DE60233227D1 - Thiophenderivate als antivirale mittel gegen flavivirus-infektion - Google Patents
Thiophenderivate als antivirale mittel gegen flavivirus-infektionInfo
- Publication number
- DE60233227D1 DE60233227D1 DE60233227T DE60233227T DE60233227D1 DE 60233227 D1 DE60233227 D1 DE 60233227D1 DE 60233227 T DE60233227 T DE 60233227T DE 60233227 T DE60233227 T DE 60233227T DE 60233227 D1 DE60233227 D1 DE 60233227D1
- Authority
- DE
- Germany
- Prior art keywords
- antiviral agents
- agents against
- flavivirus infection
- against flavivirus
- thiophen derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29673101P | 2001-06-11 | 2001-06-11 | |
PCT/CA2002/000876 WO2002100851A2 (en) | 2001-06-11 | 2002-06-11 | Thiophene derivatives as antiviral agents for flavivirus infection |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60233227D1 true DE60233227D1 (de) | 2009-09-17 |
Family
ID=23143308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60233227T Expired - Lifetime DE60233227D1 (de) | 2001-06-11 | 2002-06-11 | Thiophenderivate als antivirale mittel gegen flavivirus-infektion |
Country Status (25)
Country | Link |
---|---|
US (2) | US6881741B2 (de) |
EP (3) | EP2206709A3 (de) |
JP (2) | JP4544857B2 (de) |
KR (1) | KR100900304B1 (de) |
CN (2) | CN101624391A (de) |
AP (1) | AP1753A (de) |
AT (1) | ATE438637T1 (de) |
AU (2) | AU2002344854B2 (de) |
BR (1) | BR0210357A (de) |
CA (1) | CA2450007C (de) |
CY (1) | CY1109497T1 (de) |
CZ (1) | CZ20033368A3 (de) |
DE (1) | DE60233227D1 (de) |
DK (1) | DK1401825T3 (de) |
EA (1) | EA007484B1 (de) |
ES (1) | ES2330313T3 (de) |
MX (1) | MXPA03011452A (de) |
NO (1) | NO331721B1 (de) |
OA (1) | OA12622A (de) |
PL (2) | PL395097A1 (de) |
PT (1) | PT1401825E (de) |
SI (1) | SI1401825T1 (de) |
SK (1) | SK288015B6 (de) |
WO (1) | WO2002100851A2 (de) |
ZA (1) | ZA200309590B (de) |
Families Citing this family (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
CN101624391A (zh) * | 2001-06-11 | 2010-01-13 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
WO2003029242A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
JP2005531608A (ja) * | 2002-06-06 | 2005-10-20 | スミスクライン・ビーチャム・コーポレイション | NF−κB阻害剤 |
US7179836B2 (en) * | 2002-09-20 | 2007-02-20 | Smithkline Beecham Corporation | Chemical compounds |
TW200418863A (en) * | 2002-10-17 | 2004-10-01 | Upjohn Co | Novel anthelmintic and insecticidal compositions |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
CN100413861C (zh) * | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
BR0316771A (pt) * | 2002-12-10 | 2005-10-25 | Virochem Pharma Inc | Compostos para o tratamento ou a prevenção de infecções por flavivirus, uso de um composto e composição farmacêutica |
WO2004052879A1 (en) * | 2002-12-10 | 2004-06-24 | Virochem Pharma Inc. | Thiophenederivatives for the treatment of flavivirus infections |
US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
WO2004056746A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
US7247736B2 (en) | 2002-12-23 | 2007-07-24 | 4Sc Ag | Method of identifying inhibitors of DHODH |
JP2006514023A (ja) * | 2002-12-23 | 2006-04-27 | 4エスシー エージー | 抗炎症剤、免疫調節剤及び増殖抑制剤としての芳香族化合物 |
SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
JP4733023B2 (ja) | 2003-04-16 | 2011-07-27 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎ウイルスの大環状イソキノリンペプチド阻害剤 |
US7112601B2 (en) | 2003-09-11 | 2006-09-26 | Bristol-Myers Squibb Company | Cycloalkyl heterocycles for treating hepatitis C virus |
TWI375679B (en) | 2003-10-14 | 2012-11-01 | Hoffmann La Roche | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
EP1944042A1 (de) * | 2003-10-27 | 2008-07-16 | Vertex Pharmceuticals Incorporated | Kombinationen für die HCV-Behandlung |
SI1677827T1 (sl) * | 2003-10-27 | 2009-06-30 | Vertex Pharma | Zdravilni sestavek proti virusu hepatitisa c (hcv) |
DE10359791A1 (de) * | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Substituierte Thiophene |
GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
UA86962C2 (en) | 2004-02-20 | 2009-06-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Viral polymerase inhibitors |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
DE102004061746A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
DE102005028077A1 (de) * | 2004-12-22 | 2006-07-13 | Aicuris Gmbh & Co. Kg | Alkinyl-substituierte Thiophene |
SI1836179T1 (sl) | 2004-12-30 | 2015-07-31 | Janssen Pharmaceutica N.V. | Amidni derivati piperidin- in piperazin-1-karboksilne kisline in sorodne spojine kot modulatorji maščobnokislinske amidne hidrolaze (faah) za zdravljenje tesnobe, bolečine in drugih stanj |
CN101189230A (zh) | 2005-05-04 | 2008-05-28 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的杂环化合物 |
KR20080016597A (ko) * | 2005-05-13 | 2008-02-21 | 바이로켐 파마 인코포레이티드 | 플라비바이러스 감염의 예방 또는 치료용 화합물 및 그의예방 또는 치료 방법 |
AU2011205048B2 (en) * | 2005-05-13 | 2013-05-02 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
DE602006003661D1 (de) | 2005-06-06 | 2008-12-24 | Lilly Co Eli | Ampa-rezeptoren-verstärker |
WO2007070600A2 (en) * | 2005-12-12 | 2007-06-21 | Genelabs Technologies, Inc. | N-(5-membered heteroaromatic ring)-amido anti-viral compounds |
JP2009520735A (ja) * | 2005-12-22 | 2009-05-28 | スミスクライン・ビーチャム・コーポレイション | 抗ウイルス性2−カルボキシ−チオフェン化合物 |
GB0526255D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
WO2008008907A2 (en) * | 2006-07-14 | 2008-01-17 | Genelabs Technologies, Inc. | Antiviral agents |
WO2008017688A1 (en) * | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
CA2665804A1 (en) * | 2006-08-23 | 2008-02-28 | Astellas Pharma Inc. | Urea compound or salt thereof |
RS51643B (en) | 2006-10-10 | 2011-10-31 | Medivir Ab. | INHIBITOR HCV NUKLEOZIDA |
WO2008043791A2 (en) * | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
EP2559692A1 (de) | 2006-11-15 | 2013-02-20 | Virochem Pharma Inc. | Thiophen-Analoga zur Behandlung oder Vorbeugung von Flavivirus-Infektionen |
WO2008059042A1 (en) * | 2006-11-17 | 2008-05-22 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti viral agents |
GB0707092D0 (en) * | 2007-04-12 | 2007-05-23 | Smithkline Beecham Corp | Compounds |
NZ580917A (en) | 2007-05-04 | 2012-06-29 | Vertex Pharma | Combinations of protease inhibitors such as VX-950 and polymerase inhibitors for the treatment of HCV infection |
RU2009148304A (ru) * | 2007-05-25 | 2011-06-27 | Янссен Фармацевтика Н.В. (Be) | Модуляторы гидролазы амидов жирных кислот на основе гетероарилзамещенной мочевины |
GB0712393D0 (en) * | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
US8178699B2 (en) * | 2008-07-30 | 2012-05-15 | Pfizer Inc. | Modulators of CCR9 receptor and methods of use thereof |
EP2321303B1 (de) * | 2008-08-27 | 2019-11-27 | Calcimedica, Inc. | Verbindungen als modulatoren von intrazellulärem calcium |
WO2010031832A2 (en) * | 2008-09-18 | 2010-03-25 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Synergistic combinations of a macrocyclic inhibitor of hcv and a thiophene-2-carboxylic acid derivative |
EP3025727A1 (de) | 2008-10-02 | 2016-06-01 | The J. David Gladstone Institutes | Verfahren zur behandlung von lebererkrankungen |
WO2010068452A1 (en) * | 2008-11-25 | 2010-06-17 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
WO2010068453A1 (en) | 2008-11-25 | 2010-06-17 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
KR20110098779A (ko) | 2008-12-03 | 2011-09-01 | 프레시디오 파마슈티칼스, 인코포레이티드 | Hcv ns5a의 억제제 |
BRPI0922366B8 (pt) | 2008-12-03 | 2021-05-25 | Presidio Pharmaceuticals Inc | composto, composição farmacêutica e uso de um composto |
US8546405B2 (en) * | 2008-12-23 | 2013-10-01 | Abbott Laboratories | Anti-viral compounds |
MX2011006332A (es) * | 2008-12-23 | 2011-06-27 | Abbott Lab | Compuestos antivirales. |
WO2010101967A2 (en) * | 2009-03-04 | 2010-09-10 | Idenix Pharmaceuticals, Inc. | Phosphothiophene and phosphothiazole hcv polymerase inhibitors |
JP2012520884A (ja) | 2009-03-18 | 2012-09-10 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | フラビウイルス科ウイルス感染症を治療する方法および組成物 |
SG174883A1 (en) | 2009-03-27 | 2011-11-28 | Presidio Pharmaceuticals Inc | Fused ring inhibitors of hepatitis c |
JP5734956B2 (ja) * | 2009-04-15 | 2015-06-17 | アッヴィ・インコーポレイテッド | 抗ウィルス化合物 |
US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
US8901111B2 (en) | 2009-06-05 | 2014-12-02 | Janssen Pharmaceutica Nv | Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
SG171708A1 (en) * | 2009-06-11 | 2011-07-28 | Abbott Lab | Anti-viral compounds to treat hcv infection |
JP5841531B2 (ja) * | 2009-07-21 | 2016-01-13 | ギリアード サイエンシーズ, インコーポレイテッド | フラビウイルス科ウイルスの阻害剤 |
EP2507249B1 (de) | 2009-09-09 | 2015-11-11 | Gilead Sciences, Inc. | Hemmer von flaviviridae-viren |
KR20120104239A (ko) | 2009-11-14 | 2012-09-20 | 에프. 호프만-라 로슈 아게 | Hcv 치료에 대한 신속한 반응을 예측하기 위한 바이오마커 |
WO2011068715A1 (en) * | 2009-11-25 | 2011-06-09 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
WO2011067195A1 (en) | 2009-12-02 | 2011-06-09 | F. Hoffmann-La Roche Ag | Biomarkers for predicting sustained response to hcv treatment |
US20130072523A1 (en) | 2009-12-24 | 2013-03-21 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
CN102712632A (zh) * | 2010-01-15 | 2012-10-03 | 吉里德科学公司 | 黄病毒科病毒的抑制剂 |
PL2523950T3 (pl) | 2010-01-15 | 2017-09-29 | Gilead Sciences, Inc. | Inhibitory wirusów flaviviridae |
WO2011094489A1 (en) | 2010-01-29 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Therapies for treating hepatitis c virus infection |
EP2550262A1 (de) | 2010-03-24 | 2013-01-30 | Vertex Pharmaceuticals Incorporated | Analoga zur behandlung oder vorbeugung von flavivirus-infektionen |
WO2011119860A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
CN102869657A (zh) | 2010-03-24 | 2013-01-09 | 沃泰克斯药物股份有限公司 | 用于治疗或预防黄病毒感染的类似物 |
MX2012010919A (es) | 2010-03-24 | 2013-02-01 | Vertex Pharma | Analogos para el tratamiento o prevencion de infecciones por flavivirus. |
UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
US8877707B2 (en) | 2010-05-24 | 2014-11-04 | Presidio Pharmaceuticals, Inc. | Inhibitors of HCV NS5A |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
WO2011159826A2 (en) | 2010-06-15 | 2011-12-22 | Vertex Pharmaceuticals Incorporated | Hcv ns5b protease mutants |
WO2012006070A1 (en) | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
AU2011276526A1 (en) | 2010-06-28 | 2013-01-10 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
EP2585448A1 (de) | 2010-06-28 | 2013-05-01 | Vertex Pharmaceuticals Incorporated | Verbindungen und verfahren zur behandlung oder vorbeugung von flavivirus-infektionen |
US9040690B2 (en) * | 2010-07-22 | 2015-05-26 | Novartis Ag | 2,3,5-trisubstituted thiophene compounds and uses thereof |
WO2012020036A1 (en) | 2010-08-13 | 2012-02-16 | F. Hoffmann-La Roche Ag | Hepatitis c virus inhibitors |
CN103153978A (zh) | 2010-08-17 | 2013-06-12 | 沃泰克斯药物股份有限公司 | 用于治疗或预防黄病毒科病毒感染的化合物和方法 |
BR112013009789A2 (pt) | 2010-10-26 | 2016-07-19 | Presidio Pharmaceuticals Inc | inibidores do vírus da hepatite c |
WO2012083105A1 (en) | 2010-12-17 | 2012-06-21 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
EP2681205B1 (de) * | 2011-03-03 | 2016-11-16 | Universität des Saarlandes | Biaryl-derivate als selective 17-beta-hydroxysteroid-dehydrogenase-2-hemmer |
ES2583093T3 (es) * | 2011-03-03 | 2016-09-19 | Denovamed Inc. | Compuestos antimicrobianos/adyuvantes |
WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
US20120328565A1 (en) | 2011-06-24 | 2012-12-27 | Brinkman John A | Antiviral compounds |
PT2734515E (pt) | 2011-07-13 | 2016-03-11 | Gilead Sciences Inc | Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae |
WO2013016499A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Methods for preparation of thiophene compounds |
TW201313697A (zh) | 2011-07-26 | 2013-04-01 | Vertex Pharma | 製備噻吩化合物之方法 |
KR101621181B1 (ko) | 2011-10-10 | 2016-05-13 | 에프. 호프만-라 로슈 아게 | 항바이러스성 화합물 |
CN103059042B (zh) * | 2011-10-18 | 2015-10-07 | 银杏树药业(苏州)有限公司 | 噻吩类衍生物及其在药学中的用途 |
US9364484B2 (en) | 2011-12-06 | 2016-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating viral diseases |
CN103987723B (zh) | 2011-12-16 | 2017-03-01 | 弗·哈夫曼-拉罗切有限公司 | Hcv ns5a 的抑制剂 |
ES2626484T3 (es) | 2011-12-20 | 2017-07-25 | Riboscience Llc | Derivados nucleosídicos 4'-azido-3'-fluoro-sustituidos como inhibidores de la replicación del ARN de VHC |
EP2794629B1 (de) | 2011-12-20 | 2017-05-24 | Riboscience LLC | 2',4'-difluor-2'-methyl-substituierte nukleosidderivate als hemmer der hcv-rna-replikation |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
WO2013124335A1 (en) | 2012-02-24 | 2013-08-29 | F. Hoffmann-La Roche Ag | Antiviral compounds |
EP2827876A4 (de) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | Pharmazeutische kombinationen mit einem thionucleotidanalog |
WO2014055142A1 (en) | 2012-06-20 | 2014-04-10 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
US20140010783A1 (en) | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
CN104582794A (zh) * | 2012-08-31 | 2015-04-29 | 诺瓦药品公司 | 用于治疗病毒性疾病的杂环基氨甲酰 |
BR112015017414A2 (pt) | 2013-01-23 | 2017-07-11 | Hoffmann La Roche | derivados de triazol antivirais |
US20150065439A1 (en) | 2013-02-28 | 2015-03-05 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
CN105008350B (zh) | 2013-03-05 | 2018-05-08 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒化合物 |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
RU2534613C2 (ru) | 2013-03-22 | 2014-11-27 | Александр Васильевич Иващенко | Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения |
SG11201509424VA (en) | 2013-05-16 | 2015-12-30 | Riboscience Llc | 4'-fluor0-2'-methyl substituted nucleoside derivatives |
MA38678A1 (fr) | 2013-05-16 | 2017-07-31 | Riboscience Llc | Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués |
US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
EP3089757A1 (de) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Feste antivirale darreichungsformen |
ES2932383T3 (es) | 2014-04-17 | 2023-01-18 | Merck Sharp & Dohme Llc | Complejo de tanato de sitagliptina |
WO2016007540A2 (en) * | 2014-07-10 | 2016-01-14 | The J. David Gladstone Institutes | Compositions and methods for treating dengue virus infection |
WO2016090313A1 (en) * | 2014-12-05 | 2016-06-09 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use |
TWI731854B (zh) | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | C型肝炎病毒聚合酶之抑制劑 |
KR20200056420A (ko) | 2017-09-21 | 2020-05-22 | 리보사이언스 엘엘씨 | Hcv rna 복제의 억제제로서 4'-플루오로-2'-메틸 치환된 뉴클레오시드 유도체 |
CA3091951A1 (en) * | 2018-03-01 | 2019-09-06 | Thomas Helledays Stiftelse For Medicinsk Forskning | Substituted benzodiazoles and use thereof in therapy |
WO2019217643A1 (en) | 2018-05-09 | 2019-11-14 | Cocrystal Pharma, Inc. | Combination therapy for treatment of hcv |
CN108558822B (zh) * | 2018-06-01 | 2020-12-18 | 盐城锦明药业有限公司 | N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法 |
Family Cites Families (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3076817A (en) * | 1963-02-05 | New j-amino-thiophene-z | ||
DE1055077B (de) | 1956-02-08 | 1959-04-16 | Bayerische Schrauben Und Feder | Telephonkabelsteckverbinder |
DE1055007B (de) * | 1957-08-29 | 1959-04-16 | Dr Hans Fiesselmann | Verfahren zur Herstellung von 3-Aminothiophen-2-carbonsaeureestern und den entsprechenden freien Carbonsaeuren |
US3470151A (en) * | 1966-05-17 | 1969-09-30 | Beecham Group Ltd | Furyl- and thienyl-penicillins and salts thereof |
JPS4810463B1 (de) * | 1967-07-07 | 1973-04-03 | ||
US3823161A (en) * | 1970-05-07 | 1974-07-09 | Exxon Research Engineering Co | Aminothiophene derivatives |
US3852293A (en) | 1972-06-21 | 1974-12-03 | Uniroyal Inc | 4-phenyl-2-(3-pyridyl)-thiazole carboxamides |
AU518216B2 (en) | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
DD146952A1 (de) | 1979-11-09 | 1981-03-11 | Karl Gewald | Verfahren zur herstellung von substituierten 3-amino-4-cyan-5-phenylthiophenen |
JPS57116077A (en) | 1981-01-12 | 1982-07-19 | Kanebo Ltd | Thieno(3,2-b)pyridinecarboxylic acid derivative |
US4666502A (en) * | 1982-02-09 | 1987-05-19 | Sandoz Ltd. | Herbicidal N-thienyl-chloroacetamides |
ATE26720T1 (de) * | 1982-09-09 | 1987-05-15 | Hoffmann La Roche | Thieno(2,3-e)-1,2-thiazin-derivate. |
GB8515207D0 (en) * | 1985-06-15 | 1985-07-17 | Boots Co Plc | Therapeutic agents |
JPS63126884A (ja) | 1986-11-17 | 1988-05-30 | Sankyo Co Ltd | オキサゾロチエノピリミジン誘導体 |
GB8627698D0 (en) * | 1986-11-20 | 1986-12-17 | Boots Co Plc | Therapeutic agents |
DD263055A1 (de) | 1987-07-28 | 1988-12-21 | Univ Dresden Tech | Verfahren zur herstellung substituierter 3-amino-5-phenyl-thiophene |
DE3932052A1 (de) | 1989-09-26 | 1991-04-04 | Basf Ag | Oxazol- bzw. thiazolcarbonsaeureamide |
EP0463444B1 (de) | 1990-06-23 | 1995-08-30 | BASF Aktiengesellschaft | Dicarbonsäureimide als Herbizide |
DE4023048A1 (de) * | 1990-07-20 | 1992-01-23 | Basf Ag | Dicarbonsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
JP2574085B2 (ja) | 1991-10-28 | 1997-01-22 | 株式会社トクヤマ | 3−アミノ−2−チオフェンカルボン酸誘導体の製造方法 |
FR2689129B1 (fr) | 1992-03-27 | 1995-05-12 | Atochem Elf Sa | Nouveaux dérivés de l'acide 3-mercapto-2-thénoique et leurs procédés de préparation. |
JPH0625221A (ja) | 1992-07-10 | 1994-02-01 | Tokuyama Soda Co Ltd | 3−アミノ−2−チオフェンカルボン酸誘導体の製造方法 |
DE4244069A1 (de) | 1992-12-24 | 1994-06-30 | Hoechst Ag | Cephalosporinsalze und Verfahren zu deren Herstellung |
JPH0748360A (ja) | 1993-05-31 | 1995-02-21 | Yoshitomi Pharmaceut Ind Ltd | ビフェニルテトラゾール誘導体 |
JPH0718360A (ja) | 1993-07-07 | 1995-01-20 | Sumitomo Light Metal Ind Ltd | 耐摩耗性に優れたTi−Al系金属間化合物部材及びその製造方法 |
EP0658559A1 (de) * | 1993-12-14 | 1995-06-21 | Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. | Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren |
MX9702380A (es) * | 1995-08-02 | 1998-02-28 | Uriach & Cia Sa J | Nuevas carboxamidas con actividad antifungica. |
ES2153975T3 (es) * | 1995-08-02 | 2001-03-16 | Uriach & Cia Sa J | Derivados de pirimidona con actividad antifungica. |
WO1998008839A1 (en) * | 1996-08-26 | 1998-03-05 | Eli Lilly And Company | Combinatorial process for preparing substituted thiophene libraries |
JP4000608B2 (ja) * | 1996-11-07 | 2007-10-31 | トヨタ自動車株式会社 | 水素製造充填装置および電気自動車 |
TW523506B (en) * | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
WO1998046588A2 (en) * | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
BR9812258A (pt) * | 1997-04-28 | 2000-07-25 | Texas Biotechnology Corp | Sulfonamidas para tratamento de distúrbios mediados por endotelina |
US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
ES2153337T3 (es) * | 1997-05-23 | 2008-11-01 | Bayer Pharmaceuticals Corporation | Inhibidores de la quinasa raf. |
DE69826695T2 (de) | 1997-05-23 | 2006-02-02 | Bayer Pharmaceuticals Corp., West Haven | Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen |
US6344476B1 (en) * | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
US6187799B1 (en) | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
EP1016664B1 (de) * | 1997-09-02 | 2003-07-02 | Mitsubishi Pharma Corporation | Kondensierte thiophenderivate und ihre medizinische anwendung |
US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
AU2003204708B2 (en) | 1997-12-22 | 2006-05-25 | Bayer Healthcare Llc | Inhibition of Raf Kinase using Substituted Heterocyclic Ureas |
US20070244120A1 (en) * | 2000-08-18 | 2007-10-18 | Jacques Dumas | Inhibition of raf kinase using substituted heterocyclic ureas |
US7329670B1 (en) * | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
US6291514B1 (en) * | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
US20050119332A1 (en) * | 1998-03-12 | 2005-06-02 | Lone Jeppesen | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) |
US6262044B1 (en) * | 1998-03-12 | 2001-07-17 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPASES) |
US6214879B1 (en) * | 1998-03-24 | 2001-04-10 | Virginia Commonwealth University | Allosteric inhibitors of pyruvate kinase |
US6147085A (en) * | 1999-04-01 | 2000-11-14 | Neurogen Corporation | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives |
US6689754B1 (en) * | 1998-04-10 | 2004-02-10 | G. D. Searle & Co. | Heterocyclic glycyl β-alanine derivatives |
PT957099E (pt) * | 1998-04-15 | 2003-02-28 | Pfizer Prod Inc | Carboxamidas heterociclicas |
EP0960882A1 (de) * | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituiertre Acylguanidine und ihre Verwendung als Knochenresorptionhemmer und als Vitronectinrezeptor-Antagoniste |
US6858223B2 (en) * | 1998-06-23 | 2005-02-22 | Altana Pharma Ag | Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS) |
ATE253061T1 (de) * | 1998-06-29 | 2003-11-15 | Iaf Biochem Int | Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide |
EE200100102A (et) * | 1998-08-20 | 2002-06-17 | Agouron Pharmaceuticals, Inc. | Mittepeptiidsed GnRH agensid, nende valmistamise meetodid ja vaheühendid |
US7101878B1 (en) * | 1998-08-20 | 2006-09-05 | Agouron Pharmaceuticals, Inc. | Non-peptide GNRH agents, methods and intermediates for their preparation |
DE19903398A1 (de) * | 1999-01-29 | 2000-08-10 | Hassan Jomaa | Verwendung von Thiadiazolderivaten zur prophylaktischen und therapeutischen Behandlung von Infektionen |
US6492403B1 (en) * | 1999-02-09 | 2002-12-10 | 3-Dimensional Pharmaceuticals, Inc. | Methods of treating C1s-mediated diseases and conditions and compositions thereof |
CN1511830A (zh) * | 1999-03-12 | 2004-07-14 | ���ָ��.Ӣ��ķҩ�﹫˾ | 作为消炎剂的化合物 |
DE60023853T2 (de) * | 1999-03-12 | 2006-05-24 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Aromatische heterozyklische verbindungen als antientzündungwirkstoffe |
JP2001010957A (ja) | 1999-04-28 | 2001-01-16 | Sankyo Co Ltd | 肝障害の予防または抑制剤 |
DE19920247A1 (de) * | 1999-05-03 | 2000-11-16 | Hassan Jomaa | Arzneimittel mit einem Gehalt an Verbindungen mit einem Stickstoff-Sauerstoff-Heterocyclus als Wirkstoff und ihre Verwendung |
HN2000000051A (es) * | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
US6867217B1 (en) * | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
GB9929552D0 (en) * | 1999-12-14 | 2000-02-09 | Proteus Molecular Design | Compounds |
AU7446600A (en) | 1999-10-01 | 2001-05-10 | Japan Energy Corporation | Novel diarylamide derivatives and use thereof as medicines |
CA2388529A1 (en) * | 1999-11-29 | 2001-06-07 | Pierre Ducray | Pesticidal n-heteroaryl alpha-alkoximino-carboxamides |
DE10002424A1 (de) * | 2000-01-20 | 2001-07-26 | Siemens Ag | Di(het)arylaminothiophen-Derivate |
GB0003154D0 (en) * | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
MY138097A (en) * | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
JP2001354658A (ja) | 2000-06-15 | 2001-12-25 | Taisho Pharmaceut Co Ltd | ヒドロキシホルムアミジン化合物及びその塩並びにそれらを含む医薬 |
US6414013B1 (en) * | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
AU2002213048A1 (en) | 2000-10-05 | 2002-04-15 | Smith Kline Beecham Corporation | Phosphate transport inhibitors |
PL362930A1 (en) | 2000-11-08 | 2004-11-02 | Syngenta Participations Ag | Pyrrolcarboxamides and pyrrolcarbothioamides and their agrochemical uses |
US7015223B1 (en) * | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
US6892279B2 (en) * | 2000-11-30 | 2005-05-10 | Mosaid Technologies Incorporated | Method and apparatus for accelerating retrieval of data from a memory system with cache by reducing latency |
DE10061876A1 (de) * | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
EP1370562A1 (de) * | 2001-02-14 | 2003-12-17 | Warner-Lambert Company LLC | Thieno[2,3-d]pyrimidindion-derivate als matrix-metalloproteinase-inhibitoren |
JP4343534B2 (ja) * | 2001-03-02 | 2009-10-14 | ゲーペーツェー バイオテック アクチェンゲゼルシャフト | 3ハイブリッド・アッセイ・システム |
US20040102324A1 (en) * | 2002-02-28 | 2004-05-27 | Annis Gary David | Heterocyclic diamide invertebrate pest control agents |
EP1386166A2 (de) * | 2001-03-13 | 2004-02-04 | Queen's University At Kingston | Antiepileptogene wirkstoffe |
US6734207B2 (en) * | 2001-04-20 | 2004-05-11 | Parker Hughes Institute | Cytotoxic compounds |
US6713638B2 (en) * | 2001-05-18 | 2004-03-30 | Joel M. Linden | 2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors |
CN101624391A (zh) * | 2001-06-11 | 2010-01-13 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
WO2002100846A1 (en) * | 2001-06-11 | 2002-12-19 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
SE0102617D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
JP2003073357A (ja) | 2001-09-03 | 2003-03-12 | Mitsubishi Pharma Corp | アミド化合物を含有するRhoキナーゼ阻害剤 |
US6924276B2 (en) * | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
WO2003029242A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
US7285557B2 (en) * | 2001-10-15 | 2007-10-23 | Smithkline Beecham P.L.C. | Pyrimidinones as melanin concentrating hormone receptor 1 |
US7220777B2 (en) * | 2001-10-15 | 2007-05-22 | Smithkline Beecham P.L.C. | Lactam derivatives as antagonists for human 11cby receptors |
TWI281916B (en) * | 2001-10-25 | 2007-06-01 | Lilly Co Eli | Antitumor compounds and methods |
WO2003055479A1 (en) * | 2001-12-21 | 2003-07-10 | Consejo Superior De Investigaciones Cientificas | Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3 |
US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
US20040023961A1 (en) * | 2002-02-11 | 2004-02-05 | Bayer Corporation | Aryl ureas with raf kinase and angiogenisis inhibiting activity |
US20030220336A1 (en) * | 2002-04-05 | 2003-11-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method of treating mucus hypersecretion |
BR0311419A (pt) * | 2002-05-28 | 2005-04-05 | Dimensional Pharm Inc | Amidinas de tiofeno suas composições e métodos de tratamento de doenças e condições mediadas por complemento |
CN1155679C (zh) | 2002-09-20 | 2004-06-30 | 华南理工大学 | 含低聚噻吩骨格的液晶化合物及其制备方法 |
US7179836B2 (en) * | 2002-09-20 | 2007-02-20 | Smithkline Beecham Corporation | Chemical compounds |
AU2003268926B2 (en) * | 2002-10-24 | 2010-06-17 | Merck Patent Gmbh | Methylene urea derivatives as raf-kinase inhibitors |
US20050075331A1 (en) * | 2003-10-06 | 2005-04-07 | Pratt John K. | Anti-infective agents |
US20040162285A1 (en) * | 2002-11-01 | 2004-08-19 | Pratt John K. | Anti-infective agents |
EP2361913A1 (de) | 2002-11-01 | 2011-08-31 | Abbott Laboratories | Antiinfektiöse Mittel |
US7902203B2 (en) * | 2002-11-01 | 2011-03-08 | Abbott Laboratories, Inc. | Anti-infective agents |
US20040097492A1 (en) * | 2002-11-01 | 2004-05-20 | Pratt John K | Anti-infective agents |
WO2004052879A1 (en) | 2002-12-10 | 2004-06-24 | Virochem Pharma Inc. | Thiophenederivatives for the treatment of flavivirus infections |
CN100413861C (zh) * | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
US7098241B2 (en) * | 2002-12-16 | 2006-08-29 | Hoffmann-La Roche Inc. | Thiophene hydroxamic acid derivatives |
DE10359791A1 (de) | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Substituierte Thiophene |
RU2006138036A (ru) * | 2004-03-30 | 2008-05-10 | Чирон Корпорейшн (Us) | Производные замещенного тиофена в качестве противораковых средств |
DE102005028077A1 (de) | 2004-12-22 | 2006-07-13 | Aicuris Gmbh & Co. Kg | Alkinyl-substituierte Thiophene |
KR20080016597A (ko) * | 2005-05-13 | 2008-02-21 | 바이로켐 파마 인코포레이티드 | 플라비바이러스 감염의 예방 또는 치료용 화합물 및 그의예방 또는 치료 방법 |
-
2002
- 2002-06-11 CN CN200910139375A patent/CN101624391A/zh active Pending
- 2002-06-11 BR BR0210357-5A patent/BR0210357A/pt not_active IP Right Cessation
- 2002-06-11 CA CA2450007A patent/CA2450007C/en not_active Expired - Fee Related
- 2002-06-11 DE DE60233227T patent/DE60233227D1/de not_active Expired - Lifetime
- 2002-06-11 MX MXPA03011452A patent/MXPA03011452A/es active IP Right Grant
- 2002-06-11 US US10/166,031 patent/US6881741B2/en not_active Expired - Fee Related
- 2002-06-11 EA EA200400022A patent/EA007484B1/ru not_active IP Right Cessation
- 2002-06-11 PL PL395097A patent/PL395097A1/pl unknown
- 2002-06-11 EP EP09167203A patent/EP2206709A3/de not_active Withdrawn
- 2002-06-11 WO PCT/CA2002/000876 patent/WO2002100851A2/en active Application Filing
- 2002-06-11 DK DK02742563T patent/DK1401825T3/da active
- 2002-06-11 EP EP02742563A patent/EP1401825B1/de not_active Expired - Lifetime
- 2002-06-11 AT AT02742563T patent/ATE438637T1/de active
- 2002-06-11 PT PT02742563T patent/PT1401825E/pt unknown
- 2002-06-11 PL PL367080A patent/PL208713B1/pl not_active IP Right Cessation
- 2002-06-11 SK SK1520-2003A patent/SK288015B6/sk not_active IP Right Cessation
- 2002-06-11 KR KR1020037016240A patent/KR100900304B1/ko not_active IP Right Cessation
- 2002-06-11 JP JP2003503618A patent/JP4544857B2/ja not_active Expired - Fee Related
- 2002-06-11 ES ES02742563T patent/ES2330313T3/es not_active Expired - Lifetime
- 2002-06-11 SI SI200230851T patent/SI1401825T1/sl unknown
- 2002-06-11 CZ CZ20033368A patent/CZ20033368A3/cs unknown
- 2002-06-11 AP APAP/P/2003/002932A patent/AP1753A/en active
- 2002-06-11 AU AU2002344854A patent/AU2002344854B2/en not_active Ceased
- 2002-06-11 EP EP10185737A patent/EP2363396A1/de not_active Withdrawn
- 2002-06-11 CN CNB028157680A patent/CN100509797C/zh not_active Expired - Fee Related
- 2002-06-11 OA OA1200300320A patent/OA12622A/en unknown
-
2003
- 2003-12-10 NO NO20035485A patent/NO331721B1/no not_active IP Right Cessation
- 2003-12-10 ZA ZA200309590A patent/ZA200309590B/en unknown
-
2005
- 2005-01-26 US US11/042,442 patent/US7985769B2/en not_active Expired - Fee Related
-
2009
- 2009-02-05 AU AU2009200430A patent/AU2009200430B2/en not_active Ceased
- 2009-10-22 CY CY20091101100T patent/CY1109497T1/el unknown
-
2010
- 2010-04-28 JP JP2010103706A patent/JP5412370B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60233227D1 (de) | Thiophenderivate als antivirale mittel gegen flavivirus-infektion | |
ATE338033T1 (de) | Thiophen- und thiazolsulfonamide als antineoplastische mittel | |
DE60221392D1 (de) | Neue pyrrolderivate als pharmazeutische mittel | |
ATE516030T1 (de) | Benzimidazolidinon-derivate als muscarinische mittel | |
ATE319451T1 (de) | Tetrahydrochinolin-derivate | |
DE60317711D1 (de) | Kationische porphyrin-derivate als antibakterielle mittel | |
ATE312827T1 (de) | 3-substituierte-4-pyrimidonderivate | |
DE60039194D1 (de) | 3-aminochinazolin-2,4-dione als antibakterielle mittel | |
NO20034168L (no) | Koagulasjonsfaktor VII-derivater | |
DE60203263D1 (de) | Pyrazolderivate gegen tgf überexprimierung | |
DE60132618D1 (de) | 4,6-diphenylpyridinderivate als entzündungshemmende mittel | |
DE60226775D1 (de) | Azaindolylalkylaminderivate als 5-hydroxytryptamin-6-liganden | |
ATE335477T1 (de) | Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden | |
ATE459598T1 (de) | Sulfonamidderivate | |
DE60142257D1 (de) | Aufzug | |
DE50209245D1 (de) | Neuroprotektives medikament | |
DE60214138D1 (de) | Isoxazolin-derivate als antidepressiva | |
DE60201463D1 (de) | Indanon-Derivate als Duftstoffe | |
DE60220799D1 (de) | Hypoglykämisches mittel | |
ATE299873T1 (de) | Substituierte c-furan-2-yl-methylamin- und c- thiophen-2-yl-methylamin-derivate | |
ATE287708T1 (de) | 1-amino-alkylcyclohexanederivate als trypanocide mittel | |
DE60202381D1 (de) | Paroxetin-n-formyl-derivate | |
EE200300465A (et) | Püridoindolooni derivaatidel põhinevad farmatseutilised kompositsioonid | |
DE50203921D1 (de) | Hubzylindereinheit | |
DE60233072D1 (de) | Thiophenderivate und ihre verwendung als riechstoffe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |