DE69524400D1 - Neue carbamate und harnstoffderivate als modifikatoren der multidrugresistenz - Google Patents
Neue carbamate und harnstoffderivate als modifikatoren der multidrugresistenzInfo
- Publication number
- DE69524400D1 DE69524400D1 DE69524400T DE69524400T DE69524400D1 DE 69524400 D1 DE69524400 D1 DE 69524400D1 DE 69524400 T DE69524400 T DE 69524400T DE 69524400 T DE69524400 T DE 69524400T DE 69524400 D1 DE69524400 D1 DE 69524400D1
- Authority
- DE
- Germany
- Prior art keywords
- modificators
- multidrug resistance
- urea derivatives
- compounds
- new carbamates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21812094A | 1994-03-25 | 1994-03-25 | |
US08/377,283 US5744485A (en) | 1994-03-25 | 1995-01-23 | Carbamates and ureas as modifiers of multi-drug resistance |
PCT/US1995/003716 WO1995026337A1 (en) | 1994-03-25 | 1995-03-23 | Novel carbamates and ureas as modifiers of multi-drug resistance |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69524400D1 true DE69524400D1 (de) | 2002-01-17 |
DE69524400T2 DE69524400T2 (de) | 2002-08-22 |
Family
ID=26912595
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69524400T Expired - Lifetime DE69524400T2 (de) | 1994-03-25 | 1995-03-23 | Neue carbamate und harnstoffderivate als modifikatoren der multidrugresistenz |
DE69535805T Expired - Lifetime DE69535805D1 (de) | 1994-03-25 | 1995-03-23 | Neue Carbamate- und Harnstoffderivate als Mittel gegen Multidrugresistenz |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69535805T Expired - Lifetime DE69535805D1 (de) | 1994-03-25 | 1995-03-23 | Neue Carbamate- und Harnstoffderivate als Mittel gegen Multidrugresistenz |
Country Status (13)
Country | Link |
---|---|
US (1) | US5744485A (de) |
EP (2) | EP1138673B1 (de) |
JP (1) | JP4421680B2 (de) |
AT (2) | ATE210119T1 (de) |
AU (1) | AU704475B2 (de) |
CA (1) | CA2186380C (de) |
DE (2) | DE69524400T2 (de) |
DK (1) | DK0754176T3 (de) |
ES (2) | ES2169127T3 (de) |
HK (1) | HK1013993A1 (de) |
NZ (1) | NZ283599A (de) |
PT (1) | PT754176E (de) |
WO (1) | WO1995026337A1 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846981A (en) * | 1993-05-28 | 1998-12-08 | Gpi Nil Holdings Inc. | Inhibitors of rotamase enzyme activity |
US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
US6150527A (en) * | 1994-08-18 | 2000-11-21 | Ariad Pharmaceuticals, Inc. | Synthetic multimerizing agents |
US20030036654A1 (en) | 1994-08-18 | 2003-02-20 | Holt Dennis A. | Synthetic multimerizing agents |
US6133456A (en) * | 1994-08-18 | 2000-10-17 | Ariad Gene Therapeutics, Inc. | Synthetic multimerizing agents |
US5543423A (en) * | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
IL115685A (en) * | 1994-11-16 | 2000-08-31 | Vertex Pharma | Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
WO1997028166A1 (de) * | 1996-02-01 | 1997-08-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienochinoline |
US6218424B1 (en) | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
US5801187A (en) * | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US5780484A (en) * | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
US5935989A (en) * | 1996-12-31 | 1999-08-10 | Gpi Nil Holdings Inc. | N-linked ureas and carbamates of heterocyclic thioesters |
JP2002515050A (ja) | 1996-12-31 | 2002-05-21 | ジーピーアイ エヌアイエル ホールディングス インコーポレイテッド | ヘテロ環式チオエステルのn−結合尿素およびカルバメート |
US6242468B1 (en) | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
ZA98825B (en) * | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
US5846979A (en) | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
IT1291607B1 (it) * | 1997-04-18 | 1999-01-11 | Fabbrica Italiana Sintetici Spa | Processo di sintesi di 1,7-diaril oppure eteroaril eptan-4-oli e nuovi intermedi di sintesi |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
IL134536A0 (en) * | 1997-08-29 | 2001-04-30 | Vertex Pharma | Compounds possessing neuronal activity and pharmaceutical compositions containing the same |
US6268384B1 (en) * | 1997-08-29 | 2001-07-31 | Vertex Pharmaceuticals Incorporated | Compounds possessing neuronal activity |
WO1999051228A1 (en) * | 1998-04-08 | 1999-10-14 | Eli Lilly And Company | Methods for inhibiting mrp1 |
HUP0101736A3 (en) * | 1998-04-08 | 2002-04-29 | Lilly Co Eli | Isoxazolo[3,4-c]quinoline derivatives, their use and pharmaceutical compositions containing them |
US6410041B1 (en) | 1998-04-28 | 2002-06-25 | Trustees Of Tufts College | Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine |
AU1708099A (en) | 1998-06-03 | 1999-12-20 | Amgen, Inc. | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
PL348671A1 (en) * | 1998-06-03 | 2002-06-03 | Gpi Nil Holdings | Ureas and carbamates of n-heterocyclic carboxylic acids and carboxylic acid isosteres |
US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6335348B1 (en) | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
US6384056B1 (en) | 1998-08-14 | 2002-05-07 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters or ketones for vision and memory disorders |
US6333340B1 (en) | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6506788B1 (en) | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
WO2001008685A1 (en) * | 1999-07-30 | 2001-02-08 | Vertex Pharmaceuticals Incorporated | Acyclic and cyclic amine derivatives |
WO2001010838A1 (en) * | 1999-08-05 | 2001-02-15 | The Procter & Gamble Company | Multivalent compounds |
AU6388500A (en) * | 1999-08-05 | 2001-03-05 | Procter & Gamble Company, The | Multivalent sulfonamides |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
CA2393466C (en) | 1999-12-21 | 2010-01-19 | Gpi Nil Holdings, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
MXPA03003401A (es) * | 2000-10-16 | 2004-06-30 | Neopharm Inc | Formulacion liposomica de mitoxantrona. |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
CA2449019A1 (en) * | 2001-05-29 | 2002-12-05 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
AU2002363523A1 (en) * | 2001-11-07 | 2003-05-19 | Pharmacia Corporation | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
US6635892B2 (en) * | 2002-01-24 | 2003-10-21 | Pei Electronics, Inc. | Compact integrated infrared scene projector |
EP1402888A1 (de) * | 2002-09-18 | 2004-03-31 | Jerini AG | Verwendung von substituierte carbozyclische Verbindungen als rotamase inhibitoren |
KR101063663B1 (ko) * | 2005-02-17 | 2011-09-07 | 아스텔라스세이야쿠 가부시키가이샤 | 피리딜 비방향족 질소 함유 헤테로환-1-카르복실산에스테르유도체 |
JP2013504591A (ja) | 2009-09-11 | 2013-02-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | N−ベンジル−3−(4−クロロフェニル)−2−[メチル−[2−オキソ−2−(3,4,5−トリメトキシフェニル)アセチル]アミノ]−n−[3−(4−ピリジル)−1−[2−(4−ピリジル)エチル]プロピル]プロパンアミドの組成物およびその使用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT71653B (en) * | 1979-08-15 | 1982-01-21 | Merck & Co Inc | Process for preparing allylsulfoxide enzyme inhibitor |
NZ228855A (en) * | 1988-04-25 | 1992-08-26 | Hoffmann La Roche | Tyrosine analogues and peptides containing them especially cholecystokinin (cck) analogues |
HUT58764A (en) * | 1988-07-08 | 1992-03-30 | Smithkline Beckman Corp | Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates |
DE69016688T2 (de) * | 1989-04-20 | 1995-10-05 | Zambon Spa | Dopamin-Medikament-Vorstufe. |
CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
EP0493683A1 (de) * | 1990-12-20 | 1992-07-08 | American Cyanamid Company | Fungizide Aminosäureamide |
DE4102042A1 (de) * | 1991-01-24 | 1992-07-30 | Bayer Ag | Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide |
EP0584223B1 (de) * | 1991-05-09 | 1999-08-11 | Vertex Pharmaceuticals Incorporated | Neue immunsuppressive verbindungen |
FR2678938B1 (fr) * | 1991-07-10 | 1993-10-08 | Rhone Poulenc Rorer Sa | Derives de pyrrolidine, leur preparation et les medicaments les contenant. |
JPH06501961A (ja) * | 1991-08-26 | 1994-03-03 | 日本たばこ産業株式会社 | 免疫調節活性を有するシユードペンタペプチド |
JPH05294915A (ja) * | 1992-04-21 | 1993-11-09 | Yamanouchi Pharmaceut Co Ltd | タキキニン拮抗剤 |
US5284840A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
US5543423A (en) * | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
-
1995
- 1995-01-23 US US08/377,283 patent/US5744485A/en not_active Expired - Lifetime
- 1995-03-23 NZ NZ283599A patent/NZ283599A/en not_active IP Right Cessation
- 1995-03-23 PT PT95914866T patent/PT754176E/pt unknown
- 1995-03-23 JP JP52523595A patent/JP4421680B2/ja not_active Expired - Fee Related
- 1995-03-23 CA CA002186380A patent/CA2186380C/en not_active Expired - Fee Related
- 1995-03-23 EP EP01111169A patent/EP1138673B1/de not_active Expired - Lifetime
- 1995-03-23 EP EP95914866A patent/EP0754176B1/de not_active Expired - Lifetime
- 1995-03-23 DK DK95914866T patent/DK0754176T3/da active
- 1995-03-23 DE DE69524400T patent/DE69524400T2/de not_active Expired - Lifetime
- 1995-03-23 WO PCT/US1995/003716 patent/WO1995026337A1/en active IP Right Grant
- 1995-03-23 DE DE69535805T patent/DE69535805D1/de not_active Expired - Lifetime
- 1995-03-23 AT AT95914866T patent/ATE210119T1/de not_active IP Right Cessation
- 1995-03-23 ES ES95914866T patent/ES2169127T3/es not_active Expired - Lifetime
- 1995-03-23 AT AT01111169T patent/ATE403430T1/de not_active IP Right Cessation
- 1995-03-23 AU AU21943/95A patent/AU704475B2/en not_active Ceased
- 1995-03-23 ES ES01111169T patent/ES2311491T3/es not_active Expired - Lifetime
-
1998
- 1998-12-23 HK HK98115243A patent/HK1013993A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69535805D1 (de) | 2008-09-18 |
ATE210119T1 (de) | 2001-12-15 |
AU2194395A (en) | 1995-10-17 |
HK1013993A1 (en) | 1999-09-17 |
WO1995026337A1 (en) | 1995-10-05 |
ATE403430T1 (de) | 2008-08-15 |
CA2186380C (en) | 2008-12-02 |
EP0754176B1 (de) | 2001-12-05 |
EP1138673A3 (de) | 2001-10-17 |
NZ283599A (en) | 1998-06-26 |
US5744485A (en) | 1998-04-28 |
JP4421680B2 (ja) | 2010-02-24 |
DE69524400T2 (de) | 2002-08-22 |
ES2311491T3 (es) | 2009-02-16 |
AU704475B2 (en) | 1999-04-22 |
PT754176E (pt) | 2002-05-31 |
JPH09510974A (ja) | 1997-11-04 |
EP1138673B1 (de) | 2008-08-06 |
EP0754176A1 (de) | 1997-01-22 |
DK0754176T3 (da) | 2002-04-02 |
CA2186380A1 (en) | 1995-10-05 |
ES2169127T3 (es) | 2002-07-01 |
EP1138673A2 (de) | 2001-10-04 |
MX9604305A (es) | 1997-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69524400D1 (de) | Neue carbamate und harnstoffderivate als modifikatoren der multidrugresistenz | |
IS4073A (is) | Nýtt fjölvirknislyf gegn aukningu mótstöðu | |
ATE251140T1 (de) | N-(2 oxoacetyl oder sulphonyl)- pyrrolidine/piperidine-2-carbonsäurederivate mit verbesserter multi-drug resistenz aktivität | |
DK0839143T3 (da) | Tetralinforbindelser med MDR-aktivitet | |
DE69830341D1 (de) | Piperazin-Derivate und ihre Verwendung als entzündungshemmende Mittel | |
ID26956A (id) | Pencegahan raf kinase menggunakan simetris dan nonsimetris yang digantikan diphenil urea | |
DE69716810D1 (de) | 2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one | |
MX9703621A (es) | Nuevos derivados aminoacidos con actividad mejorada para la resistencia a drogas multiples. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |