DE69028884T2 - Protein mit Urate-Oxidase-Aktivität, dafür kodierendes rekombinantes Gen, Expressionsvektor, Mikroorganismen und Transformanten - Google Patents

Protein mit Urate-Oxidase-Aktivität, dafür kodierendes rekombinantes Gen, Expressionsvektor, Mikroorganismen und Transformanten

Info

Publication number
DE69028884T2
DE69028884T2 DE69028884T DE69028884T DE69028884T2 DE 69028884 T2 DE69028884 T2 DE 69028884T2 DE 69028884 T DE69028884 T DE 69028884T DE 69028884 T DE69028884 T DE 69028884T DE 69028884 T2 DE69028884 T2 DE 69028884T2
Authority
DE
Germany
Prior art keywords
protein
oxidase activity
transformants
microorganisms
expression vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69028884T
Other languages
English (en)
Other versions
DE69028884D1 (de
Inventor
Daniel Caput
Pascual Ferrara
Jean Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elizabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/fr
Priority claimed from FR8917466A external-priority patent/FR2656530B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE69028884D1 publication Critical patent/DE69028884D1/de
Publication of DE69028884T2 publication Critical patent/DE69028884T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Glass Compositions (AREA)
DE69028884T 1989-07-13 1990-07-13 Protein mit Urate-Oxidase-Aktivität, dafür kodierendes rekombinantes Gen, Expressionsvektor, Mikroorganismen und Transformanten Expired - Lifetime DE69028884T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (fr) 1989-12-29 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.
FR9001368A FR2657785A2 (fr) 1989-12-29 1990-02-06 Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage.

Publications (2)

Publication Number Publication Date
DE69028884D1 DE69028884D1 (de) 1996-11-21
DE69028884T2 true DE69028884T2 (de) 1997-05-07

Family

ID=27251947

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69028884T Expired - Lifetime DE69028884T2 (de) 1989-07-13 1990-07-13 Protein mit Urate-Oxidase-Aktivität, dafür kodierendes rekombinantes Gen, Expressionsvektor, Mikroorganismen und Transformanten
DE2001199042 Active DE10199042I2 (de) 1989-07-13 1990-07-13 Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und Transformanten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2001199042 Active DE10199042I2 (de) 1989-07-13 1990-07-13 Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und Transformanten

Country Status (24)

Country Link
EP (1) EP0408461B1 (de)
JP (1) JP2664804B2 (de)
AT (1) ATE144282T1 (de)
AU (1) AU636637B2 (de)
BR (1) BR9006855A (de)
CA (1) CA2035900C (de)
DE (2) DE69028884T2 (de)
DK (1) DK0408461T3 (de)
ES (1) ES2095243T3 (de)
FI (1) FI105047B (de)
GR (1) GR3022085T3 (de)
HK (1) HK1000099A1 (de)
HU (1) HU215948B (de)
IE (1) IE77158B1 (de)
IL (1) IL95057A (de)
LU (1) LU90781I2 (de)
LV (1) LV12000B (de)
MC (1) MC2145A1 (de)
NL (1) NL300046I2 (de)
NO (1) NO2001018I2 (de)
NZ (1) NZ234453A (de)
PT (1) PT94680B (de)
RU (1) RU2105812C1 (de)
WO (1) WO1991000909A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (ja) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 ウリカーゼ遺伝子およびウリカーゼの製造法
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
CA2265464C (en) * 1996-09-13 2007-06-26 Transkaryotic Therapies, Inc. Therapy for .alpha.-galactosidase a deficiency
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
CA2728907C (en) 1998-08-06 2015-11-24 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
CA2419453C (en) 2000-08-17 2010-03-09 Ajinomoto Co., Inc. Mutant transglutaminase from streptoverticillium having modified substrate specificity
ES2367257T3 (es) 2002-04-25 2011-10-31 Shire Human Genetic Therapies, Inc. Tratamiento de deficit de alfa-galactosidasa a.
HU229626B1 (hu) 2005-04-11 2014-03-28 Savient Pharmaceuticals Urát oxidáz változat és alkalmazása
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
HU229068B1 (en) 2005-04-11 2013-07-29 Savient Pharmaceuticals Variant forms of urate oxidase and use thereof
TWI418564B (zh) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc 利用陽離子界面活性劑之蛋白質純化
KR101288027B1 (ko) 2006-04-12 2013-07-22 새비언트 파마수티컬즈 인크. 양이온 계면활성제를 이용한 단백질 정제 방법
RU2443426C2 (ru) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Конъюгаты уратоксидазы, фармацевтическая композиция для снижения уровней мочевой кислоты и способ получения вышеупомянутых конъюгатов
RU2535038C2 (ru) 2009-06-25 2014-12-10 Криэлта Фармасьютикалз ЭлЭлСи Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови
CN109223707B (zh) * 2018-09-13 2020-12-08 中国药科大学 一种尿酸酶外用凝胶制剂、其制备方法及用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529675A (fr) * 1967-03-29 1968-06-21 Applic Biochimiques Soc Et Urate oxydase à haute activité et sa préparation
SU457723A1 (ru) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Штамм 313-152 - продуцент уратоксидазы
CA1341130C (en) * 1984-07-27 2000-10-31 Adrianus Marinus Ledeboer Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (ja) * 1988-08-17 1994-09-14 サッポロビール株式会社 ウリカーゼのｄｎａ配列および製法

Also Published As

Publication number Publication date
EP0408461A1 (de) 1991-01-16
AU636637B2 (en) 1993-05-06
ATE144282T1 (de) 1996-11-15
FI911212A0 (fi) 1991-03-12
IE902559A1 (en) 1991-02-27
HU215948B (hu) 1999-03-29
PT94680A (pt) 1991-04-18
DE10199042I1 (de) 2002-01-10
CA2035900C (fr) 2000-01-11
RU2105812C1 (ru) 1998-02-27
FI105047B (fi) 2000-05-31
CA2035900A1 (fr) 1991-01-14
GR3022085T3 (en) 1997-03-31
LV12000B (lv) 1998-06-20
HU906046D0 (en) 1991-07-29
DE69028884D1 (de) 1996-11-21
BR9006855A (pt) 1991-08-06
HUT56884A (en) 1991-10-28
NL300046I2 (nl) 2001-12-01
LV12000A (lv) 1998-03-20
NO2001018I2 (no) 2006-05-01
ES2095243T3 (es) 1997-02-16
PT94680B (pt) 1997-04-30
LU90781I2 (fr) 2001-07-23
JPH04501807A (ja) 1992-04-02
WO1991000909A1 (fr) 1991-01-24
NZ234453A (en) 1993-01-27
NL300046I1 (nl) 2001-09-03
MC2145A1 (fr) 1992-02-18
IE77158B1 (en) 1997-12-03
DK0408461T3 (da) 1997-03-24
HK1000099A1 (en) 1997-11-21
IL95057A0 (en) 1991-06-10
EP0408461B1 (de) 1996-10-16
AU6052390A (en) 1991-02-06
IL95057A (en) 1997-07-13
DE10199042I2 (de) 2003-10-23
JP2664804B2 (ja) 1997-10-22

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