ATE118216T1 - Dopamin-medikament-vorstufe. - Google Patents

Dopamin-medikament-vorstufe.

Info

Publication number
ATE118216T1
ATE118216T1 AT90200937T AT90200937T ATE118216T1 AT E118216 T1 ATE118216 T1 AT E118216T1 AT 90200937 T AT90200937 T AT 90200937T AT 90200937 T AT90200937 T AT 90200937T AT E118216 T1 ATE118216 T1 AT E118216T1
Authority
AT
Austria
Prior art keywords
salts
compound
formula
medicine precursor
dopamine
Prior art date
Application number
AT90200937T
Other languages
English (en)
Inventor
Cesare Casagrande
Francesco Santangelo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT8920210A external-priority patent/IT1229854B/it
Priority claimed from IT8920209A external-priority patent/IT1229853B/it
Application filed by Zambon Spa filed Critical Zambon Spa
Application granted granted Critical
Publication of ATE118216T1 publication Critical patent/ATE118216T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT90200937T 1989-04-20 1990-04-17 Dopamin-medikament-vorstufe. ATE118216T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8920210A IT1229854B (it) 1989-04-20 1989-04-20 Farmaci precursori della dopamina.
IT8920209A IT1229853B (it) 1989-04-20 1989-04-20 Farmaci precursori della dopamina.

Publications (1)

Publication Number Publication Date
ATE118216T1 true ATE118216T1 (de) 1995-02-15

Family

ID=26327445

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90200937T ATE118216T1 (de) 1989-04-20 1990-04-17 Dopamin-medikament-vorstufe.

Country Status (6)

Country Link
US (1) US5073547A (de)
EP (1) EP0393781B1 (de)
JP (1) JPH02292290A (de)
AT (1) ATE118216T1 (de)
DE (1) DE69016688T2 (de)
ES (1) ES2070994T3 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
DE19630826A1 (de) * 1996-07-31 1998-02-05 Duro Galvanit Chemie Verfahren zur Aufbereitung von Chlor und gegebenenfalls chlororganische Verbindung enthaltendem Rohwasser, insbesondere Badwasser, sowie Vorrichtung zur Durchführung des vorgenannten Verfahrens
GB9626151D0 (en) * 1996-12-17 1997-02-05 Lilly Industries Ltd Pharmaceutical compounds
DK1044017T3 (da) * 1998-01-05 2008-12-08 Univ Johns Hopkins Kosttilskud til dialysepatienter
EP1596808A4 (de) * 2003-02-07 2007-04-04 Yissum Res Dev Co L-dopa-amidderivate und ihre verwendung
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
UA88792C2 (ru) * 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
US7226188B2 (en) * 2004-11-19 2007-06-05 Whiterock Design, Llc Stage lighting methods and apparatus
CN101528698A (zh) * 2006-05-09 2009-09-09 阿斯利康公司 (2s)-(4e)-n-甲基-5-[3-(5-异丙氧基吡啶)基]-4-戊烯-2-胺的盐形式
TWI389889B (zh) * 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
US20100028447A1 (en) * 2007-01-22 2010-02-04 Targacept, Inc. Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs
WO2011146009A1 (en) 2010-05-20 2011-11-24 Targacept Inc. New process for the preparation of aryl substituted olefinic amines
RU2743347C2 (ru) * 2014-10-21 2021-02-17 Эббви Инк. Пролекарства карбидопа и l-dopa и их применение для лечения болезни паркинсона
MA41377A (fr) 2015-01-20 2017-11-28 Abbvie Inc Gel intestinal de lévodopa et de carbidona et procédés d'utilisation
JP2019515908A (ja) * 2016-04-20 2019-06-13 アッヴィ・インコーポレイテッド カルビドパ及びｌ−ドパプロドラッグ並びに使用方法
US10729710B2 (en) 2017-11-24 2020-08-04 H. Lundbeck A/S Catecholamine prodrugs for use in the treatment of Parkinson's disease
US20210363181A1 (en) 2018-02-08 2021-11-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Dopamine precursors
CN110294789A (zh) * 2018-03-21 2019-10-01 海南大学 含多巴寡肽的合成方法及其在抗帕金森病前药方面的应用
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
CN113727974A (zh) 2019-05-21 2021-11-30 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
KR20230155508A (ko) * 2021-03-10 2023-11-10 뉴로덤 엘티디 레보도파-티로신 접합체를 포함하는 안정화된 액체 조성물 및 그의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3132171A (en) * 1962-06-18 1964-05-05 Strong Cobb Arner Inc 3, 4-diphosphatophenyl-alanine and process for making same
US3891696A (en) * 1973-11-02 1975-06-24 Interx Research Corp Novel, transient pro-drug forms of l-dopa
US4695449A (en) * 1983-03-30 1987-09-22 Yale University Composition and method for treatment of melanomas
US4618484A (en) * 1983-03-30 1986-10-21 Yale University Composition and method for treatment of melanomas
US4508706A (en) * 1983-03-30 1985-04-02 Yale University Composition for increasing melanin in mammalian skin and hair
IT1213182B (it) * 1984-06-25 1989-12-14 Simes Derivati di composti a struttura catecolamminica.
IT1200427B (it) * 1985-03-22 1989-01-18 Afros Spa Procedimento ed impianto per lo stampaggio di pezzi in materiale plastico espanso,con parti o inserti preformati a spruzzo nello stesso stampo di formatura
US4663349A (en) * 1985-12-30 1987-05-05 Merck & Co., Inc. Rectally absorbable form of L-dopa

Also Published As

Publication number Publication date
DE69016688D1 (de) 1995-03-23
EP0393781B1 (de) 1995-02-08
EP0393781A3 (de) 1991-01-09
DE69016688T2 (de) 1995-10-05
EP0393781A2 (de) 1990-10-24
JPH02292290A (ja) 1990-12-03
ES2070994T3 (es) 1995-06-16
US5073547A (en) 1991-12-17

Similar Documents

Publication Publication Date Title
ATE118216T1 (de) Dopamin-medikament-vorstufe.
ES555147A0 (es) Un procedimiento para la produccion de un compuesto de tiazolidindiona hipoglicemico
PT87542A (pt) Process for the preparation of a medicament based on indolone derivatives for the treatment of the parkinson disease
FI893467A (fi) Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
ATE33835T1 (de) Verbindung mit antibronchopneumopathischer wirkung, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE89547T1 (de) Dopamin-vorlaeufer.
CA2036905A1 (en) Condensed thiazole compounds, their production and use
ES2051834T3 (es) El uso de tetrahidrobenzeno(c,d)indol-6 carboxamidas para la preparacion de un medicamento para el tratamiento de la ansiedad.
EP0376899A3 (de) Verwendung von L-Carnitinderivaten zur Herstellung eines Arzneimittels zur therapeutischen Behandlung von peripheren Neuropathien
US5330978B1 (en) Phosphonic acid derivatives and use thereof
ES2045067T3 (es) Procedimiento para preparar nuevos compuestos de tiazol.
NO900342L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 3-fenyl-5,6-dihydrobenz(c)akridin-7-karboxylsyrer og beslektede forbindelser.
NO176018C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive S-enantiomerer av substituerte 2-aminotetraliner
CA2038025A1 (en) Optically active alkylenedioxybenzene derivatives and their use in therapy
ATE109454T1 (de) Catecholaminester.
EP0295783A3 (de) Kodein-Derivat
GB8608893D0 (en) D-nor-7-ergoline derivatives
DK644487A (da) Farmaceutisk praeparat indeholdende en 2-oxo-imidazolidinforbindelse
ZA912589B (en) A therapeutic agent for dysuria comprising alpha-phenyl-alpha-pyridylalkanoic acid derivatives
OA09471A (fr) "Nouvelles benzothiazolinones substituées, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent".
TH9111A (th) สเทอริโอไอโซเมอร์ชนิดใหม่
RU93058275A (ru) Производные тиофен-2-карбоновой кислоты, способ их получения, фармацевтическая композиция и способ ее получения
TH40578A (th) อนุพันธ์ของกรดเบนซาเซฟิโนน-n-อะซิติกที่ถูกแทนที่ด้วยกรดฟอสฟอริกและกรรมวิธีเกี่ยวกับการเตรียมอนุพันธ์เหล่านี้ และสารทางเภสัชกรรมที่ประกอบด้วยสารประกอบเหล่านี้
TH13808A (th) อนุพันธ์ของพิเพอแรซิน และอนุพันธ์ของพิเพอริดิน

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties