16
DE10199042I2 (de) 2003-10-23
HUT56884A (en) 1991-10-28
PT94680B (pt) 1997-04-30
JP2664804B2 (ja) 1997-10-22
NL300046I1 (nl) 2001-09-03
FI911212A0 (fi) 1991-03-12
DE69028884D1 (de) 1996-11-21
JPH04501807A (ja) 1992-04-02
IL95057A (en) 1997-07-13
HU906046D0 (en) 1991-07-29
RU2105812C1 (ru) 1998-02-27
BR9006855A (pt) 1991-08-06
PT94680A (pt) 1991-04-18
WO1991000909A1 (fr) 1991-01-24
LV12000B (lv) 1998-06-20
DK0408461T3 (da) 1997-03-24
LU90781I2 (fr) 2001-07-23
EP0408461A1 (de) 1991-01-16
GR3022085T3 (en) 1997-03-31
NL300046I2 (nl) 2001-12-01
FI105047B (fi) 2000-05-31
CA2035900A1 (fr) 1991-01-14
AU636637B2 (en) 1993-05-06
IL95057A0 (en) 1991-06-10
IE902559A1 (en) 1991-02-27
DE10199042I1 (de) 2002-01-10
CA2035900C (fr) 2000-01-11
DE69028884T2 (de) 1997-05-07
LV12000A (lv) 1998-03-20
NZ234453A (en) 1993-01-27
MC2145A1 (fr) 1992-02-18
HK1000099A1 (en) 1997-11-21
EP0408461B1 (de) 1996-10-16
NO2001018I2 (no) 2006-05-01
HU215948B (hu) 1999-03-29

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