DE69736177D1 - Mit aminosäuren stabilisierte erythropoietinlösung - Google Patents

Mit aminosäuren stabilisierte erythropoietinlösung

Info

Publication number
DE69736177D1
DE69736177D1 DE69736177T DE69736177T DE69736177D1 DE 69736177 D1 DE69736177 D1 DE 69736177D1 DE 69736177 T DE69736177 T DE 69736177T DE 69736177 T DE69736177 T DE 69736177T DE 69736177 D1 DE69736177 D1 DE 69736177D1
Authority
DE
Germany
Prior art keywords
styberized
amino acids
erythropoietin solution
erythropoietin
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69736177T
Other languages
English (en)
Other versions
DE69736177T2 (de
Inventor
Tadao Yamazaki
Toshiari Morita
Hiroshi Nagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26466124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69736177(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE69736177D1 publication Critical patent/DE69736177D1/de
Application granted granted Critical
Publication of DE69736177T2 publication Critical patent/DE69736177T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69736177T 1996-04-26 1997-04-25 Mit aminosäuren stabilisierte erythropoietinlösung Expired - Lifetime DE69736177T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13122696 1996-04-26
JP13122696 1996-04-26
JP30395696 1996-10-30
JP30395696 1996-10-30
PCT/JP1997/001449 WO1997040850A1 (fr) 1996-04-26 1997-04-25 Preparation de solution d'erythropoietine

Publications (2)

Publication Number Publication Date
DE69736177D1 true DE69736177D1 (de) 2006-08-03
DE69736177T2 DE69736177T2 (de) 2007-05-16

Family

ID=26466124

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69736177T Expired - Lifetime DE69736177T2 (de) 1996-04-26 1997-04-25 Mit aminosäuren stabilisierte erythropoietinlösung
DE69739968T Expired - Lifetime DE69739968D1 (de) 1996-04-26 1997-04-25 Erythropoietin-Lösungszubereitung, stabilisiert mit Leucin oder Glutaminsäure

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69739968T Expired - Lifetime DE69739968D1 (de) 1996-04-26 1997-04-25 Erythropoietin-Lösungszubereitung, stabilisiert mit Leucin oder Glutaminsäure

Country Status (10)

Country Link
US (4) US6120761A (de)
EP (2) EP1712237B1 (de)
JP (3) JP3068033B2 (de)
KR (2) KR20040004414A (de)
AT (2) ATE330622T1 (de)
AU (1) AU722300B2 (de)
DE (2) DE69736177T2 (de)
ES (1) ES2267140T3 (de)
TW (2) TWI240627B (de)
WO (1) WO1997040850A1 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI240627B (en) * 1996-04-26 2005-10-01 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
JP2011025068A (ja) * 1999-02-22 2011-02-10 Chugai Pharmaceut Co Ltd プレフィルドシリンジタンパク質溶液製剤
JP2007204498A (ja) * 1999-03-01 2007-08-16 Chugai Pharmaceut Co Ltd 長期安定化製剤
MXPA01010208A (es) * 1999-04-09 2003-07-21 Johnson & Johnson Composiciones farmaceuticas de eritropoyetina.
DE60038386T2 (de) * 1999-09-08 2009-04-23 Chugai Seiyaku K.K. Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben
JP5271481B2 (ja) * 1999-09-08 2013-08-21 中外製薬株式会社 タンパク質溶液製剤およびその安定化方法
GB9930882D0 (en) * 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
WO2001064241A1 (fr) * 2000-02-29 2001-09-07 Chugai Seiyaku Kabushiki Kaisha Preparations stabilisees a long terme
AU2005225151B2 (en) * 2000-05-15 2008-05-29 F. Hoffmann-La Roche Ag New pharmaceutical composition
HU230874B1 (hu) * 2000-05-15 2018-11-29 F. Hoffmann-La Roche Ag Pegilezett humán eritropoietin-fehérjét tartalmazó, szobahőmérsékleten stabil folyékony gyógyászati készítmények
EP1336410A4 (de) * 2000-08-04 2005-10-12 Chugai Pharmaceutical Co Ltd Protein-injektionszubereitungen
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
US8703126B2 (en) 2000-10-12 2014-04-22 Genentech, Inc. Reduced-viscosity concentrated protein formulations
PT1324776E (pt) 2000-10-12 2009-12-23 Genentech Inc Formulações de proteína concentradas de viscosidade reduzida
CN100528235C (zh) 2000-12-20 2009-08-19 霍夫曼-拉罗奇有限公司 红细胞生成素共轭物
US7531358B2 (en) * 2001-04-17 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Method of quantifying surfactant
EP1428537B1 (de) 2001-08-29 2008-11-19 Chugai Seiyaku Kabushiki Kaisha Antikörper enthaltende stabilisierte zubereitungen
US7842668B1 (en) 2001-11-13 2010-11-30 Genentech, Inc. Apo-2 ligand/trail formulations
EP2332531B1 (de) * 2001-11-13 2019-07-10 Genentech, Inc. Reinigungsverfahren des Proteins Tumornekrosefaktor-verwandter Apoptose-induzierender Ligand/TRAIL
US7741285B2 (en) * 2001-11-13 2010-06-22 Genentech, Inc. APO-2 ligand/trail formulations
PL370652A1 (en) 2001-12-21 2005-05-30 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
DE60322513D1 (de) 2002-02-27 2008-09-11 Immunex Corp Stabilisierte TNFR-Fc Formulierung mit Arginin
PT1517698E (pt) 2002-06-21 2014-11-19 Novo Nordisk Healthcare Ag Composições sólidas estabilizadas de polipéptidos do fator viia
CN1703233A (zh) * 2002-07-12 2005-11-30 米德列斯公司 防止蛋白氧化降解的方法和组合物
SI21257A (sl) * 2002-07-17 2004-02-29 LEK farmacevtska dru�ba d.d. Stabilni farmacevtski pripravek, ki vsebuje eritropoietin
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
RU2333200C2 (ru) 2003-03-07 2008-09-10 Астеллас Фарма Инк. Азотсодержащие гетероциклические производные, содержащие 2,6-дизамещенный стирил
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
JP4869064B2 (ja) * 2003-04-04 2012-02-01 ジェネンテック， インコーポレイテッド 高濃度抗体及びタンパク質製剤
US20040198663A1 (en) * 2003-04-04 2004-10-07 Baker John E. Method of treating cardiac ischemia by using erythropoietin
MXPA05012476A (es) 2003-05-23 2006-02-22 Novo Nordisk Healthcare Ag Estabilizacion de proteina en solucion.
US8119595B2 (en) 2003-06-10 2012-02-21 Lg Life Sciences, Ltd. Stable, aqueous solution of human erythropoietin, not containing serum albumin
DE10333317A1 (de) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
KR100560697B1 (ko) * 2003-08-06 2006-03-16 씨제이 주식회사 알부민을 함유하지 않는 에리스로포이에틴 제제
CN1845753A (zh) * 2003-08-14 2006-10-11 诺和诺德医疗保健公司 因子ⅶ多肽类的含水液体药物组合物
US7141544B2 (en) 2003-10-10 2006-11-28 Baxter International, Inc. Stabilization of pharmaceutical protein formulations with small peptides
EP1537876A1 (de) 2003-12-01 2005-06-08 BioGeneriX AG Formulierung einer Erythropoietin Lösung
EP3378470A1 (de) 2003-12-19 2018-09-26 Novo Nordisk Health Care AG Stabilisierte zusammensetzungen aus faktor-vii-polypeptiden
DE102004011663B4 (de) * 2004-03-10 2006-04-27 Bioceuticals Arzneimittel Ag Erythropoietin-Flüssigformulierung
US20050282751A1 (en) * 2004-03-19 2005-12-22 Ajinomoto Co., Inc. Therapeutic agent for renal anemia
JP4896006B2 (ja) 2004-04-08 2012-03-14 バイオマトリカ， インコーポレイテッド ライフサイエンスのためのサンプル保存とサンプル管理との統合
US20060099567A1 (en) * 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
BRPI0510295A (pt) 2004-05-04 2007-11-06 Novo Nordisk Healthcare Ag preparação de uma glicoproteìna, e, método para produzir a mesma
US7772182B2 (en) 2004-08-05 2010-08-10 Alza Corporation Stable suspension formulations of erythropoietin receptor agonists
US20060029551A1 (en) * 2004-08-05 2006-02-09 Kui Liu Stable particle formulations of erythropoietin receptor agonists
JP4147235B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置
MX2007004302A (es) * 2004-10-12 2007-06-07 Applied Research Systems Inhibidores de pi3 cinasa gamma para el tratamiento de anemia.
MY139088A (en) * 2005-02-21 2009-08-28 Lg Life Sciences Ltd Sustained release composition of protein drug
JPWO2006115274A1 (ja) * 2005-04-26 2008-12-18 味の素株式会社 骨髄赤血球前駆細胞分化促進剤
EA012801B1 (ru) 2005-06-14 2009-12-30 Эмджен Инк. Самобуферирующиеся композиции белков
EP2264161A1 (de) * 2005-07-02 2010-12-22 Arecor Limited Stabile wässrige Systeme mit Proteinen
GB2433425B (en) * 2005-12-23 2010-11-17 Cassidy Brothers Plc Improvements relating to vacuum cleaners
JP5553506B2 (ja) * 2006-03-22 2014-07-16 中外製薬株式会社 エリスロポエチン溶液製剤
EA030606B1 (ru) 2006-05-04 2018-08-31 Бёрингер Ингельхайм Интернациональ Гмбх Способы приготовления лекарственного средства, содержащего полиморфы
EP1852108A1 (de) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Zusammensetzungen von DPP-IV-Inhibitoren
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
BRPI0712063A2 (pt) 2006-06-07 2011-12-20 Chugai Pharmaceutical Co Ltd tratamento de doenças isquêmicas usando eritropoietina
WO2008019214A1 (en) 2006-08-04 2008-02-14 Prolong Pharmaceuticals, Inc. Modified erythropoietin
WO2008023725A1 (fr) 2006-08-22 2008-02-28 Chugai Seiyaku Kabushiki Kaisha Agent préventif et/ou thérapeutique pour une neuropathie périphérique
KR100784134B1 (ko) * 2006-10-09 2007-12-12 주식회사 대웅 상피세포성장인자를 함유하는 안정한 구내염 치료용 액상조성물
JP2010515736A (ja) * 2007-01-10 2010-05-13 エジソン ファーマシューティカルズ， インコーポレイテッド エリスロポイエチン活性またはトロンボポイエチン活性を有する化合物を用いる呼吸鎖障害の治療
AR065613A1 (es) 2007-03-09 2009-06-17 Chugai Pharmaceutical Co Ltd Agentes de proteccion para organos transplantados
CA2684959A1 (en) * 2007-04-24 2009-01-15 Biomatrica, Inc. Sample storage for life science
AR067536A1 (es) 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
CL2008002053A1 (es) * 2007-07-17 2009-05-22 Hoffmann La Roche Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion.
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
JP2011519848A (ja) 2008-05-01 2011-07-14 アレコー リミテッド タンパク質製剤
EP2303309A2 (de) * 2008-05-22 2011-04-06 Edison Pharmaceuticals, Inc. Behandlung von mitochondrialen erkrankungen mit einem erythropoetin-mimetikum
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
PE20120359A1 (es) 2009-03-06 2012-04-13 Genentech Inc Formulacion con anticuerpo
CA2761675A1 (en) * 2009-05-11 2010-11-18 Biomatrica, Inc. Compositions and methods for biological sample storage
US9457029B2 (en) 2009-11-27 2016-10-04 Boehringer Ingelheim International Gmbh Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin
US8829163B2 (en) 2010-01-19 2014-09-09 Hanmi Science Co., Ltd Liquid formulations for long-acting erythropoietin conjugate
TWI609698B (zh) 2010-01-20 2018-01-01 Chugai Pharmaceutical Co Ltd 穩定化的含抗體溶液製劑
KR101903931B1 (ko) 2010-03-01 2018-10-02 바이엘 헬스케어 엘엘씨 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체
US9186392B2 (en) 2010-05-05 2015-11-17 Boehringer Ingelheim International Gmbh Combination therapy
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
JP5887893B2 (ja) * 2010-12-10 2016-03-16 大正製薬株式会社 内服液剤
AU2012345777B2 (en) 2011-11-30 2016-05-12 Kindeva Drug Delivery L.P. Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
EP3685839A1 (de) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin zur verwendung in der behandlung von albuminuria und nierenbedingten erkrankungen
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
US8613919B1 (en) 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations
EP2934572A4 (de) 2012-12-20 2016-11-23 Biomatrica Inc Formulierungen und verfahren zur stabilisierung von pcr-reagenzien
WO2015150930A1 (en) 2014-03-29 2015-10-08 Intas Pharmaceuticals Ltd. Liquid pharmaceutical composition of conjugated erythropoietin
ES2891555T3 (es) 2014-06-10 2022-01-28 Biomatrica Inc Estabilización de trombocitos a temperaturas ambiente
TW202339800A (zh) 2015-02-27 2023-10-16 日商中外製藥股份有限公司 Il-6受體抗體用於製備醫藥組成物的用途
IL297369B2 (en) 2015-04-29 2024-06-01 Radius Pharmaceuticals Inc RAD for use in a method to treat mutant estrogen receptor-positive breast cancer or mutant estrogen receptor-positive ovarian cancer
AR104847A1 (es) 2015-06-17 2017-08-16 Lilly Co Eli Formulación de anticuerpo anti-cgrp
EP3789395A1 (de) 2015-11-23 2021-03-10 Bristol-Myers Squibb Company Pegylierung von fgf21
WO2017100212A1 (en) 2015-12-08 2017-06-15 Biomatrica, Inc. Reduction of erythrocyte sedimentation rate
KR102399451B1 (ko) * 2016-05-27 2022-05-23 입센 바이오팜 리미티드 트립토판 또는 타이로신으로 안정화된 액체 신경독 제형
CA3022202A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
EP3528787A4 (de) 2016-10-21 2020-05-06 Amgen Inc. Pharmazeutische formulierungen und verfahren zur herstellung davon
PL3565542T3 (pl) 2017-01-05 2024-07-29 Radius Pharmaceuticals, Inc. Postacie polimorficzne rad1901-2hcl
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations
CN112423844B (zh) 2018-07-04 2024-08-13 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
JPH0669960B2 (ja) * 1985-11-22 1994-09-07 エーザイ株式会社 水溶性を増加したｔＰＡ含有医薬組成物
JP2577744B2 (ja) * 1986-07-18 1997-02-05 中外製薬株式会社 安定な顆粒球コロニ−刺激因子含有製剤
DE3729863A1 (de) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
US4877608A (en) * 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
JP2844351B2 (ja) * 1989-07-13 1999-01-06 株式会社科薬 安定なポリミキシン系抗生物質水性溶液
DE3939346A1 (de) * 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
JPH078804B2 (ja) * 1990-08-28 1995-02-01 三菱化学株式会社 副腎皮質刺激ホルモン放出因子含有製剤
DE4126983A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
JP3221120B2 (ja) * 1992-12-25 2001-10-22 ソニー株式会社 復号装置
US6288030B1 (en) * 1993-12-22 2001-09-11 Amgen Inc. Stem cell factor formulations and methods
JP3044333B2 (ja) 1994-06-10 2000-05-22 大日本スクリーン製造株式会社 減圧式基板処理槽の蓋開閉装置
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
GB9424902D0 (en) * 1994-12-09 1995-02-08 Cortecs Ltd Solubilisation Aids
CA2214889C (en) * 1995-03-10 2005-05-24 Hans Koll Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and a process for the production thereof
JP3170437B2 (ja) 1995-09-20 2001-05-28 株式会社日立製作所 不揮発性半導体多値記憶装置
TWI240627B (en) * 1996-04-26 2005-10-01 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation

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US20040087507A1 (en) 2004-05-06
EP1712237A2 (de) 2006-10-18
US6627187B2 (en) 2003-09-30
KR20000064995A (ko) 2000-11-06
US6120761A (en) 2000-09-19
KR20040004414A (ko) 2004-01-13
EP0909564A1 (de) 1999-04-21
AU722300B2 (en) 2000-07-27
AU2407497A (en) 1997-11-19
US20010055582A1 (en) 2001-12-27
JP4589018B2 (ja) 2010-12-01
TWI240627B (en) 2005-10-01
EP1712237B1 (de) 2010-08-18
KR100417031B1 (ko) 2004-07-19
JP3618633B2 (ja) 2005-02-09
DE69739968D1 (de) 2010-09-30
JP2000302689A (ja) 2000-10-31
ATE330622T1 (de) 2006-07-15
JP3068033B2 (ja) 2000-07-24
ATE477813T1 (de) 2010-09-15
TW518219B (en) 2003-01-21
JPH10182481A (ja) 1998-07-07
JP2004196824A (ja) 2004-07-15
US6277367B1 (en) 2001-08-21
EP0909564B1 (de) 2006-06-21
EP0909564A4 (de) 2003-03-26
EP1712237A3 (de) 2008-05-07
ES2267140T3 (es) 2007-03-01
US7011825B2 (en) 2006-03-14
DE69736177T2 (de) 2007-05-16
TW200300340A (en) 2003-06-01

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