ATE262319T1 - Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung - Google Patents

Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung

Info

Publication number
ATE262319T1
ATE262319T1 AT99953858T AT99953858T ATE262319T1 AT E262319 T1 ATE262319 T1 AT E262319T1 AT 99953858 T AT99953858 T AT 99953858T AT 99953858 T AT99953858 T AT 99953858T AT E262319 T1 ATE262319 T1 AT E262319T1
Authority
AT
Austria
Prior art keywords
microspheres
present
production
polyvinyl alcohol
relates
Prior art date
Application number
AT99953858T
Other languages
German (de)
English (en)
Inventor
Egisto Boschetti
Original Assignee
Biosphere Medical S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33462605&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE262319(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biosphere Medical S A filed Critical Biosphere Medical S A
Application granted granted Critical
Publication of ATE262319T1 publication Critical patent/ATE262319T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99953858T 1998-10-16 1999-10-15 Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung ATE262319T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9813019A FR2784580B1 (fr) 1998-10-16 1998-10-16 Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
PCT/EP1999/007846 WO2000023054A1 (en) 1998-10-16 1999-10-15 Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same

Publications (1)

Publication Number Publication Date
ATE262319T1 true ATE262319T1 (de) 2004-04-15

Family

ID=33462605

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99953858T ATE262319T1 (de) 1998-10-16 1999-10-15 Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung

Country Status (10)

Country Link
US (4) US6680046B1 (enExample)
EP (1) EP1128816B1 (enExample)
JP (1) JP4467799B2 (enExample)
AT (1) ATE262319T1 (enExample)
AU (1) AU1039600A (enExample)
CA (1) CA2345205A1 (enExample)
DE (1) DE69915858T2 (enExample)
ES (1) ES2219072T3 (enExample)
FR (1) FR2784580B1 (enExample)
WO (1) WO2000023054A1 (enExample)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
EP1163019B1 (en) * 1999-03-25 2007-10-24 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
EP1263325B1 (en) * 2000-03-06 2009-07-01 Boston Scientific Limited Embolic agents visible under ultrasound
EP1263803B1 (en) * 2000-03-13 2007-09-19 BioCure, Inc. Embolic compositions
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
WO2001068722A1 (en) 2000-03-13 2001-09-20 Biocure, Inc. Hydrogel biomedical articles
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
AU2001249221A1 (en) 2000-03-20 2001-10-03 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
EP1267839B1 (en) * 2000-03-24 2007-10-03 Biosphere Medical, Inc. Microspheres for active embolization
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
US20040266983A1 (en) * 2000-08-17 2004-12-30 Reeve Lorraine E Purified polyoxyalkylene block copolymers
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
KR100786907B1 (ko) 2001-09-12 2007-12-17 바이렉스 메디칼 코포레이션 고정화된 혈소판 결합제를 갖는 혈관 폐색 고형상 제제
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7131997B2 (en) * 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
CA2492339A1 (en) * 2002-06-12 2003-12-24 Boston Scientific Limited Bulking agents
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7588825B2 (en) * 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
CA2507404A1 (en) * 2002-11-04 2004-05-21 Biosphere Medical Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same
WO2004073688A1 (en) * 2003-02-21 2004-09-02 Biocompatibles Uk Limited Drug delivery from embolic agents
CN1794980A (zh) * 2003-03-24 2006-06-28 生物领域医疗公司 利用逆向热敏聚合物的暂时栓塞
JP2004313759A (ja) * 2003-03-31 2004-11-11 Toray Ind Inc 血管塞栓材料
ES2819189T3 (es) 2003-05-08 2021-04-15 Tepha Inc Tejidos y fibras médicos de polihidroxialcanoato
US20050025809A1 (en) * 2003-07-08 2005-02-03 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
WO2005020825A1 (en) * 2003-08-22 2005-03-10 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
WO2005018600A2 (en) * 2003-08-22 2005-03-03 Cube Medical A/S Method of treating a patient suffering from a solid tumour
US7976823B2 (en) * 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7901770B2 (en) * 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7700086B2 (en) * 2003-11-06 2010-04-20 Pluromed, Inc. Internal clamp for surgical procedures
US7736671B2 (en) * 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US20050238870A1 (en) * 2004-04-22 2005-10-27 Marcia Buiser Embolization
JP4655505B2 (ja) * 2004-04-28 2011-03-23 東レ株式会社 架橋生分解性粒子およびその製造方法
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
WO2006004941A2 (en) 2004-06-29 2006-01-12 Biocure, Inc. Biomaterial
EP2221069B1 (en) * 2004-08-03 2012-05-09 Tepha, Inc. Non-curling polyhydroxyalkanoate sutures
US20070258939A1 (en) * 2004-08-03 2007-11-08 Biocamparibles Uk Limited Drug Delivery from Embolic Agents
US20070281028A1 (en) * 2004-08-04 2007-12-06 Biocompatibles Uk Limited Drug Delivery of a Cox Inhibitor from Embolic Agents
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
KR101153785B1 (ko) 2004-10-25 2012-07-09 셀로노바 바이오사이언시스 저머니 게엠베하 치료 및/또는 진단용으로 부가할 수 있는 중합체 입자 및이의 제조 및 사용 방법
US9114162B2 (en) * 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US8663225B2 (en) * 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) * 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) * 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
MX2007013914A (es) 2005-05-09 2008-02-22 Biosphere Medical S A Composiciones y metodos que usan microesferas y agentes de contraste no ionicos.
US20070004973A1 (en) * 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
EP1900381A4 (en) 2005-07-01 2012-01-11 Nippon Synthetic Chem Ind PVA PARTICLES FOR THE USE IN THE TEMPORARY EMBOLIZATION OF A BLOOD VESSEL, METHOD OF MANUFACTURING THEREOF AND ACTIVE FOR THE TEMPORARY EMBOLIZATION OF A BLOOD VESSEL
US20070083219A1 (en) * 2005-10-12 2007-04-12 Buiser Marcia S Embolic coil introducer sheath locking mechanisms
US8007509B2 (en) * 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US20070093907A1 (en) * 2005-10-26 2007-04-26 Goupil Dennis W Hydrogel spinal disc implants with swellable articles
US8152839B2 (en) * 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US20070142859A1 (en) * 2005-12-19 2007-06-21 Boston Scientific Scimed, Inc. Embolic coils
US7501179B2 (en) * 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) * 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US20070142560A1 (en) * 2005-12-21 2007-06-21 Young-Ho Song Block copolymer particles
JP5075130B2 (ja) * 2006-01-24 2012-11-14 バイオコンパティブルズ ユーケー リミテッド ポリマー粒子を薬物で負荷する方法
EP1986707A2 (en) * 2006-01-30 2008-11-05 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
WO2007090130A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Porous intravascular embolization particles and related methods
US7838035B2 (en) 2006-04-11 2010-11-23 E. I. Du Pont De Nemours And Company Microsphere powder of high density, swellable, deformable, durable occlusion-forming microspheres
US8062673B2 (en) 2006-04-11 2011-11-22 E I Du Pont De Nemours And Company Process for embolization using swellable and deformable microspheres
US8252339B2 (en) 2006-04-11 2012-08-28 Massachusetts Institute Of Technology Medical treatment applications of swellable and deformable microspheres
US7794755B2 (en) 2006-04-11 2010-09-14 E.I. Du Pont De Nemours And Company Process for preparation of swellable and deformable microspheres
US20070299461A1 (en) * 2006-06-21 2007-12-27 Boston Scientific Scimed, Inc. Embolic coils and related components, systems, and methods
WO2008014065A1 (en) * 2006-07-27 2008-01-31 Boston Scientific Limited Particles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20080145658A1 (en) * 2006-12-15 2008-06-19 Boston Scientific Scimed, Inc. Freeze Thaw Methods For Making Polymer Particles
WO2009046281A2 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Injectable particles
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US8114436B2 (en) 2008-03-25 2012-02-14 Boston Scientific Scimed, Inc. Compositions and methods for delivery of embolics
CN102143996A (zh) * 2008-10-30 2011-08-03 大卫·刘 微球形多孔可生物相容支架及制造该支架的方法和装置
KR101386799B1 (ko) * 2009-10-06 2014-04-21 리전츠 오브 더 유니버스티 오브 미네소타 생분해성 색전술용 미소구체
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
GB201008843D0 (en) * 2010-05-27 2010-07-14 Aubin Ltd Method and composition
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
CN101885852B (zh) * 2010-07-07 2012-01-11 天津大学 表面光滑明胶微球与制备方法
WO2012050879A2 (en) * 2010-09-29 2012-04-19 Scion Cardio-Vascular, Inc. Methods for processing microspheres, microspheres processed thereby, and uses thereof
EP2646000B1 (en) 2010-11-29 2015-04-29 Centre Hospitalier Universitaire Vaudois Chemoembolization composition comprising anti-angiogenic agents
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
IT1404015B1 (it) * 2011-02-04 2013-11-08 Hsd Holding Smart Device S R L Uso di un polimero di destrano reticolato come filtro contro l'inalazione di sostanze nocive per la salute
CN102492178B (zh) * 2011-11-29 2014-12-24 中国科学院过程工程研究所 一种尺寸均一的魔芋葡甘聚糖微球及其制备方法
EP3984556B8 (en) 2012-06-14 2025-07-09 Microvention, Inc. Polymeric treatment compositions
CN104717983B (zh) 2012-10-15 2018-09-18 微仙美国有限公司 聚合治疗组合物
US8936795B2 (en) 2012-12-19 2015-01-20 Regents Of The University Of Minnesota Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose
EP2968165B1 (en) 2013-03-13 2023-09-13 Biosphere Medical, Inc. Compositions and associated methods for radioisotope-binding microparticles
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
US9408916B2 (en) 2013-09-19 2016-08-09 Microvention, Inc. Polymer films
EP3046952B1 (en) 2013-09-19 2021-05-12 Terumo Corporation Polymer particles
US9688788B2 (en) 2013-11-08 2017-06-27 Terumo Corporation Polymer particles
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
CA2969429C (en) 2014-12-11 2020-10-27 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
US10517910B2 (en) * 2015-06-19 2019-12-31 Sillajen, Inc. Compositions and methods for viral embolization
CN105148327B (zh) * 2015-07-29 2019-07-12 广东博与再生医学有限公司 一种多糖-聚乙烯醇栓塞微球的制备方法
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
JP2019518428A (ja) * 2016-04-12 2019-07-04 ユニシテ エーファウ アクチェンゲゼルシャフト 体液試料からの細胞外小胞(ev)の単離
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
KR102162370B1 (ko) 2016-09-28 2020-10-06 테루모 가부시키가이샤 중합체 입자
EA038657B1 (ru) * 2016-10-12 2021-09-29 Общество С Ограниченной Ответственностью "Технология Лекарств" Химиоэмболизирующие частицы для лечения солидных опухолей
CN111200976B (zh) 2017-10-09 2023-07-07 微仙美国有限公司 放射性液体栓塞
CN108744020A (zh) * 2018-06-12 2018-11-06 杭州艾力康医药科技有限公司 一种离子交换型聚乙烯醇微球的制备方法
US12043706B2 (en) 2018-11-21 2024-07-23 Kuraray Co., Ltd. Monodisperse hydrogel particles
JP2023507044A (ja) * 2019-06-19 2023-02-20 ザイロ セラピューティクス,インコーポレーテッド 医薬品および化粧用途のための一酸化窒素担体としての硫黄官能化モノリスおよびそれに由来する粒子
JPWO2021166746A1 (enExample) * 2020-02-18 2021-08-26
CN114159554B (zh) * 2021-11-22 2022-12-13 广州优理氏生物科技有限公司 一种纤连蛋白-聚乙烯醇微球的制备方法及其应用
CN114642640B (zh) * 2022-05-23 2022-09-16 杭州旸顺医疗科技有限公司 微球及其制备方法、制备系统
CN120769874A (zh) 2023-02-22 2025-10-10 株式会社可乐丽 干燥水凝胶形成性物品、水凝胶、和干燥水凝胶形成性物品的制造方法
WO2024182477A2 (en) * 2023-02-28 2024-09-06 Medstar Health, Inc. Angiogenesis inhibitors coupled to embolic microparticles
CN116159178B (zh) * 2023-04-18 2023-07-04 上海汇禾医疗器械有限公司 一种小粒径栓塞微球及其制备方法

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US499188A (en) * 1893-06-06 Territory
US3919411A (en) 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant
JPS49108168A (enExample) 1973-02-16 1974-10-15
JPS49108158A (enExample) 1973-02-19 1974-10-15
JPS5350290A (en) 1976-10-18 1978-05-08 Sumitomo Chem Co Ltd Preparation f hydrogel
CA1134977A (en) * 1978-09-07 1982-11-02 Sumitomo Chemical Co., Ltd. Method for preparing highly absorbent polymers
US4314032A (en) * 1978-10-26 1982-02-02 Kureha Kagaku Kogyo Kabushiki Kaisha Crosslinked polyvinyl alcohol gel
US4268495A (en) 1979-01-08 1981-05-19 Ethicon, Inc. Injectable embolization and occlusion solution
US4306031A (en) * 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
GB2088392B (en) * 1980-12-03 1984-05-02 Sumitomo Chemical Co Production of hydrogels
JPS57128709A (en) 1981-02-03 1982-08-10 Sumitomo Chem Co Ltd Preparation of hydrogel
CA1225585A (en) 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
GB8418772D0 (en) 1984-07-24 1984-08-30 Geistlich Soehne Ag Chemical substances
US5186922A (en) * 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
US4680171A (en) * 1985-03-15 1987-07-14 William Shell Visualization of a bloodstream circulation with biodegradable microspheres
WO1987000062A1 (en) 1985-07-02 1987-01-15 Target Therapeutics Vaso-occlusive collagen composition and method
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
JPS6317904A (ja) * 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd 多孔質架橋ポリビニルアルコ−ル粒子の製造法
CA1329800C (en) * 1987-12-29 1994-05-24 Hiroaki Takayanagi Composite separating agent
GB8813425D0 (en) 1988-06-07 1988-07-13 Hall L D Magnetic resonance imaging
JPH064713B2 (ja) * 1988-07-22 1994-01-19 テルモ株式会社 生体適合性材料
JPH0286838A (ja) * 1988-09-22 1990-03-27 Terumo Corp 水不溶性ヒドロゲルおよびその製造方法
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5258028A (en) 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US5092883A (en) 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
GB8900376D0 (en) * 1989-01-09 1989-03-08 Nycomed As Iodinated esters
US5007940A (en) 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
DE69114782T2 (de) * 1990-08-08 1996-04-18 Takeda Chemical Industries Ltd Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff.
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
JPH06505991A (ja) * 1991-02-25 1994-07-07 デビオファルム ソシエテ アノニム 癌の多剤耐性を抑制するための薬剤
FR2676927B1 (fr) 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
JP3356447B2 (ja) * 1991-10-16 2002-12-16 テルモ株式会社 乾燥高分子ゲルからなる血管病変塞栓材料
NZ249770A (en) * 1992-02-28 1996-09-25 Univ Texas Biodegradable, polymerisable, substantially water soluble macromer comprising at least one water soluble region, at least one degradable region and at least two free radical polymerisable regions separated by at least one degradable region
JPH0656676A (ja) 1992-08-05 1994-03-01 Hori Shinichi 血管塞栓用懸濁液
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
EP0688429B1 (en) 1993-03-09 1998-02-11 Epic Therapeutics, Inc.. Macromolecular microparticles and methods of production
UA10911C2 (uk) 1994-08-10 1996-12-25 Мале Впроваджувальне Підприємство "Іhтерфалл" Біосумісhий гідрогель
US5955108A (en) 1994-12-16 1999-09-21 Quadrant Healthcare (Uk) Limited Cross-linked microparticles and their use as therapeutic vehicles
WO1996022736A1 (en) * 1995-01-27 1996-08-01 Scimed Life Systems, Inc. Embolizing system
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
DE19601699A1 (de) * 1996-01-18 1997-07-24 Wacker Chemie Gmbh Redispergierbare Polymerisatpulver und daraus erhältliche wäßrige Polymerisat-Dispersionen
US5785977A (en) 1996-02-07 1998-07-28 Breithbarth; Richard Non-metallic microparticle carrier materials
US5803075A (en) * 1996-03-15 1998-09-08 Yaru Llc Surgical mask with adhesive strip to improve breathing
US5925683A (en) * 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
US6139963A (en) * 1996-11-28 2000-10-31 Kuraray Co., Ltd. Polyvinyl alcohol hydrogel and process for producing the same
WO1999011196A1 (en) 1997-09-04 1999-03-11 Point Biomedical Corporation Injectable tissue reconstruction material
WO1999012577A1 (en) * 1997-09-05 1999-03-18 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising a contrast agent for chemoembolization
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
AU742786B2 (en) 1998-03-06 2002-01-10 Biosphere Medical, Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
US6165193A (en) * 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6710126B1 (en) * 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
KR100335866B1 (ko) * 2000-01-06 2002-05-10 박호군 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법
EP1263803B1 (en) * 2000-03-13 2007-09-19 BioCure, Inc. Embolic compositions
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
AU2001249221A1 (en) 2000-03-20 2001-10-03 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
EP1267839B1 (en) 2000-03-24 2007-10-03 Biosphere Medical, Inc. Microspheres for active embolization
US20030212022A1 (en) 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
US6537569B2 (en) * 2001-02-14 2003-03-25 Microvention, Inc. Radiation cross-linked hydrogels
WO2002100444A1 (en) 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
US6488952B1 (en) * 2001-08-28 2002-12-03 John P. Kennedy Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system
US6911219B2 (en) 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
MX2007013914A (es) 2005-05-09 2008-02-22 Biosphere Medical S A Composiciones y metodos que usan microesferas y agentes de contraste no ionicos.
EP1986707A2 (en) 2006-01-30 2008-11-05 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
WO2007090130A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Porous intravascular embolization particles and related methods

Also Published As

Publication number Publication date
DE69915858T2 (de) 2005-03-03
US6680046B1 (en) 2004-01-20
DE69915858D1 (de) 2004-04-29
US20090117196A1 (en) 2009-05-07
US8673266B2 (en) 2014-03-18
CA2345205A1 (en) 2000-04-27
WO2000023054A1 (en) 2000-04-27
US20040091425A1 (en) 2004-05-13
AU1039600A (en) 2000-05-08
US7670592B2 (en) 2010-03-02
FR2784580A1 (fr) 2000-04-21
FR2784580B1 (fr) 2004-06-25
EP1128816A1 (en) 2001-09-05
US20100119572A1 (en) 2010-05-13
ES2219072T3 (es) 2004-11-16
JP4467799B2 (ja) 2010-05-26
JP2002527206A (ja) 2002-08-27
US7591993B2 (en) 2009-09-22
EP1128816B1 (en) 2004-03-24

Similar Documents

Publication Publication Date Title
ATE262319T1 (de) Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung
ID26207A (id) ESTRATRIENA TERSUBSTITUSI 11β-HALOGEN-7 αTERSUBSTITUTASI, PROSES UNTUK MEMPRODUKSI SEDIAAN FARMASI YANG MENGANDUNG ESTRATRIENA 11β-HALOGEN-7 αINI DAN JUGA PENGGUNAANNYA UNTUK PRODUKSI ZAT-ZAT FARMASI
DE69623460D1 (de) Verfahren zur herstellung von 3-haloalkyl-1h-pyrazole
DE68911346D1 (de) Länglich geformte Teilchen enthaltendes Kieselsäuresol sowie Verfahren zur Herstellung desselben.
DE69718942D1 (de) Verfahren zur herstellung von erythromicin a-oxim
DE69216642D1 (de) Verfahren zur herstellung von tabletten mit hoher festigkeit
DE68923727D1 (de) Verfahren zur Herstellung eines aktiven Matrixsubstrats.
DE69611743D1 (de) Verfahren zur Herstellung von Ethylenoxid verkappten Polyolen aus Doppelmetallcyanid katalysierten Polyolen
ID25950A (id) Katalis-katalis untuk memproduksi aldehid tidak jenuh dan asam karboksilat tidak jenuh dan proses untuk produksi aldehid tidak jenuh dan asam karboksilat tidak jenuh menggunakan katalis
DE3868700D1 (de) Verfahren zur herstellung eines optisch aktiven alkohols.
DE69522479D1 (de) Verfahren zur herstellung von terephtalischer säure
DE59005902D1 (de) Verfahren zur Herstellung niederer, mehrwertiger Alkohole.
FI940203L (fi) Geeni, joka koodaa eikosapeutaanihappoa syntetisoivia entsyymejä, ja menetelmä eikospentaanihapon valmistamiseksi
DE69403210D1 (de) Verfahren zur herstellung von n-acetylneuraminsäure
DE68908223D1 (de) Verfahren zur herstellung von sehr reiner, dichter grossteiliger kieselsaeure.
ID21462A (id) Katalis, proses untuk memproduksi katalis tersebut dan proses pembuatan vinil asetat menggunakan katalis tersebut
DE59001349D1 (de) Verfahren zur herstellung katalytisch wirksamer beschichtigungen fuer die cyanwasserstoffherstellung.
CA2191687A1 (en) Method of treating a catalyst
EP1069122A4 (en) PROCESS FOR PRODUCING 5-HYDROXYBENZO b] THIOPHENE-3-CARBOXYLIC ACID DERIVATIVES
ATE309286T1 (de) Verfahren zur herstellung von polyesterpolyolen mehrwertiger alkohole
ATE207880T1 (de) Verfahren zur herstellung von kontrastmitteln
DE69605460D1 (de) Verfahren zur Herstellung von Isopropylalkohol
DE69002017D1 (de) Katalytisches verfahren zur herstellung von oximen.
ATE160367T1 (de) Verfahren zur herstellung resorbierbarem polymer
ATE246250T1 (de) Immunogenes konstrukt, verfahren zu dessen herstellung und verwendung als vakzine

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties