ATE239003T1 - Dibenzothiophene derivate und ihre verwendung - Google Patents

Dibenzothiophene derivate und ihre verwendung

Info

Publication number
ATE239003T1
ATE239003T1 AT99930662T AT99930662T ATE239003T1 AT E239003 T1 ATE239003 T1 AT E239003T1 AT 99930662 T AT99930662 T AT 99930662T AT 99930662 T AT99930662 T AT 99930662T AT E239003 T1 ATE239003 T1 AT E239003T1
Authority
AT
Austria
Prior art keywords
dicationic
formula
methods
effective amount
therapeutically effective
Prior art date
Application number
AT99930662T
Other languages
English (en)
Inventor
Richard R Tidwell
James Edwin Hall
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE239003T1 publication Critical patent/ATE239003T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
AT99930662T 1998-08-20 1999-06-24 Dibenzothiophene derivate und ihre verwendung ATE239003T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9727398P 1998-08-20 1998-08-20
PCT/US1999/014313 WO2000010990A2 (en) 1998-08-20 1999-06-24 Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE239003T1 true ATE239003T1 (de) 2003-05-15

Family

ID=22262567

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99930662T ATE239003T1 (de) 1998-08-20 1999-06-24 Dibenzothiophene derivate und ihre verwendung

Country Status (9)

Country Link
US (1) US6172104B1 (de)
EP (1) EP1105381B1 (de)
JP (1) JP2003523927A (de)
AT (1) ATE239003T1 (de)
AU (1) AU758563B2 (de)
CA (1) CA2340912C (de)
DE (1) DE69907476T2 (de)
ES (1) ES2198139T3 (de)
WO (1) WO2000010990A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2784678B1 (fr) * 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
JP2002255960A (ja) * 2001-02-27 2002-09-11 Sumitomo Chem Co Ltd ジベンゾチオフェン化合物、中間体およびその製造方法
GB2380192B8 (en) * 2001-02-09 2005-09-14 Sumitomo Chemical Co Phenylacetylene compounds liquid crystal compositions polymers optically anisotropic products & optical & liquid crystal elements derived therefrom
US6825228B2 (en) 2001-06-13 2004-11-30 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
JP2005504053A (ja) * 2001-08-31 2005-02-10 ニューロケム （インターナショナル） リミテッド アミロイドーシス治療のためのアミジン誘導体
SG124249A1 (en) * 2001-12-07 2006-08-30 Sumitomo Chemical Co New polymer and polymer light-emitting device using the same
JP4957669B2 (ja) * 2002-03-15 2012-06-20 住友化学株式会社 高分子化合物およびそれを用いた高分子発光素子
DE60326735D1 (de) 2002-08-02 2009-04-30 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
AU2003285958A1 (en) * 2002-10-25 2004-05-25 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
CA2508769A1 (en) * 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
WO2005020913A2 (en) * 2003-08-25 2005-03-10 Combinatorx, Incorporated Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
JP2007513888A (ja) * 2003-11-24 2007-05-31 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 縮合環ジカチオン性抗原虫剤及びそれらのプロドラッグ
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
US7365193B2 (en) 2004-02-04 2008-04-29 Abbott Laboratories Amino-substituted tricyclic derivatives and methods of use
JP2008500965A (ja) * 2004-03-17 2008-01-17 エムペックス・ファーマシューティカルズ・インコーポレーテッド 細菌の排出ポンプ阻害剤の使用および投与
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
DE102007013855A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydrochinoline
DE102007013856A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydropyrrolochinoline
DE102007013854A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Tetrahydrochinoline
BRPI0916649A2 (pt) * 2008-07-28 2015-08-04 Polymedix Inc E The Trustees Of The University Of Pennsylvania Composto, composição, uso de um composto, e, método para exterminar ou inibir o crescimento de uma espécie de plasmodium.
US8278309B2 (en) 2008-10-27 2012-10-02 Polymedix, Inc. Synthetic mimetics of host defense and uses thereof
WO2011084970A1 (en) * 2010-01-07 2011-07-14 Polymedix Inc. Anti-heparin compounds
MX2013013330A (es) 2011-05-16 2014-07-09 Cellceutix Corp Compuestos para utilizar en el tratamiento de mucositis.
WO2021248008A1 (en) 2020-06-05 2021-12-09 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2500734A (en) * 1946-06-13 1950-03-14 Gen Electric Process of preparing 2-ethyldibenzofuran
GB932813A (en) * 1960-12-01 1963-07-31 Monsanto Chemicals New heterocyclic chemical compounds
GB951797A (en) * 1960-12-20 1964-03-11 Monsanto Chemicals Heterocyclic compounds
US4362883A (en) * 1981-10-28 1982-12-07 The Halcon Sd Group, Inc. Preparation of dibenzofuran
AU626033B2 (en) * 1988-10-25 1992-07-23 Government Of The United States Of America, As Represented By The Secretary Of The Army, The Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods
IL115875A (en) 1994-11-14 2000-12-06 Univ Georgia State Res Found Methods of inhibiting pneumocystis carinii pneumonia giardia lamblia and cryptosporidium parvum in an animal subject and compounds useful therefor
US5668167A (en) * 1995-06-07 1997-09-16 Duke University Methods of treating microbial infections
ES2211958T3 (es) 1995-06-07 2004-07-16 The University Of North Carolina At Chapel Hill Carbazoles para tratar infecciones microbianas.
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents

Also Published As

Publication number Publication date
EP1105381B1 (de) 2003-05-02
WO2000010990A3 (en) 2003-04-17
DE69907476D1 (de) 2003-06-05
US6172104B1 (en) 2001-01-09
CA2340912A1 (en) 2000-03-02
CA2340912C (en) 2008-11-18
AU4715299A (en) 2000-03-14
DE69907476T2 (de) 2004-04-15
EP1105381A1 (de) 2001-06-13
JP2003523927A (ja) 2003-08-12
WO2000010990A2 (en) 2000-03-02
AU758563B2 (en) 2003-03-27
ES2198139T3 (es) 2004-01-16

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