CA2345205A1 - Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same - Google Patents
Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same Download PDFInfo
- Publication number
- CA2345205A1 CA2345205A1 CA002345205A CA2345205A CA2345205A1 CA 2345205 A1 CA2345205 A1 CA 2345205A1 CA 002345205 A CA002345205 A CA 002345205A CA 2345205 A CA2345205 A CA 2345205A CA 2345205 A1 CA2345205 A1 CA 2345205A1
- Authority
- CA
- Canada
- Prior art keywords
- microspheres
- polyvinylalcohol
- agent
- cell adhesion
- crosslinked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000004372 Polyvinyl alcohol Substances 0.000 title claims abstract description 180
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- 230000001225 therapeutic effect Effects 0.000 title description 5
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims abstract description 179
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR98/13019 | 1998-10-16 | ||
| FR9813019A FR2784580B1 (fr) | 1998-10-16 | 1998-10-16 | Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci |
| PCT/EP1999/007846 WO2000023054A1 (en) | 1998-10-16 | 1999-10-15 | Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2345205A1 true CA2345205A1 (en) | 2000-04-27 |
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|---|---|---|---|
| CA002345205A Abandoned CA2345205A1 (en) | 1998-10-16 | 1999-10-15 | Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same |
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|---|---|
| US (4) | US6680046B1 (enExample) |
| EP (1) | EP1128816B1 (enExample) |
| JP (1) | JP4467799B2 (enExample) |
| AT (1) | ATE262319T1 (enExample) |
| AU (1) | AU1039600A (enExample) |
| CA (1) | CA2345205A1 (enExample) |
| DE (1) | DE69915858T2 (enExample) |
| ES (1) | ES2219072T3 (enExample) |
| FR (1) | FR2784580B1 (enExample) |
| WO (1) | WO2000023054A1 (enExample) |
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| US6660301B1 (en) | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
| FR2784580B1 (fr) | 1998-10-16 | 2004-06-25 | Biosepra Inc | Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci |
| ES2295021T3 (es) * | 1999-03-25 | 2008-04-16 | Metabolix, Inc. | Utilizacion y aplicaciones medicas de polimeros de poli(hidroxialcanoatos). |
| WO2001066016A1 (en) * | 2000-03-06 | 2001-09-13 | Scimed Life Systems, Inc. | Embolic agents visible under ultrasound |
| CA2402773C (en) | 2000-03-13 | 2011-10-11 | Biocure, Inc. | Tissue bulking and coating compositions |
| US6652883B2 (en) | 2000-03-13 | 2003-11-25 | Biocure, Inc. | Tissue bulking and coating compositions |
| WO2001068720A1 (en) * | 2000-03-13 | 2001-09-20 | Biocure, Inc. | Embolic compositions |
| AU2001249221A1 (en) | 2000-03-20 | 2001-10-03 | Biosphere Medical, Inc. | Injectable and swellable microspheres for tissue bulking |
| US6436424B1 (en) | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| US7338657B2 (en) * | 2001-03-15 | 2008-03-04 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
| US20030212022A1 (en) * | 2001-03-23 | 2003-11-13 | Jean-Marie Vogel | Compositions and methods for gene therapy |
| EP2286799B1 (en) | 2000-03-24 | 2015-07-29 | Biosphere Medical, Inc. | Microspheres for active embolization |
| US20040266983A1 (en) * | 2000-08-17 | 2004-12-30 | Reeve Lorraine E | Purified polyoxyalkylene block copolymers |
| US9080146B2 (en) * | 2001-01-11 | 2015-07-14 | Celonova Biosciences, Inc. | Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface |
| IL160799A0 (en) | 2001-09-12 | 2004-08-31 | Virexx Medical Corp | Vascular occlusion solid-phase agent with immobilised platelet binding agent |
| US7094369B2 (en) | 2002-03-29 | 2006-08-22 | Scimed Life Systems, Inc. | Processes for manufacturing polymeric microspheres |
| US7131997B2 (en) | 2002-03-29 | 2006-11-07 | Scimed Life Systems, Inc. | Tissue treatment |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| US7053134B2 (en) * | 2002-04-04 | 2006-05-30 | Scimed Life Systems, Inc. | Forming a chemically cross-linked particle of a desired shape and diameter |
| EP1511522B1 (en) * | 2002-06-12 | 2011-08-10 | Boston Scientific Limited | Bulking agents |
| US20080226723A1 (en) * | 2002-07-05 | 2008-09-18 | Celonova Biosciences, Inc. | Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same |
| US7449236B2 (en) | 2002-08-09 | 2008-11-11 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US7842377B2 (en) * | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
| US7883490B2 (en) * | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
| US7588825B2 (en) | 2002-10-23 | 2009-09-15 | Boston Scientific Scimed, Inc. | Embolic compositions |
| AU2003285905A1 (en) * | 2002-11-04 | 2004-06-07 | Biosphere Medical, Inc. | Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same |
| ES2298724T3 (es) * | 2003-02-21 | 2008-05-16 | Biocompatibles Uk Limited | Suministro de un ains a partir de agentes embolicos. |
| AU2004224439B2 (en) * | 2003-03-24 | 2010-07-15 | Genzyme Corporation | Temporary embolization using inverse thermosensitive polymers |
| JP2004313759A (ja) * | 2003-03-31 | 2004-11-11 | Toray Ind Inc | 血管塞栓材料 |
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| US6911219B2 (en) | 2001-09-27 | 2005-06-28 | Surgica Corporation | Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them |
| EP2484344B1 (en) | 2005-05-09 | 2016-02-10 | Biosphere Medical, S.A. | Compositions and methods of using microspheres and non-ionic contrast agents |
| EP1986706B1 (en) | 2006-01-30 | 2011-08-17 | Biosphere Medical, Inc. | Porous intravascular embolization particles and methods of making them |
| US20080033366A1 (en) | 2006-01-30 | 2008-02-07 | Surgica Corporation | Compressible intravascular embolization particles and related methods and delivery systems |
-
1998
- 1998-10-16 FR FR9813019A patent/FR2784580B1/fr not_active Expired - Fee Related
-
1999
- 1999-10-15 AU AU10396/00A patent/AU1039600A/en not_active Abandoned
- 1999-10-15 JP JP2000576829A patent/JP4467799B2/ja not_active Expired - Lifetime
- 1999-10-15 EP EP99953858A patent/EP1128816B1/en not_active Revoked
- 1999-10-15 CA CA002345205A patent/CA2345205A1/en not_active Abandoned
- 1999-10-15 US US09/419,114 patent/US6680046B1/en not_active Expired - Lifetime
- 1999-10-15 DE DE69915858T patent/DE69915858T2/de not_active Expired - Lifetime
- 1999-10-15 ES ES99953858T patent/ES2219072T3/es not_active Expired - Lifetime
- 1999-10-15 AT AT99953858T patent/ATE262319T1/de not_active IP Right Cessation
- 1999-10-15 WO PCT/EP1999/007846 patent/WO2000023054A1/en not_active Ceased
-
2003
- 2003-10-27 US US10/692,785 patent/US7591993B2/en not_active Expired - Fee Related
-
2009
- 2009-01-05 US US12/348,867 patent/US7670592B2/en not_active Expired - Fee Related
-
2010
- 2010-01-12 US US12/686,320 patent/US8673266B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6680046B1 (en) | 2004-01-20 |
| DE69915858T2 (de) | 2005-03-03 |
| FR2784580A1 (fr) | 2000-04-21 |
| FR2784580B1 (fr) | 2004-06-25 |
| DE69915858D1 (de) | 2004-04-29 |
| JP4467799B2 (ja) | 2010-05-26 |
| EP1128816B1 (en) | 2004-03-24 |
| ES2219072T3 (es) | 2004-11-16 |
| US20100119572A1 (en) | 2010-05-13 |
| WO2000023054A1 (en) | 2000-04-27 |
| EP1128816A1 (en) | 2001-09-05 |
| US7670592B2 (en) | 2010-03-02 |
| US20090117196A1 (en) | 2009-05-07 |
| JP2002527206A (ja) | 2002-08-27 |
| US7591993B2 (en) | 2009-09-22 |
| ATE262319T1 (de) | 2004-04-15 |
| AU1039600A (en) | 2000-05-08 |
| US8673266B2 (en) | 2014-03-18 |
| US20040091425A1 (en) | 2004-05-13 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20021015 |