CN1362969A - 抗微生物/中和内毒素的多肽 - Google Patents

抗微生物/中和内毒素的多肽 Download PDF

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Publication number
CN1362969A
CN1362969A CN00804843A CN00804843A CN1362969A CN 1362969 A CN1362969 A CN 1362969A CN 00804843 A CN00804843 A CN 00804843A CN 00804843 A CN00804843 A CN 00804843A CN 1362969 A CN1362969 A CN 1362969A
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CN
China
Prior art keywords
polypeptide
amino acid
functional variant
antimicrobial
seq
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Pending
Application number
CN00804843A
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English (en)
Chinese (zh)
Inventor
D·M·曼
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EJINEX Co Ltd
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EJINEX Co Ltd
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Publication of CN1362969A publication Critical patent/CN1362969A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN00804843A 1999-02-05 2000-01-27 抗微生物/中和内毒素的多肽 Pending CN1362969A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/245,527 US6399570B1 (en) 1999-02-05 1999-02-05 Antimicrobial/endotoxin neutralizing polypeptide
US09/245,527 1999-02-05

Publications (1)

Publication Number Publication Date
CN1362969A true CN1362969A (zh) 2002-08-07

Family

ID=22927039

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00804843A Pending CN1362969A (zh) 1999-02-05 2000-01-27 抗微生物/中和内毒素的多肽

Country Status (12)

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US (2) US6399570B1 (enExample)
EP (1) EP1151009B1 (enExample)
JP (1) JP2002541066A (enExample)
CN (1) CN1362969A (enExample)
AT (1) ATE373679T1 (enExample)
AU (1) AU758150B2 (enExample)
CA (1) CA2362153C (enExample)
DE (1) DE60036456T2 (enExample)
DK (1) DK1151009T3 (enExample)
ES (1) ES2293892T3 (enExample)
MX (1) MXPA01007956A (enExample)
WO (1) WO2000049040A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101294188B (zh) * 2008-06-20 2011-06-15 江南大学 乳铁蛋白抗菌肽及其制备方法与它们的用途
CN101798337B (zh) * 2010-01-29 2013-04-24 中国人民解放军第三军医大学第一附属医院 内毒素中和肽突变体及其应用
CN103459419A (zh) * 2011-01-26 2013-12-18 佩加马公司 具有抗炎活性的基于人乳铁蛋白的肽
CN101878226B (zh) * 2007-11-14 2014-06-25 I·马特斯贝-巴尔策 精氨酸取代的新型合成肽及其应用
TWI495642B (zh) * 2013-02-06 2015-08-11 Academia Sinica 衍生自ｂ型肝炎病毒核蛋白精胺酸密集區之抗菌胜肽
CN109641938A (zh) * 2016-05-27 2019-04-16 中央研究院 衍生自精氨酸富集结构域的经修饰抗菌肽

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US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US7060677B1 (en) 1999-11-11 2006-06-13 Am-Pharma B.V. Antimicrobial activity of the first cationic cluster of human lactoferrin
AU2003273182B8 (en) 2002-05-10 2009-05-07 Agennix Incorporated Lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
WO2003099207A2 (en) * 2002-05-24 2003-12-04 Agennix Incorporated Oral lactoferrin in the treatment of respiratory disorders
DE60335997D1 (de) * 2002-09-16 2011-03-24 Agennix Inc Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus
US20040152624A1 (en) * 2002-12-06 2004-08-05 Atul Varadhachary Oral lactoferrin in the treatment of sepsis
US7592306B2 (en) 2002-12-10 2009-09-22 Agennix, Inc. Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
WO2004103285A2 (en) 2003-05-14 2004-12-02 Agennix Incorporated Lactoferrin in the treatment of diabetes mellitus
US8105615B2 (en) * 2003-06-06 2012-01-31 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
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WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
WO2007076904A1 (en) 2005-12-30 2007-07-12 Evonik Röhm Gmbh Peptides useful as cell-penetrating peptides
EP2050461A1 (en) 2007-10-19 2009-04-22 PharmaSurgics in Sweden AB Peptides based on the sequence of human lactoferrin and their use
US20090209487A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
US20090209488A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of exercise induced asthma
US20090208588A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown GERD carbohydrate compositions
US20090209486A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
US20090209489A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system
JP5177901B2 (ja) * 2009-12-02 2013-04-10 株式会社明治 栄養組成物
JP5763024B2 (ja) * 2012-09-07 2015-08-12 株式会社明治 栄養組成物
JPWO2016056665A1 (ja) * 2014-10-08 2017-08-10 学校法人慶應義塾 白血球の細胞外トラップ形成の阻害剤
CA2964119C (en) 2014-11-03 2022-10-18 Merck Patent Gmbh Soluble intein fusion proteins and methods for purifying biomolecules
CN105999236A (zh) * 2016-07-06 2016-10-12 方雅悯 一种治疗牛乳房炎的药剂及其应用

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101878226B (zh) * 2007-11-14 2014-06-25 I·马特斯贝-巴尔策 精氨酸取代的新型合成肽及其应用
CN101294188B (zh) * 2008-06-20 2011-06-15 江南大学 乳铁蛋白抗菌肽及其制备方法与它们的用途
CN101798337B (zh) * 2010-01-29 2013-04-24 中国人民解放军第三军医大学第一附属医院 内毒素中和肽突变体及其应用
CN103459419A (zh) * 2011-01-26 2013-12-18 佩加马公司 具有抗炎活性的基于人乳铁蛋白的肽
CN103459419B (zh) * 2011-01-26 2016-05-11 佩加马公司 具有抗炎活性的基于人乳铁蛋白的肽
TWI495642B (zh) * 2013-02-06 2015-08-11 Academia Sinica 衍生自ｂ型肝炎病毒核蛋白精胺酸密集區之抗菌胜肽
CN105101796B (zh) * 2013-02-06 2017-06-06 中央研究院 衍生自b型肝炎病毒核蛋白精氨酸密集区的抗菌胜肽
CN109641938A (zh) * 2016-05-27 2019-04-16 中央研究院 衍生自精氨酸富集结构域的经修饰抗菌肽

Also Published As

Publication number Publication date
DE60036456T2 (de) 2008-06-19
AU758150B2 (en) 2003-03-13
DK1151009T3 (da) 2008-01-28
US7244706B2 (en) 2007-07-17
WO2000049040A3 (en) 2000-12-14
AU2822600A (en) 2000-09-04
WO2000049040A2 (en) 2000-08-24
JP2002541066A (ja) 2002-12-03
EP1151009B1 (en) 2007-09-19
ES2293892T3 (es) 2008-04-01
EP1151009A2 (en) 2001-11-07
MXPA01007956A (es) 2004-08-19
US20030105006A1 (en) 2003-06-05
ATE373679T1 (de) 2007-10-15
US6399570B1 (en) 2002-06-04
DE60036456D1 (de) 2007-10-31
CA2362153A1 (en) 2000-08-24
CA2362153C (en) 2009-11-24

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