DE60036456D1 - Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid - Google Patents
Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptidInfo
- Publication number
- DE60036456D1 DE60036456D1 DE60036456T DE60036456T DE60036456D1 DE 60036456 D1 DE60036456 D1 DE 60036456D1 DE 60036456 T DE60036456 T DE 60036456T DE 60036456 T DE60036456 T DE 60036456T DE 60036456 D1 DE60036456 D1 DE 60036456D1
- Authority
- DE
- Germany
- Prior art keywords
- present
- polypeptide
- patient
- endotoxin
- antimicrobial effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- General Preparation And Processing Of Foods (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US245527 | 1999-02-05 | ||
US09/245,527 US6399570B1 (en) | 1999-02-05 | 1999-02-05 | Antimicrobial/endotoxin neutralizing polypeptide |
PCT/IB2000/000271 WO2000049040A2 (en) | 1999-02-05 | 2000-01-27 | Antimicrobial/endotoxin neutralizing polypeptide |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60036456D1 true DE60036456D1 (de) | 2007-10-31 |
DE60036456T2 DE60036456T2 (de) | 2008-06-19 |
Family
ID=22927039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60036456T Expired - Lifetime DE60036456T2 (de) | 1999-02-05 | 2000-01-27 | Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid |
Country Status (12)
Country | Link |
---|---|
US (2) | US6399570B1 (de) |
EP (1) | EP1151009B1 (de) |
JP (1) | JP2002541066A (de) |
CN (1) | CN1362969A (de) |
AT (1) | ATE373679T1 (de) |
AU (1) | AU758150B2 (de) |
CA (1) | CA2362153C (de) |
DE (1) | DE60036456T2 (de) |
DK (1) | DK1151009T3 (de) |
ES (1) | ES2293892T3 (de) |
MX (1) | MXPA01007956A (de) |
WO (1) | WO2000049040A2 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US6399570B1 (en) | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
US7060677B1 (en) | 1999-11-11 | 2006-06-13 | Am-Pharma B.V. | Antimicrobial activity of the first cationic cluster of human lactoferrin |
PT1507554E (pt) | 2002-05-10 | 2011-11-21 | Agennix Inc | Lactoferrina no tratamento de neoplasmas malignos e outras doenças hiperproliferativas |
US7238661B2 (en) * | 2002-05-24 | 2007-07-03 | Agennix, Inc. | Oral lactoferrin in the treatment of respiratory disorders |
JP4516844B2 (ja) * | 2002-09-16 | 2010-08-04 | エイジェニックス インコーポレイテッド | 創傷の処置におけるラクトフェリン |
WO2004052281A2 (en) * | 2002-12-06 | 2004-06-24 | Agennix Incorporated | Oral lactoferrin in the treatment of sepsis |
WO2004052305A2 (en) | 2002-12-10 | 2004-06-24 | Agennix Incorporated | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
US7034126B2 (en) | 2003-05-14 | 2006-04-25 | Agennix, Inc. | Lactoferrin in the treatment of diabetes mellitus |
WO2005046571A2 (en) * | 2003-06-06 | 2005-05-26 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
US20050075277A1 (en) * | 2003-07-10 | 2005-04-07 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
WO2005085287A1 (en) * | 2004-03-03 | 2005-09-15 | En-N-Tech, Inc. | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions |
WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
WO2007076904A1 (en) | 2005-12-30 | 2007-07-12 | Evonik Röhm Gmbh | Peptides useful as cell-penetrating peptides |
EP2050461A1 (de) | 2007-10-19 | 2009-04-22 | PharmaSurgics in Sweden AB | Peptide basierend auf der menschlichen Lactoferrinsequenz und ihre Verwendung |
EP2060586A1 (de) | 2007-11-14 | 2009-05-20 | PharmaSurgics in Sweden AB | Neue synthetische Arginin-substituierte Peptide und ihre Verwendung |
US20090208588A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | GERD carbohydrate compositions |
US20090209488A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions for the treatment of exercise induced asthma |
US20090209487A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions of carbohydrates as dietary supplements |
US20090209489A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system |
US20090209486A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions of carbohydrates as dietary supplements |
CN101294188B (zh) * | 2008-06-20 | 2011-06-15 | 江南大学 | 乳铁蛋白抗菌肽及其制备方法与它们的用途 |
JP5177901B2 (ja) * | 2009-12-02 | 2013-04-10 | 株式会社明治 | 栄養組成物 |
CN101798337B (zh) * | 2010-01-29 | 2013-04-24 | 中国人民解放军第三军医大学第一附属医院 | 内毒素中和肽突变体及其应用 |
EP2481751A1 (de) * | 2011-01-26 | 2012-08-01 | PharmaSurgics in Sweden AB | Humanem Lactoferrin abgeleitete Peptide |
JP5763024B2 (ja) * | 2012-09-07 | 2015-08-12 | 株式会社明治 | 栄養組成物 |
CN105101796B (zh) * | 2013-02-06 | 2017-06-06 | 中央研究院 | 衍生自b型肝炎病毒核蛋白精氨酸密集区的抗菌胜肽 |
JPWO2016056665A1 (ja) * | 2014-10-08 | 2017-08-10 | 学校法人慶應義塾 | 白血球の細胞外トラップ形成の阻害剤 |
WO2016073228A1 (en) | 2014-11-03 | 2016-05-12 | Merck Patent Gmbh | Soluble intein fusion proteins and methods for purifying biomolecules |
SG11201809928VA (en) * | 2016-05-27 | 2018-12-28 | Chiaho Shih | Modified antimicrobial peptide derived from an arginine-rich domain |
CN105999236A (zh) * | 2016-07-06 | 2016-10-12 | 方雅悯 | 一种治疗牛乳房炎的药剂及其应用 |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4977137B1 (en) | 1987-06-03 | 1994-06-28 | Baylor College Medicine | Lactoferrin as a dietary ingredient promoting the growth of the gastrointestinal tract |
US6020015A (en) * | 1988-09-22 | 2000-02-01 | Gaull; Gerald E. | Infant formula compositions and nutrition containing genetically engineered human milk proteins |
JP2805490B2 (ja) * | 1989-02-07 | 1998-09-30 | 雪印乳業株式会社 | 細菌毒素中和剤 |
US5141743A (en) * | 1989-04-27 | 1992-08-25 | University Technologies International, Inc. | Method for isolating and purifying transferrin and lactoferrin receptor proteins and vaccines containing the same |
IL94183A (en) | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US5849881A (en) * | 1989-05-05 | 1998-12-15 | Baylor College Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms |
US6100054A (en) | 1989-05-05 | 2000-08-08 | Baylor College Of Medicine | Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms |
US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
US5766939A (en) | 1989-05-05 | 1998-06-16 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
US5571691A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
US5198419A (en) * | 1989-12-08 | 1993-03-30 | Immuno Japan Inc. | Formulated medicines for enhancing the efficacy of beta-lactam antibiotics in prophylaxis and treatment against infectious disease due to pathogenic bacteria |
EP0536805B1 (de) | 1990-01-23 | 1995-03-15 | Morinaga Milk Industry Co., Ltd. | Lactoferrinhydrolysat zur Verwendung als tyrosinagehemmendes Mittel |
US6066469A (en) * | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
US5240909B1 (en) * | 1990-03-14 | 1998-01-20 | Dietrich Nitsche | Use of lactoferrin for treatment of toxic effects of endotoxins |
DE4008033A1 (de) | 1990-03-14 | 1991-09-19 | Nitsche Dietrich | Verwendung von lactoferrin zur bekaempfung der toxischen wirkung des endotoxins |
JP2818056B2 (ja) | 1990-09-07 | 1998-10-30 | 森永乳業株式会社 | 抗菌性ペプチドおよび抗菌剤 |
DE69124627T2 (de) * | 1990-11-13 | 1997-06-12 | Bio Serae Lab | Therapeutische agens bei hornhautverletzungen |
JP3110078B2 (ja) | 1991-06-21 | 2000-11-20 | 森永乳業株式会社 | 高純度抗菌性ペプチドの大量製造法 |
US5656591A (en) | 1992-01-23 | 1997-08-12 | Morinaga Milk Industry Co., Ltd. | Antimicrobial agents and method for treating products therewith |
DE69322896T2 (de) * | 1992-03-02 | 1999-05-27 | Immuno Japan Inc., Tokio/Tokyo | Verwendung von Proteinen der Transferrin/Lactoferrin-Familie zur Stimulation des Immunsystems |
ZA932568B (en) | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
JP3100005B2 (ja) * | 1992-07-28 | 2000-10-16 | 雪印乳業株式会社 | ヒト免疫不全ウィルス感染・増殖抑制剤 |
US5733872A (en) | 1993-03-12 | 1998-03-31 | Xoma Corporation | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
JP3770624B2 (ja) | 1993-09-02 | 2006-04-26 | 雪印乳業株式会社 | ウィルス感染・増殖抑制剤 |
EP1142484A2 (de) * | 1994-02-16 | 2001-10-10 | Pharming Intellectual Property BV | Isolierung von Lactoferrin aus Milch |
NL1000332C1 (nl) | 1994-08-31 | 1996-03-04 | Victor Smit | Graduele chemische modificatie van biologisch actieve peptiden en eiwitten. |
JP3506274B2 (ja) | 1994-09-01 | 2004-03-15 | 雪印乳業株式会社 | 新規ペプチドおよび免疫賦活剤 |
US5531989A (en) * | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Immunoglobulin and fiber-containing composition for human gastrointestinal health |
JPH08165248A (ja) | 1994-12-15 | 1996-06-25 | Nobuo Kuriiwa | エンドトキシンによる炎症の抑止剤 |
US5712247A (en) * | 1995-02-21 | 1998-01-27 | University Of North Carolina | Use of lactoferrin to modulate and/or neutralize heparin activity |
WO1996031537A1 (en) * | 1995-04-05 | 1996-10-10 | The Picower Institute For Medical Research | Agents for binding to advanced glycosylation endproducts, and methods of their use |
US20020016289A1 (en) * | 1995-06-01 | 2002-02-07 | Orla M. Conneely | Methods for treatment and prevention of helicobacter pylori infection using lactoferrin |
US5834424A (en) * | 1995-07-12 | 1998-11-10 | Gambit International Limited | Use of lactoferrin for therapy of acute of chronic infectious diseases by the intracellular gram-positive pathogens streptococcus pyogenes and staphylococcus aureus |
SE506529C2 (sv) * | 1996-01-23 | 1997-12-22 | Semper Ab | Användning av ett laktoperoxidassystem för framställning av ett läkemedel mot Helicobacter pylori |
US6111081A (en) * | 1996-05-31 | 2000-08-29 | Baylor College Of Medicine | Lactoferrin variants and uses thereof |
BR9713166A (pt) * | 1996-08-14 | 2000-02-01 | Novartis Ag | Peptideo com atividade inibidora para fungos patogênicos de plantas |
US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
WO1998033509A2 (en) * | 1997-02-03 | 1998-08-06 | Pharming Intellectual Property Bv | Useful properties of human lactoferrin and variants thereof |
WO1998044940A1 (en) * | 1997-04-10 | 1998-10-15 | Agennix, Inc. | Use of lactoferin in the treatment of allergen induced disorders |
FR2762850B1 (fr) * | 1997-05-02 | 2000-02-11 | Biocem | Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations |
ATE255130T1 (de) | 1997-09-16 | 2003-12-15 | Wolf-Georg Forssmann | Bifidogene peptide und deren verwendung |
US20020165128A1 (en) * | 1998-04-13 | 2002-11-07 | Plaut Andrew G. | Compositions and methods for proteolytically inactivating infectious agents using lactoferrin and related molecules |
EP1074250B1 (de) * | 1998-04-30 | 2004-03-24 | Morinaga Milk Industry Co., Ltd. | Zuckerbeschichtete tabletten |
CA2279791C (en) * | 1998-08-14 | 2011-11-08 | Marcus B. Gohlke | Dietary supplement combining colostrum and lactorferrin in a mucosal delivery format |
GB9818938D0 (en) * | 1998-08-28 | 1998-10-21 | Alpharma As | Bioactive peptides |
US6719973B1 (en) * | 1998-12-24 | 2004-04-13 | National University Of Singapore | Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics |
US6399570B1 (en) | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
US6613741B2 (en) * | 1999-10-29 | 2003-09-02 | Ferro Dynamics, Inc. | Method for treating aseptic SIRS in humans and other animals |
TWI237695B (en) * | 1999-12-14 | 2005-08-11 | Joy Biomedical Corp | Helicobacter pylori antigens in blood |
US20040157277A1 (en) * | 2002-03-08 | 2004-08-12 | Clancy Robert Llewellyn | Methods for predicting and/or diagnosing the risk of gastric cancer |
RU2165769C1 (ru) | 2000-07-13 | 2001-04-27 | Якубовская Раиса Ивановна | Антибактериальный, антиоксидантный, иммуномодулирующий и антиканцерогенный препарат и способ его применения |
US7020715B2 (en) * | 2000-08-22 | 2006-03-28 | Adaptec, Inc. | Protocol stack for linking storage area networks over an existing LAN, MAN, or WAN |
KR100454595B1 (ko) * | 2001-11-30 | 2004-10-28 | 주식회사 이지바이오 시스템 | 락토페리신 유전자 및 이를 도입한 형질전환 대장균 |
PT1507554E (pt) | 2002-05-10 | 2011-11-21 | Agennix Inc | Lactoferrina no tratamento de neoplasmas malignos e outras doenças hiperproliferativas |
US7238661B2 (en) * | 2002-05-24 | 2007-07-03 | Agennix, Inc. | Oral lactoferrin in the treatment of respiratory disorders |
SE526038C2 (sv) * | 2002-07-08 | 2005-06-21 | Gambro Lundia Ab | Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav |
JP4516844B2 (ja) * | 2002-09-16 | 2010-08-04 | エイジェニックス インコーポレイテッド | 創傷の処置におけるラクトフェリン |
WO2004052281A2 (en) * | 2002-12-06 | 2004-06-24 | Agennix Incorporated | Oral lactoferrin in the treatment of sepsis |
CA2530454A1 (en) * | 2003-06-24 | 2005-01-13 | Akzo Nobel N.V. | Removal of lipopolysaccharides from protein- lipopolysaccharide complex es by nonflammable solvents |
US20050075277A1 (en) * | 2003-07-10 | 2005-04-07 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
-
1999
- 1999-02-05 US US09/245,527 patent/US6399570B1/en not_active Expired - Fee Related
-
2000
- 2000-01-27 DE DE60036456T patent/DE60036456T2/de not_active Expired - Lifetime
- 2000-01-27 DK DK00906569T patent/DK1151009T3/da active
- 2000-01-27 JP JP2000599777A patent/JP2002541066A/ja active Pending
- 2000-01-27 EP EP00906569A patent/EP1151009B1/de not_active Expired - Lifetime
- 2000-01-27 CN CN00804843A patent/CN1362969A/zh active Pending
- 2000-01-27 ES ES00906569T patent/ES2293892T3/es not_active Expired - Lifetime
- 2000-01-27 CA CA002362153A patent/CA2362153C/en not_active Expired - Fee Related
- 2000-01-27 AT AT00906569T patent/ATE373679T1/de not_active IP Right Cessation
- 2000-01-27 WO PCT/IB2000/000271 patent/WO2000049040A2/en active IP Right Grant
- 2000-01-27 AU AU28226/00A patent/AU758150B2/en not_active Ceased
- 2000-01-27 MX MXPA01007956A patent/MXPA01007956A/es not_active IP Right Cessation
-
2002
- 2002-05-13 US US10/145,651 patent/US7244706B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2002541066A (ja) | 2002-12-03 |
ES2293892T3 (es) | 2008-04-01 |
AU758150B2 (en) | 2003-03-13 |
CA2362153A1 (en) | 2000-08-24 |
MXPA01007956A (es) | 2004-08-19 |
EP1151009A2 (de) | 2001-11-07 |
DE60036456T2 (de) | 2008-06-19 |
ATE373679T1 (de) | 2007-10-15 |
EP1151009B1 (de) | 2007-09-19 |
DK1151009T3 (da) | 2008-01-28 |
US20030105006A1 (en) | 2003-06-05 |
US6399570B1 (en) | 2002-06-04 |
WO2000049040A3 (en) | 2000-12-14 |
WO2000049040A2 (en) | 2000-08-24 |
AU2822600A (en) | 2000-09-04 |
US7244706B2 (en) | 2007-07-17 |
CN1362969A (zh) | 2002-08-07 |
CA2362153C (en) | 2009-11-24 |
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