JP5698537B2 - 生物医学的使用のためのハイドロゲルフィラメント - Google Patents
生物医学的使用のためのハイドロゲルフィラメント Download PDFInfo
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- JP5698537B2 JP5698537B2 JP2010539913A JP2010539913A JP5698537B2 JP 5698537 B2 JP5698537 B2 JP 5698537B2 JP 2010539913 A JP2010539913 A JP 2010539913A JP 2010539913 A JP2010539913 A JP 2010539913A JP 5698537 B2 JP5698537 B2 JP 5698537B2
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- hydrogel
- ethylenically unsaturated
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Classifications
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Description
本出願は、2007年12月21日に出願された米国仮特許出願第61/016,342号の利益を主張し、この出願の全開示は本明細書中に参考として援用される。
本発明は、全体として医療装置および方法に関し、より詳しくは蛍光X線透視法および磁気共鳴法において見ることができるハイドロゲルフィラメント、および生物医学的治療におけるそのような材料の使用のための方法に関する。
現在、脳血管疾患および/または末梢血管疾患の患者に対して、介入的神経放射線医/神経外科医には3つの主要な塞栓デバイスの選択肢、すなわち白金コイル、ハイドロゲル/白金コイル、または分解性高分子/白金コイルがある。3種類のコイルはすべて動脈瘤の中に留置され、それぞれに固有の利点および弱点がある。白金コイルは標準的なマイクロカテーテルを通して留置しやすく、広い範囲の柔らかさのものが手に入り、サイズが小さいかまたはくびれのある動脈瘤に最も適している。ハイドロゲル/白金コイルも標準的なマイクロカテーテルを通して留置しやすい。ハイドロゲル/白金コイルは白金コイルと比べると固く、動脈瘤の内部に留置するのが困難なことがあるが、より広い範囲の嚢およびくびれサイズの場合に満足な結果が得られる。分解性高分子/白金コイルは容易に移動し、動脈瘤嚢の中に留置されるが、サイズが小さいかまたはくびれのある動脈瘤の場合にしか満足な結果が得られない。
本明細書には、1つ以上の脳血管疾患および/または末梢血管疾患の結果として生じる構造物および機能不全部を閉塞するための装置、組成物、システム、および関連する方法が記載されている。遅延制御された膨脹速度を有する1つ以上の可視化剤を含むハイドロゲルフィラメントを用いてこれらの構造物および機能不全部を処置し、それによって構造物または機能不全部の内部に入ったデバイスの位置の移動を可能にする。さらに、1つ以上の可視化剤、例えば制御された膨脹速度を有する放射不透過成分または充填材を含むハイドロゲルフィラメントによって、フィラメントを適切に配置するのに十分な時間が外科医にもたらされ、フィラメントが直ぐに膨脹するせいで急ぐ必要がなくなる。
PEG1000ジアクリルアミドの調製
最初に、200mLのトルエンとの共沸蒸留によって18gのポリエチレングリコール(PEG)1000を脱水した。次に、7.0mLのトリエチルアミンを4.6mLのメシルクロリドとともに加えて4時間撹拌した。次に、この溶液をろ過して塩を除去し、溶媒を蒸発させた。得られた生成物を150mLの25%アンモニア水酸化物に加え、2日間撹拌した。水を取り除き、トルエンとの共沸蒸留によって生成物を脱水した。得られた無水PEGジアミンを20mLのジクロロメタンおよび50mLのトルエンに溶かした。次に、7.0mLのトリエチルアミンおよび4.9mLのアクリロイルクロリドを加え、撹拌しながら4時間反応させた。得られた溶液をろ過し、溶媒を除去してPEG1000ジアクリルアミドを得た。
放射不透過モノマーの調製
最初に、9gのトリヨードフェノールをアルゴン下150mLのジクロロメタンに溶かした。次に、撹拌しながら3.15mLのペンテノイルクロリドを加えた。次に、トリエチルアミンをゆっくり加え、4時間撹拌した。この溶液を100mLの水で洗浄し、蒸発乾固させて2,4,6−トリヨードフェニルペンタ−4−エノエートを得た。
クロロホルム中の放射不透過ハイドロゲルフィラメントの調製
有機溶媒中の放射不透過ハイドロゲルを調製するために、2gの2,4,6−トリヨードフェニルペンタ−4−エノエート、0.67gのアクリル酸、1.2gのPEGジアクリルアミド400、24mgのN,N−メチレンビスアクリルアミド、および75mgのアゾビス(2−メチルプロピオニトリル)を2.5mLのクロロホルムに溶かした。次に、溶液にアルゴンを10分間吹き込んだ後、3ccの注射器を用いて0.020インチのポリエチレン管の中に注入した。チューブの両端を熱で封止し、80℃のオーブンの中に一夜置いて溶液を重合させた。
バリウム充填放射不透過ハイドロゲルフィラメントの調製
有機溶媒中のバリウム充填放射不透過ハイドロゲルを調製するために、7gの硫酸バリウム、0.5gのアクリル酸、5gのポリ(テトラメチレンオキシド)ジアクリルアミド1000、1.25gの2−ヒドロキシエチルメタクリレート、212mgのN,N−メチレンビスアクリルアミド、および100mgのアゾビス(2−メチルプロピオニトリル)を3.5mLのイソプロピルアルコールに溶かした。次に、溶液にアルゴンを10分間吹き込んだ後、3ccの注射器を用いて4mmのマンドレルの周りにかぶせた0.010インチのHYTREL(登録商標)管の中に注入した。チューブの両端を熱で封止し、100℃の湯浴中に1時間、次に80℃のオーブン中に一夜置いて溶液を重合させた。
水中の放射不透過ハイドロゲルフィラメントの調製
水中の放射不透過ハイドロゲルを調製するために、5gの2,5−アクリルアミド−2,4,6−トリヨード−n,n’−ビス−(2,3ジヒドロキシプロピル)イソフタルアミド、1.33gのアクリル酸、2.5gのPEGジアクリルアミド400、50mgのn−ビニル−2−ピロリジノン、および100mgの2,2’アゾビス(2−メチルプロピオンアミジン)2塩酸塩を10mLの水に溶かした。次に、この溶液にアルゴンを10分間吹き込んだ後、3ccの注射器を用いて0.020インチのポリエチレン管の中に注入した。チューブの両端を熱で封止し、80℃のオーブンの中に一夜置いて溶液を重合させた。
放射不透過ハイドロゲルフィラメントの洗浄および酸処理
実施例3に従って重合したハイドロゲルの場合には管を3インチ区画に切り、アセトン中に1時間置いた。アセトン中でハイドロゲルはチューブの端を越えて膨脹し、チューブから取り出すことができた。ハイドロゲルをアセトン中で2時間洗浄した。2時間後にアセトンを取り替え、ハイドロゲルをさらに2時間洗浄した。アセトンを除去し、ハイドロゲルを真空オーブン中50℃で2時間乾燥した。
放射不透過ハイドロゲルフィラメントの押し具への取り付け
放射不透過ハイドロゲルフィラメントは、V−TRAK(登録商標)(MicroVention Terumo Inc.,Aliso Viejo,CA)または油圧押し具に取り付けることができる。ハイドロゲルをV−TRACK(登録商標)押し具に取り付けるために0.0022インチのポリ(エチレン)管縫合糸をカプラの中に通した。カプラは、一端を中空にしたチタン円筒体と貫通孔とからなっていた。ポリ(エチレン)管縫合糸が引き抜かれてしまわないように結び目をつくった。接着剤を用いてハイドロゲルを結び目の上でカプラに接着した。ポリ(エチレン)管糸の他方の端をV−TRAK(登録商標)押し具の中に通し、結んだ。
座屈力の測定
動脈瘤嚢の内部に留置する実施例6の放射不透過ハイドロゲルフィラメントの能力を他の現在市販されているコイルと比較するために、さまざまなデバイスの座屈力を測定した。この試験では、大体1インチのデバイスのピースをロウ付けまたはポリ(エチレン)収縮管のどちらかによって約15インチのハイポ管のピースに取り付けた。構成物のハイポ管の端を材料の力のデータを測定するために用いたシステムであるInstron 5543 Single Column Testing Systemに取り付けた。構成物をポリ(カーボネート)ブロックの中の行き止まりのチャネルの中に進ませた。デバイスがチャネルの底に達したら、座屈するように力を加え、対応する力を測定した。
曲げ抵抗の測定
測定ベインに取り付けた5gのおもりを有するGurley 4171ET管状試料硬さ試験機を用いて、膨脹していないハイドロゲル試料の曲げ抵抗および注入可能な白金マイクロコイルの曲げ抵抗を得た。試料の長さは1インチであった。3回の繰り返しの平均をそれぞれ以下の表にまとめた。
注入可能な放射不透過ハイドロゲルフィラメントの評価
バリウム充填放射不透過ハイドロゲル調合物から構成したデバイスを、屈曲血管に合わせた流れモデルの中で評価した。流れ誘導マイクロカテーテル(Boston Scientific Spinnaker 1.5F)を血管の中に配置した。3ccの注射器を用いてマイクロカテーテルの中に5cmから30cmの範囲の長さのデバイスを注入した。導入、移動、留置、および充填についてデバイスを評価した。導入、移動、および留置について合格を実現するために、インプラントは3ccの注射器を用いて支障なく導入、移動、および留置しなければならない。充填について合格を実現するために、インプラントは0.008インチ白金コイルと同様に屈曲血管の中に充填しなければならない。
実験動脈瘤中の放射不透過高分子ハイドロゲルの評価
放射不透過高分子フィラメントによって3つのウサギエラスターゼ動脈瘤を塞栓した。動脈瘤の幅、長さ、およびくびれ部はそれぞれ2.4から3.6mm、4.7から8.8mm、および2.4から4.2mmの範囲であった。マイクロカテーテル(Cordis RAPIDTRANSIT(登録商標),Cordis Corporation,Miami Lake,FL)を動脈瘤嚢の内部に配置した。動脈瘤嚢の中に1つから3つの放射不透過ハイドロゲルフィラメントを留置した。血管造影法は、塞栓の結果として3つの動脈瘤すべての完全な閉塞を示した。塞栓後6週の時点で血管造影法によって3つの動脈瘤すべての完全な閉塞を示した。動脈瘤を回収し、組織学的に処理した。切片は、放射不透過ハイドロゲルフィラメントによる動脈瘤嚢の完全な充填、放射不透過ハイドロゲルフィラメント間の隙間における組織化中/組織化済み線維組織、ならびにマクロファージおよびいくつかの巨大細胞からなる炎症性応答を示した。これらの結果は、放射不透過ハイドロゲルフィラメントを実験動脈瘤の中に留置し、他の塞栓デバイスと同様な異物応答を誘発することができることを示した。
Claims (22)
- 移植のためのデバイスであって、
2官能低分子量エチレン系不飽和成形性マクロマー、ここで当該マクロマーは400グラム/モルおよび1,000グラム/モルの間の分子量を有する;
エチレン系不飽和モノマー;および
40%から60%重量/重量の硫酸バリウム;
を含み、ここで当該デバイスは支持部材を含まず、そしてハイドロゲルフィラメントが0.5±0.4gfの座屈力を有する、前記デバイス。 - 前記ハイドロゲルは、環境応答性である、請求項1に記載のデバイス。
- 前記マクロマーは、ポリエチレングリコール、プロピレングリコール、ポリ(テトラメチレンオキシド)、ポリ(エチレングリコール)ジアクリルアミド、ポリ(エチレングリコール)ジアクリレート、ポリ(エチレングリコール)ジメタクリレート、それらの誘導体、またはそれらの組み合わせを含む、請求項1に記載のデバイス。
- 前記エチレン系不飽和モノマーは、1つ以上のイオン化可能な官能基を含む、請求項1に記載のデバイス。
- 前記エチレン系不飽和モノマーは、N,N’−メチレンビスアクリルアミド、N−ビニルピロリジノン、2−ヒドロキシエチルメタクリレート、それらの誘導体、またはそれらの組み合わせを含む、請求項1に記載のデバイス。
- 前記エチレン系不飽和モノマーは、2,4,6−トリヨードフェニルペンタ−4−エノエート、5−アクリルアミド−2,4,6−トリヨード−n,n’−ビス−(2,3ジヒドロキシプロピル)イソフタルアミド、それらの誘導体、またはそれらの組み合わせを含む、請求項1に記載のデバイス。
- 前記マクロマーおよび前記モノマーは、N,N,N’,N’−テトラメチルエチレンジアミン、過硫酸アンモニウム、アゾビスイソブチロニトリル、過酸化ベンゾイル、2,2’−アゾビス(2−メチルプロピオンアミジン)2塩酸塩、それらの誘導体、またはそれらの組み合わせを用いて架橋される、請求項1に記載のデバイス。
- 前記イオン化可能な官能基は、塩基性基または酸性基を含む、請求項4に記載のデバイス。
- 前記イオン化可能な官能基は、アミン基、その誘導体、またはそれらの組み合わせを含む、請求項8に記載のデバイス。
- 前記酸性基は、カルボン酸、その誘導体、またはそれらの組み合わせを含む、請求項8に記載のデバイス。
- 前記ハイドロゲルは、実質的にアクリルアミドを含まない、請求項1に記載のデバイス。
- 前記ハイドロゲルは、実質的に非生体再吸収性である、請求項1に記載のデバイス。
- 前記ハイドロゲルは、生体再吸収性である、請求項1に記載のデバイス。
- a)400グラム/モルおよび1,000グラム/モルの間の分子量を有する2官能低分子量エチレン系不飽和成形性マクロマー、エチレン系不飽和モノマー、40%から60%重量/重量の硫酸バリウム、および溶媒を一緒にしてプレポリマ溶液を調製するステップ、および
b)前記プレポリマ溶液を処理して生理条件下で膨脹可能であり、かつ0.5±0.4gfの座屈力を有するハイドロゲルを調製するステップ
を含む動物における移植のためのデバイスを調製するための方法。 - 前記溶媒は、水、ジクロロメタン、アセトン、イソプロピルアルコール、エタノール、またはそれらの組み合わせを含む、請求項14に記載の方法。
- 前記エチレン系不飽和モノマーは、イオン化可能な官能基を含む、請求項14に記載の方法。
- 前記溶媒は、前記プレポリマ溶液の20%重量/重量から80%重量/重量を構成する、請求項14に記載の方法。
- 前記モノマーは、重量で前記プレポリマ溶液の40%から80%を構成する、請求項14に記載の方法。
- 前記プレポリマ溶液に第2のエチレン系不飽和モノマーを加えるステップをさらに含む、請求項14に記載の方法。
- 前記イオン化可能な官能基は塩基性基を含み、前記処理するステップはpKaより大きなpHにおいて前記塩基性基を脱プロトンすることまたは前記塩基性基のpKaより小さなpHにおいて前記塩基性基をプロトン化することを含む、請求項16に記載の方法。
- 前記イオン化可能な官能基は酸性基を含み、前記処理するステップは前記pKaより小さなpHにおいて前記酸性基をプロトン化することまたは前記酸性基の前記pKaより大きなpHにおいて前記酸性基を脱プロトンすることを含む、請求項16に記載の方法。
- 動物における移植のためのデバイスであって、
400グラム/モルから1000グラム/モルの分子量を有する2官能低分子量エチレン系不飽和成形性マクロマー;
エチレン系不飽和モノマー;および
40%から60%重量/重量の硫酸バリウム;
を含み、ここで当該デバイスは金属支持部材を含まず、そしてハイドロゲルフィラメントが0.5±0.4gfの座屈力を有する、前記デバイス。
Applications Claiming Priority (3)
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US61/016,342 | 2007-12-21 | ||
PCT/US2008/087846 WO2009086208A2 (en) | 2007-12-21 | 2008-12-19 | Hydrogel filaments for biomedical uses |
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Families Citing this family (192)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2625826C (en) | 2005-10-19 | 2014-08-05 | Pulsar Vascular, Inc. | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
EP2015698B1 (en) | 2006-04-20 | 2017-11-15 | Sonendo, Inc. | Apparatus for treating root canals of teeth |
JP2010500917A (ja) | 2006-06-15 | 2010-01-14 | マイクロベンション, インコーポレイテッド | 膨張性ポリマーで構成される塞栓形成デバイス |
US7980854B2 (en) | 2006-08-24 | 2011-07-19 | Medical Dental Advanced Technologies Group, L.L.C. | Dental and medical treatments and procedures |
CA2709379C (en) | 2007-12-21 | 2016-08-16 | Microvention, Inc. | Hydrogel filaments for biomedical uses |
US10028747B2 (en) | 2008-05-01 | 2018-07-24 | Aneuclose Llc | Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm |
US10716573B2 (en) | 2008-05-01 | 2020-07-21 | Aneuclose | Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm |
US9402707B2 (en) | 2008-07-22 | 2016-08-02 | Neuravi Limited | Clot capture systems and associated methods |
KR101652804B1 (ko) | 2008-09-05 | 2016-08-31 | 펄사 배스큘라, 아이엔씨. | 생리적 구멍 또는 공동을 지지하거나 또는 폐쇄하기 위한 시스템과 방법 |
EP2480166B1 (en) * | 2009-09-24 | 2017-11-29 | Microvention, Inc. | Injectable hydrogel filaments for biomedical uses |
WO2011053555A1 (en) | 2009-10-26 | 2011-05-05 | Microvention, Inc. | Embolization device constructed from expansile polymer |
US9358140B1 (en) | 2009-11-18 | 2016-06-07 | Aneuclose Llc | Stent with outer member to embolize an aneurysm |
US9463036B2 (en) | 2010-10-22 | 2016-10-11 | Neuravi Limited | Clot engagement and removal system |
US11259824B2 (en) | 2011-03-09 | 2022-03-01 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US12076037B2 (en) | 2011-03-09 | 2024-09-03 | Neuravi Limited | Systems and methods to restore perfusion to a vessel |
US9301769B2 (en) | 2011-03-09 | 2016-04-05 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US9456823B2 (en) * | 2011-04-18 | 2016-10-04 | Terumo Corporation | Embolic devices |
CN103582460B (zh) | 2011-06-03 | 2019-03-19 | 帕尔萨维斯库勒公司 | 具有额外锚固机构的动脉瘤装置以及相关系统及方法 |
EP2739217B1 (en) | 2011-08-05 | 2022-07-20 | Route 92 Medical, Inc. | Systems for treatment of acute ischemic stroke |
US9119625B2 (en) | 2011-10-05 | 2015-09-01 | Pulsar Vascular, Inc. | Devices, systems and methods for enclosing an anatomical opening |
WO2013158781A1 (en) | 2012-04-18 | 2013-10-24 | Microvention, Inc. | Embolic devices |
EP2967824B1 (en) | 2013-03-12 | 2020-11-04 | Carnegie Mellon University | Coated vaso-occlusive device for treatment of aneurysms |
US10603157B2 (en) | 2013-03-13 | 2020-03-31 | DePuy Synthes Products, Inc. | Braid implant delivery and retraction device with distal engagement |
US10561509B2 (en) | 2013-03-13 | 2020-02-18 | DePuy Synthes Products, Inc. | Braided stent with expansion ring and method of delivery |
US9433429B2 (en) | 2013-03-14 | 2016-09-06 | Neuravi Limited | Clot retrieval devices |
TR201901830T4 (tr) | 2013-03-14 | 2019-03-21 | Neuravi Ltd | Kan damarlarından akut tıkanıkların giderilmesine yönelik cihazlar ve metotlar. |
CN105208950A (zh) | 2013-03-14 | 2015-12-30 | 尼尔拉维有限公司 | 一种用于从血管去除堵塞凝块的凝块收取装置 |
EP3013277B1 (en) | 2013-06-26 | 2023-07-19 | Sonendo, Inc. | Apparatus and methods for filling teeth and root canals |
BR112016005770B1 (pt) | 2013-09-19 | 2021-07-27 | Terumo Corporation | Partículas de polímero |
CA2923741C (en) | 2013-09-19 | 2022-06-07 | Microvention, Inc. | Polymer films |
KR102287781B1 (ko) | 2013-11-08 | 2021-08-06 | 테루모 가부시키가이샤 | 중합체 입자 |
US9265512B2 (en) | 2013-12-23 | 2016-02-23 | Silk Road Medical, Inc. | Transcarotid neurovascular catheter |
US10285720B2 (en) | 2014-03-11 | 2019-05-14 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US11076860B2 (en) | 2014-03-31 | 2021-08-03 | DePuy Synthes Products, Inc. | Aneurysm occlusion device |
US11154302B2 (en) | 2014-03-31 | 2021-10-26 | DePuy Synthes Products, Inc. | Aneurysm occlusion device |
US10124090B2 (en) | 2014-04-03 | 2018-11-13 | Terumo Corporation | Embolic devices |
US10092663B2 (en) | 2014-04-29 | 2018-10-09 | Terumo Corporation | Polymers |
CN110433326A (zh) * | 2014-04-29 | 2019-11-12 | 微仙美国有限公司 | 包含活性剂的聚合物 |
EP3154452B1 (en) | 2014-06-13 | 2024-09-18 | Neuravi Limited | Devices for removal of acute blockages from blood vessels |
US10265086B2 (en) | 2014-06-30 | 2019-04-23 | Neuravi Limited | System for removing a clot from a blood vessel |
US9918718B2 (en) | 2014-08-08 | 2018-03-20 | DePuy Synthes Products, Inc. | Embolic coil delivery system with retractable mechanical release mechanism |
US10206796B2 (en) | 2014-08-27 | 2019-02-19 | DePuy Synthes Products, Inc. | Multi-strand implant with enhanced radiopacity |
US9782178B2 (en) | 2014-09-19 | 2017-10-10 | DePuy Synthes Products, Inc. | Vasculature occlusion device detachment system with tapered corewire and heater activated fiber detachment |
US11253278B2 (en) | 2014-11-26 | 2022-02-22 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US10617435B2 (en) | 2014-11-26 | 2020-04-14 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
WO2016083472A1 (en) | 2014-11-26 | 2016-06-02 | Neuravi Limited | A clot retrieval device for removing occlusive clot from a blood vessel |
US9637442B2 (en) * | 2014-12-24 | 2017-05-02 | L'oreal | Photo-activated hydrogels |
US9616013B2 (en) * | 2014-12-24 | 2017-04-11 | L'oreal | Photo-activated hydrogels |
CN107108879B (zh) * | 2014-12-24 | 2020-06-05 | 欧莱雅公司 | 光活化的水凝胶 |
US11065019B1 (en) | 2015-02-04 | 2021-07-20 | Route 92 Medical, Inc. | Aspiration catheter systems and methods of use |
EP3253437B1 (en) | 2015-02-04 | 2019-12-04 | Route 92 Medical, Inc. | Rapid aspiration thrombectomy system |
US9907880B2 (en) | 2015-03-26 | 2018-03-06 | Microvention, Inc. | Particles |
WO2016201250A1 (en) * | 2015-06-11 | 2016-12-15 | Microvention, Inc. | Expansile device for implantation |
WO2017019563A1 (en) | 2015-07-24 | 2017-02-02 | Route 92 Medical, Inc. | Anchoring delivery system and methods |
US10335154B2 (en) | 2015-09-10 | 2019-07-02 | Ikonano Venture Partners, Llc | Polymeric electrospun embolization device and methods of use |
US10471183B2 (en) * | 2015-12-22 | 2019-11-12 | Access Vascular, Inc. | High strength biomedical materials |
KR101864674B1 (ko) * | 2016-02-17 | 2018-06-05 | 한양대학교 산학협력단 | 외부자극응답성 연성 나노입자를 이용한 패턴화된 나노구조체 및 이의 제조방법 |
WO2017147493A1 (en) | 2016-02-24 | 2017-08-31 | Incept, Llc | Enhanced flexibility neurovascular catheter |
US10285710B2 (en) | 2016-06-01 | 2019-05-14 | DePuy Synthes Products, Inc. | Endovascular detachment system with flexible distal end and heater activated detachment |
KR102457315B1 (ko) | 2016-08-17 | 2022-10-24 | 뉴라비 리미티드 | 혈관으로부터 폐색 혈전을 제거하기 위한 혈전 회수 시스템 |
US10076428B2 (en) | 2016-08-25 | 2018-09-18 | DePuy Synthes Products, Inc. | Expansion ring for a braided stent |
EP3509509B1 (en) | 2016-09-06 | 2021-03-31 | Neuravi Limited | A clot retrieval device for removing occlusive clot from a blood vessel |
CA3038642C (en) | 2016-09-28 | 2021-11-02 | Terumo Corporation | Polymer particles comprising polymerizable pharmaceutical agents |
US10292851B2 (en) | 2016-09-30 | 2019-05-21 | DePuy Synthes Products, Inc. | Self-expanding device delivery apparatus with dual function bump |
US10517708B2 (en) | 2016-10-26 | 2019-12-31 | DePuy Synthes Products, Inc. | Multi-basket clot capturing device |
US10653426B2 (en) | 2017-01-06 | 2020-05-19 | Incept, Llc | Thromboresistant coatings for aneurysm treatment devices |
WO2018132387A1 (en) | 2017-01-10 | 2018-07-19 | Route 92 Medical, Inc. | Aspiration catheter systems and methods of use |
US10905853B2 (en) | 2017-01-17 | 2021-02-02 | DePuy Synthes Products, Inc. | System and method for delivering a catheter |
US10881497B2 (en) | 2017-01-26 | 2021-01-05 | DePuy Synthes Products, Inc. | Composite vascular flow diverter |
WO2018156833A1 (en) | 2017-02-23 | 2018-08-30 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US11577008B2 (en) | 2017-06-21 | 2023-02-14 | Access Vascular, Inc. | High strength porous materials incorporating water soluble polymers |
CN111164115B (zh) * | 2017-10-18 | 2021-11-23 | 富士胶片株式会社 | 固化性组合物、膜、固化物及医疗用部件 |
EP3699210A4 (en) * | 2017-10-18 | 2020-09-23 | FUJIFILM Corporation | HARDENABLE COMPOSITION, FILM, HARDENED PRODUCT AND MEDICAL ELEMENT |
US10806462B2 (en) | 2017-12-21 | 2020-10-20 | DePuy Synthes Products, Inc. | Implantable medical device detachment system with split tube and cylindrical coupling |
US10751065B2 (en) | 2017-12-22 | 2020-08-25 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US10905430B2 (en) | 2018-01-24 | 2021-02-02 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
JP7248654B2 (ja) | 2018-03-29 | 2023-03-29 | テルモ株式会社 | 塞栓材 |
US10786259B2 (en) | 2018-03-30 | 2020-09-29 | DePuy Synthes Products, Inc. | Split balloon assist device and method for using the same |
US10918390B2 (en) | 2018-03-30 | 2021-02-16 | DePuy Synthes Products, Inc. | Helical balloon assist device and method for using the same |
US10806461B2 (en) | 2018-04-27 | 2020-10-20 | DePuy Synthes Products, Inc. | Implantable medical device detachment system with split tube |
CN112203593A (zh) | 2018-05-01 | 2021-01-08 | 因赛普特有限责任公司 | 用于从血管内部位去除闭塞性物质的装置和方法 |
US11395665B2 (en) | 2018-05-01 | 2022-07-26 | Incept, Llc | Devices and methods for removing obstructive material, from an intravascular site |
CN115920204A (zh) | 2018-05-17 | 2023-04-07 | 92号医疗公司 | 抽吸导管系统和使用方法 |
US11058430B2 (en) | 2018-05-25 | 2021-07-13 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US11596412B2 (en) | 2018-05-25 | 2023-03-07 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US10939915B2 (en) | 2018-05-31 | 2021-03-09 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US10667833B2 (en) | 2018-06-08 | 2020-06-02 | Neuravi Limited | Guidewire with an atraumatic clot-circumventing configured distal end for use in an endovascular medical system |
US10898216B2 (en) | 2018-06-13 | 2021-01-26 | DePuy Synthes Products, Inc. | Vasculature obstruction capture device |
US11517335B2 (en) | 2018-07-06 | 2022-12-06 | Incept, Llc | Sealed neurovascular extendable catheter |
US11471582B2 (en) | 2018-07-06 | 2022-10-18 | Incept, Llc | Vacuum transfer tool for extendable catheter |
AU2019204522A1 (en) | 2018-07-30 | 2020-02-13 | DePuy Synthes Products, Inc. | Systems and methods of manufacturing and using an expansion ring |
US10905431B2 (en) | 2018-08-03 | 2021-02-02 | DePuy Synthes Products, Inc. | Spiral delivery system for embolic braid |
US10456280B1 (en) | 2018-08-06 | 2019-10-29 | DePuy Synthes Products, Inc. | Systems and methods of using a braided implant |
US10278848B1 (en) | 2018-08-06 | 2019-05-07 | DePuy Synthes Products, Inc. | Stent delivery with expansion assisting delivery wire |
US11051825B2 (en) | 2018-08-08 | 2021-07-06 | DePuy Synthes Products, Inc. | Delivery system for embolic braid |
US10813780B2 (en) | 2018-08-08 | 2020-10-27 | DePuy Synthes Products, Inc. | Intraluminal implant delivery system and method |
US10842498B2 (en) | 2018-09-13 | 2020-11-24 | Neuravi Limited | Systems and methods of restoring perfusion to a vessel |
JP2020044335A (ja) | 2018-09-20 | 2020-03-26 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | 成形されたワイヤを有するステント |
US11123077B2 (en) | 2018-09-25 | 2021-09-21 | DePuy Synthes Products, Inc. | Intrasaccular device positioning and deployment system |
US11406416B2 (en) | 2018-10-02 | 2022-08-09 | Neuravi Limited | Joint assembly for vasculature obstruction capture device |
US11253287B2 (en) | 2018-10-04 | 2022-02-22 | Neuravi Limited | Retrograde blood flow occlusion flushing device |
US11076861B2 (en) | 2018-10-12 | 2021-08-03 | DePuy Synthes Products, Inc. | Folded aneurysm treatment device and delivery method |
US11147562B2 (en) | 2018-12-12 | 2021-10-19 | DePuy Synthes Products, Inc. | Systems and methods for embolic implant detachment |
US11406392B2 (en) | 2018-12-12 | 2022-08-09 | DePuy Synthes Products, Inc. | Aneurysm occluding device for use with coagulating agents |
US11272939B2 (en) | 2018-12-18 | 2022-03-15 | DePuy Synthes Products, Inc. | Intrasaccular flow diverter for treating cerebral aneurysms |
US11039944B2 (en) | 2018-12-27 | 2021-06-22 | DePuy Synthes Products, Inc. | Braided stent system with one or more expansion rings |
US11134953B2 (en) | 2019-02-06 | 2021-10-05 | DePuy Synthes Products, Inc. | Adhesive cover occluding device for aneurysm treatment |
US11273285B2 (en) | 2019-02-07 | 2022-03-15 | DePuy Synthes Products, Inc. | Ancillary device for detaching implants |
ES2910600T3 (es) | 2019-03-04 | 2022-05-12 | Neuravi Ltd | Catéter de recuperación de coágulos accionado |
US11382633B2 (en) | 2019-03-06 | 2022-07-12 | DePuy Synthes Products, Inc. | Strut flow diverter for cerebral aneurysms and methods for preventing strut entanglement |
US11337706B2 (en) | 2019-03-27 | 2022-05-24 | DePuy Synthes Products, Inc. | Aneurysm treatment device |
US11185334B2 (en) | 2019-03-28 | 2021-11-30 | DePuy Synthes Products, Inc. | Single lumen reduced profile occlusion balloon catheter |
US11766539B2 (en) | 2019-03-29 | 2023-09-26 | Incept, Llc | Enhanced flexibility neurovascular catheter |
US11051928B2 (en) | 2019-04-11 | 2021-07-06 | Neuravi Limited | Floating carotid filter |
US11957855B2 (en) | 2019-05-09 | 2024-04-16 | Neuravi Limited | Balloon guide catheter with positive venting of residual air |
US11571553B2 (en) | 2019-05-09 | 2023-02-07 | Neuravi Limited | Balloon guide catheter with thermally expandable material |
US11931522B2 (en) | 2019-05-09 | 2024-03-19 | Neuravi Limited | Inflation lumen kink protection and balloon profile |
US11607531B2 (en) | 2019-05-09 | 2023-03-21 | Neuravi Limited | Balloon catheter with venting of residual air in a proximal direction |
USD959659S1 (en) | 2019-05-10 | 2022-08-02 | DePuy Synthes Products, Inc. | Implant release handle |
US11672542B2 (en) | 2019-05-21 | 2023-06-13 | DePuy Synthes Products, Inc. | Aneurysm treatment with pushable ball segment |
US11413046B2 (en) | 2019-05-21 | 2022-08-16 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device |
US10653425B1 (en) | 2019-05-21 | 2020-05-19 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device |
US11497504B2 (en) | 2019-05-21 | 2022-11-15 | DePuy Synthes Products, Inc. | Aneurysm treatment with pushable implanted braid |
US11278292B2 (en) | 2019-05-21 | 2022-03-22 | DePuy Synthes Products, Inc. | Inverting braided aneurysm treatment system and method |
US11602350B2 (en) | 2019-12-05 | 2023-03-14 | DePuy Synthes Products, Inc. | Intrasaccular inverting braid with highly flexible fill material |
US11607226B2 (en) | 2019-05-21 | 2023-03-21 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device with corrugations |
US11406403B2 (en) | 2019-06-14 | 2022-08-09 | Neuravi Limited | Visibility of mechanical thrombectomy device during diagnostic imaging |
US11109939B2 (en) | 2019-06-14 | 2021-09-07 | DePuy Synthes Products, Inc. | Intravascular devices with radiopaque body markers |
US11253265B2 (en) | 2019-06-18 | 2022-02-22 | DePuy Synthes Products, Inc. | Pull wire detachment for intravascular devices |
US11207494B2 (en) | 2019-07-03 | 2021-12-28 | DePuy Synthes Products, Inc. | Medical device delivery member with flexible stretch resistant distal portion |
US11426174B2 (en) | 2019-10-03 | 2022-08-30 | DePuy Synthes Products, Inc. | Medical device delivery member with flexible stretch resistant mechanical release |
US11266426B2 (en) | 2019-07-10 | 2022-03-08 | DePuy Synthes Products, Inc. | Streamlined treatment of clot removal, angioplasty and prevention of restenosis using a single integrated intravascular device |
US11266427B2 (en) | 2019-07-10 | 2022-03-08 | Neuravi Limited | Self-expanding intravascular medical device |
US11395675B2 (en) | 2019-07-11 | 2022-07-26 | DePuy Synthes Products, Inc. | Clot retriever cleaning for reinsertion |
JP2021041169A (ja) | 2019-09-11 | 2021-03-18 | ニューラヴィ・リミテッド | 拡大可能な口腔カテーテル |
US11439403B2 (en) | 2019-09-17 | 2022-09-13 | DePuy Synthes Products, Inc. | Embolic coil proximal connecting element and stretch resistant fiber |
CN110859999B (zh) * | 2019-10-11 | 2021-02-02 | 南方医科大学 | 一种三维血管网络水凝胶的构建方法 |
WO2021076642A1 (en) | 2019-10-15 | 2021-04-22 | Imperative Care, Inc. | Systems and methods for multivariate stroke detection |
US11712231B2 (en) | 2019-10-29 | 2023-08-01 | Neuravi Limited | Proximal locking assembly design for dual stent mechanical thrombectomy device |
US11376013B2 (en) | 2019-11-18 | 2022-07-05 | DePuy Synthes Products, Inc. | Implant delivery system with braid cup formation |
US11628282B2 (en) | 2019-11-25 | 2023-04-18 | Neuravi Limited | No preparation balloon guide catheter |
US11779364B2 (en) | 2019-11-27 | 2023-10-10 | Neuravi Limited | Actuated expandable mouth thrombectomy catheter |
US11839725B2 (en) | 2019-11-27 | 2023-12-12 | Neuravi Limited | Clot retrieval device with outer sheath and inner catheter |
US11517340B2 (en) | 2019-12-03 | 2022-12-06 | Neuravi Limited | Stentriever devices for removing an occlusive clot from a vessel and methods thereof |
US11457926B2 (en) | 2019-12-18 | 2022-10-04 | DePuy Synthes Products, Inc. | Implant having an intrasaccular section and intravascular section |
US20210315598A1 (en) | 2019-12-18 | 2021-10-14 | Imperative Care, Inc. | Methods of placing large bore aspiration catheters |
EP4076611A4 (en) | 2019-12-18 | 2023-11-15 | Imperative Care, Inc. | METHODS AND SYSTEMS FOR THE TREATMENT OF VENOUS THROMBOEMBOLIC DISEASE |
US11638637B2 (en) | 2019-12-18 | 2023-05-02 | Imperative Care, Inc. | Method of removing embolic material with thrombus engagement tool |
US11457922B2 (en) | 2020-01-22 | 2022-10-04 | DePuy Synthes Products, Inc. | Medical device delivery member with flexible stretch resistant distal portion |
US11992241B2 (en) | 2020-01-31 | 2024-05-28 | DePuy Synthes Products, Inc. | System to assist delivery of a mechanical intravascular treatment device |
US11957354B2 (en) | 2020-02-10 | 2024-04-16 | DePuy Synthes Products, Inc. | Aneurysm implant support device |
US11432822B2 (en) | 2020-02-14 | 2022-09-06 | DePuy Synthes Products, Inc. | Intravascular implant deployment system |
US11944327B2 (en) | 2020-03-05 | 2024-04-02 | Neuravi Limited | Expandable mouth aspirating clot retrieval catheter |
US11633198B2 (en) | 2020-03-05 | 2023-04-25 | Neuravi Limited | Catheter proximal joint |
EP4117762A4 (en) | 2020-03-10 | 2024-05-08 | Imperative Care, Inc. | NEUROVASCULAR CATHETER WITH INCREASED FLEXIBILITY |
WO2021199883A1 (ja) | 2020-03-31 | 2021-10-07 | テルモ株式会社 | 塞栓剤 |
US11883043B2 (en) | 2020-03-31 | 2024-01-30 | DePuy Synthes Products, Inc. | Catheter funnel extension |
WO2021199884A1 (ja) * | 2020-03-31 | 2021-10-07 | テルモ株式会社 | 塞栓剤キット |
US11759217B2 (en) | 2020-04-07 | 2023-09-19 | Neuravi Limited | Catheter tubular support |
US11730501B2 (en) | 2020-04-17 | 2023-08-22 | Neuravi Limited | Floating clot retrieval device for removing clots from a blood vessel |
US11717308B2 (en) | 2020-04-17 | 2023-08-08 | Neuravi Limited | Clot retrieval device for removing heterogeneous clots from a blood vessel |
US11871946B2 (en) | 2020-04-17 | 2024-01-16 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11523831B2 (en) | 2020-04-30 | 2022-12-13 | DePuy Synthes Products, Inc. | Intrasaccular flow diverter |
US11737771B2 (en) | 2020-06-18 | 2023-08-29 | Neuravi Limited | Dual channel thrombectomy device |
US11937836B2 (en) | 2020-06-22 | 2024-03-26 | Neuravi Limited | Clot retrieval system with expandable clot engaging framework |
US11395669B2 (en) | 2020-06-23 | 2022-07-26 | Neuravi Limited | Clot retrieval device with flexible collapsible frame |
US11439418B2 (en) | 2020-06-23 | 2022-09-13 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
CA3183979A1 (en) | 2020-06-30 | 2022-01-06 | Michael Bassett | Articles comprising markings and related methods |
US11951026B2 (en) | 2020-06-30 | 2024-04-09 | DePuy Synthes Products, Inc. | Implantable medical device detachment system with flexible braid section |
US11207497B1 (en) | 2020-08-11 | 2021-12-28 | Imperative Care, Inc. | Catheter with enhanced tensile strength |
US20220062609A1 (en) * | 2020-08-28 | 2022-03-03 | Bard Peripheral Vascular, Inc. | Compositions, Dispensers, and Methods Thereof for Establishing a Urine Passageway Through a Ureter |
US11864781B2 (en) | 2020-09-23 | 2024-01-09 | Neuravi Limited | Rotating frame thrombectomy device |
USD997355S1 (en) | 2020-10-07 | 2023-08-29 | Sonendo, Inc. | Dental treatment instrument |
US20240016706A1 (en) | 2020-11-04 | 2024-01-18 | Sonendo, Inc. | Materials for obturation |
US11826520B2 (en) | 2020-12-08 | 2023-11-28 | DePuy Synthes Products, Inc. | Catheter designs for enhanced column strength |
US11786698B2 (en) | 2020-12-08 | 2023-10-17 | DePuy Synthes Products, Inc. | Catheter with textured surface |
US11937837B2 (en) | 2020-12-29 | 2024-03-26 | Neuravi Limited | Fibrin rich / soft clot mechanical thrombectomy device |
US12029442B2 (en) | 2021-01-14 | 2024-07-09 | Neuravi Limited | Systems and methods for a dual elongated member clot retrieval apparatus |
US11872354B2 (en) | 2021-02-24 | 2024-01-16 | Neuravi Limited | Flexible catheter shaft frame with seam |
US12064130B2 (en) | 2021-03-18 | 2024-08-20 | Neuravi Limited | Vascular obstruction retrieval device having sliding cages pinch mechanism |
JP2024075522A (ja) * | 2021-03-31 | 2024-06-04 | テルモ株式会社 | 塞栓物、および塞栓物の製造方法 |
US11974764B2 (en) | 2021-06-04 | 2024-05-07 | Neuravi Limited | Self-orienting rotating stentriever pinching cells |
US11998213B2 (en) | 2021-07-14 | 2024-06-04 | DePuy Synthes Products, Inc. | Implant delivery with modified detachment feature and pull wire engagement |
US11937839B2 (en) | 2021-09-28 | 2024-03-26 | Neuravi Limited | Catheter with electrically actuated expandable mouth |
US12011186B2 (en) | 2021-10-28 | 2024-06-18 | Neuravi Limited | Bevel tip expandable mouth catheter with reinforcing ring |
US11751881B2 (en) | 2021-11-26 | 2023-09-12 | DePuy Synthes Products, Inc. | Securement wire withstanding forces during deployment of implantable intravascular treatment device using a delivery and detachment system |
US11937824B2 (en) | 2021-12-30 | 2024-03-26 | DePuy Synthes Products, Inc. | Implant detachment systems with a modified pull wire |
US11844490B2 (en) | 2021-12-30 | 2023-12-19 | DePuy Synthes Products, Inc. | Suture linkage for inhibiting premature embolic implant deployment |
US12011171B2 (en) | 2022-01-06 | 2024-06-18 | DePuy Synthes Products, Inc. | Systems and methods for inhibiting premature embolic implant deployment |
CN114533938A (zh) * | 2022-02-25 | 2022-05-27 | 上海益思妙医疗器械有限公司 | 一种液体栓塞剂及其在制备栓塞剂中的应用 |
US11937825B2 (en) | 2022-03-02 | 2024-03-26 | DePuy Synthes Products, Inc. | Hook wire for preventing premature embolic implant detachment |
US11937826B2 (en) | 2022-03-14 | 2024-03-26 | DePuy Synthes Products, Inc. | Proximal link wire for preventing premature implant detachment |
Family Cites Families (272)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3749085A (en) | 1970-06-26 | 1973-07-31 | J Willson | Vascular tissue removing device |
CS154391B1 (ja) | 1970-09-10 | 1974-04-30 | ||
US4020829A (en) | 1975-10-23 | 1977-05-03 | Willson James K V | Spring guide wire with torque control for catheterization of blood vessels and method of using same |
US4509504A (en) | 1978-01-18 | 1985-04-09 | Medline Ab | Occlusion of body channels |
US4301803A (en) | 1978-10-06 | 1981-11-24 | Kuraray Co., Ltd. | Balloon catheter |
US4304232A (en) | 1979-03-14 | 1981-12-08 | Alza Corporation | Unit system having multiplicity of means for dispensing useful agent |
US4346712A (en) | 1979-04-06 | 1982-08-31 | Kuraray Company, Ltd. | Releasable balloon catheter |
SE419597B (sv) | 1979-05-04 | 1981-08-17 | Medline Ab | Anordning for temporer eller permanent tillslutning av kroppskanaler eller halrum hos menniskor och djur |
HU184722B (en) | 1980-02-18 | 1984-10-29 | Laszlo Lazar | Therapeutically suitable silicone rubber mixture and therapeuticaid |
US4493329A (en) | 1982-08-19 | 1985-01-15 | Lynn Crawford | Implantable electrode having different stiffening and curvature maintaining characteristics along its length |
GB8305797D0 (en) | 1983-03-02 | 1983-04-07 | Graham N B | Hydrogel-containing envelopes |
US4529739A (en) | 1984-07-24 | 1985-07-16 | The Dow Chemical Company | Foamed polymeric materials |
JPH0678460B2 (ja) | 1985-05-01 | 1994-10-05 | 株式会社バイオマテリアル・ユニバース | 多孔質透明ポリビニルアルユールゲル |
US4795741A (en) | 1987-05-06 | 1989-01-03 | Biomatrix, Inc. | Compositions for therapeutic percutaneous embolization and the use thereof |
US4819637A (en) | 1987-09-01 | 1989-04-11 | Interventional Therapeutics Corporation | System for artificial vessel embolization and devices for use therewith |
US5154705A (en) | 1987-09-30 | 1992-10-13 | Lake Region Manufacturing Co., Inc. | Hollow lumen cable apparatus |
US5165421A (en) | 1987-09-30 | 1992-11-24 | Lake Region Manufacturing Co., Inc. | Hollow lumen cable apparatus |
US4932419A (en) | 1988-03-21 | 1990-06-12 | Boston Scientific Corporation | Multi-filar, cross-wound coil for medical devices |
US4951677A (en) | 1988-03-21 | 1990-08-28 | Prutech Research And Development Partnership Ii | Acoustic imaging catheter and the like |
US4994069A (en) | 1988-11-02 | 1991-02-19 | Target Therapeutics | Vaso-occlusion coil and method |
US5354290A (en) | 1989-05-31 | 1994-10-11 | Kimberly-Clark Corporation | Porous structure of an absorbent polymer |
KR920703016A (ko) | 1989-10-03 | 1992-12-17 | 데이비드 더블유, 라이트 | 용해성의 마이크로다공성 하이드로겔 입자 및 그것의 제조방법 |
US6425893B1 (en) | 1990-03-13 | 2002-07-30 | The Regents Of The University Of California | Method and apparatus for fast electrolytic detachment of an implant |
US5122136A (en) | 1990-03-13 | 1992-06-16 | The Regents Of The University Of California | Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
EP0544671A4 (en) | 1990-04-18 | 1993-09-15 | The University Of Utah | Colonic-targeted oral drug-dosage forms based on crosslinked hydrogels containing azobonds and exhibiting ph-dependent swelling |
US5163952A (en) | 1990-09-14 | 1992-11-17 | Michael Froix | Expandable polymeric stent with memory and delivery apparatus and method |
US5133731A (en) | 1990-11-09 | 1992-07-28 | Catheter Research, Inc. | Embolus supply system and method |
US5120349A (en) | 1990-12-07 | 1992-06-09 | Landec Labs, Inc. | Microcapsule having temperature-dependent permeability profile |
US5129180A (en) | 1990-12-07 | 1992-07-14 | Landec Labs, Inc. | Temperature sensitive seed germination control |
US6524274B1 (en) | 1990-12-28 | 2003-02-25 | Scimed Life Systems, Inc. | Triggered release hydrogel drug delivery system |
DE4104702C2 (de) | 1991-02-15 | 1996-01-18 | Malte Neuss | Implantate für Organwege in Wendelform |
US5217484A (en) | 1991-06-07 | 1993-06-08 | Marks Michael P | Retractable-wire catheter device and method |
CA2117088A1 (en) | 1991-09-05 | 1993-03-18 | David R. Holmes | Flexible tubular device for use in medical applications |
US5304194A (en) | 1991-10-02 | 1994-04-19 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
US5226911A (en) | 1991-10-02 | 1993-07-13 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
JP3356447B2 (ja) | 1991-10-16 | 2002-12-16 | テルモ株式会社 | 乾燥高分子ゲルからなる血管病変塞栓材料 |
US5258042A (en) | 1991-12-16 | 1993-11-02 | Henry Ford Health System | Intravascular hydrogel implant |
EP0625070B1 (en) | 1991-12-20 | 1998-07-08 | AlliedSignal Inc. | Low density materials having high surface areas and articles formed therefrom for use in the recovery of metals |
US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
US5469867A (en) | 1992-09-02 | 1995-11-28 | Landec Corporation | Cast-in place thermoplastic channel occluder |
US5443478A (en) | 1992-09-02 | 1995-08-22 | Board Of Regents, The University Of Texas System | Multi-element intravascular occlusion device |
WO1994006460A1 (en) | 1992-09-21 | 1994-03-31 | Vitaphore Corporation | Embolization plugs for blood vessels |
US5350397A (en) | 1992-11-13 | 1994-09-27 | Target Therapeutics, Inc. | Axially detachable embolic coil assembly |
US5312415A (en) | 1992-09-22 | 1994-05-17 | Target Therapeutics, Inc. | Assembly for placement of embolic coils using frictional placement |
US5447727A (en) | 1992-10-14 | 1995-09-05 | The Dow Chemical Company | Water-absorbent polymer having improved properties |
US5382259A (en) | 1992-10-26 | 1995-01-17 | Target Therapeutics, Inc. | Vasoocclusion coil with attached tubular woven or braided fibrous covering |
US5382260A (en) | 1992-10-30 | 1995-01-17 | Interventional Therapeutics Corp. | Embolization device and apparatus including an introducer cartridge and method for delivering the same |
US5690666A (en) | 1992-11-18 | 1997-11-25 | Target Therapeutics, Inc. | Ultrasoft embolism coils and process for using them |
EP0746373A1 (en) | 1992-12-01 | 1996-12-11 | Intelliwire, Inc. | Vibratory element for crossing stenoses |
WO1994021324A1 (en) | 1993-03-23 | 1994-09-29 | Focal, Inc. | Apparatus and method for local application of polymeric material to tissue |
US5554147A (en) * | 1994-02-01 | 1996-09-10 | Caphco, Inc. | Compositions and devices for controlled release of active ingredients |
US5883705A (en) | 1994-04-12 | 1999-03-16 | The Board Of Trustees Of The Leland Stanford, Jr. University | Atomic force microscope for high speed imaging including integral actuator and sensor |
US5483022A (en) | 1994-04-12 | 1996-01-09 | Ventritex, Inc. | Implantable conductor coil formed from cabled composite wire |
US5573994A (en) | 1994-05-13 | 1996-11-12 | University Of Cincinnati | Superabsorbent foams, and method for producing the same |
JP2535785B2 (ja) | 1994-06-03 | 1996-09-18 | 工業技術院長 | 血管塞栓剤 |
US5549624A (en) | 1994-06-24 | 1996-08-27 | Target Therapeutics, Inc. | Fibered vasooclusion coils |
EP1716821A3 (en) | 1994-07-08 | 2009-07-08 | ev3 Inc. | Intravascular filtering device |
US5582610A (en) | 1994-09-30 | 1996-12-10 | Circon Corporation | Grooved slider electrode for a resectoscope |
US5690671A (en) | 1994-12-13 | 1997-11-25 | Micro Interventional Systems, Inc. | Embolic elements and methods and apparatus for their delivery |
US5578074A (en) | 1994-12-22 | 1996-11-26 | Target Therapeutics, Inc. | Implant delivery method and assembly |
US5814062A (en) | 1994-12-22 | 1998-09-29 | Target Therapeutics, Inc. | Implant delivery assembly with expandable coupling/decoupling mechanism |
CA2207667A1 (en) | 1995-01-27 | 1996-08-01 | Scimed Life Systems, Inc. | Embolizing system |
US5634936A (en) | 1995-02-06 | 1997-06-03 | Scimed Life Systems, Inc. | Device for closing a septal defect |
US5651979A (en) * | 1995-03-30 | 1997-07-29 | Gel Sciences, Inc. | Apparatus and method for delivering a biologically active compound into a biological environment |
US5750585A (en) * | 1995-04-04 | 1998-05-12 | Purdue Research Foundation | Super absorbent hydrogel foams |
US5645558A (en) | 1995-04-20 | 1997-07-08 | Medical University Of South Carolina | Anatomically shaped vasoocclusive device and method of making the same |
US6171326B1 (en) | 1998-08-27 | 2001-01-09 | Micrus Corporation | Three dimensional, low friction vasoocclusive coil, and method of manufacture |
US5766160A (en) | 1995-06-06 | 1998-06-16 | Target Therapeutics, Inc. | Variable stiffness coils |
US5624461A (en) | 1995-06-06 | 1997-04-29 | Target Therapeutics, Inc. | Three dimensional in-filling vaso-occlusive coils |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US6705323B1 (en) | 1995-06-07 | 2004-03-16 | Conceptus, Inc. | Contraceptive transcervical fallopian tube occlusion devices and methods |
US5725568A (en) | 1995-06-27 | 1998-03-10 | Scimed Life Systems, Inc. | Method and device for recanalizing and grafting arteries |
US6013084A (en) | 1995-06-30 | 2000-01-11 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils (II) |
US5853418A (en) | 1995-06-30 | 1998-12-29 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils (II) |
NO962761L (no) | 1995-06-30 | 1997-01-02 | Target Therapeutics Inc | Strekkmotstandige vasookklusive spiraler |
US5582619A (en) | 1995-06-30 | 1996-12-10 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils |
US5580568A (en) | 1995-07-27 | 1996-12-03 | Micro Therapeutics, Inc. | Cellulose diacetate compositions for use in embolizing blood vessels |
US5667767A (en) | 1995-07-27 | 1997-09-16 | Micro Therapeutics, Inc. | Compositions for use in embolizing blood vessels |
JPH11510837A (ja) * | 1995-07-28 | 1999-09-21 | フォーカル,インコーポレイテッド | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
US5658308A (en) | 1995-12-04 | 1997-08-19 | Target Therapeutics, Inc. | Bioactive occlusion coil |
US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
JP4104656B2 (ja) | 1995-12-19 | 2008-06-18 | ブラッコ・リサーチ・ソシエテ・アノニム | トリヨードベンゼンポリマーからなる胃腸管の画像形成用組成物 |
US5749894A (en) | 1996-01-18 | 1998-05-12 | Target Therapeutics, Inc. | Aneurysm closure method |
US5702361A (en) | 1996-01-31 | 1997-12-30 | Micro Therapeutics, Inc. | Method for embolizing blood vessels |
US5792154A (en) | 1996-04-10 | 1998-08-11 | Target Therapeutics, Inc. | Soft-ended fibered micro vaso-occlusive devices |
WO1997045131A1 (en) | 1996-05-31 | 1997-12-04 | Micro Therapeutics, Inc. | Compositions for use in embolizing blood vessels |
WO1998001421A1 (en) | 1996-07-10 | 1998-01-15 | University Of Utah Research Foundation | pH SENSITIVE HYDROGELS WITH ADJUSTABLE SWELLING KINETICS FOR COLON-SPECIFIC DELIVERY OF PEPTIDES AND PROTEINS |
US5980514A (en) | 1996-07-26 | 1999-11-09 | Target Therapeutics, Inc. | Aneurysm closure device assembly |
US6096034A (en) | 1996-07-26 | 2000-08-01 | Target Therapeutics, Inc. | Aneurysm closure device assembly |
US5830178A (en) | 1996-10-11 | 1998-11-03 | Micro Therapeutics, Inc. | Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide |
US5695480A (en) | 1996-07-29 | 1997-12-09 | Micro Therapeutics, Inc. | Embolizing compositions |
US5823198A (en) | 1996-07-31 | 1998-10-20 | Micro Therapeutics, Inc. | Method and apparatus for intravasculer embolization |
US6706690B2 (en) | 1999-06-10 | 2004-03-16 | Baxter Healthcare Corporation | Hemoactive compositions and methods for their manufacture and use |
WO1998012274A1 (en) | 1996-09-23 | 1998-03-26 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
US5690667A (en) | 1996-09-26 | 1997-11-25 | Target Therapeutics | Vasoocclusion coil having a polymer tip |
US5863551A (en) | 1996-10-16 | 1999-01-26 | Organogel Canada Ltee | Implantable polymer hydrogel for therapeutic uses |
US5785642A (en) | 1996-10-18 | 1998-07-28 | Micro Therapeutics, Inc. | Methods for treating urinary incontinence in mammals |
US5672634A (en) | 1996-12-23 | 1997-09-30 | Isp Investments Inc. | Crosslinked PVP-I2 foam product |
US5853419A (en) | 1997-03-17 | 1998-12-29 | Surface Genesis, Inc. | Stent |
YU49699A (sh) | 1997-04-02 | 2002-12-10 | Purdue Research Foundation | Farmaceutska kompozicija i postupak njenog dobijanja |
US6399886B1 (en) | 1997-05-02 | 2002-06-04 | General Science & Technology Corp. | Multifilament drawn radiopaque high elastic cables and methods of making the same |
DE19724796A1 (de) | 1997-06-06 | 1998-12-10 | Max Delbrueck Centrum | Mittel zur Antitumortherapie |
EP0989870A4 (en) | 1997-06-13 | 2000-08-30 | Micro Therapeutics Inc | CONTOURED SYRINGE AND INNOVATIVE LUER APPROACH AND METHOD FOR EMBOLIZING BLOOD VESSELS |
US6860893B2 (en) | 1997-08-29 | 2005-03-01 | Boston Scientific Scimed, Inc. | Stable coil designs |
US6066149A (en) | 1997-09-30 | 2000-05-23 | Target Therapeutics, Inc. | Mechanical clot treatment device with distal filter |
US6004573A (en) | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6146373A (en) | 1997-10-17 | 2000-11-14 | Micro Therapeutics, Inc. | Catheter system and method for injection of a liquid embolic composition and a solidification agent |
US6511468B1 (en) | 1997-10-17 | 2003-01-28 | Micro Therapeutics, Inc. | Device and method for controlling injection of liquid embolic composition |
WO1999023954A1 (en) | 1997-11-07 | 1999-05-20 | Salviac Limited | Implantable occluder devices for medical use |
US6136015A (en) | 1998-08-25 | 2000-10-24 | Micrus Corporation | Vasoocclusive coil |
US6159165A (en) | 1997-12-05 | 2000-12-12 | Micrus Corporation | Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand |
US6168570B1 (en) | 1997-12-05 | 2001-01-02 | Micrus Corporation | Micro-strand cable with enhanced radiopacity |
US7070607B2 (en) | 1998-01-27 | 2006-07-04 | The Regents Of The University Of California | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
WO1999044538A1 (en) | 1998-01-27 | 1999-09-10 | The Regents Of The University Of California | Biodegradable polymer/protein based coils for intralumenal implants |
US5935145A (en) | 1998-02-13 | 1999-08-10 | Target Therapeutics, Inc. | Vaso-occlusive device with attached polymeric materials |
US6063100A (en) | 1998-03-10 | 2000-05-16 | Cordis Corporation | Embolic coil deployment system with improved embolic coil |
US6015424A (en) | 1998-04-28 | 2000-01-18 | Microvention, Inc. | Apparatus and method for vascular embolization |
US6113629A (en) | 1998-05-01 | 2000-09-05 | Micrus Corporation | Hydrogel for the therapeutic treatment of aneurysms |
US5980550A (en) | 1998-06-18 | 1999-11-09 | Target Therapeutics, Inc. | Water-soluble coating for bioactive vasoocclusive devices |
US6051607A (en) | 1998-07-02 | 2000-04-18 | Micro Therapeutics, Inc. | Vascular embolizing compositions comprising ethyl lactate and methods for their use |
KR20000012970A (ko) * | 1998-08-03 | 2000-03-06 | 김효근 | 썰폰아마이드기를 포함하는 ph 민감성 고분자 및 그의 제조방법 |
US6093199A (en) | 1998-08-05 | 2000-07-25 | Endovascular Technologies, Inc. | Intra-luminal device for treatment of body cavities and lumens and method of use |
US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
CA2340652C (en) | 1998-08-20 | 2013-09-24 | Cook Incorporated | Coated implantable medical device comprising paclitaxel |
US5952232A (en) * | 1998-09-17 | 1999-09-14 | Rothman; James Edward | Expandible microparticle intracellular delivery system |
US6187024B1 (en) | 1998-11-10 | 2001-02-13 | Target Therapeutics, Inc. | Bioactive coating for vaso-occlusive devices |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
EP1031354A3 (en) * | 1999-01-19 | 2003-02-05 | Rohm And Haas Company | Polymeric MRI Contrast agents |
US6179857B1 (en) | 1999-02-22 | 2001-01-30 | Cordis Corporation | Stretch resistant embolic coil with variable stiffness |
US6303100B1 (en) | 1999-03-19 | 2001-10-16 | Micro Therapeutics, Inc. | Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms |
US6333020B1 (en) | 1999-05-13 | 2001-12-25 | Micro Therapeutics, Inc. | Methods for treating AVM's using radio active compositions |
WO2000071196A1 (en) | 1999-05-21 | 2000-11-30 | Micro Therapeutics, Inc. | Interface needle and method for creating a blunt interface between delivered liquids |
EP1185223A1 (en) | 1999-05-21 | 2002-03-13 | Micro Therapeutics, Inc. | Methods for delivering in vivo uniform dispersed embolic compositions of high viscosity |
US7018365B2 (en) | 1999-05-21 | 2006-03-28 | Micro Therapeutics, Inc. | Threaded syringe with quick stop |
JP5148030B2 (ja) | 1999-05-21 | 2013-02-20 | タイコ ヘルスケア グループ リミテッド パートナーシップ | 新規の高粘度塞栓形成組成物 |
US6645167B1 (en) | 1999-05-21 | 2003-11-11 | Micro Therapeutics, Inc. | Methods for embolizing vascular sites with an embolizing composition |
US20020169473A1 (en) | 1999-06-02 | 2002-11-14 | Concentric Medical, Inc. | Devices and methods for treating vascular malformations |
US6280457B1 (en) | 1999-06-04 | 2001-08-28 | Scimed Life Systems, Inc. | Polymer covered vaso-occlusive devices and methods of producing such devices |
US6521431B1 (en) | 1999-06-22 | 2003-02-18 | Access Pharmaceuticals, Inc. | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments |
US6312421B1 (en) | 1999-07-23 | 2001-11-06 | Neurovasx, Inc. | Aneurysm embolization material and device |
US6238403B1 (en) | 1999-10-04 | 2001-05-29 | Microvention, Inc. | Filamentous embolic device with expansible elements |
US6602261B2 (en) | 1999-10-04 | 2003-08-05 | Microvention, Inc. | Filamentous embolic device with expansile elements |
WO2001030411A1 (en) | 1999-10-26 | 2001-05-03 | Kaken Pharmaceutical Co., Ltd. | Vessel embolic material comprising hydrogel and therapy with the use thereof |
US6623450B1 (en) | 1999-12-17 | 2003-09-23 | Advanced Cardiovascular Systems, Inc. | System for blocking the passage of emboli through a body vessel |
AU4566001A (en) * | 2000-03-13 | 2001-09-24 | Biocure Inc | Embolic compositions |
US7338657B2 (en) | 2001-03-15 | 2008-03-04 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
EP1142535B1 (en) | 2000-04-07 | 2012-10-03 | Collagen Matrix, Inc. | Embolization device |
US6599448B1 (en) | 2000-05-10 | 2003-07-29 | Hydromer, Inc. | Radio-opaque polymeric compositions |
US7291673B2 (en) * | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
WO2002005731A1 (en) | 2000-07-18 | 2002-01-24 | Teitelbaum George P | Biocompatible, expansile material and stent |
US6723108B1 (en) | 2000-09-18 | 2004-04-20 | Cordis Neurovascular, Inc | Foam matrix embolization device |
US8313504B2 (en) | 2000-09-18 | 2012-11-20 | Cordis Corporation | Foam matrix embolization device |
US7033374B2 (en) | 2000-09-26 | 2006-04-25 | Microvention, Inc. | Microcoil vaso-occlusive device with multi-axis secondary configuration |
AU2001245283A1 (en) | 2000-10-11 | 2002-04-22 | Micro Thereapeutics, Inc. | Methods for treating aneurysms |
US6537569B2 (en) | 2001-02-14 | 2003-03-25 | Microvention, Inc. | Radiation cross-linked hydrogels |
US6503244B2 (en) | 2001-03-07 | 2003-01-07 | Micro Therapeutics, Inc. | High pressure injection system |
US6878384B2 (en) * | 2001-03-13 | 2005-04-12 | Microvention, Inc. | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
ATE516759T1 (de) | 2001-05-29 | 2011-08-15 | Microvention Inc | Verfahren zur herstellung von expandierbaren filamentösen embolisierungsvorrichtungen |
US8101196B2 (en) | 2001-06-26 | 2012-01-24 | Biointeractions, Ltd. | Polysaccharide biomaterials and methods of use thereof |
WO2003020357A1 (en) | 2001-09-04 | 2003-03-13 | Micro Therapeutics, Inc. | Occlusion catheter having compliant balloon for use with complex vasculature |
EP1460982A4 (en) * | 2001-11-16 | 2010-04-14 | Biocure Inc | METHODS FOR INITIATING IN SITU FORMATION OF HYDROGELS |
CA2469734A1 (en) | 2002-01-14 | 2003-07-24 | Micro Therapeutics, Inc. | Methods for embolizing aneurysmal sites with a high viscosity embolizing composition |
CA2476656C (en) | 2002-02-21 | 2008-11-25 | Encelle, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
AU2003234159A1 (en) * | 2002-04-22 | 2003-11-03 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
US7008979B2 (en) | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
US7459142B2 (en) | 2002-06-06 | 2008-12-02 | Micro Therapeutics, Inc. | High viscosity embolizing compositions comprising prepolymers |
AU2003278792A1 (en) | 2002-06-20 | 2004-01-06 | Ka Shun Kevin Fung | Method and system for improving the liquidity of transactions |
US20040006354A1 (en) | 2002-07-02 | 2004-01-08 | Dean Schaefer | Coaxial stretch-resistant vaso-occlusive device |
US7608058B2 (en) | 2002-07-23 | 2009-10-27 | Micrus Corporation | Stretch resistant therapeutic device |
US7067606B2 (en) | 2002-07-30 | 2006-06-27 | University Of Connecticut | Nonionic telechelic polymers incorporating polyhedral oligosilsesquioxane (POSS) and uses thereof |
CA2494287C (en) * | 2002-07-31 | 2010-11-09 | Microvention, Inc. | Three element coaxial vaso-occlusive device |
US20050171572A1 (en) | 2002-07-31 | 2005-08-04 | Microvention, Inc. | Multi-layer coaxial vaso-occlusive device |
ATE451135T1 (de) | 2002-10-10 | 2009-12-15 | Micro Therapeutics Inc | Mit drahtgeflecht verstärkter mikrokatheter |
US7588825B2 (en) | 2002-10-23 | 2009-09-15 | Boston Scientific Scimed, Inc. | Embolic compositions |
US20040115164A1 (en) * | 2002-12-17 | 2004-06-17 | Pierce Ryan K. | Soft filament occlusive device delivery system |
EP1578843B1 (en) | 2002-12-31 | 2008-07-09 | Nektar Therapeutics Al, Corporation | Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof |
EP1435248A1 (en) | 2003-01-02 | 2004-07-07 | Vesalius N.V. | Composition for in vivo vessel repair |
US20050043585A1 (en) | 2003-01-03 | 2005-02-24 | Arindam Datta | Reticulated elastomeric matrices, their manufacture and use in implantable devices |
ES2311803T3 (es) | 2003-02-26 | 2009-02-16 | Micro Therapeutics Inc | Composiciones embolicas de silicie pirogena. |
US20040228797A1 (en) | 2003-03-07 | 2004-11-18 | Bein Richard S. | Compositions for use in embolizing blood vessels comprising high levels of contrast agent |
US20050008610A1 (en) | 2003-03-24 | 2005-01-13 | Alexander Schwarz | Temporary embolization using inverse thermosensitive polymers |
JP2006521180A (ja) * | 2003-03-25 | 2006-09-21 | バイオキュア・インコーポレーテッド | ヒドロゲル糸による医療装置 |
GB0307834D0 (en) * | 2003-04-04 | 2003-05-14 | Ta Contrast Ab | Composition |
US8383158B2 (en) | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
EP1620140B1 (en) | 2003-05-05 | 2013-10-09 | Ben-Gurion University Of The Negev Research And Development Authority | Injectable cross-linked polymeric preparations and uses thereof |
US20050119687A1 (en) * | 2003-09-08 | 2005-06-02 | Dacey Ralph G.Jr. | Methods of, and materials for, treating vascular defects with magnetically controllable hydrogels |
EP1673109B1 (en) | 2003-09-25 | 2019-03-20 | Rutgers, The State University of New Jersey | Inherently radiopaque polymeric products for embolotherapy |
US7901770B2 (en) | 2003-11-04 | 2011-03-08 | Boston Scientific Scimed, Inc. | Embolic compositions |
US20050175709A1 (en) | 2003-12-11 | 2005-08-11 | Baty Ace M.Iii | Therapeutic microparticles |
EP1722834B1 (en) | 2003-12-22 | 2012-06-27 | Regentis Biomaterials Ltd. | Matrix comprising naturally-occurring crosslinked protein backbone |
US7736671B2 (en) | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
KR100974733B1 (ko) | 2004-04-28 | 2010-08-06 | 안지오디바이스 인터내셔널 게엠베하 | 가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및이와 관련된 제조 및 사용 방법 |
CA2578076C (en) | 2004-08-25 | 2016-04-26 | Microvention, Inc. | Thermal detachment system for implantable devices |
EP1796693A2 (en) | 2004-08-26 | 2007-06-20 | Chandrashekhar P. Pathak | Implantable tissue compositions and method |
US20060074370A1 (en) | 2004-09-24 | 2006-04-06 | Medennium, Inc. | Ocular occluder and method of insertion |
JP5079510B2 (ja) | 2004-09-24 | 2012-11-21 | バイオスフィア メディカル, インコーポレイテッド | 放射性同位体を結合し得、任意選択的に金属微粒子を含むミクロスフェア、およびそれらの使用方法 |
US8075906B2 (en) | 2005-02-01 | 2011-12-13 | Boston Scientific Scimed, Inc. | Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species |
WO2007016371A2 (en) | 2005-07-28 | 2007-02-08 | Akina, Inc. | Readily shapeable xerogels having controllably delayed swelling properties |
US20070026039A1 (en) | 2005-07-29 | 2007-02-01 | Drumheller Paul D | Composite self-cohered web materials |
CA2635374C (en) | 2006-01-11 | 2015-12-08 | Hyperbranch Medical Technology, Inc. | Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices |
WO2007090130A2 (en) | 2006-01-30 | 2007-08-09 | Surgica Corporation | Porous intravascular embolization particles and related methods |
US7732539B2 (en) | 2006-02-16 | 2010-06-08 | National Science Foundation | Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives |
US20070202046A1 (en) | 2006-02-24 | 2007-08-30 | Vipul Dave | Implantable device formed from polymer blends |
US20070224234A1 (en) | 2006-03-22 | 2007-09-27 | Mark Steckel | Medical devices having biodegradable polymeric regions |
US8795709B2 (en) | 2006-03-29 | 2014-08-05 | Incept Llc | Superabsorbent, freeze dried hydrogels for medical applications |
CN101415449A (zh) | 2006-04-06 | 2009-04-22 | 雷瓦医药公司 | 用于治疗血管动脉瘤的栓塞假体 |
US8252339B2 (en) | 2006-04-11 | 2012-08-28 | Massachusetts Institute Of Technology | Medical treatment applications of swellable and deformable microspheres |
CA2650473C (en) | 2006-04-24 | 2013-06-18 | Incept, Llc | Protein crosslinkers, crosslinking methods and applications thereof |
US20070288084A1 (en) | 2006-06-09 | 2007-12-13 | Medlogics Device Corporation | Implantable Stent with Degradable Portions |
JP2010500917A (ja) | 2006-06-15 | 2010-01-14 | マイクロベンション, インコーポレイテッド | 膨張性ポリマーで構成される塞栓形成デバイス |
EP2037977A2 (en) | 2006-06-28 | 2009-03-25 | SurModics, Inc. | Active agent eluting matrices with particulates |
US20080019921A1 (en) | 2006-06-30 | 2008-01-24 | Invitrogen Corporation | Uniform fluorescent microsphere with hydrophobic surfaces |
MX2009000046A (es) | 2006-07-06 | 2009-06-05 | Abbott Respiratory Llc | Hidrogeles superporosos para aplicaciones de alto rendimiento. |
US8414927B2 (en) | 2006-11-03 | 2013-04-09 | Boston Scientific Scimed, Inc. | Cross-linked polymer particles |
SG175690A1 (en) | 2006-11-09 | 2011-11-28 | Kci Licensing Inc | Porous bioresorbable dressing conformable to a wound and methods of making same |
CN101541857B (zh) | 2006-11-27 | 2012-12-12 | 阿克塔马克斯手术器材有限责任公司 | 多官能聚环氧烷、水凝胶和组织粘合剂 |
CA2686563A1 (en) | 2007-05-11 | 2008-11-20 | Aeris Therapeutics, Llc | Lung volume reduction therapy using crosslinked non-natural polymers |
US20100241160A1 (en) | 2007-06-11 | 2010-09-23 | Kieran Murphy | Method and kit for cyst aspiration and treatment |
GB0711952D0 (en) | 2007-06-20 | 2007-08-01 | King S College London | Microspheres |
US7887846B2 (en) | 2007-08-07 | 2011-02-15 | E. I. Du Pont De Nemours And Company | Process for preparation of swellable and degradable microspheres |
WO2009021287A1 (en) | 2007-08-14 | 2009-02-19 | Commonwealth Scientific And Industrial Research Organisation | Photoactivated crosslinking of a protein or peptide |
US20090048659A1 (en) | 2007-08-17 | 2009-02-19 | Boston Scientific Scimed, Inc. | Medical devices having sol-gel derived ceramic regions with molded submicron surface features |
US8241609B2 (en) | 2007-08-24 | 2012-08-14 | E I Du Pont De Nemours And Company | Method for embolization using liquid embolic materials |
JP5474798B2 (ja) | 2007-09-19 | 2014-04-16 | サーモディクス,インコーポレイティド | 生体適合性フォーム、系及び方法 |
WO2009042191A1 (en) | 2007-09-25 | 2009-04-02 | Surmodics, Inc. | Durable swellable hydrogel matrix, method for preparation and method for encapsulation |
US8246998B2 (en) | 2007-11-01 | 2012-08-21 | Boston Scientific Scimed, Inc. | Injectable biodegradable particles |
JP2011505179A (ja) | 2007-11-23 | 2011-02-24 | テヒニーシェ ウニヴェルジテート ウィーン | ポリビニルアルコールベースの生分解性、生体適合性、架橋ポリマーの調製用重合硬化性組成物 |
WO2009110939A2 (en) | 2007-12-10 | 2009-09-11 | Massachusetts Institute Of Technology | Drug delivery system for pharmaceuticals and radiation |
CA2709379C (en) | 2007-12-21 | 2016-08-16 | Microvention, Inc. | Hydrogel filaments for biomedical uses |
US20090181068A1 (en) | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
US8668863B2 (en) | 2008-02-26 | 2014-03-11 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
US8324292B2 (en) | 2008-02-29 | 2012-12-04 | Ethicon, Inc. | Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant |
EP2103313A1 (en) | 2008-03-19 | 2009-09-23 | Koninklijke Philips Electronics N.V. | Method for the synthesis of hollow spheres |
US8128983B2 (en) | 2008-04-11 | 2012-03-06 | Abbott Cardiovascular Systems Inc. | Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network |
US8207264B2 (en) | 2008-07-11 | 2012-06-26 | Tyco Healthcare Group Lp | Functionalized inclusion complexes as crosslinkers |
DE102008040787A1 (de) | 2008-07-28 | 2010-02-04 | Biotronik Vi Patent Ag | Biokorrodierbares Implantat mit einer Beschichtung enthaltend ein Hydrogel |
US8133436B2 (en) | 2008-08-05 | 2012-03-13 | Howmedica Osteonics Corp. | Polyethylene cross-linked with an anthocyanin |
US8246876B2 (en) | 2008-08-18 | 2012-08-21 | Cook Medical Technologies Llc | Embolization particles and method for making same |
US20100092533A1 (en) | 2008-10-15 | 2010-04-15 | Joshua Stopek | Bioabsorbable Surgical Composition |
EP2344556A1 (en) | 2008-10-22 | 2011-07-20 | Surmodics Inc. | Swellable biodegradable polymeric matrices and methods |
WO2010114633A1 (en) | 2009-04-03 | 2010-10-07 | Biomerix Corporation | At least partially resorbable reticulated elastomeric matrix elements and methods of making same |
WO2010123946A2 (en) | 2009-04-20 | 2010-10-28 | Allergan, Inc. | Silk fibroin hydrogels and uses thereof |
ES2639310T3 (es) | 2009-07-02 | 2017-10-26 | Sloan-Kettering Institute For Cancer Research | Nanopartículas fluorescentes basadas en sílice |
WO2011003902A2 (en) | 2009-07-07 | 2011-01-13 | Soenke Bartling | Multimodal visible polymer embolization material |
US20110202016A1 (en) | 2009-08-24 | 2011-08-18 | Arsenal Medical, Inc. | Systems and methods relating to polymer foams |
KR101103423B1 (ko) | 2009-09-04 | 2012-01-06 | 아주대학교산학협력단 | 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도 |
EP2480166B1 (en) | 2009-09-24 | 2017-11-29 | Microvention, Inc. | Injectable hydrogel filaments for biomedical uses |
US20110093057A1 (en) | 2009-10-16 | 2011-04-21 | Confluent Surgical, Inc. | Mitigating Thrombus Formation On Medical Devices By Influencing pH Microenvironment Near The Surface |
WO2011053555A1 (en) | 2009-10-26 | 2011-05-05 | Microvention, Inc. | Embolization device constructed from expansile polymer |
CA2780274C (en) | 2009-11-09 | 2018-06-26 | Spotlight Technology Partners Llc | Fragmented hydrogels |
AU2010314992B2 (en) | 2009-11-09 | 2016-09-15 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
RU2012125200A (ru) | 2009-12-04 | 2014-01-20 | Магле Аб | Микросферы гидролизованного крахмала с эндогенными заряженными лигандами |
EP2351779B1 (en) | 2010-01-27 | 2019-04-24 | Biosphere Medical, Inc. | Microspheres and method of making the microspheres |
EP2365009A1 (en) | 2010-03-10 | 2011-09-14 | Universite Claude Bernard Lyon 1 (UCBL) | Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof |
WO2011151832A1 (en) | 2010-06-03 | 2011-12-08 | Ramot At Tel-Aviv University Ltd. | Malleable hydrogel hybrids made of self-assembled peptides and biocompatible polymers and uses thereof |
CN102107025B (zh) | 2010-08-27 | 2014-05-21 | 上海微创医疗器械(集团)有限公司 | 一种栓塞材料组合物及其制备方法 |
BR112013006861A2 (pt) | 2010-09-21 | 2019-07-02 | Cristal Delivery B V | ligante para ser utilizado em um sistema de liberação de fármaco, composto compreendendo um ligante, uso de um composto, sistema de liberação controlada e método para preparar um sistema de liberação controlada |
US20120164100A1 (en) | 2010-11-02 | 2012-06-28 | Ren-Ke Li | Temperature sensitive hydrogel and block copolymers |
EP2683750B1 (en) | 2011-03-09 | 2017-04-19 | Occlugel | Implantable swellable bio-resorbable polymer |
US9456823B2 (en) | 2011-04-18 | 2016-10-04 | Terumo Corporation | Embolic devices |
CN102266591A (zh) | 2011-06-17 | 2011-12-07 | 微创医疗器械(上海)有限公司 | 一种基于胶原蛋白的新型液体栓塞材料及其制备方法 |
US9561961B2 (en) | 2011-08-19 | 2017-02-07 | Pioneer Surgical Technology, Inc. | Injectable fillers for aesthetic medical enhancement and for therapeutic applications |
US9295761B2 (en) | 2011-10-13 | 2016-03-29 | Rowan University | Self-assembling biomimetic hydrogels having bioadhesive properties |
WO2013158781A1 (en) | 2012-04-18 | 2013-10-24 | Microvention, Inc. | Embolic devices |
US9662119B2 (en) | 2013-03-13 | 2017-05-30 | Lawrence Livermore National Security, Llc | Shape-memory polymer foam device for treating aneurysms |
US10328095B2 (en) | 2013-03-15 | 2019-06-25 | Covidien Lp | Resorbable oxidized cellulose embolization microspheres |
US10124090B2 (en) | 2014-04-03 | 2018-11-13 | Terumo Corporation | Embolic devices |
US10092663B2 (en) | 2014-04-29 | 2018-10-09 | Terumo Corporation | Polymers |
CN110433326A (zh) | 2014-04-29 | 2019-11-12 | 微仙美国有限公司 | 包含活性剂的聚合物 |
WO2016201250A1 (en) | 2015-06-11 | 2016-12-15 | Microvention, Inc. | Expansile device for implantation |
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US8470035B2 (en) | 2013-06-25 |
WO2009086208A3 (en) | 2010-04-01 |
WO2009086208A2 (en) | 2009-07-09 |
AU2008345590B2 (en) | 2014-10-30 |
CA2709379C (en) | 2016-08-16 |
KR101567111B1 (ko) | 2015-11-06 |
BRPI0821070B1 (pt) | 2018-10-23 |
CN101903051A (zh) | 2010-12-01 |
CN101903051B (zh) | 2013-07-31 |
AU2008345590A1 (en) | 2009-07-09 |
US20130253087A1 (en) | 2013-09-26 |
JP2011507637A (ja) | 2011-03-10 |
EP2231215A2 (en) | 2010-09-29 |
KR20100105663A (ko) | 2010-09-29 |
EP2231215B1 (en) | 2019-01-30 |
CA2709379A1 (en) | 2009-07-09 |
BRPI0821070A2 (pt) | 2015-06-16 |
US9486221B2 (en) | 2016-11-08 |
EP2266639A1 (en) | 2010-12-29 |
EP2266639B1 (en) | 2016-10-05 |
US20090164013A1 (en) | 2009-06-25 |
US20170007264A1 (en) | 2017-01-12 |
US10194915B2 (en) | 2019-02-05 |
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