ATE373682T1 - Embolische zusammensetzungen - Google Patents

Embolische zusammensetzungen

Info

Publication number
ATE373682T1
ATE373682T1 AT01918602T AT01918602T ATE373682T1 AT E373682 T1 ATE373682 T1 AT E373682T1 AT 01918602 T AT01918602 T AT 01918602T AT 01918602 T AT01918602 T AT 01918602T AT E373682 T1 ATE373682 T1 AT E373682T1
Authority
AT
Austria
Prior art keywords
embolic
crosslinked
compositions
macromers
embolic compositions
Prior art date
Application number
AT01918602T
Other languages
English (en)
Inventor
Dennis Goupil
Hassan Chaouk
Troy Holland
Bruktawit Asfaw
Stephen Goodrich
Lucas Latini
Original Assignee
Biocure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocure Inc filed Critical Biocure Inc
Application granted granted Critical
Publication of ATE373682T1 publication Critical patent/ATE373682T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
    • C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
    • C08F271/02—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00 on to polymers of monomers containing heterocyclic nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F277/00—Macromolecular compounds obtained by polymerising monomers on to polymers of carbocyclic or heterocyclic monomers as defined respectively in group C08F32/00 or in group C08F34/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12—Polymers provided for in subclasses C08C or C08F
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/14—Polymers provided for in subclass C08G
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/08—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Materials Engineering (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01918602T 2000-03-13 2001-03-13 Embolische zusammensetzungen ATE373682T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18897500P 2000-03-13 2000-03-13
US25469700P 2000-12-11 2000-12-11

Publications (1)

Publication Number Publication Date
ATE373682T1 true ATE373682T1 (de) 2007-10-15

Family

ID=26884649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01918602T ATE373682T1 (de) 2000-03-13 2001-03-13 Embolische zusammensetzungen

Country Status (8)

Country Link
US (6) US6676971B2 (de)
EP (1) EP1263803B1 (de)
JP (1) JP4871476B2 (de)
AT (1) ATE373682T1 (de)
AU (2) AU4566001A (de)
CA (1) CA2403218C (de)
DE (1) DE60130544T2 (de)
WO (1) WO2001068720A1 (de)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
JP4871476B2 (ja) * 2000-03-13 2012-02-08 バイオコンパティブルズ ユーケー リミテッド 塞栓組成物
ATE374597T1 (de) 2000-03-24 2007-10-15 Biosphere Medical Inc Mikrokugeln zur aktiven embolisierung
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
US20030180251A1 (en) * 2000-08-02 2003-09-25 Volker Friedrich Medical technical product, method for producing the same and providing the same for surgery
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
WO2002072166A1 (en) * 2001-03-13 2002-09-19 Biocure, Inc. Compositions for drug delivery
EP1392175A2 (de) * 2001-05-04 2004-03-03 Concentric Medical Mit hydrogelfasern versehene vaso-okklusionsvorrichtung
US20030014075A1 (en) * 2001-07-16 2003-01-16 Microvention, Inc. Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation
EP1460982A4 (de) * 2001-11-16 2010-04-14 Biocure Inc Verfahren zur einleitung der in situ bildung von hydrogelen
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof
US8062251B2 (en) * 2002-02-01 2011-11-22 Vascular Designs, Inc. Multi-function catheter and use thereof
WO2003065872A2 (en) * 2002-02-01 2003-08-14 Goldman Robert J Multi-function catheter and use thereof
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7207996B2 (en) 2002-04-04 2007-04-24 Vascular Control Systems, Inc. Doppler directed suturing and compression device and method
US6713646B2 (en) 2002-04-12 2004-03-30 Biosphere Medical Degradable crosslinkers, and degradable crosslinked hydrogels comprising them
US7105031B2 (en) * 2002-04-26 2006-09-12 Medtronic Vascular, Inc. Balloon-tipped, multi-lumen catheter for endoluminal repair of endoluminal leaks in aortic or aorto-iliac endoluminal grafts
US7838699B2 (en) * 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US20040037887A1 (en) 2002-06-12 2004-02-26 Scimed Life Systems, Inc. Bulking agent
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US6884905B2 (en) 2002-07-23 2005-04-26 Biosphere Medical Degradable carbamate-containing bis(acryloyl) crosslinkers, and degradable crosslinked hydrogels comprising them
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
AU2003267602A1 (en) * 2002-09-25 2004-04-19 Biocompatibles Uk Limited Polymer compositions for administration to animals
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
CN1747721A (zh) * 2003-02-12 2006-03-15 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
ES2308149T3 (es) * 2003-02-12 2008-12-01 Biocompatibles Uk Limited Composicion para la quimioemboloterapia de tumores solidos.
US20040161466A1 (en) 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
ES2298724T3 (es) * 2003-02-21 2008-05-16 Biocompatibles Uk Limited Suministro de un ains a partir de agentes embolicos.
EP2724719A1 (de) * 2003-03-24 2014-04-30 Biosphere Medical, Inc. Temporäre Embolisation mit inversen, wärmeempfindlichen Polymeren
WO2004087007A2 (en) * 2003-03-25 2004-10-14 Biocure, Inc. Hydrogel string medical device
US20040202694A1 (en) * 2003-04-11 2004-10-14 Vascular Control Systems, Inc. Embolic occlusion of uterine arteries
US7396540B2 (en) * 2003-04-25 2008-07-08 Medtronic Vascular, Inc. In situ blood vessel and aneurysm treatment
US7022747B2 (en) * 2003-04-29 2006-04-04 Basf Corporation Method for creating microsphere polymers and particles
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
AU2003272255A1 (en) * 2003-09-02 2005-04-06 University Of Florida Polymeric reconstrainable, repositionable, detachable, percutaneous endovascular stentgraft
US20050107867A1 (en) * 2003-11-17 2005-05-19 Taheri Syde A. Temporary absorbable venous occlusive stent and superficial vein treatment method
ES2396689T3 (es) 2003-12-11 2013-02-25 Isto Technologies Inc. Sistema de cartílago particulado
EP1708763A4 (de) * 2004-01-07 2011-03-23 Trivascular Inc Verfahren, zusammensetzungen und vorrichtungen zur embolisierung von körperlumen
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
DE102004014633A1 (de) * 2004-03-22 2005-10-13 Aesculap Ag & Co. Kg Zusammensetzung zur Adhäsionsprophylaxe
US8067073B2 (en) * 2004-03-25 2011-11-29 Boston Scientific Scimed, Inc. Thermoplastic medical device
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
JP4655505B2 (ja) * 2004-04-28 2011-03-23 東レ株式会社 架橋生分解性粒子およびその製造方法
CA2565721C (en) * 2004-05-06 2015-10-06 Bioresponse, L.L.C. Diindolymethane formulations for the treatment of leiomyomas
US20050266043A1 (en) * 2004-05-27 2005-12-01 Medtronic Vascular, Inc. Methods and compounds for treatment of aneurysmal tissue
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
ATE489058T1 (de) * 2004-06-29 2010-12-15 Inc Biocure Bandscheiben-nucleus-pulposus-implantat
WO2006013309A1 (en) * 2004-08-03 2006-02-09 Biocompatibles Uk Limited Drug delivery from embolic agents
US20070281028A1 (en) * 2004-08-04 2007-12-06 Biocompatibles Uk Limited Drug Delivery of a Cox Inhibitor from Embolic Agents
US20060045900A1 (en) * 2004-08-27 2006-03-02 Robert Richard Embolization
WO2006026412A2 (en) * 2004-08-31 2006-03-09 Vnus Medical Technologies, Inc. Apparatus and material composition for permanent occlusion of a hollow anatomical structure
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
KR101153785B1 (ko) 2004-10-25 2012-07-09 셀로노바 바이오사이언시스 저머니 게엠베하 치료 및/또는 진단용으로 부가할 수 있는 중합체 입자 및이의 제조 및 사용 방법
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US7780645B2 (en) * 2004-10-26 2010-08-24 Codman & Shurtleff, Inc. Method of delivering embolic particles to an aneurysm
US7201918B2 (en) * 2004-11-16 2007-04-10 Microvention, Inc. Compositions, systems and methods for treatment of defects in blood vessels
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
JP2008522735A (ja) * 2004-12-08 2008-07-03 パーバシス セラピューティクス， インコーポレイテッド 血管アクセスを強化するための方法および組成物
WO2006062871A2 (en) * 2004-12-08 2006-06-15 Pervasis Therapeutics, Inc. Materials and methods for minimally-invasive administration of a cell-containing flowable composition
ATE497762T1 (de) 2004-12-30 2011-02-15 Bioresponse Llc Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus
US20080213593A1 (en) * 2005-01-21 2008-09-04 President And Fellows Of Harvard College Systems And Methods For Forming Fluidic Droplets Encapsulated In Particles Such As Colloidal Particles
EP2586385B1 (de) * 2005-01-25 2019-03-20 Covidien LP Strukturen für dauerhaften Vershluss einer hohlen anatomischen Struktur
US20060178696A1 (en) * 2005-02-04 2006-08-10 Porter Stephen C Macroporous materials for use in aneurysms
US20100080757A1 (en) * 2005-02-08 2010-04-01 Haaga John R Method of detecting abnormal tissue
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
ATE470701T1 (de) * 2005-04-21 2010-06-15 Massachusetts Inst Technology Materialien und verfahren zur änderung einer immunreaktion auf exogene und endogene immunogene,einschliesslich genidentischer und nicht- genidentischer zellen, gewebe oder organe
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
KR20140090270A (ko) 2005-05-09 2014-07-16 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및 방법
SG161258A1 (en) 2005-06-21 2010-05-27 Pervasis Therapeutics Inc Methods and compositions for enhancing vascular access
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
EP1900381A4 (de) * 2005-07-01 2012-01-11 Nippon Synthetic Chem Ind Pva-partikel zur verwendung bei der vorübergehenden embolisierung eines blutgefässes, herstellungsverfahren dafür und wirkstoff zur vorübergehenden embolisierung eines blutgefässes
WO2007025290A2 (en) * 2005-08-26 2007-03-01 Isto Technologies, Inc. Implants and methods for repair, replacement and treatment of joint disease
US20070078480A1 (en) * 2005-10-04 2007-04-05 Boston Scientific Scimed, Inc. Self-expanding biodegradable or water-soluble vaso-occlusive devices
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
EP1948096A2 (de) * 2005-10-26 2008-07-30 BioCure, Inc. Hydrogel-bandscheibenimplantate mit quellbaren artikeln
US20100204783A1 (en) * 2005-12-06 2010-08-12 Helen Marie Nugent Methods and compositions for enhancing vascular access
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US20070149641A1 (en) * 2005-12-28 2007-06-28 Goupil Dennis W Injectable bone cement
ES2554527T3 (es) * 2006-01-24 2015-12-21 Biocompatibles Uk Limited Proceso para rellenar partículas poliméricas con un fármaco
EP1986707A2 (de) 2006-01-30 2008-11-05 Surgica Corporation Komprimierbare intravaskuläre embolisationsteilchen und relevante verfahren und abgabesysteme
EP2368581B1 (de) * 2006-01-30 2018-08-29 Biosphere Medical, Inc. Poröse intravaskuläre Embolisierungspartikel und zugehörige Verfahren
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US9017361B2 (en) 2006-04-20 2015-04-28 Covidien Lp Occlusive implant and methods for hollow anatomical structure
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
CA2655026C (en) 2006-06-15 2016-08-02 Microvention, Inc. Embolization device constructed from expansible polymer
US8242179B2 (en) * 2006-06-23 2012-08-14 Surmodics, Inc. Hydrogel-based joint repair system and method
US8586621B2 (en) * 2006-10-27 2013-11-19 Michael A. Zeligs Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
AU2007317789B2 (en) * 2006-11-07 2011-02-10 Shire Regenerative Medicine, Inc. Materials and methods for treating and managing angiogenesis-mediated diseases
US20080154233A1 (en) * 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US7720533B2 (en) * 2006-12-20 2010-05-18 Zimmer Orthobiologicals, Inc. Apparatus and method for delivering a biocompatible material to a surgical site
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
US9642693B2 (en) * 2007-04-13 2017-05-09 W. L. Gore & Associates, Inc. Medical apparatus and method of making the same
US20080255678A1 (en) * 2007-04-13 2008-10-16 Cully Edward H Medical apparatus and method of making the same
US9717584B2 (en) * 2007-04-13 2017-08-01 W. L. Gore & Associates, Inc. Medical apparatus and method of making the same
US20080287633A1 (en) * 2007-05-18 2008-11-20 Drumheller Paul D Hydrogel Materials
WO2008156705A1 (en) * 2007-06-13 2008-12-24 Pervasis Therapeutics, Inc. Methods and devices for minimally-invasive delivery of cell-containing flowable compositions
EP2162101B1 (de) 2007-06-25 2019-02-20 MicroVention, Inc. Selbstexpandierende prothese
US8480651B2 (en) * 2007-08-02 2013-07-09 Covidien Lp Cannula system
US7887846B2 (en) * 2007-08-07 2011-02-15 E. I. Du Pont De Nemours And Company Process for preparation of swellable and degradable microspheres
JP5179308B2 (ja) * 2007-10-03 2013-04-10 株式会社クラレ ポリビニルアセタール
WO2009046281A2 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Injectable particles
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US20090123519A1 (en) * 2007-11-12 2009-05-14 Surmodics, Inc. Swellable hydrogel matrix and methods
JP5698537B2 (ja) * 2007-12-21 2015-04-08 マイクロベンション インコーポレイテッド 生物医学的使用のためのハイドロゲルフィラメント
US20110201926A1 (en) * 2008-02-29 2011-08-18 Pluromed, Inc. Local embolization via heating of thermosensitive polymers
US20110087207A1 (en) * 2008-02-29 2011-04-14 Pluromed, Inc. Local embolization using thermosensitive polymers
US20090226531A1 (en) * 2008-03-07 2009-09-10 Allergan, Inc. Methods and composition for intraocular delivery of therapeutic sirna
US8114436B2 (en) * 2008-03-25 2012-02-14 Boston Scientific Scimed, Inc. Compositions and methods for delivery of embolics
WO2009124148A1 (en) * 2008-04-04 2009-10-08 Curaseal, Inc. Implantable fistula closure device
US8246876B2 (en) * 2008-08-18 2012-08-21 Cook Medical Technologies Llc Embolization particles and method for making same
CA2735748C (en) * 2008-09-04 2017-08-29 Curaseal Inc. Inflatable devices for enteric fistula treatment
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
WO2010048177A2 (en) * 2008-10-20 2010-04-29 IMDS, Inc. Systems and methods for aneurysm treatment and vessel occlusion
EP2344578A2 (de) * 2008-10-30 2011-07-20 David Liu Mikrosphärische poröse biokompatible gerüste und verfahren und gerät zu ihrer herstellung
US20120123355A1 (en) * 2009-07-30 2012-05-17 Cook Medical Technologied Erodible embolization material
US20110065809A1 (en) * 2009-09-15 2011-03-17 Medtronic, Inc. Polymerization of Multifunctional Azides, and Polymers Therefrom
JP2013505791A (ja) 2009-09-24 2013-02-21 マイクロベンション インコーポレイテッド 医学的使用のための注射用ヒドロゲル繊維
US9993252B2 (en) 2009-10-26 2018-06-12 Microvention, Inc. Embolization device constructed from expansile polymer
EP2498764B1 (de) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmentierte hydrogele
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
CN102883752B (zh) * 2010-01-13 2016-03-02 G·比索夫 用于制备临时肠道堵塞的组合物
US7955301B1 (en) 2010-01-27 2011-06-07 Warsaw Orthopedic, Inc. Injection shut off valve with pressure actuator for delivery of compositions
US9125902B2 (en) * 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
US9486500B2 (en) 2010-01-28 2016-11-08 Warsaw Orthopedic, Inc. Osteoimplant and methods for making
US9050274B2 (en) * 2010-01-28 2015-06-09 Warsaw Orthopedic, Inc. Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
US9511077B2 (en) 2011-04-25 2016-12-06 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for wound healing
US9592243B2 (en) 2011-04-25 2017-03-14 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for treatment of an injury
JP6122424B2 (ja) 2011-06-16 2017-04-26 キュラシール インコーポレイテッド 瘻孔処置用デバイス及びその関連方法
WO2012174468A1 (en) 2011-06-17 2012-12-20 Curaseal Inc. Fistula treatment devices and methods
US10137280B2 (en) * 2011-06-30 2018-11-27 Incube Labs, Llc System and method for treatment of hemorrhagic stroke
AT511671A1 (de) * 2011-07-13 2013-01-15 Bischof Georg Dr Zusammensetzung zur erzeugung einer vorübergehenden okklusion des darms eines säugetiers
EP2838577B1 (de) 2012-04-02 2019-02-27 SurModics, Inc. Hydrophile polymerbeschichtungen für medizinische artikel mit einem visualisierungsteil
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
US9351993B2 (en) 2012-06-14 2016-05-31 Microvention, Inc. Polymeric treatment compositions
EP2906254B1 (de) 2012-10-15 2020-01-08 Microvention, Inc. Polymere behandlungszusammensetzungen
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
WO2014152488A2 (en) 2013-03-15 2014-09-25 Dreher Matthew R Imageable embolic microsphere
GB2521997A (en) * 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
FR3017295B1 (fr) * 2014-02-07 2018-01-12 Guerbet Composition destinee a vectoriser un agent anticancereux
CN112869873A (zh) 2014-03-26 2021-06-01 文科罗斯公司 静脉疾病治疗
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
WO2015167752A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers including active agents
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
US10080877B2 (en) 2014-07-25 2018-09-25 Warsaw Orthopedic, Inc. Drug delivery device and methods having a drug cartridge
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US10456235B2 (en) 2015-03-02 2019-10-29 Accurate Medical Therapeutics Ltd. Embolization particulates for occluding a blood vessel
EP4299019A3 (de) 2015-04-01 2024-03-06 Boston Scientific Scimed, Inc. Systeme zur bereitstellung von gelembolie
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
CA2984614C (en) 2015-05-06 2020-07-14 Zoetis Services Llc Hydrogel formulation with mild adhesion
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
FR3039767B1 (fr) 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
GB201515602D0 (en) * 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
US20170216346A1 (en) * 2016-01-28 2017-08-03 Cook Medical Technologies Llc Injectable compositions and methods of use thereof
USD802757S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
CN111315368A (zh) 2017-05-26 2020-06-19 布鲁因生物科学公司 化学栓塞剂
CN111200976B (zh) 2017-10-09 2023-07-07 微仙美国有限公司 放射性液体栓塞
CN107812232A (zh) * 2017-11-08 2018-03-20 华威（深圳）医疗器械有限责任公司 可显影羧基改性聚乙烯醇微球栓塞剂及其制备工艺
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
WO2019222064A1 (en) * 2018-05-15 2019-11-21 Incept, Llc Embolic compositions and methods
WO2019222482A1 (en) 2018-05-16 2019-11-21 Spirox, Inc. Allergic rhinitis drug delivery implant
CN112334497A (zh) 2018-06-29 2021-02-05 生物相容英国有限公司 不透射线聚合物
GB201810784D0 (en) * 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Radiopaque polymers
US20220017703A1 (en) * 2018-11-21 2022-01-20 Kuraray Co., Ltd. Monodisperse hydrogel particles
US20210022743A1 (en) * 2019-07-22 2021-01-28 Boston Scientific Scimed, Inc. In vivo crosslinking of embolic hydrogels using bioorthogonal click chemistry
WO2021199883A1 (ja) * 2020-03-31 2021-10-07 テルモ株式会社 塞栓剤
WO2022010850A1 (en) * 2020-07-06 2022-01-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Polymeric carriers for delivery of therapeutic agents
CN116322652A (zh) * 2020-09-04 2023-06-23 黑天鹅血管股份有限公司 具有不透射线、治疗性化合物的控释的液体栓塞组合物及其使用方法
US20230021742A1 (en) 2021-07-12 2023-01-26 Boston Scientific Scimed, Inc. Radiopaque compositions
US20230037198A1 (en) * 2021-07-29 2023-02-02 Varian Medical Systems, Inc. Apparatuses and methods for producing embolic particles with activated loading sites
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
CN116115818A (zh) * 2021-11-12 2023-05-16 刘庄 活性金属微球、基于活性金属微球的复合栓塞剂及其应用
WO2023122292A1 (en) 2021-12-23 2023-06-29 Boston Scientific Medical Device Limited Chemoembolic compositions and methods of treatment using them
CN115501378B (zh) * 2022-09-23 2023-08-22 江南大学 一种改性聚乙烯醇栓塞微球及其制备方法

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1566330A (en) * 1977-02-16 1980-04-30 Farmaceutici Italia Anthracycline glycosides
JPS6317904A (ja) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd 多孔質架橋ポリビニルアルコ−ル粒子の製造法
JPS63242272A (ja) * 1987-03-31 1988-10-07 テルモ株式会社 バルーンカテーテルのバルーン拡張用組成物
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
DE3841401A1 (de) 1988-12-08 1990-06-13 Martin Lemperle Alloplastisches implantat
DE69114782T2 (de) 1990-08-08 1996-04-18 Takeda Chemical Industries Ltd Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff.
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
JP2576292B2 (ja) * 1991-01-29 1997-01-29 株式会社日立製作所 復水器及びそれを用いた発電プラント
FR2676927B1 (fr) 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
TW272976B (de) * 1993-08-06 1996-03-21 Ciba Geigy Ag
US5394727A (en) * 1993-08-18 1995-03-07 Aluminum Company Of America Method of forming a metal container body
ATE198979T1 (de) 1994-10-12 2001-02-15 Focal Inc Zielgerichte verabreichung mittels biologisch abbaubarer polymere
AU4438696A (en) * 1995-02-03 1996-08-21 Novartis Ag Crosslinked polymers
DE69521025T2 (de) 1995-03-07 2001-10-04 Menlo Care Inc Mittel zur Verbesserung der Schliessmuskelfunktion mit kontrollierter Ausdehnung
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
ES2194110T3 (es) 1995-07-27 2003-11-16 Micro Therapeutics Inc Nuevas composiciones embolizantes.
US5667767A (en) 1995-07-27 1997-09-16 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5580568A (en) 1995-07-27 1996-12-03 Micro Therapeutics, Inc. Cellulose diacetate compositions for use in embolizing blood vessels
CA2228118A1 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents
US5833652A (en) 1995-09-18 1998-11-10 Y. Pierre Gobin Component mixing catheter
ES2420106T3 (es) 1995-12-18 2013-08-22 Angiodevice International Gmbh Composiciones de polímeros reticulados y métodos para su uso
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5702361A (en) * 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
US5902599A (en) 1996-02-20 1999-05-11 Massachusetts Institute Of Technology Biodegradable polymer networks for use in orthopedic and dental applications
BR9708046A (pt) 1996-03-11 2000-01-04 Focal Inc Método para radioterapia local nim paciente e respectiva composição.
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
EP0923399B1 (de) 1996-07-29 2004-06-16 Micro Therapeutics, Inc. Kit aus drei glasfläschen zur vaskulären embolisierung unter verwendung eines dimethylsulfoxyd enthaltenden mittels
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
AR008108A1 (es) * 1996-08-01 1999-12-09 Novartis Ag Un metodo para formar un articulo polimerico absorbente de radiacion, un articulo polimerico asi formado, y un metodo para formar un tintepolimerico
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5925683A (en) 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
AU4672597A (en) 1996-10-18 1998-05-15 Micro Therapeutics, Inc. Method for treating urinary reflux
US5785642A (en) 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
US5981826A (en) 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
BR9811793A (pt) 1997-07-18 2000-09-26 Infimed Inc MacrÈmeros biodegradáveis para a liberação controlada de substâncias biologicamente ativas.
US6265509B1 (en) * 1997-07-30 2001-07-24 Novartis Ag Crosslinked polymers
US5854382A (en) 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
AU8877098A (en) 1997-09-05 1999-03-29 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization
US6037366A (en) 1997-09-11 2000-03-14 Prohold Medical Technologies, Inc. Composition for creating vascular occlusions
JP5095049B2 (ja) 1998-03-06 2012-12-12 バイオスフィアー メディカル，インク． 組織バルキング、および胃食道逆流疾患、尿失禁、皮膚のしわの治療のための移植可能な粒子
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
AU5560899A (en) 1998-08-14 2000-03-06 Incept Llc Methods and apparatus for in situ formation of hydrogels
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6231613B1 (en) 1998-12-15 2001-05-15 Enteric Medical Technologies, Inc. Methods for soft tissue augmentation in mammals
EP1148895B1 (de) 1999-02-05 2004-11-17 The Regents of the University of California Thermoreversibles polymer für intralumenalimplantate
AU3503700A (en) 1999-02-25 2000-09-14 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US6303100B1 (en) 1999-03-19 2001-10-16 Micro Therapeutics, Inc. Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms
US6203779B1 (en) 1999-03-19 2001-03-20 Charlie Ricci Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
WO2000064977A1 (en) 1999-04-26 2000-11-02 California Institute Of Technology In situ forming hydrogels
DK2093245T3 (da) 1999-08-27 2012-06-04 Angiodevice Internat Gmbh Biocompatible polymer device
EP1231950B1 (de) 1999-09-10 2006-06-14 Genzyme Corporation Hydrogele zur orthopädischen reparatur
WO2001044307A2 (en) 1999-11-15 2001-06-21 Biocure, Inc. Degradable poly(vinyl alcohol) hydrogels
KR100335866B1 (ko) 2000-01-06 2002-05-10 박호군 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법
EP1255823A4 (de) 2000-01-28 2007-10-31 Azopax Therapeutics Llc Proteinpolymere mit langsamer freisetzung
JP4871476B2 (ja) 2000-03-13 2012-02-08 バイオコンパティブルズ ユーケー リミテッド 塞栓組成物
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
ATE327783T1 (de) 2000-03-20 2006-06-15 Biosphere Medical Inc Injizierbare mikrokügelchen für den gewebeaufbau
EP1274472A2 (de) 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injizierbare und schwellfähige mikrokügelchen zur gewebeverstärkung
ATE374597T1 (de) 2000-03-24 2007-10-15 Biosphere Medical Inc Mikrokugeln zur aktiven embolisierung
WO2002016443A1 (en) 2000-08-23 2002-02-28 Phairson Medical Inc. Novel polymer compounds

Also Published As

Publication number Publication date
USRE47121E1 (en) 2018-11-13
US20030223956A1 (en) 2003-12-04
DE60130544T2 (de) 2008-06-26
JP2003527402A (ja) 2003-09-16
AU4566001A (en) 2001-09-24
CA2403218A1 (en) 2001-09-20
USRE48302E1 (en) 2020-11-10
CA2403218C (en) 2011-10-18
US20010036451A1 (en) 2001-11-01
EP1263803B1 (de) 2007-09-19
EP1263803A1 (de) 2002-12-11
USRE47873E1 (en) 2020-02-25
US6676971B2 (en) 2004-01-13
WO2001068720A1 (en) 2001-09-20
US20090209658A1 (en) 2009-08-20
JP4871476B2 (ja) 2012-02-08
AU2001245660B2 (en) 2006-06-15
US8221735B2 (en) 2012-07-17
DE60130544D1 (de) 2007-10-31

Similar Documents

Publication Publication Date Title
ATE373682T1 (de) Embolische zusammensetzungen
DE60115212D1 (de) Biomedizinische artikel aus hydrogel
WO2005059860A3 (fr) Polymeres zwitterioniques comprenant des unites de type betaine et utilisation de polymeres zwitterioniques dans des fluides de forage
ATE520721T1 (de) Wässrige gelartige zusammensetzungen auf basis von blockcopolymeren mit hydrophilen und hydrophoben blöcken
CA2323925A1 (en) Crosslinkable macromers bearing initiator groups
BR0106238B1 (pt) massa para moldagem com boa capacidade de moldagem por sopro, bem como uso da referida massa de moldagem e artigo moldado que a contÉm.
WO2003020790A3 (de) Konjugierte polymere enthaltend spirobifluoren-einheiten und deren verwendung
ATE517932T1 (de) Aus der schmelze verarbeitbare polymerzusammensetzung, die fluorpolymer mit langkettenverzweigungen enthält
BR0214136A (pt) Polìmeros de enxerto, processo para a preparação e uso dos mesmos
ATE400352T1 (de) Herstellung von polymergegenständen mit hydrophiler oberfläche
WO2006130575A3 (en) Polymer-containing detergent compositions and their use
MX22234A (es) Mejoras en composiciones de polimero y poliol, y el proceso para preparar polimero fenol-funcional.
DE60134147D1 (de) Träger in partikelform zur verbesserung der oral- absorption von wikstoffen
BR0110067A (pt) Composição polimérica para canos
ATE362776T1 (de) Quellbare hydrogelbildende polymere mit geringem feinstaubanteil
ATE336547T1 (de) Polymerzusammensetzung, enthaltend wenigstens ein mittelmolekulares reaktives polyisobuten
ATE410473T1 (de) Polymerstrukturen mit einem hydrophil/lipophil- system
MY149404A (en) Polyvinyl ether compound
CA2426923A1 (en) Dispersed hydrated potassium borate compositions having improved properties in lubricating oil compositions
AR020532A1 (es) Hidrogeles opticamente transparentes y procesos para su produccion.
BR0111139B1 (pt) utilizaÇço de pelo menos uma hidrotalcita, composiÇço de polÍmero, artigo acabado, e, pneumÁtico.
PL366468A1 (en) Stabilizer compositions for halogenated polymers, the use thereof and polymers containing said compositions
DE60006951T2 (de) Verfahren zur herstellung von alkylierten diphenylaminzusammensetzungen
BR0009325B1 (pt) composições moldadas de policarbonato modificadas por polìmero de enxerto, uso das mesmas e corpos moldados.
ATE362512T1 (de) Stickstoffhaltige polymere umfassende reinigungsmittelzusammensetzung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties