DE69925721T2 - Verfahren zur herstellung eines geschützten 4-aminomethyl-pyrrolidin-3-ons - Google Patents
Verfahren zur herstellung eines geschützten 4-aminomethyl-pyrrolidin-3-ons Download PDFInfo
- Publication number
- DE69925721T2 DE69925721T2 DE69925721T DE69925721T DE69925721T2 DE 69925721 T2 DE69925721 T2 DE 69925721T2 DE 69925721 T DE69925721 T DE 69925721T DE 69925721 T DE69925721 T DE 69925721T DE 69925721 T2 DE69925721 T2 DE 69925721T2
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compound
- group
- butoxycarbonyl
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 **(CC1=*ICC2=C*2)CC1=O Chemical compound **(CC1=*ICC2=C*2)CC1=O 0.000 description 6
- GRIDUIXYSLSGIC-UHFFFAOYSA-N N#CC(CN(C1)P)C1=O Chemical compound N#CC(CN(C1)P)C1=O GRIDUIXYSLSGIC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR19980007079 | 1998-03-04 | ||
| KR7007998 | 1998-03-04 | ||
| KR4363698 | 1998-10-19 | ||
| KR1019980043636A KR100286874B1 (ko) | 1998-03-04 | 1998-10-19 | 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법 |
| PCT/KR1999/000099 WO1999044991A1 (en) | 1998-03-04 | 1999-03-04 | Process for preparing a protected 4-aminomethyl-pyrrolidin-3-one |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69925721D1 DE69925721D1 (de) | 2005-07-14 |
| DE69925721T2 true DE69925721T2 (de) | 2006-03-23 |
Family
ID=26633492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69925721T Expired - Lifetime DE69925721T2 (de) | 1998-03-04 | 1999-03-04 | Verfahren zur herstellung eines geschützten 4-aminomethyl-pyrrolidin-3-ons |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6307059B1 (enExample) |
| EP (1) | EP1068182B1 (enExample) |
| JP (1) | JP3374155B2 (enExample) |
| KR (1) | KR100286874B1 (enExample) |
| CN (1) | CN1149192C (enExample) |
| AP (1) | AP1305A (enExample) |
| AT (1) | ATE297379T1 (enExample) |
| AU (1) | AU742497B2 (enExample) |
| BG (1) | BG64674B1 (enExample) |
| BR (1) | BRPI9908472B8 (enExample) |
| CA (1) | CA2322540C (enExample) |
| CZ (1) | CZ301011B6 (enExample) |
| DE (1) | DE69925721T2 (enExample) |
| EA (1) | EA002499B1 (enExample) |
| ES (1) | ES2242382T3 (enExample) |
| HU (1) | HU228309B1 (enExample) |
| ID (1) | ID25901A (enExample) |
| IL (1) | IL137828A0 (enExample) |
| IN (1) | IN190979B (enExample) |
| IS (1) | IS2296B (enExample) |
| NO (1) | NO317258B1 (enExample) |
| NZ (2) | NZ506312A (enExample) |
| OA (1) | OA11482A (enExample) |
| PT (1) | PT1068182E (enExample) |
| SK (1) | SK285595B6 (enExample) |
| TR (3) | TR200101801T2 (enExample) |
| TW (1) | TW453993B (enExample) |
| UA (1) | UA71907C2 (enExample) |
| WO (1) | WO1999044991A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA24500A1 (fr) * | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | Derive du sel d'acide carboxylique de naphthyridine . |
| US20020032216A1 (en) * | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
| GB9820405D0 (en) | 1998-09-18 | 1998-11-11 | Smithkline Beecham Plc | Process |
| GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
| GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
| KR20020018560A (ko) * | 2000-09-01 | 2002-03-08 | 성재갑 | 3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법 |
| PT1412078E (pt) * | 2001-08-02 | 2009-01-08 | Lg Life Sciences Ltd | Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal |
| PL369531A1 (en) * | 2001-09-26 | 2005-05-02 | Bayer Pharmaceuticals Corporation | 1,8-naphthyridine derivatives as antidiabetics |
| KR100517638B1 (ko) * | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
| KR100515591B1 (ko) * | 2003-02-12 | 2005-09-16 | 주식회사 엘지화학 | 4[Ｎ-(ｔ-부톡시카르보닐)아미노)메틸렌]-1-Ｎ-(ｔ-부톡시카르보닌)피롤리돈-3-온의 제조방법 |
| KR100653334B1 (ko) * | 2003-03-07 | 2006-12-04 | 주식회사 엘지생명과학 | 4-아미노메틸-3-알콕시이미노피롤리딘 메탄설폰산염의 신규한 제조 방법 |
| DE102004010943A1 (de) * | 2004-03-03 | 2005-09-29 | Degussa Ag | Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten |
| US7185495B2 (en) * | 2004-09-07 | 2007-03-06 | General Electric Company | System and method for improving thermal efficiency of dry low emissions combustor assemblies |
| CN104693088B (zh) * | 2013-12-06 | 2018-01-05 | 常州市勇毅生物药业有限公司 | 一种吉米沙星侧链的制备方法 |
| CN106349083A (zh) * | 2016-08-26 | 2017-01-25 | 大连奇凯医药科技有限公司 | 2,4,6‑三氟苯甲胺的制备方法 |
| KR102233456B1 (ko) | 2017-05-31 | 2021-03-29 | 주식회사 대웅제약 | 4-메톡시피롤 유도체의 중간체 제조 방법 |
| CN113773240B (zh) * | 2021-10-12 | 2022-05-31 | 北京阳光诺和药物研究股份有限公司 | 吉米沙星侧链化合物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3309368A (en) | 1965-11-19 | 1967-03-14 | American Cyanamid Co | Substituted isoxazoles and methods of preparing the same |
| US5137892A (en) * | 1990-12-12 | 1992-08-11 | Abbott Laboratories | Quinoline, naphthyridine and pyridobenzoxazine derivatives |
| JPH0673056A (ja) * | 1992-08-26 | 1994-03-15 | Kaken Pharmaceut Co Ltd | キノリンカルボン酸誘導体およびその塩 |
| DK0688772T3 (da) * | 1994-06-16 | 1999-11-01 | Lg Chemical Ltd | Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling |
-
1998
- 1998-10-19 KR KR1019980043636A patent/KR100286874B1/ko not_active Expired - Lifetime
-
1999
- 1999-03-02 TW TW088103118A patent/TW453993B/zh not_active IP Right Cessation
- 1999-03-03 IN IN361DE1999 patent/IN190979B/en unknown
- 1999-03-04 CN CNB998034827A patent/CN1149192C/zh not_active Expired - Lifetime
- 1999-03-04 WO PCT/KR1999/000099 patent/WO1999044991A1/en not_active Ceased
- 1999-03-04 CZ CZ20003109A patent/CZ301011B6/cs not_active IP Right Cessation
- 1999-03-04 NZ NZ506312A patent/NZ506312A/en not_active IP Right Cessation
- 1999-03-04 BR BRPI9908472A patent/BRPI9908472B8/pt not_active IP Right Cessation
- 1999-03-04 AT AT99906566T patent/ATE297379T1/de active
- 1999-03-04 DE DE69925721T patent/DE69925721T2/de not_active Expired - Lifetime
- 1999-03-04 EA EA200000900A patent/EA002499B1/ru not_active IP Right Cessation
- 1999-03-04 JP JP2000534535A patent/JP3374155B2/ja not_active Expired - Fee Related
- 1999-03-04 TR TR2001/01801T patent/TR200101801T2/xx unknown
- 1999-03-04 ID IDW20001694A patent/ID25901A/id unknown
- 1999-03-04 TR TR2001/01800T patent/TR200101800T2/xx unknown
- 1999-03-04 US US09/623,214 patent/US6307059B1/en not_active Expired - Lifetime
- 1999-03-04 NZ NZ516778A patent/NZ516778A/xx not_active IP Right Cessation
- 1999-03-04 ES ES99906566T patent/ES2242382T3/es not_active Expired - Lifetime
- 1999-03-04 HU HU0101094A patent/HU228309B1/hu not_active IP Right Cessation
- 1999-03-04 EP EP99906566A patent/EP1068182B1/en not_active Expired - Lifetime
- 1999-03-04 AU AU26433/99A patent/AU742497B2/en not_active Ceased
- 1999-03-04 TR TR2000/02526T patent/TR200002526T2/xx unknown
- 1999-03-04 SK SK1299-2000A patent/SK285595B6/sk not_active IP Right Cessation
- 1999-03-04 PT PT99906566T patent/PT1068182E/pt unknown
- 1999-03-04 CA CA002322540A patent/CA2322540C/en not_active Expired - Lifetime
- 1999-03-04 AP APAP/P/2000/001890A patent/AP1305A/en active
- 1999-03-04 IL IL13782899A patent/IL137828A0/xx active IP Right Grant
- 1999-04-03 UA UA2000095149A patent/UA71907C2/uk unknown
-
2000
- 2000-08-22 IS IS5600A patent/IS2296B/is unknown
- 2000-08-25 NO NO20004288A patent/NO317258B1/no not_active IP Right Cessation
- 2000-09-01 OA OA1200000237A patent/OA11482A/en unknown
- 2000-09-14 BG BG104767A patent/BG64674B1/bg unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |