DK0754176T3 - Hidtil ukendte carbamater og urinstoffer som modifikatorer for multidrugsresistens - Google Patents

Hidtil ukendte carbamater og urinstoffer som modifikatorer for multidrugsresistens

Info

Publication number
DK0754176T3
DK0754176T3 DK95914866T DK95914866T DK0754176T3 DK 0754176 T3 DK0754176 T3 DK 0754176T3 DK 95914866 T DK95914866 T DK 95914866T DK 95914866 T DK95914866 T DK 95914866T DK 0754176 T3 DK0754176 T3 DK 0754176T3
Authority
DK
Denmark
Prior art keywords
ureas
modifiers
multidrug resistance
compounds
newly known
Prior art date
Application number
DK95914866T
Other languages
English (en)
Inventor
Matthew W Harding
Robert Edward Zelle
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of DK0754176T3 publication Critical patent/DK0754176T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
DK95914866T 1994-03-25 1995-03-23 Hidtil ukendte carbamater og urinstoffer som modifikatorer for multidrugsresistens DK0754176T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21812094A 1994-03-25 1994-03-25
US08/377,283 US5744485A (en) 1994-03-25 1995-01-23 Carbamates and ureas as modifiers of multi-drug resistance
PCT/US1995/003716 WO1995026337A1 (en) 1994-03-25 1995-03-23 Novel carbamates and ureas as modifiers of multi-drug resistance

Publications (1)

Publication Number Publication Date
DK0754176T3 true DK0754176T3 (da) 2002-04-02

Family

ID=26912595

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95914866T DK0754176T3 (da) 1994-03-25 1995-03-23 Hidtil ukendte carbamater og urinstoffer som modifikatorer for multidrugsresistens

Country Status (13)

Country Link
US (1) US5744485A (da)
EP (2) EP1138673B1 (da)
JP (1) JP4421680B2 (da)
AT (2) ATE403430T1 (da)
AU (1) AU704475B2 (da)
CA (1) CA2186380C (da)
DE (2) DE69535805D1 (da)
DK (1) DK0754176T3 (da)
ES (2) ES2169127T3 (da)
HK (1) HK1013993A1 (da)
NZ (1) NZ283599A (da)
PT (1) PT754176E (da)
WO (1) WO1995026337A1 (da)

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IL140039A0 (en) * 1998-06-03 2002-02-10 Guilford Pharm Inc Ureas and carbamates of n-heterocyclic carboxylic acids and carboxylic acid isosteres
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
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Also Published As

Publication number Publication date
MX9604305A (es) 1997-12-31
EP0754176B1 (en) 2001-12-05
AU2194395A (en) 1995-10-17
US5744485A (en) 1998-04-28
HK1013993A1 (en) 1999-09-17
DE69524400D1 (de) 2002-01-17
JPH09510974A (ja) 1997-11-04
JP4421680B2 (ja) 2010-02-24
ATE210119T1 (de) 2001-12-15
ES2311491T3 (es) 2009-02-16
EP1138673A3 (en) 2001-10-17
AU704475B2 (en) 1999-04-22
WO1995026337A1 (en) 1995-10-05
ES2169127T3 (es) 2002-07-01
CA2186380A1 (en) 1995-10-05
EP1138673A2 (en) 2001-10-04
EP0754176A1 (en) 1997-01-22
NZ283599A (en) 1998-06-26
DE69535805D1 (de) 2008-09-18
CA2186380C (en) 2008-12-02
EP1138673B1 (en) 2008-08-06
ATE403430T1 (de) 2008-08-15
PT754176E (pt) 2002-05-31
DE69524400T2 (de) 2002-08-22

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