DE10199042I2 - Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und Transformanten - Google Patents
Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und TransformantenInfo
- Publication number
- DE10199042I2 DE10199042I2 DE2001199042 DE10199042C DE10199042I2 DE 10199042 I2 DE10199042 I2 DE 10199042I2 DE 2001199042 DE2001199042 DE 2001199042 DE 10199042 C DE10199042 C DE 10199042C DE 10199042 I2 DE10199042 I2 DE 10199042I2
- Authority
- DE
- Germany
- Prior art keywords
- protein
- transformants
- oxidase activity
- expression vector
- gene expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Glass Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8909550A FR2649720A1 (en) | 1989-07-13 | 1989-07-13 | Recombinant gene which encodes a protein such as urate oxidase |
FR8917466A FR2656530B1 (fr) | 1989-12-29 | 1989-12-29 | Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase. |
FR9001368A FR2657785A2 (fr) | 1989-12-29 | 1990-02-06 | Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE10199042I1 DE10199042I1 (de) | 2002-01-10 |
DE10199042I2 true DE10199042I2 (de) | 2003-10-23 |
Family
ID=27251947
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69028884T Expired - Lifetime DE69028884T2 (de) | 1989-07-13 | 1990-07-13 | Protein mit Urate-Oxidase-Aktivität, dafür kodierendes rekombinantes Gen, Expressionsvektor, Mikroorganismen und Transformanten |
DE2001199042 Active DE10199042I2 (de) | 1989-07-13 | 1990-07-13 | Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und Transformanten |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69028884T Expired - Lifetime DE69028884T2 (de) | 1989-07-13 | 1990-07-13 | Protein mit Urate-Oxidase-Aktivität, dafür kodierendes rekombinantes Gen, Expressionsvektor, Mikroorganismen und Transformanten |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0408461B1 (de) |
JP (1) | JP2664804B2 (de) |
AT (1) | ATE144282T1 (de) |
AU (1) | AU636637B2 (de) |
BR (1) | BR9006855A (de) |
CA (1) | CA2035900C (de) |
DE (2) | DE69028884T2 (de) |
DK (1) | DK0408461T3 (de) |
ES (1) | ES2095243T3 (de) |
FI (1) | FI105047B (de) |
GR (1) | GR3022085T3 (de) |
HK (1) | HK1000099A1 (de) |
HU (1) | HU215948B (de) |
IE (1) | IE77158B1 (de) |
IL (1) | IL95057A (de) |
LU (1) | LU90781I2 (de) |
LV (1) | LV12000B (de) |
MC (1) | MC2145A1 (de) |
NL (1) | NL300046I2 (de) |
NO (1) | NO2001018I2 (de) |
NZ (1) | NZ234453A (de) |
PT (1) | PT94680B (de) |
RU (1) | RU2105812C1 (de) |
WO (1) | WO1991000909A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2971218B2 (ja) * | 1991-12-04 | 1999-11-02 | 協和醗酵工業株式会社 | ウリカーゼ遺伝子およびウリカーゼの製造法 |
US5691188A (en) | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
ATE286120T1 (de) * | 1996-09-13 | 2005-01-15 | Transkaryotic Therapies Inc | Therapie für alpha galactosidase a insuffizienz |
US6083725A (en) | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
CA2338665C (en) | 1998-08-06 | 2011-01-18 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
CA2419453C (en) | 2000-08-17 | 2010-03-09 | Ajinomoto Co., Inc. | Mutant transglutaminase from streptoverticillium having modified substrate specificity |
EP1503788B1 (de) | 2002-04-25 | 2011-06-29 | Shire Human Genetic Therapies, Inc. | Behandlung des alpha-galactosidase a mangels |
US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
TWI418564B (zh) * | 2005-04-11 | 2013-12-11 | Savient Pharmaceuticals Inc | 利用陽離子界面活性劑之蛋白質純化 |
EP1871877A2 (de) | 2005-04-11 | 2008-01-02 | Savient Pharmaceuticals, Inc. | Nebenform von uratoxidase und ihre verwendung |
ES2856881T3 (es) | 2005-04-11 | 2021-09-28 | Horizon Pharma Rheumatology Llc | Formas variantes de urato oxidasa y su uso |
ES2532804T3 (es) | 2006-04-12 | 2015-03-31 | Crealta Pharmaceuticals Llc | Purificación de proteínas con tensioactivo catiónico |
RU2443426C2 (ru) * | 2008-11-07 | 2012-02-27 | Мунтэн Вью Фармасьютикэлз, Инк. | Конъюгаты уратоксидазы, фармацевтическая композиция для снижения уровней мочевой кислоты и способ получения вышеупомянутых конъюгатов |
AU2010265964B2 (en) | 2009-06-25 | 2014-09-18 | Horizon Therapeutics Usa, Inc. | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy |
CN109223707B (zh) * | 2018-09-13 | 2020-12-08 | 中国药科大学 | 一种尿酸酶外用凝胶制剂、其制备方法及用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1529675A (fr) * | 1967-03-29 | 1968-06-21 | Applic Biochimiques Soc Et | Urate oxydase à haute activité et sa préparation |
SU457723A1 (ru) * | 1973-04-09 | 1977-08-05 | Всесоюзный Научно-Исследовательский Витаминный Институт | Штамм 313-152 - продуцент уратоксидазы |
EP0173378B1 (de) * | 1984-07-27 | 1991-06-12 | Unilever N.V. | Verfahren zur Herstellung von einem Polypeptid mittels eines transformierten Mikroorganismus, ein dazu geeigneter transformierter Mikroorganismus, und zur Herstellung dieser Mikroorganismen geeignete DNS Sequenzen |
WO1988008450A1 (en) * | 1987-05-01 | 1988-11-03 | Birdwell Finlayson | Gene therapy for metabolite disorders |
JPH0671428B2 (ja) * | 1988-08-17 | 1994-09-14 | サッポロビール株式会社 | ウリカーゼのdna配列および製法 |
-
1990
- 1990-07-11 NZ NZ234453A patent/NZ234453A/xx unknown
- 1990-07-12 PT PT94680A patent/PT94680B/pt not_active IP Right Cessation
- 1990-07-12 IL IL95057A patent/IL95057A/xx active IP Right Grant
- 1990-07-13 CA CA002035900A patent/CA2035900C/fr not_active Expired - Lifetime
- 1990-07-13 HU HU906046A patent/HU215948B/hu active Protection Beyond IP Right Term
- 1990-07-13 DE DE69028884T patent/DE69028884T2/de not_active Expired - Lifetime
- 1990-07-13 EP EP90402023A patent/EP0408461B1/de not_active Expired - Lifetime
- 1990-07-13 ES ES90402023T patent/ES2095243T3/es not_active Expired - Lifetime
- 1990-07-13 DK DK90402023.7T patent/DK0408461T3/da active
- 1990-07-13 WO PCT/FR1990/000532 patent/WO1991000909A1/fr active IP Right Grant
- 1990-07-13 MC MC@@@@D patent/MC2145A1/xx unknown
- 1990-07-13 BR BR909006855A patent/BR9006855A/pt not_active Application Discontinuation
- 1990-07-13 AU AU60523/90A patent/AU636637B2/en not_active Expired
- 1990-07-13 DE DE2001199042 patent/DE10199042I2/de active Active
- 1990-07-13 RU SU4895030/13A patent/RU2105812C1/ru active
- 1990-07-13 JP JP2510514A patent/JP2664804B2/ja not_active Expired - Lifetime
- 1990-07-13 AT AT90402023T patent/ATE144282T1/de active
- 1990-07-13 IE IE255990A patent/IE77158B1/en not_active IP Right Cessation
-
1991
- 1991-03-12 FI FI911212A patent/FI105047B/fi active Protection Beyond IP Right Term
-
1996
- 1996-12-18 GR GR960403531T patent/GR3022085T3/el unknown
-
1997
- 1997-07-08 HK HK97101519A patent/HK1000099A1/xx not_active IP Right Cessation
- 1997-10-15 LV LVP-97-200A patent/LV12000B/lv unknown
-
2001
- 2001-05-23 LU LU90781C patent/LU90781I2/fr unknown
- 2001-06-12 NL NL300046C patent/NL300046I2/nl unknown
- 2001-10-30 NO NO2001018C patent/NO2001018I2/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE10199042I2 (de) | Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und Transformanten | |
DE59812730D1 (de) | Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolindinderivaten | |
NO20024945D0 (no) | Ekspresjonsregulerende sekvenser og ekspresjonsprodukter | |
DK1003379T3 (da) | Hidtil ukendt phytase | |
FR2573436B1 (fr) | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins | |
FR2638643B1 (fr) | Sequence d'adn codant pour le facteur ix humain ou une proteine analogue, vecteur d'expression, cellules transformees, procede de preparation du facteur ix et produits obtenus correspondants | |
ATE153069T1 (de) | Vektoren und zusammensetzungen zur expression von glykosilationsmutanten des menschlichen proteins- c | |
DE3854456D1 (de) | Charakterisierung und Struktur der Gene für Protease A und Protease B von Streptomyces griseus. | |
ES2124694T3 (es) | Clonacion de la n-metil-hidantoinasa. | |
ATE139571T1 (de) | Rekombinante dna-expressionsvektoren und dna- zusammensetzungen, die isopenizillin n-epimerase- aktivität kodieren | |
DE3853479D1 (de) | Ausgeglichenes, konstitutives, induzierbares transkriptionssystem. | |
DE59109126D1 (de) | N-Carbamoylsarcosin-Amidohydrolase, kloniert | |
DE69830528D1 (de) | Cytochrom P450 Gen | |
ATE154074T1 (de) | Verfahren zur herstellung und reinigung des carboxyterminalen fragments der dna-polymerase i von streptococcus pneumoniae |