DE60036456T2 - Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid - Google Patents

Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid Download PDF

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Publication number
DE60036456T2
DE60036456T2 DE60036456T DE60036456T DE60036456T2 DE 60036456 T2 DE60036456 T2 DE 60036456T2 DE 60036456 T DE60036456 T DE 60036456T DE 60036456 T DE60036456 T DE 60036456T DE 60036456 T2 DE60036456 T2 DE 60036456T2
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DE
Germany
Prior art keywords
polypeptide
amino acids
endotoxin
antimicrobial
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036456T
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German (de)
English (en)
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DE60036456D1 (de
Inventor
David M. Gaithersburg MANN
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Agennix Inc
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Agennix Inc
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Filing date
Publication date
Application filed by Agennix Inc filed Critical Agennix Inc
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Publication of DE60036456D1 publication Critical patent/DE60036456D1/de
Publication of DE60036456T2 publication Critical patent/DE60036456T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE60036456T 1999-02-05 2000-01-27 Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid Expired - Lifetime DE60036456T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/245,527 US6399570B1 (en) 1999-02-05 1999-02-05 Antimicrobial/endotoxin neutralizing polypeptide
US245527 1999-02-05
PCT/IB2000/000271 WO2000049040A2 (en) 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide

Publications (2)

Publication Number Publication Date
DE60036456D1 DE60036456D1 (de) 2007-10-31
DE60036456T2 true DE60036456T2 (de) 2008-06-19

Family

ID=22927039

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036456T Expired - Lifetime DE60036456T2 (de) 1999-02-05 2000-01-27 Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid

Country Status (12)

Country Link
US (2) US6399570B1 (enExample)
EP (1) EP1151009B1 (enExample)
JP (1) JP2002541066A (enExample)
CN (1) CN1362969A (enExample)
AT (1) ATE373679T1 (enExample)
AU (1) AU758150B2 (enExample)
CA (1) CA2362153C (enExample)
DE (1) DE60036456T2 (enExample)
DK (1) DK1151009T3 (enExample)
ES (1) ES2293892T3 (enExample)
MX (1) MXPA01007956A (enExample)
WO (1) WO2000049040A2 (enExample)

Families Citing this family (31)

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IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US7060677B1 (en) 1999-11-11 2006-06-13 Am-Pharma B.V. Antimicrobial activity of the first cationic cluster of human lactoferrin
AU2003273182B8 (en) 2002-05-10 2009-05-07 Agennix Incorporated Lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
WO2003099207A2 (en) * 2002-05-24 2003-12-04 Agennix Incorporated Oral lactoferrin in the treatment of respiratory disorders
DE60335997D1 (de) * 2002-09-16 2011-03-24 Agennix Inc Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus
US20040152624A1 (en) * 2002-12-06 2004-08-05 Atul Varadhachary Oral lactoferrin in the treatment of sepsis
US7592306B2 (en) 2002-12-10 2009-09-22 Agennix, Inc. Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
WO2004103285A2 (en) 2003-05-14 2004-12-02 Agennix Incorporated Lactoferrin in the treatment of diabetes mellitus
US8105615B2 (en) * 2003-06-06 2012-01-31 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
US20050075277A1 (en) * 2003-07-10 2005-04-07 Agennix Incorporated Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects
WO2005085287A1 (en) * 2004-03-03 2005-09-15 En-N-Tech, Inc. Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
WO2007076904A1 (en) 2005-12-30 2007-07-12 Evonik Röhm Gmbh Peptides useful as cell-penetrating peptides
EP2050461A1 (en) 2007-10-19 2009-04-22 PharmaSurgics in Sweden AB Peptides based on the sequence of human lactoferrin and their use
EP2060586A1 (en) * 2007-11-14 2009-05-20 PharmaSurgics in Sweden AB New synthetic arginine substituted peptides and their use
US20090209487A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
US20090209488A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of exercise induced asthma
US20090208588A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown GERD carbohydrate compositions
US20090209486A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
US20090209489A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system
CN101294188B (zh) * 2008-06-20 2011-06-15 江南大学 乳铁蛋白抗菌肽及其制备方法与它们的用途
JP5177901B2 (ja) * 2009-12-02 2013-04-10 株式会社明治 栄養組成物
CN101798337B (zh) * 2010-01-29 2013-04-24 中国人民解放军第三军医大学第一附属医院 内毒素中和肽突变体及其应用
EP2481751A1 (en) 2011-01-26 2012-08-01 PharmaSurgics in Sweden AB Human lactoferrin derived peptides
JP5763024B2 (ja) * 2012-09-07 2015-08-12 株式会社明治 栄養組成物
EP2986115A4 (en) 2013-02-06 2017-03-01 Academia Sinica Antimicrobial peptides derived from hepatitis b virus core protein arginine-rich domain
JPWO2016056665A1 (ja) * 2014-10-08 2017-08-10 学校法人慶應義塾 白血球の細胞外トラップ形成の阻害剤
CA2964119C (en) 2014-11-03 2022-10-18 Merck Patent Gmbh Soluble intein fusion proteins and methods for purifying biomolecules
AU2017270201A1 (en) * 2016-05-27 2018-11-29 Academia Sinica Modified antimicrobial peptide derived from an arginine-rich domain
CN105999236A (zh) * 2016-07-06 2016-10-12 方雅悯 一种治疗牛乳房炎的药剂及其应用

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US6020015A (en) * 1988-09-22 2000-02-01 Gaull; Gerald E. Infant formula compositions and nutrition containing genetically engineered human milk proteins
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SE526038C2 (sv) * 2002-07-08 2005-06-21 Gambro Lundia Ab Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav
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WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof

Also Published As

Publication number Publication date
AU758150B2 (en) 2003-03-13
DK1151009T3 (da) 2008-01-28
US7244706B2 (en) 2007-07-17
WO2000049040A3 (en) 2000-12-14
AU2822600A (en) 2000-09-04
WO2000049040A2 (en) 2000-08-24
JP2002541066A (ja) 2002-12-03
EP1151009B1 (en) 2007-09-19
ES2293892T3 (es) 2008-04-01
EP1151009A2 (en) 2001-11-07
CN1362969A (zh) 2002-08-07
MXPA01007956A (es) 2004-08-19
US20030105006A1 (en) 2003-06-05
ATE373679T1 (de) 2007-10-15
US6399570B1 (en) 2002-06-04
DE60036456D1 (de) 2007-10-31
CA2362153A1 (en) 2000-08-24
CA2362153C (en) 2009-11-24

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