DE69527195T2 - Anti gram positive bakterielle verfahren und mittel - Google Patents
Anti gram positive bakterielle verfahren und mittelInfo
- Publication number
- DE69527195T2 DE69527195T2 DE69527195T DE69527195T DE69527195T2 DE 69527195 T2 DE69527195 T2 DE 69527195T2 DE 69527195 T DE69527195 T DE 69527195T DE 69527195 T DE69527195 T DE 69527195T DE 69527195 T2 DE69527195 T2 DE 69527195T2
- Authority
- DE
- Germany
- Prior art keywords
- gram
- positive bacterial
- protein product
- gram positive
- bpi protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18322294A | 1994-01-14 | 1994-01-14 | |
US08/209,762 US5733872A (en) | 1993-03-12 | 1994-03-11 | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
US27429994A | 1994-07-11 | 1994-07-11 | |
PCT/US1994/010427 WO1995019372A1 (en) | 1994-01-14 | 1994-09-15 | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
PCT/US1995/000656 WO1995019180A1 (en) | 1994-01-14 | 1995-01-13 | Anti-gram-positive bacterial methods and materials |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69527195D1 DE69527195D1 (de) | 2002-08-01 |
DE69527195T2 true DE69527195T2 (de) | 2003-03-06 |
Family
ID=27391655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69527195T Expired - Fee Related DE69527195T2 (de) | 1994-01-14 | 1995-01-13 | Anti gram positive bakterielle verfahren und mittel |
Country Status (12)
Country | Link |
---|---|
US (3) | US5578572A (de) |
EP (1) | EP0754050B1 (de) |
JP (1) | JPH09508359A (de) |
AT (1) | ATE219684T1 (de) |
AU (1) | AU703192B2 (de) |
CA (1) | CA2181164C (de) |
DE (1) | DE69527195T2 (de) |
DK (1) | DK0754050T3 (de) |
ES (1) | ES2179095T3 (de) |
HK (1) | HK1014160A1 (de) |
PT (1) | PT754050E (de) |
WO (1) | WO1995019180A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
DK0754050T3 (da) * | 1994-01-14 | 2002-10-21 | Xoma Technology Ltd | Anti-gram-positive bakterielle fremgangsmåder og materialer |
US5447913A (en) * | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
US5912228A (en) * | 1995-01-13 | 1999-06-15 | Xoma Corporation | Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products |
CA2227292A1 (en) * | 1995-07-20 | 1997-02-06 | Xoma Corporation | Anti-fungal peptides |
PT914144E (pt) * | 1996-05-10 | 2001-05-31 | Univ Texas | Utilizacoes terapeuticas de produtos de proteinas bip contra a meningococcemia humana |
US5741779A (en) | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
DE69719754D1 (de) * | 1996-05-23 | 2003-04-17 | Xoma Technology Ltd | Therapeutische verwendungen von bpi-protein produkten bei menschen mit durch trauma verursachter blutung |
US5888973A (en) * | 1996-08-09 | 1999-03-30 | Xoma Corporation | Anti-chlamydial uses of BPI protein products |
US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
US6503881B2 (en) | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
US6482796B2 (en) * | 1996-11-01 | 2002-11-19 | Xoma Corporation | Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients |
US6093573A (en) * | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
US6013631A (en) | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
WO2000018798A1 (en) * | 1998-09-25 | 2000-04-06 | Xoma Technology Ltd. | Antifungal and antibacterial peptide |
US6239113B1 (en) * | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
US7056893B2 (en) * | 1999-03-31 | 2006-06-06 | Insite Vision, Inc. | Topical treatment for prevention of ocular infections |
US6284517B1 (en) * | 1999-05-28 | 2001-09-04 | Lawrence Restaino | Plating media for the presumptive identification of Bacillus cereus and Bacillus thuringiensis |
EP1280772A2 (de) * | 2000-04-26 | 2003-02-05 | Wisconsin Alumni Research Foundation | Triarylkation-enthaltene antibiotika aus umweltproben stammender dna |
US7527807B2 (en) * | 2000-06-21 | 2009-05-05 | Cubist Pharmaceuticals, Inc. | Compositions and methods for increasing the oral absorption of antimicrobials |
CA2430588A1 (en) * | 2000-12-01 | 2002-07-18 | Xoma Technology Ltd. | Modulation of pericyte proliferation using bpi protein products or bpi inhibitors |
PT1341769E (pt) | 2000-12-15 | 2007-12-31 | Vertex Pharma | Inibidores de girase bacteriana e suas utilizações |
US7214364B2 (en) | 2000-12-27 | 2007-05-08 | Corus Pharma, Inc. | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections |
IL156596A0 (en) | 2000-12-27 | 2004-01-04 | Salus Pharma Inc | Inhalable aztreonam for treatment and prevention of pulmonary bacterial infections |
US7138419B2 (en) * | 2000-12-27 | 2006-11-21 | Corus Pharma, Inc. | Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate |
US7490625B1 (en) | 2001-04-23 | 2009-02-17 | John Leslie Johnson | Pilot valve manifold |
US6835536B2 (en) | 2001-08-21 | 2004-12-28 | Micrologix Biotech Inc. | Antimicrobial cationic peptides and formulations thereof |
US20040037895A1 (en) * | 2002-08-23 | 2004-02-26 | Alex Zhu | Methods of treating involuntary facial spasms and facial wrinkles |
GB0230221D0 (en) * | 2002-12-24 | 2003-02-05 | South Tyneside Healthcare | Antibiotic resistance testing |
NZ561169A (en) * | 2003-01-21 | 2008-06-30 | Thallion Pharmaceuticals Inc | Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals |
US7655646B2 (en) * | 2003-01-21 | 2010-02-02 | Thallion Pharmaceuticals, Inc. | Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals |
US20050005101A1 (en) * | 2003-07-03 | 2005-01-06 | Yenduri Bhargava K. | Kernel cryptographic module signature verification system and method |
WO2005024025A1 (en) * | 2003-09-11 | 2005-03-17 | Ecopia Biosciences Inc. | Polyene polyketides and methods of production |
US7455840B2 (en) * | 2003-11-19 | 2008-11-25 | The Scripps Research Institute | Compositions and methods to reduce mutagenesis |
WO2007001332A2 (en) * | 2004-08-04 | 2007-01-04 | University Of Massachusetts | Anti-pathogen immunoadhesins |
WO2006047891A1 (en) * | 2004-11-08 | 2006-05-11 | Ecopia Biosciences Inc. | Polycyclic aromatics and derivatives thereof and processes for their preparation |
US20060286574A1 (en) * | 2005-04-05 | 2006-12-21 | The Scripps Research Institute & Achaogen, Inc. | Compositions and methods for enhancing drug sensitivity and treating drug resistant infections and diseases |
US20060241040A1 (en) * | 2005-04-06 | 2006-10-26 | Alberto Visintin | Methods of treating disorders associated with toll-like receptor 4 (TLR4) signalling |
AU2006242535B2 (en) * | 2005-04-29 | 2012-08-09 | Merck Sharp & Dohme Corp. | Therapeutic compositions |
US20080206276A1 (en) * | 2005-07-08 | 2008-08-28 | Michael Otto | Targeting Poly-Gamma-Glutamic Acid to Treat Staphylococcus Epidermidis and Related Infections |
EP1741440A1 (de) | 2005-07-08 | 2007-01-10 | Mellitus S.L. | Verwendung von BPI-proteine zur Behandlung von stoffwechselbedingten Erkrankungen und Herzkreislaufstörungen |
WO2009039004A1 (en) * | 2007-09-20 | 2009-03-26 | Dow Global Technologies Inc. | A high throughput test method for evaluation of biocides against anaerobic microorganisms |
US20100069827A1 (en) | 2008-09-12 | 2010-03-18 | Barry Neil Silberg | Pre-Surgical Prophylactic Administration of Antibiotics and Therapeutic Agents |
US9446227B2 (en) | 2008-09-12 | 2016-09-20 | Sonescence, Inc. | Ultrasonic dispersion of compositions in tissue |
EP2601194B1 (de) | 2010-08-03 | 2016-05-25 | Merck Sharp & Dohme Corp. | Als antimikrobielle wirkstoffe geeignete fusionierte imidazoylverbindungen |
US8182842B1 (en) | 2010-11-10 | 2012-05-22 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Physico-chemical-managed killing of penicillin-resistant static and growing gram-positive and gram-negative vegetative bacteria |
AU2012205415B2 (en) | 2011-01-14 | 2017-02-02 | Spero Therapeutics, Inc. | Pyrimidine gyrase and topoisomerase IV inhibitors |
TWI554515B (zh) | 2011-06-20 | 2016-10-21 | 維泰克斯製藥公司 | 旋轉酶(gyrase)及拓樸異構酶抑制劑之磷酸酯 |
US9018216B2 (en) | 2012-07-18 | 2015-04-28 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
GB201319621D0 (en) | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Antimicrobial agents and their use in therapy |
GB201319620D0 (en) | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Immunosuppressive agents and their use in therapy |
CN106414552B (zh) | 2014-03-25 | 2020-08-25 | 豪夫迈·罗氏有限公司 | 制备用于细胞培养基中的泊洛沙姆的方法 |
WO2015187968A1 (en) | 2014-06-04 | 2015-12-10 | Sonescence, Inc. | Systems and methods for therapeutic agent delivery |
WO2017075189A1 (en) | 2015-10-27 | 2017-05-04 | University Of Massachusetts | Factor h-fc immunotherapy |
RU2678447C2 (ru) * | 2017-02-01 | 2019-01-29 | Александр Николаевич Швыдков | Способ исследования повышения антибиотикочувствительности условно-патогенной микрофлоры in vitro молочнокислой кормовой добавкой, содержащей культуру микроорганизмов streptococcus termophilus th-4 |
JP2019174077A (ja) * | 2018-03-29 | 2019-10-10 | ダイキン工業株式会社 | 薬剤入りカプセルおよび空気処理装置の部品 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
EP0375724B1 (de) * | 1987-08-11 | 1995-05-31 | New York University | Biologisch aktive bakterientötende/durchlässigkeitserhöhende proteinfragmente |
US5308834A (en) * | 1989-02-14 | 1994-05-03 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and prevention thereof using a BPI protein |
US5089274A (en) * | 1989-02-14 | 1992-02-18 | Incyte Pharmaceuticals, Inc. | Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders |
US5234912A (en) * | 1989-02-14 | 1993-08-10 | Incyte Pharmaceuticals, Inc. | Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof |
US5334584A (en) * | 1989-02-14 | 1994-08-02 | Incyte Pharamaceuticals, Inc. | Recombinant, non-glycosylated bpi protein and uses thereof |
US5171739A (en) * | 1989-02-14 | 1992-12-15 | Incyte Pharmaceuticals, Inc. | Treatment of endotoxin-associated shock and preventation thereof using a BPI protein |
US5447914A (en) * | 1990-06-21 | 1995-09-05 | Emory University | Antimicrobial peptides |
DE69128968T2 (de) * | 1990-12-03 | 1998-10-08 | Univ New York | Biologisch aktive bakterizide/permeabilitätserhöhende proteinbruchstücke |
AU2872792A (en) * | 1991-09-26 | 1993-04-27 | Incyte Pharmaceuticals, Inc. | A new form of liposaccharide binding protein (lbp) |
CA2136208C (en) * | 1992-05-19 | 1999-08-10 | Lynn S. Grinna | Improved methods for the preparation of endotoxin-binding proteins |
AU4382193A (en) * | 1992-05-19 | 1993-12-13 | Xoma Corporation | BPI-immunoglobulin fusion proteins |
US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
ATE206308T1 (de) * | 1993-02-02 | 2001-10-15 | Xoma Technology Ltd | Arzneizusammensetzungen enthaltend ein bakterizides permeabilität erhöhendes protein und ein tensid |
JP4139863B2 (ja) * | 1993-03-12 | 2008-08-27 | ゾーマ テクノロジー リミテッド | 殺菌性/透過性が向上したタンパク質の機能領域に由来する生物学的に活性なペプチドおよびその使用 |
DE69410254T2 (de) * | 1993-03-12 | 1998-12-17 | Xoma Corp | Behandlung von mycobakteriellen erkrankungen durch verabreichung von bakrerientötende, durchlässigkeitserhöhende proteinfragmente |
US5348942A (en) * | 1993-03-12 | 1994-09-20 | Xoma Corporation | Therapeutic uses of bactericidal/permeability increasing protein products |
DE69427582T2 (de) * | 1993-03-12 | 2001-10-04 | Xoma Technology Ltd | Therapeutische verwendungen von antibakteriellen/durchlässigkeitserhöhenden proteinprodukten |
DK0754050T3 (da) * | 1994-01-14 | 2002-10-21 | Xoma Technology Ltd | Anti-gram-positive bakterielle fremgangsmåder og materialer |
-
1995
- 1995-01-13 DK DK95908545T patent/DK0754050T3/da active
- 1995-01-13 EP EP95908545A patent/EP0754050B1/de not_active Expired - Lifetime
- 1995-01-13 DE DE69527195T patent/DE69527195T2/de not_active Expired - Fee Related
- 1995-01-13 JP JP7519190A patent/JPH09508359A/ja not_active Ceased
- 1995-01-13 US US08/372,783 patent/US5578572A/en not_active Expired - Lifetime
- 1995-01-13 AU AU16822/95A patent/AU703192B2/en not_active Ceased
- 1995-01-13 PT PT95908545T patent/PT754050E/pt unknown
- 1995-01-13 AT AT95908545T patent/ATE219684T1/de not_active IP Right Cessation
- 1995-01-13 ES ES95908545T patent/ES2179095T3/es not_active Expired - Lifetime
- 1995-01-13 CA CA002181164A patent/CA2181164C/en not_active Expired - Fee Related
- 1995-01-13 WO PCT/US1995/000656 patent/WO1995019180A1/en active IP Right Grant
-
1996
- 1996-11-25 US US08/758,116 patent/US5783561A/en not_active Expired - Fee Related
-
1998
- 1998-07-20 US US09/119,263 patent/US6054431A/en not_active Expired - Fee Related
- 1998-12-24 HK HK98115461A patent/HK1014160A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1995019180A1 (en) | 1995-07-20 |
ES2179095T3 (es) | 2003-01-16 |
DE69527195D1 (de) | 2002-08-01 |
AU1682295A (en) | 1995-08-01 |
JPH09508359A (ja) | 1997-08-26 |
CA2181164C (en) | 2008-01-08 |
EP0754050B1 (de) | 2002-06-26 |
PT754050E (pt) | 2002-11-29 |
DK0754050T3 (da) | 2002-10-21 |
US5783561A (en) | 1998-07-21 |
EP0754050A1 (de) | 1997-01-22 |
US6054431A (en) | 2000-04-25 |
ATE219684T1 (de) | 2002-07-15 |
US5578572A (en) | 1996-11-26 |
HK1014160A1 (en) | 1999-09-24 |
AU703192B2 (en) | 1999-03-18 |
CA2181164A1 (en) | 1995-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |