ATE262319T1 - Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung - Google Patents
Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellungInfo
- Publication number
- ATE262319T1 ATE262319T1 AT99953858T AT99953858T ATE262319T1 AT E262319 T1 ATE262319 T1 AT E262319T1 AT 99953858 T AT99953858 T AT 99953858T AT 99953858 T AT99953858 T AT 99953858T AT E262319 T1 ATE262319 T1 AT E262319T1
- Authority
- AT
- Austria
- Prior art keywords
- microspheres
- present
- production
- polyvinyl alcohol
- relates
- Prior art date
Links
- 239000004372 Polyvinyl alcohol Substances 0.000 title abstract 5
- 239000004005 microsphere Substances 0.000 title abstract 5
- 229920002451 polyvinyl alcohol Polymers 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 235000019422 polyvinyl alcohol Nutrition 0.000 abstract 4
- 230000010102 embolization Effects 0.000 abstract 2
- 229940102213 injectable suspension Drugs 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000013162 therapeutic embolization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9813019A FR2784580B1 (fr) | 1998-10-16 | 1998-10-16 | Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci |
| PCT/EP1999/007846 WO2000023054A1 (en) | 1998-10-16 | 1999-10-15 | Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE262319T1 true ATE262319T1 (de) | 2004-04-15 |
Family
ID=33462605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99953858T ATE262319T1 (de) | 1998-10-16 | 1999-10-15 | Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US6680046B1 (enExample) |
| EP (1) | EP1128816B1 (enExample) |
| JP (1) | JP4467799B2 (enExample) |
| AT (1) | ATE262319T1 (enExample) |
| AU (1) | AU1039600A (enExample) |
| CA (1) | CA2345205A1 (enExample) |
| DE (1) | DE69915858T2 (enExample) |
| ES (1) | ES2219072T3 (enExample) |
| FR (1) | FR2784580B1 (enExample) |
| WO (1) | WO2000023054A1 (enExample) |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660301B1 (en) | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
| FR2784580B1 (fr) * | 1998-10-16 | 2004-06-25 | Biosepra Inc | Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci |
| EP1163019B1 (en) * | 1999-03-25 | 2007-10-24 | Metabolix, Inc. | Medical devices and applications of polyhydroxyalkanoate polymers |
| EP1263325B1 (en) * | 2000-03-06 | 2009-07-01 | Boston Scientific Limited | Embolic agents visible under ultrasound |
| EP1263803B1 (en) * | 2000-03-13 | 2007-09-19 | BioCure, Inc. | Embolic compositions |
| US6652883B2 (en) | 2000-03-13 | 2003-11-25 | Biocure, Inc. | Tissue bulking and coating compositions |
| WO2001068722A1 (en) | 2000-03-13 | 2001-09-20 | Biocure, Inc. | Hydrogel biomedical articles |
| US6436424B1 (en) | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| AU2001249221A1 (en) | 2000-03-20 | 2001-10-03 | Biosphere Medical, Inc. | Injectable and swellable microspheres for tissue bulking |
| US7338657B2 (en) * | 2001-03-15 | 2008-03-04 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
| EP1267839B1 (en) * | 2000-03-24 | 2007-10-03 | Biosphere Medical, Inc. | Microspheres for active embolization |
| US20030212022A1 (en) * | 2001-03-23 | 2003-11-13 | Jean-Marie Vogel | Compositions and methods for gene therapy |
| US20040266983A1 (en) * | 2000-08-17 | 2004-12-30 | Reeve Lorraine E | Purified polyoxyalkylene block copolymers |
| US9080146B2 (en) * | 2001-01-11 | 2015-07-14 | Celonova Biosciences, Inc. | Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface |
| KR100786907B1 (ko) | 2001-09-12 | 2007-12-17 | 바이렉스 메디칼 코포레이션 | 고정화된 혈소판 결합제를 갖는 혈관 폐색 고형상 제제 |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| US7094369B2 (en) * | 2002-03-29 | 2006-08-22 | Scimed Life Systems, Inc. | Processes for manufacturing polymeric microspheres |
| US7131997B2 (en) * | 2002-03-29 | 2006-11-07 | Scimed Life Systems, Inc. | Tissue treatment |
| US7053134B2 (en) | 2002-04-04 | 2006-05-30 | Scimed Life Systems, Inc. | Forming a chemically cross-linked particle of a desired shape and diameter |
| CA2492339A1 (en) * | 2002-06-12 | 2003-12-24 | Boston Scientific Limited | Bulking agents |
| US20080226723A1 (en) * | 2002-07-05 | 2008-09-18 | Celonova Biosciences, Inc. | Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same |
| US7449236B2 (en) | 2002-08-09 | 2008-11-11 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US7842377B2 (en) * | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
| US7588825B2 (en) * | 2002-10-23 | 2009-09-15 | Boston Scientific Scimed, Inc. | Embolic compositions |
| US7883490B2 (en) * | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
| CA2507404A1 (en) * | 2002-11-04 | 2004-05-21 | Biosphere Medical | Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same |
| WO2004073688A1 (en) * | 2003-02-21 | 2004-09-02 | Biocompatibles Uk Limited | Drug delivery from embolic agents |
| CN1794980A (zh) * | 2003-03-24 | 2006-06-28 | 生物领域医疗公司 | 利用逆向热敏聚合物的暂时栓塞 |
| JP2004313759A (ja) * | 2003-03-31 | 2004-11-11 | Toray Ind Inc | 血管塞栓材料 |
| ES2819189T3 (es) | 2003-05-08 | 2021-04-15 | Tepha Inc | Tejidos y fibras médicos de polihidroxialcanoato |
| US20050025809A1 (en) * | 2003-07-08 | 2005-02-03 | Tepha, Inc. | Poly-4-hydroxybutyrate matrices for sustained drug delivery |
| WO2005020825A1 (en) * | 2003-08-22 | 2005-03-10 | Tepha, Inc. | Polyhydroxyalkanoate nerve regeneration devices |
| WO2005018600A2 (en) * | 2003-08-22 | 2005-03-03 | Cube Medical A/S | Method of treating a patient suffering from a solid tumour |
| US7976823B2 (en) * | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
| US7901770B2 (en) * | 2003-11-04 | 2011-03-08 | Boston Scientific Scimed, Inc. | Embolic compositions |
| US7700086B2 (en) * | 2003-11-06 | 2010-04-20 | Pluromed, Inc. | Internal clamp for surgical procedures |
| US7736671B2 (en) * | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
| US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
| US20050238870A1 (en) * | 2004-04-22 | 2005-10-27 | Marcia Buiser | Embolization |
| JP4655505B2 (ja) * | 2004-04-28 | 2011-03-23 | 東レ株式会社 | 架橋生分解性粒子およびその製造方法 |
| US7311861B2 (en) | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
| WO2006004941A2 (en) | 2004-06-29 | 2006-01-12 | Biocure, Inc. | Biomaterial |
| EP2221069B1 (en) * | 2004-08-03 | 2012-05-09 | Tepha, Inc. | Non-curling polyhydroxyalkanoate sutures |
| US20070258939A1 (en) * | 2004-08-03 | 2007-11-08 | Biocamparibles Uk Limited | Drug Delivery from Embolic Agents |
| US20070281028A1 (en) * | 2004-08-04 | 2007-12-06 | Biocompatibles Uk Limited | Drug Delivery of a Cox Inhibitor from Embolic Agents |
| US20210299056A9 (en) | 2004-10-25 | 2021-09-30 | Varian Medical Systems, Inc. | Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods |
| KR101153785B1 (ko) | 2004-10-25 | 2012-07-09 | 셀로노바 바이오사이언시스 저머니 게엠베하 | 치료 및/또는 진단용으로 부가할 수 있는 중합체 입자 및이의 제조 및 사용 방법 |
| US9114162B2 (en) * | 2004-10-25 | 2015-08-25 | Celonova Biosciences, Inc. | Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same |
| US9107850B2 (en) * | 2004-10-25 | 2015-08-18 | Celonova Biosciences, Inc. | Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
| US8663225B2 (en) * | 2004-11-12 | 2014-03-04 | Medtronic, Inc. | Hydrogel bone void filler |
| US8425550B2 (en) | 2004-12-01 | 2013-04-23 | Boston Scientific Scimed, Inc. | Embolic coils |
| US7727555B2 (en) * | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
| US7858183B2 (en) * | 2005-03-02 | 2010-12-28 | Boston Scientific Scimed, Inc. | Particles |
| US7963287B2 (en) * | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
| MX2007013914A (es) | 2005-05-09 | 2008-02-22 | Biosphere Medical S A | Composiciones y metodos que usan microesferas y agentes de contraste no ionicos. |
| US20070004973A1 (en) * | 2005-06-15 | 2007-01-04 | Tan Sharon M L | Tissue treatment methods |
| US9463426B2 (en) | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
| EP1900381A4 (en) | 2005-07-01 | 2012-01-11 | Nippon Synthetic Chem Ind | PVA PARTICLES FOR THE USE IN THE TEMPORARY EMBOLIZATION OF A BLOOD VESSEL, METHOD OF MANUFACTURING THEREOF AND ACTIVE FOR THE TEMPORARY EMBOLIZATION OF A BLOOD VESSEL |
| US20070083219A1 (en) * | 2005-10-12 | 2007-04-12 | Buiser Marcia S | Embolic coil introducer sheath locking mechanisms |
| US8007509B2 (en) * | 2005-10-12 | 2011-08-30 | Boston Scientific Scimed, Inc. | Coil assemblies, components and methods |
| US20070093907A1 (en) * | 2005-10-26 | 2007-04-26 | Goupil Dennis W | Hydrogel spinal disc implants with swellable articles |
| US8152839B2 (en) * | 2005-12-19 | 2012-04-10 | Boston Scientific Scimed, Inc. | Embolic coils |
| US8101197B2 (en) | 2005-12-19 | 2012-01-24 | Stryker Corporation | Forming coils |
| US20070142859A1 (en) * | 2005-12-19 | 2007-06-21 | Boston Scientific Scimed, Inc. | Embolic coils |
| US7501179B2 (en) * | 2005-12-21 | 2009-03-10 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| US7947368B2 (en) * | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| US20070142560A1 (en) * | 2005-12-21 | 2007-06-21 | Young-Ho Song | Block copolymer particles |
| JP5075130B2 (ja) * | 2006-01-24 | 2012-11-14 | バイオコンパティブルズ ユーケー リミテッド | ポリマー粒子を薬物で負荷する方法 |
| EP1986707A2 (en) * | 2006-01-30 | 2008-11-05 | Surgica Corporation | Compressible intravascular embolization particles and related methods and delivery systems |
| WO2007090130A2 (en) * | 2006-01-30 | 2007-08-09 | Surgica Corporation | Porous intravascular embolization particles and related methods |
| US7838035B2 (en) | 2006-04-11 | 2010-11-23 | E. I. Du Pont De Nemours And Company | Microsphere powder of high density, swellable, deformable, durable occlusion-forming microspheres |
| US8062673B2 (en) | 2006-04-11 | 2011-11-22 | E I Du Pont De Nemours And Company | Process for embolization using swellable and deformable microspheres |
| US8252339B2 (en) | 2006-04-11 | 2012-08-28 | Massachusetts Institute Of Technology | Medical treatment applications of swellable and deformable microspheres |
| US7794755B2 (en) | 2006-04-11 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Process for preparation of swellable and deformable microspheres |
| US20070299461A1 (en) * | 2006-06-21 | 2007-12-27 | Boston Scientific Scimed, Inc. | Embolic coils and related components, systems, and methods |
| WO2008014065A1 (en) * | 2006-07-27 | 2008-01-31 | Boston Scientific Limited | Particles |
| US8414927B2 (en) | 2006-11-03 | 2013-04-09 | Boston Scientific Scimed, Inc. | Cross-linked polymer particles |
| US7943683B2 (en) * | 2006-12-01 | 2011-05-17 | Tepha, Inc. | Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers |
| US20080145658A1 (en) * | 2006-12-15 | 2008-06-19 | Boston Scientific Scimed, Inc. | Freeze Thaw Methods For Making Polymer Particles |
| WO2009046281A2 (en) * | 2007-10-05 | 2009-04-09 | Boston Scientific Scimed, Inc. | Injectable particles |
| US20090110738A1 (en) * | 2007-10-26 | 2009-04-30 | Celonova Biosciences, Inc. | Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same |
| US20090111763A1 (en) * | 2007-10-26 | 2009-04-30 | Celonova Biosciences, Inc. | Loadable polymeric particles for bone augmentation and methods of preparing and using the same |
| US20090110730A1 (en) * | 2007-10-30 | 2009-04-30 | Celonova Biosciences, Inc. | Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same |
| US20090110731A1 (en) * | 2007-10-30 | 2009-04-30 | Celonova Biosciences, Inc. | Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same |
| US8114436B2 (en) | 2008-03-25 | 2012-02-14 | Boston Scientific Scimed, Inc. | Compositions and methods for delivery of embolics |
| CN102143996A (zh) * | 2008-10-30 | 2011-08-03 | 大卫·刘 | 微球形多孔可生物相容支架及制造该支架的方法和装置 |
| KR101386799B1 (ko) * | 2009-10-06 | 2014-04-21 | 리전츠 오브 더 유니버스티 오브 미네소타 | 생분해성 색전술용 미소구체 |
| WO2011057131A1 (en) | 2009-11-09 | 2011-05-12 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
| JP2013509963A (ja) | 2009-11-09 | 2013-03-21 | スポットライト テクノロジー パートナーズ エルエルシー | 断片化ヒドロゲル |
| GB201008843D0 (en) * | 2010-05-27 | 2010-07-14 | Aubin Ltd | Method and composition |
| US9232805B2 (en) | 2010-06-29 | 2016-01-12 | Biocure, Inc. | In-situ forming hydrogel wound dressings containing antimicrobial agents |
| CN101885852B (zh) * | 2010-07-07 | 2012-01-11 | 天津大学 | 表面光滑明胶微球与制备方法 |
| WO2012050879A2 (en) * | 2010-09-29 | 2012-04-19 | Scion Cardio-Vascular, Inc. | Methods for processing microspheres, microspheres processed thereby, and uses thereof |
| EP2646000B1 (en) | 2010-11-29 | 2015-04-29 | Centre Hospitalier Universitaire Vaudois | Chemoembolization composition comprising anti-angiogenic agents |
| GB201101429D0 (en) * | 2011-01-27 | 2011-03-16 | Biocompatibles Uk Ltd | Drug delivery system |
| IT1404015B1 (it) * | 2011-02-04 | 2013-11-08 | Hsd Holding Smart Device S R L | Uso di un polimero di destrano reticolato come filtro contro l'inalazione di sostanze nocive per la salute |
| CN102492178B (zh) * | 2011-11-29 | 2014-12-24 | 中国科学院过程工程研究所 | 一种尺寸均一的魔芋葡甘聚糖微球及其制备方法 |
| EP3984556B8 (en) | 2012-06-14 | 2025-07-09 | Microvention, Inc. | Polymeric treatment compositions |
| CN104717983B (zh) | 2012-10-15 | 2018-09-18 | 微仙美国有限公司 | 聚合治疗组合物 |
| US8936795B2 (en) | 2012-12-19 | 2015-01-20 | Regents Of The University Of Minnesota | Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose |
| EP2968165B1 (en) | 2013-03-13 | 2023-09-13 | Biosphere Medical, Inc. | Compositions and associated methods for radioisotope-binding microparticles |
| GB2519738A (en) * | 2013-09-06 | 2015-05-06 | Biocompatibles Uk Ltd | Radiopaque polymers |
| US9408916B2 (en) | 2013-09-19 | 2016-08-09 | Microvention, Inc. | Polymer films |
| EP3046952B1 (en) | 2013-09-19 | 2021-05-12 | Terumo Corporation | Polymer particles |
| US9688788B2 (en) | 2013-11-08 | 2017-06-27 | Terumo Corporation | Polymer particles |
| US10500303B2 (en) | 2014-08-15 | 2019-12-10 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
| CA2969429C (en) | 2014-12-11 | 2020-10-27 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
| US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
| WO2016154592A1 (en) | 2015-03-26 | 2016-09-29 | Microvention, Inc. | Embiolic particles |
| US10071181B1 (en) | 2015-04-17 | 2018-09-11 | Teleflex Innovations S.À.R.L. | Resorbable embolization spheres |
| US10517910B2 (en) * | 2015-06-19 | 2019-12-31 | Sillajen, Inc. | Compositions and methods for viral embolization |
| CN105148327B (zh) * | 2015-07-29 | 2019-07-12 | 广东博与再生医学有限公司 | 一种多糖-聚乙烯醇栓塞微球的制备方法 |
| US10182979B2 (en) | 2016-03-22 | 2019-01-22 | Regents Of The University Of Minnesota | Biodegradable microspheres |
| JP2019518428A (ja) * | 2016-04-12 | 2019-07-04 | ユニシテ エーファウ アクチェンゲゼルシャフト | 体液試料からの細胞外小胞(ev)の単離 |
| US10368874B2 (en) | 2016-08-26 | 2019-08-06 | Microvention, Inc. | Embolic compositions |
| KR102162370B1 (ko) | 2016-09-28 | 2020-10-06 | 테루모 가부시키가이샤 | 중합체 입자 |
| EA038657B1 (ru) * | 2016-10-12 | 2021-09-29 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Химиоэмболизирующие частицы для лечения солидных опухолей |
| CN111200976B (zh) | 2017-10-09 | 2023-07-07 | 微仙美国有限公司 | 放射性液体栓塞 |
| CN108744020A (zh) * | 2018-06-12 | 2018-11-06 | 杭州艾力康医药科技有限公司 | 一种离子交换型聚乙烯醇微球的制备方法 |
| US12043706B2 (en) | 2018-11-21 | 2024-07-23 | Kuraray Co., Ltd. | Monodisperse hydrogel particles |
| JP2023507044A (ja) * | 2019-06-19 | 2023-02-20 | ザイロ セラピューティクス,インコーポレーテッド | 医薬品および化粧用途のための一酸化窒素担体としての硫黄官能化モノリスおよびそれに由来する粒子 |
| JPWO2021166746A1 (enExample) * | 2020-02-18 | 2021-08-26 | ||
| CN114159554B (zh) * | 2021-11-22 | 2022-12-13 | 广州优理氏生物科技有限公司 | 一种纤连蛋白-聚乙烯醇微球的制备方法及其应用 |
| CN114642640B (zh) * | 2022-05-23 | 2022-09-16 | 杭州旸顺医疗科技有限公司 | 微球及其制备方法、制备系统 |
| CN120769874A (zh) | 2023-02-22 | 2025-10-10 | 株式会社可乐丽 | 干燥水凝胶形成性物品、水凝胶、和干燥水凝胶形成性物品的制造方法 |
| WO2024182477A2 (en) * | 2023-02-28 | 2024-09-06 | Medstar Health, Inc. | Angiogenesis inhibitors coupled to embolic microparticles |
| CN116159178B (zh) * | 2023-04-18 | 2023-07-04 | 上海汇禾医疗器械有限公司 | 一种小粒径栓塞微球及其制备方法 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US499188A (en) * | 1893-06-06 | Territory | ||
| US3919411A (en) | 1972-01-31 | 1975-11-11 | Bayvet Corp | Injectable adjuvant and compositions including such adjuvant |
| JPS49108168A (enExample) | 1973-02-16 | 1974-10-15 | ||
| JPS49108158A (enExample) | 1973-02-19 | 1974-10-15 | ||
| JPS5350290A (en) | 1976-10-18 | 1978-05-08 | Sumitomo Chem Co Ltd | Preparation f hydrogel |
| CA1134977A (en) * | 1978-09-07 | 1982-11-02 | Sumitomo Chemical Co., Ltd. | Method for preparing highly absorbent polymers |
| US4314032A (en) * | 1978-10-26 | 1982-02-02 | Kureha Kagaku Kogyo Kabushiki Kaisha | Crosslinked polyvinyl alcohol gel |
| US4268495A (en) | 1979-01-08 | 1981-05-19 | Ethicon, Inc. | Injectable embolization and occlusion solution |
| US4306031A (en) * | 1979-08-14 | 1981-12-15 | Mitsubishi Chemical Industries Limited | Weakly acidic cation exchange resin and process for producing same |
| GB2088392B (en) * | 1980-12-03 | 1984-05-02 | Sumitomo Chemical Co | Production of hydrogels |
| JPS57128709A (en) | 1981-02-03 | 1982-08-10 | Sumitomo Chem Co Ltd | Preparation of hydrogel |
| CA1225585A (en) | 1983-06-30 | 1987-08-18 | Maria T. Litvinova | Composition for embolization of blood vessels |
| GB8418772D0 (en) | 1984-07-24 | 1984-08-30 | Geistlich Soehne Ag | Chemical substances |
| US5186922A (en) * | 1985-03-15 | 1993-02-16 | See/Shell Biotechnology, Inc. | Use of biodegradable microspheres labeled with imaging energy constrast materials |
| US4680171A (en) * | 1985-03-15 | 1987-07-14 | William Shell | Visualization of a bloodstream circulation with biodegradable microspheres |
| WO1987000062A1 (en) | 1985-07-02 | 1987-01-15 | Target Therapeutics | Vaso-occlusive collagen composition and method |
| US4803075A (en) | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
| JPS6317904A (ja) * | 1986-07-09 | 1988-01-25 | Mitsubishi Chem Ind Ltd | 多孔質架橋ポリビニルアルコ−ル粒子の製造法 |
| CA1329800C (en) * | 1987-12-29 | 1994-05-24 | Hiroaki Takayanagi | Composite separating agent |
| GB8813425D0 (en) | 1988-06-07 | 1988-07-13 | Hall L D | Magnetic resonance imaging |
| JPH064713B2 (ja) * | 1988-07-22 | 1994-01-19 | テルモ株式会社 | 生体適合性材料 |
| JPH0286838A (ja) * | 1988-09-22 | 1990-03-27 | Terumo Corp | 水不溶性ヒドロゲルおよびその製造方法 |
| US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5258028A (en) | 1988-12-12 | 1993-11-02 | Ersek Robert A | Textured micro implants |
| US5092883A (en) | 1988-12-28 | 1992-03-03 | Eppley Barry L | Method for promoting soft connective tissue growth and repair in mammals |
| GB8900376D0 (en) * | 1989-01-09 | 1989-03-08 | Nycomed As | Iodinated esters |
| US5007940A (en) | 1989-06-09 | 1991-04-16 | American Medical Systems, Inc. | Injectable polymeric bodies |
| DE69114782T2 (de) * | 1990-08-08 | 1996-04-18 | Takeda Chemical Industries Ltd | Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff. |
| US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| JPH06505991A (ja) * | 1991-02-25 | 1994-07-07 | デビオファルム ソシエテ アノニム | 癌の多剤耐性を抑制するための薬剤 |
| FR2676927B1 (fr) | 1991-05-29 | 1995-06-23 | Ibf | Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant. |
| JP3356447B2 (ja) * | 1991-10-16 | 2002-12-16 | テルモ株式会社 | 乾燥高分子ゲルからなる血管病変塞栓材料 |
| NZ249770A (en) * | 1992-02-28 | 1996-09-25 | Univ Texas | Biodegradable, polymerisable, substantially water soluble macromer comprising at least one water soluble region, at least one degradable region and at least two free radical polymerisable regions separated by at least one degradable region |
| JPH0656676A (ja) | 1992-08-05 | 1994-03-01 | Hori Shinichi | 血管塞栓用懸濁液 |
| US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| EP0688429B1 (en) | 1993-03-09 | 1998-02-11 | Epic Therapeutics, Inc.. | Macromolecular microparticles and methods of production |
| UA10911C2 (uk) | 1994-08-10 | 1996-12-25 | Мале Впроваджувальне Підприємство "Іhтерфалл" | Біосумісhий гідрогель |
| US5955108A (en) | 1994-12-16 | 1999-09-21 | Quadrant Healthcare (Uk) Limited | Cross-linked microparticles and their use as therapeutic vehicles |
| WO1996022736A1 (en) * | 1995-01-27 | 1996-08-01 | Scimed Life Systems, Inc. | Embolizing system |
| US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
| DE19601699A1 (de) * | 1996-01-18 | 1997-07-24 | Wacker Chemie Gmbh | Redispergierbare Polymerisatpulver und daraus erhältliche wäßrige Polymerisat-Dispersionen |
| US5785977A (en) | 1996-02-07 | 1998-07-28 | Breithbarth; Richard | Non-metallic microparticle carrier materials |
| US5803075A (en) * | 1996-03-15 | 1998-09-08 | Yaru Llc | Surgical mask with adhesive strip to improve breathing |
| US5925683A (en) * | 1996-10-17 | 1999-07-20 | Target Therapeutics, Inc. | Liquid embolic agents |
| US6139963A (en) * | 1996-11-28 | 2000-10-31 | Kuraray Co., Ltd. | Polyvinyl alcohol hydrogel and process for producing the same |
| WO1999011196A1 (en) | 1997-09-04 | 1999-03-11 | Point Biomedical Corporation | Injectable tissue reconstruction material |
| WO1999012577A1 (en) * | 1997-09-05 | 1999-03-18 | Nycomed Imaging As | Polymer particles made of polyvinyl alcohol and comprising a contrast agent for chemoembolization |
| US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6660301B1 (en) | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
| AU742786B2 (en) | 1998-03-06 | 2002-01-10 | Biosphere Medical, Inc. | Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles |
| US6165193A (en) * | 1998-07-06 | 2000-12-26 | Microvention, Inc. | Vascular embolization with an expansible implant |
| FR2784580B1 (fr) | 1998-10-16 | 2004-06-25 | Biosepra Inc | Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci |
| US6710126B1 (en) * | 1999-11-15 | 2004-03-23 | Bio Cure, Inc. | Degradable poly(vinyl alcohol) hydrogels |
| KR100335866B1 (ko) * | 2000-01-06 | 2002-05-10 | 박호군 | 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법 |
| EP1263803B1 (en) * | 2000-03-13 | 2007-09-19 | BioCure, Inc. | Embolic compositions |
| US6652883B2 (en) * | 2000-03-13 | 2003-11-25 | Biocure, Inc. | Tissue bulking and coating compositions |
| AU2001249221A1 (en) | 2000-03-20 | 2001-10-03 | Biosphere Medical, Inc. | Injectable and swellable microspheres for tissue bulking |
| US6436424B1 (en) | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| US7338657B2 (en) | 2001-03-15 | 2008-03-04 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
| EP1267839B1 (en) | 2000-03-24 | 2007-10-03 | Biosphere Medical, Inc. | Microspheres for active embolization |
| US20030212022A1 (en) | 2001-03-23 | 2003-11-13 | Jean-Marie Vogel | Compositions and methods for gene therapy |
| US6537569B2 (en) * | 2001-02-14 | 2003-03-25 | Microvention, Inc. | Radiation cross-linked hydrogels |
| WO2002100444A1 (en) | 2001-06-08 | 2002-12-19 | Biosphere Medical Inc. | Colloidal metal labelled microparticles, their production and use |
| US6488952B1 (en) * | 2001-08-28 | 2002-12-03 | John P. Kennedy | Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system |
| US6911219B2 (en) | 2001-09-27 | 2005-06-28 | Surgica Corporation | Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them |
| MX2007013914A (es) | 2005-05-09 | 2008-02-22 | Biosphere Medical S A | Composiciones y metodos que usan microesferas y agentes de contraste no ionicos. |
| EP1986707A2 (en) | 2006-01-30 | 2008-11-05 | Surgica Corporation | Compressible intravascular embolization particles and related methods and delivery systems |
| WO2007090130A2 (en) | 2006-01-30 | 2007-08-09 | Surgica Corporation | Porous intravascular embolization particles and related methods |
-
1998
- 1998-10-16 FR FR9813019A patent/FR2784580B1/fr not_active Expired - Fee Related
-
1999
- 1999-10-15 DE DE69915858T patent/DE69915858T2/de not_active Expired - Lifetime
- 1999-10-15 AU AU10396/00A patent/AU1039600A/en not_active Abandoned
- 1999-10-15 WO PCT/EP1999/007846 patent/WO2000023054A1/en not_active Ceased
- 1999-10-15 US US09/419,114 patent/US6680046B1/en not_active Expired - Lifetime
- 1999-10-15 JP JP2000576829A patent/JP4467799B2/ja not_active Expired - Lifetime
- 1999-10-15 ES ES99953858T patent/ES2219072T3/es not_active Expired - Lifetime
- 1999-10-15 CA CA002345205A patent/CA2345205A1/en not_active Abandoned
- 1999-10-15 AT AT99953858T patent/ATE262319T1/de not_active IP Right Cessation
- 1999-10-15 EP EP99953858A patent/EP1128816B1/en not_active Revoked
-
2003
- 2003-10-27 US US10/692,785 patent/US7591993B2/en not_active Expired - Fee Related
-
2009
- 2009-01-05 US US12/348,867 patent/US7670592B2/en not_active Expired - Fee Related
-
2010
- 2010-01-12 US US12/686,320 patent/US8673266B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69915858T2 (de) | 2005-03-03 |
| US6680046B1 (en) | 2004-01-20 |
| DE69915858D1 (de) | 2004-04-29 |
| US20090117196A1 (en) | 2009-05-07 |
| US8673266B2 (en) | 2014-03-18 |
| CA2345205A1 (en) | 2000-04-27 |
| WO2000023054A1 (en) | 2000-04-27 |
| US20040091425A1 (en) | 2004-05-13 |
| AU1039600A (en) | 2000-05-08 |
| US7670592B2 (en) | 2010-03-02 |
| FR2784580A1 (fr) | 2000-04-21 |
| FR2784580B1 (fr) | 2004-06-25 |
| EP1128816A1 (en) | 2001-09-05 |
| US20100119572A1 (en) | 2010-05-13 |
| ES2219072T3 (es) | 2004-11-16 |
| JP4467799B2 (ja) | 2010-05-26 |
| JP2002527206A (ja) | 2002-08-27 |
| US7591993B2 (en) | 2009-09-22 |
| EP1128816B1 (en) | 2004-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE262319T1 (de) | Mikrosphären aus polyvinylalkohol sowie verfahren zu deren herstellung | |
| ID26207A (id) | ESTRATRIENA TERSUBSTITUSI 11β-HALOGEN-7 αTERSUBSTITUTASI, PROSES UNTUK MEMPRODUKSI SEDIAAN FARMASI YANG MENGANDUNG ESTRATRIENA 11β-HALOGEN-7 αINI DAN JUGA PENGGUNAANNYA UNTUK PRODUKSI ZAT-ZAT FARMASI | |
| DE69623460D1 (de) | Verfahren zur herstellung von 3-haloalkyl-1h-pyrazole | |
| DE68911346D1 (de) | Länglich geformte Teilchen enthaltendes Kieselsäuresol sowie Verfahren zur Herstellung desselben. | |
| DE69718942D1 (de) | Verfahren zur herstellung von erythromicin a-oxim | |
| DE69216642D1 (de) | Verfahren zur herstellung von tabletten mit hoher festigkeit | |
| DE68923727D1 (de) | Verfahren zur Herstellung eines aktiven Matrixsubstrats. | |
| DE69611743D1 (de) | Verfahren zur Herstellung von Ethylenoxid verkappten Polyolen aus Doppelmetallcyanid katalysierten Polyolen | |
| ID25950A (id) | Katalis-katalis untuk memproduksi aldehid tidak jenuh dan asam karboksilat tidak jenuh dan proses untuk produksi aldehid tidak jenuh dan asam karboksilat tidak jenuh menggunakan katalis | |
| DE3868700D1 (de) | Verfahren zur herstellung eines optisch aktiven alkohols. | |
| DE69522479D1 (de) | Verfahren zur herstellung von terephtalischer säure | |
| DE59005902D1 (de) | Verfahren zur Herstellung niederer, mehrwertiger Alkohole. | |
| FI940203L (fi) | Geeni, joka koodaa eikosapeutaanihappoa syntetisoivia entsyymejä, ja menetelmä eikospentaanihapon valmistamiseksi | |
| DE69403210D1 (de) | Verfahren zur herstellung von n-acetylneuraminsäure | |
| DE68908223D1 (de) | Verfahren zur herstellung von sehr reiner, dichter grossteiliger kieselsaeure. | |
| ID21462A (id) | Katalis, proses untuk memproduksi katalis tersebut dan proses pembuatan vinil asetat menggunakan katalis tersebut | |
| DE59001349D1 (de) | Verfahren zur herstellung katalytisch wirksamer beschichtigungen fuer die cyanwasserstoffherstellung. | |
| CA2191687A1 (en) | Method of treating a catalyst | |
| EP1069122A4 (en) | PROCESS FOR PRODUCING 5-HYDROXYBENZO b] THIOPHENE-3-CARBOXYLIC ACID DERIVATIVES | |
| ATE309286T1 (de) | Verfahren zur herstellung von polyesterpolyolen mehrwertiger alkohole | |
| ATE207880T1 (de) | Verfahren zur herstellung von kontrastmitteln | |
| DE69605460D1 (de) | Verfahren zur Herstellung von Isopropylalkohol | |
| DE69002017D1 (de) | Katalytisches verfahren zur herstellung von oximen. | |
| ATE160367T1 (de) | Verfahren zur herstellung resorbierbarem polymer | |
| ATE246250T1 (de) | Immunogenes konstrukt, verfahren zu dessen herstellung und verwendung als vakzine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |