DE69915858T2 - Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung - Google Patents
Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung Download PDFInfo
- Publication number
- DE69915858T2 DE69915858T2 DE69915858T DE69915858T DE69915858T2 DE 69915858 T2 DE69915858 T2 DE 69915858T2 DE 69915858 T DE69915858 T DE 69915858T DE 69915858 T DE69915858 T DE 69915858T DE 69915858 T2 DE69915858 T2 DE 69915858T2
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- Germany
- Prior art keywords
- microspheres
- polyvinyl alcohol
- cell adhesion
- cross
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000004372 Polyvinyl alcohol Substances 0.000 title claims abstract description 202
- 239000004005 microsphere Substances 0.000 title claims abstract description 164
- 238000000034 method Methods 0.000 title claims abstract description 72
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims abstract description 201
- 230000010102 embolization Effects 0.000 claims abstract description 46
- 229940102213 injectable suspension Drugs 0.000 claims abstract description 36
- 230000008569 process Effects 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 241000124008 Mammalia Species 0.000 claims abstract description 11
- 238000013162 therapeutic embolization Methods 0.000 claims abstract description 11
- 230000000069 prophylactic effect Effects 0.000 claims abstract description 10
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- 239000002318 adhesion promoter Substances 0.000 claims description 26
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- A61K9/1629—Organic macromolecular compounds
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
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-
1998
- 1998-10-16 FR FR9813019A patent/FR2784580B1/fr not_active Expired - Fee Related
-
1999
- 1999-10-15 JP JP2000576829A patent/JP4467799B2/ja not_active Expired - Lifetime
- 1999-10-15 AT AT99953858T patent/ATE262319T1/de not_active IP Right Cessation
- 1999-10-15 WO PCT/EP1999/007846 patent/WO2000023054A1/en not_active Ceased
- 1999-10-15 DE DE69915858T patent/DE69915858T2/de not_active Expired - Lifetime
- 1999-10-15 AU AU10396/00A patent/AU1039600A/en not_active Abandoned
- 1999-10-15 US US09/419,114 patent/US6680046B1/en not_active Expired - Lifetime
- 1999-10-15 EP EP99953858A patent/EP1128816B1/en not_active Revoked
- 1999-10-15 ES ES99953858T patent/ES2219072T3/es not_active Expired - Lifetime
- 1999-10-15 CA CA002345205A patent/CA2345205A1/en not_active Abandoned
-
2003
- 2003-10-27 US US10/692,785 patent/US7591993B2/en not_active Expired - Fee Related
-
2009
- 2009-01-05 US US12/348,867 patent/US7670592B2/en not_active Expired - Fee Related
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2010
- 2010-01-12 US US12/686,320 patent/US8673266B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7670592B2 (en) | 2010-03-02 |
| DE69915858D1 (de) | 2004-04-29 |
| JP2002527206A (ja) | 2002-08-27 |
| ATE262319T1 (de) | 2004-04-15 |
| JP4467799B2 (ja) | 2010-05-26 |
| US8673266B2 (en) | 2014-03-18 |
| FR2784580A1 (fr) | 2000-04-21 |
| FR2784580B1 (fr) | 2004-06-25 |
| EP1128816A1 (en) | 2001-09-05 |
| ES2219072T3 (es) | 2004-11-16 |
| US20090117196A1 (en) | 2009-05-07 |
| US20040091425A1 (en) | 2004-05-13 |
| CA2345205A1 (en) | 2000-04-27 |
| EP1128816B1 (en) | 2004-03-24 |
| US20100119572A1 (en) | 2010-05-13 |
| AU1039600A (en) | 2000-05-08 |
| US7591993B2 (en) | 2009-09-22 |
| WO2000023054A1 (en) | 2000-04-27 |
| US6680046B1 (en) | 2004-01-20 |
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