CN103582460B - 具有额外锚固机构的动脉瘤装置以及相关系统及方法 - Google Patents

具有额外锚固机构的动脉瘤装置以及相关系统及方法 Download PDF

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CN103582460B
CN103582460B CN201280027366.7A CN201280027366A CN103582460B CN 103582460 B CN103582460 B CN 103582460B CN 201280027366 A CN201280027366 A CN 201280027366A CN 103582460 B CN103582460 B CN 103582460B
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布伦特·杰伯丁
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Abstract

本发明与具有额外的锚固机构的动脉瘤装置，以及相关的系统和方法有关。在一些实施例中，所述动脉瘤装置是可以在血管内被输送到相近于在具有分叉分支的载瘤动脉附近的动脉瘤的位置。所述动脉瘤装置包括具有被设置为至少部分地封闭动脉瘤的面向远端的方面，以及被设置为锚固在分叉分支腔上的面向近端的方面的封闭结构(102)。所述装置进一步包括连接到封闭结构的辅助稳定器(103)。所述辅助稳定器被设置为处在载瘤动脉上。所述封闭结构包括铰接点(175)，在该点，所述封闭结构折叠形成为了在至少一个分叉分支内部固定而设置的环状组件。

Description

具有额外锚固机构的动脉瘤装置以及相关系统及方法
对于相关申请的交叉引用
本申请要求专利申请号为61/493,356，申请日为2011年6月3目的未决的美国临时专利申请的优先权，并以全部引用形式于此合并。
技术领域
本发明涉及在例如动脉瘤的颈部的开口之类的目标位置的可植入的用于治疗的装置。具体地，本发明通常指向具有额外锚固机构的动脉瘤装置以及相关系统及方法。
背景技术
许多现有的为了关闭开口以及修复解剖内腔以及组织(例如血管)的缺陷、间隔缺损以及其他类型的解剖不规律以及缺陷的外科手术方法具有高度的侵略性。例如夹住脑动脉瘤的外科手术方法需要打开颅骨、切除或者移除上覆脑组织、夹住并修复血管外部的动脉瘤，并接下来重组组织并关闭颅骨。与这些步骤相关联的麻醉、出血以及感染的风险是很高的，在这些步骤中所影响到的组织可能存活并继续发挥作用，也可能不存活并不再继续发挥作用。
对于治疗动脉瘤的最小侵略性的技术的需求相对很高。通常，最小侵略性的治疗目标是防止在动脉瘤腔内所收集的或者形成的组织进入血液循环，以及防止血液进入或者被动脉瘤收集。通常，这些是通过向动脉瘤中引入不同的材料以及装置而完成。例如，可植入的血管闭塞金属装置是众所周知的并且经常被使用。许多传统的血管闭塞装置具有由形状记忆材料或者贵金属构成的螺旋线圈，该螺旋线圈构成了在输送导管远端需要的线圈结构。所述线圈的功能是填满由组织缺陷形成的空间以及与相关辅助组织一起帮助栓塞物的形成。在一个步骤中多个相同或者不同结构的线圈可能相继地被植入一个动脉瘤或者其他血管缺陷。可植入的框架结构也被用于在例如线圈的填充材料被引入之前固定动脉瘤或者缺陷的组织壁。在腔体内部空间准确地植入血管闭塞装置并在动脉瘤内部空间维持所述装置是十分重要的。从腔体迁移或者投送血管闭塞装置可能被血流或者附近的生理结构影响并引发一系列的健康威胁。
除了输送可植入闭塞装置以外，一些类型的动脉瘤之所以难以治疗是因为这些动脉瘤的结构特点或者是因为位置的特殊性。例如，宽颈动脉瘤很难放置并保留血管阻塞线圈是众所周知的。在血管分叉位置上的动脉瘤是解剖组织对治疗典型侧壁动脉瘤有效的方法和装置造成挑战的另一个例子。因此，在部署过程中放置传统的可植入装置，在部署之后防止这些装置的位移和移动，以及在部署之后保持在邻近血管中的血液流动是具有挑战性的。
附图说明
图1是与本发明的一个实施例相应设置的动脉瘤装置的一个实施例的俯视图。
图2是图1中的动脉瘤装置部分部署设置状态的侧视图。
图3是图1和图2中的动脉瘤装置部署在动脉瘤颈部并且嵌入分叉侧动脉分支的视图。
具体实施方式
本公开描述了可植入治疗装置以及将装置血管内放置在目标位置的方法，例如动脉瘤颈部的开口处。具体地，本技术选定的实施例指向具有额外锚固机构以在动脉瘤的颈部嵌入到分叉分支的装置。以下描述提供了为了对本公开的实施例有完整的理解的具体细节以及详细描述。经常与动脉瘤治疗系统相关联的众所周知的结构、系统以及方法并未被具体展示或者描述，以避免不必要地使得对于本公开的不同实施方式的描述模糊。此外，本领域的普通技术人员可以知道，在没有以下几个具体描述下，额外的实施例可以被实施。
图1和图2展示了与本发明相应设置的动脉瘤装置150的实施例。具体地，图1是动脉瘤装置150在基本上放平、未装配的状态下的俯视图。图2是动脉瘤装置150部署设置状态的侧视图。如图1所示，动脉瘤装置150可以包括封闭结构102以及从所述封闭结构102延伸出来的辅助稳定器或者支撑103。所述封闭结构102可以是框架、支架或者其他至少部分使动脉瘤的颈部闭塞以防止动脉瘤中栓塞线圈或者其他凝固材料进入血液。所述闭塞结构102包括周边支撑160以及内支撑170。所述周边支撑160以及内支撑170可以在结合点162以及164处结合。所述辅助稳定器103在图1中展示的是未组装阶段。一旦其被组装，所述封闭结构102的相近延伸边以及辅助稳定器103控制住封闭结构102在动脉瘤颈部的弯曲部。
所述动脉瘤装置150具有从结合点162和164处延伸出的支撑物180a-d。支撑物180a及180c可以在连接点162处连接，支撑物180b及180d可以在连接点164处连接以形成具有近端锚固部分的辅助稳定器103。在一个实施例中，所述支撑物180a-d的每一个包括铰接点或者弯曲点175a-d。所述铰接点175a-d确定了破裂点，并且允许所述支撑物180a-d以形成使得动脉瘤装置150在动脉瘤颈部可以嵌入到侧动脉分支的额外支撑组件的方式优先地下折。
在图1所展示的实施例中，所述动脉瘤装置150通过剪切、蚀刻、冲压的方法，或者通过形成所述封闭结构102、所述未装配的辅助稳定器103以及所述铰接点175a-d的框架由基本扁平的基材构成。所述封闭结构102以及所述辅助稳定器103可以由具有基本一致厚度的平面材料构成，但是在另外的实施例中，不同部分的扁平材料可以具有相应于所述封闭结构102及/或所述服务稳定器103不同部分所需要的不同厚度。
图2是动脉瘤装置150部分部署设置状态的侧视图。具体地，所述动脉瘤装置150是从输送导管202处部署的，环状组件185a及185b组成并开始完全打开。所述环状组件185a-b开始打开，同时输送导管202撤回，当输送导管202完全撤回，环状组件185a-b完全打开。如以下同引用图3更详细的描述，所述环状组件185a-b设置为提供当被部署在横跨动脉瘤颈部的位置时，动脉瘤装置150锚固在分叉侧动脉分支上的机构。在另一个实施例中，所述环状组件185a-b具有不同的布置和/或所述动脉瘤装置可以包括不同数量的环状组件185。
图3展示了图1和图2中的动脉瘤装置150利用锚固脚240部署在动脉瘤A的颈部。如上文所述，当所述动脉瘤装置150被部署，所述环状组件185a-b打开并能够分别嵌入到侧动脉分支血管SB1和SB2。环状组件185a-b在侧动脉分支血管SB1以及SB2的嵌入被期望为所述动脉瘤装置150在动脉瘤A上提供额外的锚固机构，并且其被期望提供对于动脉瘤装置150而言更可靠的嵌入/部署。
图3进一步展示了使用动脉瘤装置150留住碎片和/或其他动脉瘤腔体内的材料，例如栓塞线圈集群250。例如，在一个实施例中，本发明的可植入装置可以被部署以留住碎片和/或之前在动脉瘤腔体内放置的材料。在另一个实施例中，本发明的可植入装置可以在于动脉瘤腔体内放置例如栓塞材料、线圈以及类似物前部署，并且接下来所述材料可以通过所述封闭结构的开口放置。在这种情况下，所述动脉瘤装置可以在所述栓塞材料放置之后被收回，或者其可以被分离并留在该位置。
示例
1.一种动脉瘤装置，所述装置可以在血管内被输送到相近于具有分叉分支的动脉的位置，所述动脉瘤装置包括：
封闭结构，包括被设置为至少部分锁住动脉瘤开口的面向远端方面以及被设置为在分叉分支血管腔体上锚固的面向近端方面；以及
辅助稳定器，被连接到所述封闭结构，所述辅助稳定器被设置为位于动脉上；
其中所述封闭结构包括铰接点，在该铰接点处所述封闭结构折叠以形成设置为在至少一个所述分叉分支血管中锚固的环形组件。
2.如示例1所述的动脉瘤装置，其中所述封闭结构包括支撑物。
3.如示例2所述的动脉瘤装置，其中所述铰接点是在其中一个所述支撑物上形成的。
4.如示例1所述的动脉瘤装置，其中所述封闭结构包括四个铰接点。
5.如示例1所述的动脉瘤装置，其中所述封闭结构可变形于被压缩的状态和部署状态间。
6.如示例5所述的动脉瘤装置，进一步包括被设置以将所述封闭结构保留在压缩状态的导管。
7.如示例1所述的动脉瘤装置，其中所述封闭结构包括两个环状组件，每一个单独的环状组件被市值为嵌入到所述分叉分支血管的其中一个中。
8.如示例1所述的动脉瘤装置，其中所述封闭结构包括形状记忆材料。
9.一种治疗动脉瘤的系统，所述系统包括
远端框架部分，包括被设置以围住动脉瘤的面向远端的方面，其中所述远端框架包括数个支撑物，以及其中每一个支撑物包括铰接点；以及
连接到所述远端框架部分的近端支撑框架，所述支撑框架被设置为在载瘤动脉中并偏向外向腔壁施加压力。
10.如示例9所述的系统，进一步包括输送护套，被设置为临时地使远端框架部分保持在压缩状态。
11.如示例9所述的系统，其中所述支撑物包括大致上地可变形的材料，优先地在所述铰接点处弯曲。
12.如示例9所述的系统，其中所述单独的支撑物包括在所述铰接点处弯曲的环状体。
13.如示例9所述的系统，其中所述远端框架部分是由通常扁平的且未组装的部分形成于三维的且组装完毕的组件。
14.一种治疗位于临近分叉成下游分支血管的载瘤动脉的位置的动脉瘤的方法，所述方法包括：
在临近动脉瘤的位置处，展开轴向压缩的包括远端部分和近端部分的框架，其中，所述远端部分包括数个具有弯曲点的支撑物；以及
将所述框架的所述远端部分不显眼地锚固到所述下游分支血管腔上，其中所述支撑物包括在弯曲点弯曲的环，所述环被设置以嵌入到下游分支血管。
15.如示例14所述的方法，进一步包括用基本上扁平的材料形成所述框架。
16.如示例14所述的方法，进一步包括与导管一起输送所述框架，其中输送所述导管包括将所述框架临时地保持在基本上压缩的状态。
17.如示例14所述的方法，进一步包括从载瘤动脉中提取所述框架。
18.如示例17所述的方法，其中提取所述框架包括将所述框架以基本上压缩的状态保留在导管中。
19.如示例14所述的方法，进一步包括基本上用所述框架的远端部分围住动脉瘤。
20.如示例14所述的方法，进一步包括从输送设备上分离所述框架。
上文对于本发明的具体实施例的具体描述并不是详尽无遗或者将本发明限制在如上文所公开的精确的范围中。虽然本发明的具体的实施例以及示例在上文以展示为目的被描述，不同的等同的修改实例在本发明的范围内是可能的，并且本领域技术人员是可以想到的。例如，当步骤被按顺序实施，可替代的实施例可以以不同的顺序实施步骤。此处所描述的不同实施例同样可以被合并以提供更进一步的实施例。具体地，上文所描述的，引用特别地实施例的凝结物移除装置可以包括一个或者多个额外的特征或者组成部分，或者上文所描述的一个或者多个特征可以被省略。
如上文所述，应注意的是，本发明的具体的实施例在这里以展示为目的而被描述，但是众所周知的结构和功能并没有被展示或者详细地描述，这是为了避免时本发明的实施例的描述模糊。上下文允许的话，单数或者复数的术语也分别包含了复数或单数的术语的意思。
此外，除非词语“或”被清楚地限于表示只有一个单数物体而排除两个或者更多物体的清单上的其他物体，那么“或”在该清单的的使用可以被理解为包括(a)在该清单上的任何物体，(b)该清单上的所有物体，(c)该清单的物体的任何组合。此外，术语“包括”被通篇使用，表示至少包括所列的特征，这样任何更多的相同特征和/或其他特征的额外类型没有被排除。同样应当注意的是，这里以展示为目的描述了具体的实施例，但是在不背离本发明的情况下，可以做出不同的修改的实施例。进一步，当与本发明的某一个实施例相关的优点在那些实施例的内容中被描述，其他的实施例可能同样显示出这些优点，并且不是所有的实施例需要展示出此类优点以落入本发明的范围。相应地，本公开以及相关的技术可以包括没有表示或者于此描述的其他实施例。

Claims (10)

1.一种动脉瘤装置，其能够在血管内被输送到邻近于具有分叉分支的动脉的位置，所述动脉瘤装置包括：
封闭结构；以及
辅助稳定器，其被连接到所述封闭结构，所述辅助稳定器被设置为位于动脉中；
所述封闭结构包括被设置为至少部分阻塞通向动脉瘤的开口的面向远端方面以及被设置为在分叉分支的腔上拱起的面向近端方面，
其中，所述封闭结构包括周边支撑、内支撑和支撑物，所述周边支撑和所述内支撑在结合点处结合，所述支撑物从所述结合点处延伸出，
其特征在于，所述封闭结构包括四个铰接点，所述铰接点允许所述支撑物下折以形成两个环状组件，每一个单独的环状组件被设置为嵌入到一个分叉分支中且在分叉分支中横跨锚固。
2.如权利要求1所述的动脉瘤装置，其中所述铰接点在所述支撑物上形成。
3.如权利要求1所述的动脉瘤装置，其中所述封闭结构能够在压缩状态和部署状态之间变形。
4.如权利要求3所述的动脉瘤装置，进一步包括被设置以将所述封闭结构保留在压缩状态的导管。
5.如权利要求1所述的动脉瘤装置，其中所述封闭结构包括形状记忆材料。
6.如权利要求1所述的动脉瘤装置，其中所述封闭结构是远端框架部分，所述远端框架部分包括四个支撑物，每个支撑物包括一个铰接点；以及
其中所述辅助稳定器是连接到所述远端框架部分的近端支撑框架，所述支撑框架被设置为在载瘤动脉中并偏向外向腔壁施加压力。
7.如权利要求6所述的动脉瘤装置，进一步包括输送护套，被设置为临时地使远端框架部分保持在压缩状态。
8.如权利要求6所述的动脉瘤装置，其中所述支撑物包括大致上地可变形的材料，优先地在所述铰接点处弯曲。
9.如权利要求6所述的动脉瘤装置，其中所述远端框架部分的所述支撑物和所述支撑框架的所述支撑物被配置作为在所述铰接点处弯曲的环状体。
10.如权利要求6所述的动脉瘤装置，其中所述远端框架部分和所述支撑框架是由通常扁平且未组装的部件形成的三维且组装完毕的部件。
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US11344311B2 (en) 2022-05-31
US20220280164A1 (en) 2022-09-08
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US20150039015A1 (en) 2015-02-05
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US10624647B2 (en) 2020-04-21
JP2014523285A (ja) 2014-09-11
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US20200214713A1 (en) 2020-07-09

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