IL160208A0 - Amidine derivatives for treating amyloidosis - Google Patents
Amidine derivatives for treating amyloidosisInfo
- Publication number
- IL160208A0 IL160208A0 IL16020802A IL16020802A IL160208A0 IL 160208 A0 IL160208 A0 IL 160208A0 IL 16020802 A IL16020802 A IL 16020802A IL 16020802 A IL16020802 A IL 16020802A IL 160208 A0 IL160208 A0 IL 160208A0
- Authority
- IL
- Israel
- Prior art keywords
- amidine derivatives
- treating amyloidosis
- amyloidosis
- treating
- amidine
- Prior art date
Links
- 150000001409 amidines Chemical class 0.000 title 1
- 206010002022 amyloidosis Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31676101P | 2001-08-31 | 2001-08-31 | |
US38700102P | 2002-06-07 | 2002-06-07 | |
PCT/CA2002/001353 WO2003017994A1 (en) | 2001-08-31 | 2002-09-03 | Amidine derivatives for treating amyloidosis |
Publications (1)
Publication Number | Publication Date |
---|---|
IL160208A0 true IL160208A0 (en) | 2004-07-25 |
Family
ID=26980581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16020802A IL160208A0 (en) | 2001-08-31 | 2002-09-03 | Amidine derivatives for treating amyloidosis |
Country Status (11)
Country | Link |
---|---|
US (3) | US20040006092A1 (ru) |
EP (1) | EP1420773A1 (ru) |
JP (1) | JP2005504053A (ru) |
KR (1) | KR20040036908A (ru) |
CN (1) | CN1658852A (ru) |
BR (1) | BR0212078A (ru) |
CA (1) | CA2455497A1 (ru) |
EA (1) | EA200400135A1 (ru) |
IL (1) | IL160208A0 (ru) |
MX (1) | MXPA04001153A (ru) |
WO (1) | WO2003017994A1 (ru) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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MXPA01010835A (es) * | 1999-04-28 | 2003-07-14 | Univ Kingston | Composiciones y metodos para tratar amiloidosis. |
AU5994900A (en) * | 1999-07-09 | 2001-01-30 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
US6737440B2 (en) | 2000-11-06 | 2004-05-18 | The University Of North Carolina At Chapel Hill | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” |
AU2002246600B2 (en) * | 2000-11-06 | 2005-08-25 | Duke University | Synthesis and antimicrobial activity of novel dicationic "Reversed amidines" |
CA2488493A1 (en) * | 2002-06-07 | 2003-12-18 | Richard R. Tidwell | Amidine derivatives for treating amyloidosis |
US20040049134A1 (en) * | 2002-07-02 | 2004-03-11 | Tosaya Carol A. | System and methods for treatment of alzheimer's and other deposition-related disorders of the brain |
US20050020945A1 (en) * | 2002-07-02 | 2005-01-27 | Tosaya Carol A. | Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy |
US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
JP2007521237A (ja) * | 2003-09-05 | 2007-08-02 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 微生物感染症処置用の新規アミジン化合物 |
CN1898214A (zh) * | 2003-10-24 | 2007-01-17 | 北卡罗来纳大学查珀尔希尔分校 | 作为抗原虫药的双阳离子三芳基类似物 |
EP1689732A4 (en) * | 2003-12-05 | 2008-10-22 | Univ North Carolina | Cationically substituted benzoufurans as antimicrobial agents |
CA2552094A1 (en) * | 2004-01-23 | 2005-09-01 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
CA2592320C (en) | 2004-12-22 | 2015-11-24 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
AU2006201739A1 (en) * | 2005-05-05 | 2006-11-23 | The University Of North Carolina At Chapel Hill | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles |
WO2007023389A2 (en) * | 2005-07-21 | 2007-03-01 | Neurochem (International) Limited | Polymorphic forms of 3-amino-1-propanesulfonic acid |
EP1954287B2 (en) * | 2005-10-31 | 2016-02-24 | Merck Sharp & Dohme Corp. | Cetp inhibitors |
US8372886B2 (en) * | 2005-12-22 | 2013-02-12 | Kiacta Sarl | Treatment of renal disorders, diabetic nephropathy and dyslipidemias |
PL3851447T3 (pl) | 2006-10-12 | 2024-03-04 | Bellus Health Inc. | Sposoby, związki, kompozycje i nośniki dostarczające kwas 3-amino-1-propanosulfonowy |
CA2673022A1 (en) * | 2006-12-22 | 2008-07-03 | Bellus Health (International) Limited | Methods, compounds, and compositions for treating metabolic disorders and diabetes |
EP2121633A2 (en) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
FI2247558T4 (fi) | 2008-02-14 | 2024-09-19 | Eli Lilly And Company | Uusia kuvantamisaineita neurologisen toimintahäiriön toteamiseen |
EP2116236A1 (en) * | 2008-04-21 | 2009-11-11 | Université de Mons-Hainaut | Bisbenzamidine derivatives for use as antioxidant |
FR2933692B1 (fr) * | 2008-07-10 | 2022-12-02 | Univ Nancy 1 Henri Poincare | Nouveaux composes, leur utilisation comme medicaments, et leur procede de preparation |
ES2355031B2 (es) * | 2009-07-15 | 2011-12-26 | Universidade De Santiago De Compostela | Derivados de bis-benzamidinios y su uso como agentes de reconocimiento de secuencias de adn. |
ES2368276B2 (es) * | 2010-04-27 | 2012-06-28 | Universidad De Santiago De Compostela | Compuestos derivados de bis-benzamidinios como agentes fluorogénicos para señalizar secuencias específicas de adn de doble cadena. |
CN103012200B (zh) * | 2011-09-20 | 2014-12-17 | 北京大学 | 具有β-分泌酶抑制功能的化合物及其制备方法与应用 |
GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
CN109553608B (zh) * | 2017-09-26 | 2020-12-08 | 北京大学 | 一类五元六元杂环化合物及其制备方法和治疗肿瘤的用途 |
CN112566631A (zh) * | 2018-06-14 | 2021-03-26 | 乔治亚州大学研究基金会 | 用于治疗细菌感染和增强抗生素的脒和脒类似物 |
CN113264925A (zh) * | 2020-02-14 | 2021-08-17 | 上海美悦生物科技发展有限公司 | 一种杂环化合物及其制备方法和用途 |
EP4426673A1 (en) * | 2021-11-05 | 2024-09-11 | Mcmaster University | Pentamidine analogs |
CN115850219B (zh) * | 2022-11-30 | 2024-05-28 | 三峡大学 | 泽兰素开链多聚体,制备方法及用途 |
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US5434050A (en) * | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
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WO2000015212A2 (en) * | 1998-09-17 | 2000-03-23 | The University Of North Carolina At Chapel Hill | Antifungal activity of dicationic molecules |
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-
2002
- 2002-09-03 BR BR0212078-0A patent/BR0212078A/pt not_active IP Right Cessation
- 2002-09-03 WO PCT/CA2002/001353 patent/WO2003017994A1/en not_active Application Discontinuation
- 2002-09-03 IL IL16020802A patent/IL160208A0/xx unknown
- 2002-09-03 JP JP2003522514A patent/JP2005504053A/ja not_active Withdrawn
- 2002-09-03 KR KR10-2004-7002085A patent/KR20040036908A/ko not_active Application Discontinuation
- 2002-09-03 US US10/234,643 patent/US20040006092A1/en not_active Abandoned
- 2002-09-03 EA EA200400135A patent/EA200400135A1/ru unknown
- 2002-09-03 CA CA002455497A patent/CA2455497A1/en not_active Abandoned
- 2002-09-03 CN CN028157702A patent/CN1658852A/zh active Pending
- 2002-09-03 MX MXPA04001153A patent/MXPA04001153A/es not_active Application Discontinuation
- 2002-09-03 EP EP02758012A patent/EP1420773A1/en not_active Withdrawn
-
2003
- 2003-12-05 US US10/731,463 patent/US20040147531A1/en not_active Abandoned
-
2006
- 2006-01-19 US US11/335,171 patent/US20070021483A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20070021483A1 (en) | 2007-01-25 |
CN1658852A (zh) | 2005-08-24 |
EP1420773A1 (en) | 2004-05-26 |
CA2455497A1 (en) | 2003-03-06 |
BR0212078A (pt) | 2004-09-28 |
WO2003017994A1 (en) | 2003-03-06 |
MXPA04001153A (es) | 2005-02-17 |
EA200400135A1 (ru) | 2004-08-26 |
US20040147531A1 (en) | 2004-07-29 |
JP2005504053A (ja) | 2005-02-10 |
KR20040036908A (ko) | 2004-05-03 |
US20040006092A1 (en) | 2004-01-08 |
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