EA200400135A1 - Применение производных амидинов для лечения амилоидоза - Google Patents
Применение производных амидинов для лечения амилоидозаInfo
- Publication number
- EA200400135A1 EA200400135A1 EA200400135A EA200400135A EA200400135A1 EA 200400135 A1 EA200400135 A1 EA 200400135A1 EA 200400135 A EA200400135 A EA 200400135A EA 200400135 A EA200400135 A EA 200400135A EA 200400135 A1 EA200400135 A1 EA 200400135A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- amyloidosis
- amidines
- amyloid
- compounds
- Prior art date
Links
- 150000001409 amidines Chemical class 0.000 title abstract 3
- 206010002022 amyloidosis Diseases 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003941 amyloidogenesis Effects 0.000 abstract 1
- 230000007541 cellular toxicity Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение относится к применению амидинов для лечения амилоидных заболеваний. В частности, изобретение относится к способу лечения или предупреждения амилоидного заболевания у субъекта, заключающемуся во введении субъекту терапевтического количества амидина. Среди соединений для применения по изобретению соединения нижеприведённой формулы, которые при введении уменьшают или подавляют образование амилоидных фибрилл, нейродегенерацию или клеточную токсичность.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31676101P | 2001-08-31 | 2001-08-31 | |
US38700102P | 2002-06-07 | 2002-06-07 | |
PCT/CA2002/001353 WO2003017994A1 (en) | 2001-08-31 | 2002-09-03 | Amidine derivatives for treating amyloidosis |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200400135A1 true EA200400135A1 (ru) | 2004-08-26 |
Family
ID=26980581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400135A EA200400135A1 (ru) | 2001-08-31 | 2002-09-03 | Применение производных амидинов для лечения амилоидоза |
Country Status (11)
Country | Link |
---|---|
US (3) | US20040006092A1 (ru) |
EP (1) | EP1420773A1 (ru) |
JP (1) | JP2005504053A (ru) |
KR (1) | KR20040036908A (ru) |
CN (1) | CN1658852A (ru) |
BR (1) | BR0212078A (ru) |
CA (1) | CA2455497A1 (ru) |
EA (1) | EA200400135A1 (ru) |
IL (1) | IL160208A0 (ru) |
MX (1) | MXPA04001153A (ru) |
WO (1) | WO2003017994A1 (ru) |
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DE60042896D1 (de) * | 1999-04-28 | 2009-10-15 | Bellus Health Int Ltd | Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten |
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AU2002246600B2 (en) * | 2000-11-06 | 2005-08-25 | Duke University | Synthesis and antimicrobial activity of novel dicationic "Reversed amidines" |
US6737440B2 (en) | 2000-11-06 | 2004-05-18 | The University Of North Carolina At Chapel Hill | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” |
JP2006501160A (ja) * | 2002-06-07 | 2006-01-12 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | アミロイド症を処置するためのアミジン誘導体 |
US20040049134A1 (en) * | 2002-07-02 | 2004-03-11 | Tosaya Carol A. | System and methods for treatment of alzheimer's and other deposition-related disorders of the brain |
US20050020945A1 (en) * | 2002-07-02 | 2005-01-27 | Tosaya Carol A. | Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy |
US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
EP1663959A4 (en) * | 2003-09-05 | 2007-10-31 | Univ North Carolina | NEW AMIDINE COMPOUNDS FOR THE TREATMENT OF MICROBIAL INFECTIONS |
CA2543079A1 (en) * | 2003-10-24 | 2005-05-06 | University Of North Carolina At Chapel Hill | Dicationic triaryl analogs as anti-protozoan agents |
CN1914188A (zh) * | 2003-12-05 | 2007-02-14 | 北卡罗来纳大学查珀尔希尔分校 | 用作抗微生物剂的阳离子取代的苯并呋喃 |
CA2552094A1 (en) * | 2004-01-23 | 2005-09-01 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
CA2592320C (en) | 2004-12-22 | 2015-11-24 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
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FR2933692B1 (fr) * | 2008-07-10 | 2022-12-02 | Univ Nancy 1 Henri Poincare | Nouveaux composes, leur utilisation comme medicaments, et leur procede de preparation |
ES2355031B2 (es) * | 2009-07-15 | 2011-12-26 | Universidade De Santiago De Compostela | Derivados de bis-benzamidinios y su uso como agentes de reconocimiento de secuencias de adn. |
ES2368276B2 (es) * | 2010-04-27 | 2012-06-28 | Universidad De Santiago De Compostela | Compuestos derivados de bis-benzamidinios como agentes fluorogénicos para señalizar secuencias específicas de adn de doble cadena. |
CN103012200B (zh) * | 2011-09-20 | 2014-12-17 | 北京大学 | 具有β-分泌酶抑制功能的化合物及其制备方法与应用 |
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GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
CN109553608B (zh) * | 2017-09-26 | 2020-12-08 | 北京大学 | 一类五元六元杂环化合物及其制备方法和治疗肿瘤的用途 |
US20210309641A1 (en) * | 2018-06-14 | 2021-10-07 | Georgia State University Research Foundation, Inc. | Amidines and amidine analogs for the treatment of bacterial infections and potentiation antibiotics |
CN113264925A (zh) * | 2020-02-14 | 2021-08-17 | 上海美悦生物科技发展有限公司 | 一种杂环化合物及其制备方法和用途 |
WO2023077235A1 (en) * | 2021-11-05 | 2023-05-11 | Mcmaster University | Pentamidine analogs |
CN115850219B (zh) * | 2022-11-30 | 2024-05-28 | 三峡大学 | 泽兰素开链多聚体,制备方法及用途 |
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DE69907476T2 (de) * | 1998-08-20 | 2004-04-15 | The University Of North Carolina At Chapel Hill Office Of Technology Development | Dibenzothiophene derivate und ihre verwendung |
ES2275362T3 (es) * | 1998-09-17 | 2007-06-01 | The University Of North Carolina At Chapel Hill | Actividad antifungica de moleculas dicationicas. |
US6319944B1 (en) * | 1999-05-10 | 2001-11-20 | Merck & Co., Inc. | Aryl amidines, compositions containing such compounds and methods of use |
US6627647B1 (en) * | 2000-03-23 | 2003-09-30 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)imidazoles and their use as anti-inflammatory agents |
US20010036949A1 (en) * | 2000-05-09 | 2001-11-01 | Coe Jotham Wadsworth | Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal |
US6625612B1 (en) * | 2000-06-14 | 2003-09-23 | Ezchip Technologies Ltd. | Deterministic search algorithm |
WO2002002516A2 (en) * | 2000-06-30 | 2002-01-10 | Thomas Jefferson University | Inhibitors of hiv integrase |
US6737440B2 (en) * | 2000-11-06 | 2004-05-18 | The University Of North Carolina At Chapel Hill | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” |
JP4368582B2 (ja) * | 2001-01-13 | 2009-11-18 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 牛ウイルス性下痢ウイルス(bvdv)感染およびc型肝炎ウイルス(hcv)感染を処置するのに有用な化合物、方法、および組成物 |
-
2002
- 2002-09-03 IL IL16020802A patent/IL160208A0/xx unknown
- 2002-09-03 CN CN028157702A patent/CN1658852A/zh active Pending
- 2002-09-03 MX MXPA04001153A patent/MXPA04001153A/es not_active Application Discontinuation
- 2002-09-03 KR KR10-2004-7002085A patent/KR20040036908A/ko not_active Application Discontinuation
- 2002-09-03 WO PCT/CA2002/001353 patent/WO2003017994A1/en not_active Application Discontinuation
- 2002-09-03 EP EP02758012A patent/EP1420773A1/en not_active Withdrawn
- 2002-09-03 CA CA002455497A patent/CA2455497A1/en not_active Abandoned
- 2002-09-03 US US10/234,643 patent/US20040006092A1/en not_active Abandoned
- 2002-09-03 BR BR0212078-0A patent/BR0212078A/pt not_active IP Right Cessation
- 2002-09-03 JP JP2003522514A patent/JP2005504053A/ja not_active Withdrawn
- 2002-09-03 EA EA200400135A patent/EA200400135A1/ru unknown
-
2003
- 2003-12-05 US US10/731,463 patent/US20040147531A1/en not_active Abandoned
-
2006
- 2006-01-19 US US11/335,171 patent/US20070021483A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA04001153A (es) | 2005-02-17 |
WO2003017994A1 (en) | 2003-03-06 |
EP1420773A1 (en) | 2004-05-26 |
IL160208A0 (en) | 2004-07-25 |
KR20040036908A (ko) | 2004-05-03 |
CN1658852A (zh) | 2005-08-24 |
US20070021483A1 (en) | 2007-01-25 |
JP2005504053A (ja) | 2005-02-10 |
BR0212078A (pt) | 2004-09-28 |
US20040006092A1 (en) | 2004-01-08 |
CA2455497A1 (en) | 2003-03-06 |
US20040147531A1 (en) | 2004-07-29 |
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