JP2002541066A - 抗微生物薬／エンドトキシンを中和するポリペプチド - Google Patents
抗微生物薬／エンドトキシンを中和するポリペプチドInfo
- Publication number
- JP2002541066A JP2002541066A JP2000599777A JP2000599777A JP2002541066A JP 2002541066 A JP2002541066 A JP 2002541066A JP 2000599777 A JP2000599777 A JP 2000599777A JP 2000599777 A JP2000599777 A JP 2000599777A JP 2002541066 A JP2002541066 A JP 2002541066A
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- Prior art keywords
- polypeptide
- amino acids
- endotoxin
- functional variant
- antimicrobial
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- General Preparation And Processing Of Foods (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/245,527 US6399570B1 (en) | 1999-02-05 | 1999-02-05 | Antimicrobial/endotoxin neutralizing polypeptide |
| US09/245,527 | 1999-02-05 | ||
| PCT/IB2000/000271 WO2000049040A2 (en) | 1999-02-05 | 2000-01-27 | Antimicrobial/endotoxin neutralizing polypeptide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002541066A true JP2002541066A (ja) | 2002-12-03 |
| JP2002541066A5 JP2002541066A5 (enExample) | 2007-03-08 |
Family
ID=22927039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000599777A Pending JP2002541066A (ja) | 1999-02-05 | 2000-01-27 | 抗微生物薬／エンドトキシンを中和するポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6399570B1 (enExample) |
| EP (1) | EP1151009B1 (enExample) |
| JP (1) | JP2002541066A (enExample) |
| CN (1) | CN1362969A (enExample) |
| AT (1) | ATE373679T1 (enExample) |
| AU (1) | AU758150B2 (enExample) |
| CA (1) | CA2362153C (enExample) |
| DE (1) | DE60036456T2 (enExample) |
| DK (1) | DK1151009T3 (enExample) |
| ES (1) | ES2293892T3 (enExample) |
| MX (1) | MXPA01007956A (enExample) |
| WO (1) | WO2000049040A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4795021B2 (ja) * | 2002-12-06 | 2011-10-19 | エイジェニックス インコーポレイテッド | 敗血症治療における経口用ラクトフェリン |
| JP2014505062A (ja) * | 2011-01-26 | 2014-02-27 | ペルガモン アクティエボラーグ | ヒトラクトフェリン由来ペプチド及びその使用 |
| JP2020180162A (ja) * | 2014-11-03 | 2020-11-05 | メルク パテント ゲーエムベーハー | 可溶性インテイン融合タンパク質、及び生体分子を精製する方法 |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
| US6399570B1 (en) | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
| US7060677B1 (en) | 1999-11-11 | 2006-06-13 | Am-Pharma B.V. | Antimicrobial activity of the first cationic cluster of human lactoferrin |
| AU2003273182B8 (en) | 2002-05-10 | 2009-05-07 | Agennix Incorporated | Lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases |
| WO2003099207A2 (en) * | 2002-05-24 | 2003-12-04 | Agennix Incorporated | Oral lactoferrin in the treatment of respiratory disorders |
| DE60335997D1 (de) * | 2002-09-16 | 2011-03-24 | Agennix Inc | Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus |
| US7592306B2 (en) | 2002-12-10 | 2009-09-22 | Agennix, Inc. | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
| WO2004103285A2 (en) | 2003-05-14 | 2004-12-02 | Agennix Incorporated | Lactoferrin in the treatment of diabetes mellitus |
| US8105615B2 (en) * | 2003-06-06 | 2012-01-31 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
| US20050075277A1 (en) * | 2003-07-10 | 2005-04-07 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
| WO2005085287A1 (en) * | 2004-03-03 | 2005-09-15 | En-N-Tech, Inc. | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions |
| WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
| WO2007076904A1 (en) | 2005-12-30 | 2007-07-12 | Evonik Röhm Gmbh | Peptides useful as cell-penetrating peptides |
| EP2050461A1 (en) | 2007-10-19 | 2009-04-22 | PharmaSurgics in Sweden AB | Peptides based on the sequence of human lactoferrin and their use |
| EP2060586A1 (en) * | 2007-11-14 | 2009-05-20 | PharmaSurgics in Sweden AB | New synthetic arginine substituted peptides and their use |
| US20090209487A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions of carbohydrates as dietary supplements |
| US20090209488A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions for the treatment of exercise induced asthma |
| US20090208588A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | GERD carbohydrate compositions |
| US20090209486A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions of carbohydrates as dietary supplements |
| US20090209489A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system |
| CN101294188B (zh) * | 2008-06-20 | 2011-06-15 | 江南大学 | 乳铁蛋白抗菌肽及其制备方法与它们的用途 |
| JP5177901B2 (ja) * | 2009-12-02 | 2013-04-10 | 株式会社明治 | 栄養組成物 |
| CN101798337B (zh) * | 2010-01-29 | 2013-04-24 | 中国人民解放军第三军医大学第一附属医院 | 内毒素中和肽突变体及其应用 |
| JP5763024B2 (ja) * | 2012-09-07 | 2015-08-12 | 株式会社明治 | 栄養組成物 |
| EP2986115A4 (en) | 2013-02-06 | 2017-03-01 | Academia Sinica | Antimicrobial peptides derived from hepatitis b virus core protein arginine-rich domain |
| JPWO2016056665A1 (ja) * | 2014-10-08 | 2017-08-10 | 学校法人慶應義塾 | 白血球の細胞外トラップ形成の阻害剤 |
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- 2000-01-27 ES ES00906569T patent/ES2293892T3/es not_active Expired - Lifetime
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- 2000-01-27 JP JP2000599777A patent/JP2002541066A/ja active Pending
- 2000-01-27 CN CN00804843A patent/CN1362969A/zh active Pending
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- 2000-01-27 WO PCT/IB2000/000271 patent/WO2000049040A2/en not_active Ceased
- 2000-01-27 DK DK00906569T patent/DK1151009T3/da active
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4795021B2 (ja) * | 2002-12-06 | 2011-10-19 | エイジェニックス インコーポレイテッド | 敗血症治療における経口用ラクトフェリン |
| JP2014505062A (ja) * | 2011-01-26 | 2014-02-27 | ペルガモン アクティエボラーグ | ヒトラクトフェリン由来ペプチド及びその使用 |
| JP2014505061A (ja) * | 2011-01-26 | 2014-02-27 | ペルガモン アクティエボラーグ | 新規合成ペプチド及びそれらの使用 |
| JP2020180162A (ja) * | 2014-11-03 | 2020-11-05 | メルク パテント ゲーエムベーハー | 可溶性インテイン融合タンパク質、及び生体分子を精製する方法 |
| JP7054722B2 (ja) | 2014-11-03 | 2022-04-14 | メルク パテント ゲーエムベーハー | 可溶性インテイン融合タンパク質、及び生体分子を精製する方法 |
| JP7058560B2 (ja) | 2014-11-03 | 2022-04-22 | メルク パテント ゲーエムベーハー | 可溶性インテイン融合タンパク質、及び生体分子を精製する方法 |
| US11326154B2 (en) | 2014-11-03 | 2022-05-10 | Merck Patent Gmbh | Soluble intein fusion proteins and methods for purifying biomolecules |
| US11926854B2 (en) | 2014-11-03 | 2024-03-12 | Merck Patent Gmbh | Soluble intein fusion proteins and methods for purifying biomolecules |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60036456T2 (de) | 2008-06-19 |
| AU758150B2 (en) | 2003-03-13 |
| DK1151009T3 (da) | 2008-01-28 |
| US7244706B2 (en) | 2007-07-17 |
| WO2000049040A3 (en) | 2000-12-14 |
| AU2822600A (en) | 2000-09-04 |
| WO2000049040A2 (en) | 2000-08-24 |
| EP1151009B1 (en) | 2007-09-19 |
| ES2293892T3 (es) | 2008-04-01 |
| EP1151009A2 (en) | 2001-11-07 |
| CN1362969A (zh) | 2002-08-07 |
| MXPA01007956A (es) | 2004-08-19 |
| US20030105006A1 (en) | 2003-06-05 |
| ATE373679T1 (de) | 2007-10-15 |
| US6399570B1 (en) | 2002-06-04 |
| DE60036456D1 (de) | 2007-10-31 |
| CA2362153A1 (en) | 2000-08-24 |
| CA2362153C (en) | 2009-11-24 |
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