ATE118216T1 - Dopamin-medikament-vorstufe. - Google Patents
Dopamin-medikament-vorstufe.Info
- Publication number
- ATE118216T1 ATE118216T1 AT90200937T AT90200937T ATE118216T1 AT E118216 T1 ATE118216 T1 AT E118216T1 AT 90200937 T AT90200937 T AT 90200937T AT 90200937 T AT90200937 T AT 90200937T AT E118216 T1 ATE118216 T1 AT E118216T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- compound
- formula
- medicine precursor
- dopamine
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 monophosphorylated L-dopa ester Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8920209A IT1229853B (it) | 1989-04-20 | 1989-04-20 | Farmaci precursori della dopamina. |
IT8920210A IT1229854B (it) | 1989-04-20 | 1989-04-20 | Farmaci precursori della dopamina. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE118216T1 true ATE118216T1 (de) | 1995-02-15 |
Family
ID=26327445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90200937T ATE118216T1 (de) | 1989-04-20 | 1990-04-17 | Dopamin-medikament-vorstufe. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5073547A (de) |
EP (1) | EP0393781B1 (de) |
JP (1) | JPH02292290A (de) |
AT (1) | ATE118216T1 (de) |
DE (1) | DE69016688T2 (de) |
ES (1) | ES2070994T3 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
DE19630826A1 (de) * | 1996-07-31 | 1998-02-05 | Duro Galvanit Chemie | Verfahren zur Aufbereitung von Chlor und gegebenenfalls chlororganische Verbindung enthaltendem Rohwasser, insbesondere Badwasser, sowie Vorrichtung zur Durchführung des vorgenannten Verfahrens |
GB9626151D0 (en) * | 1996-12-17 | 1997-02-05 | Lilly Industries Ltd | Pharmaceutical compounds |
DK1044017T3 (da) * | 1998-01-05 | 2008-12-08 | Univ Johns Hopkins | Kosttilskud til dialysepatienter |
EP1596808A4 (de) * | 2003-02-07 | 2007-04-04 | Yissum Res Dev Co | L-dopa-amidderivate und ihre verwendung |
UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
US7226188B2 (en) * | 2004-11-19 | 2007-06-05 | Whiterock Design, Llc | Stage lighting methods and apparatus |
EP2357174A1 (de) * | 2006-05-09 | 2011-08-17 | AstraZeneca AB | Salzformen von (2S)-(4E)-N-Methyl-5-[(5-Isopropoxy)pyridin-3-yl]-4-Penten-2-Amin |
TWI389889B (zh) * | 2006-05-09 | 2013-03-21 | Targacept Inc | (2s)-(4e)-n-甲基-5-〔3-(5-異丙氧基吡啶)基〕-4-戊烯-2-胺之新穎多晶型 |
WO2008091592A1 (en) * | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
SG185497A1 (en) | 2010-05-20 | 2012-12-28 | Astrazeneca Ab | New process for the preparation of aryl substituted olefinic amines |
PT3209302T (pt) * | 2014-10-21 | 2019-07-19 | Abbvie Inc | Profármacos de carbidopa e l-dopa e a sua utilização para tratar doença de parkinson |
MA41377A (fr) | 2015-01-20 | 2017-11-28 | Abbvie Inc | Gel intestinal de lévodopa et de carbidona et procédés d'utilisation |
US20190224220A1 (en) * | 2016-04-20 | 2019-07-25 | Abbvie Inc. | Carbidopa and L-Dopa Prodrugs and Methods of Use |
CR20200225A (es) | 2017-11-24 | 2020-07-25 | H Lundbeck As | Nuevos fármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson |
WO2019155464A1 (en) | 2018-02-08 | 2019-08-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Dopamine precursors |
CN110294789A (zh) * | 2018-03-21 | 2019-10-01 | 海南大学 | 含多巴寡肽的合成方法及其在抗帕金森病前药方面的应用 |
US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
CN113727974A (zh) | 2019-05-21 | 2021-11-30 | H.隆德贝克有限公司 | 用于治疗帕金森病的新儿茶酚胺前药 |
US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
KR20230155508A (ko) * | 2021-03-10 | 2023-11-10 | 뉴로덤 엘티디 | 레보도파-티로신 접합체를 포함하는 안정화된 액체 조성물 및 그의 용도 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3132171A (en) * | 1962-06-18 | 1964-05-05 | Strong Cobb Arner Inc | 3, 4-diphosphatophenyl-alanine and process for making same |
US3891696A (en) * | 1973-11-02 | 1975-06-24 | Interx Research Corp | Novel, transient pro-drug forms of l-dopa |
US4508706A (en) * | 1983-03-30 | 1985-04-02 | Yale University | Composition for increasing melanin in mammalian skin and hair |
US4618484A (en) * | 1983-03-30 | 1986-10-21 | Yale University | Composition and method for treatment of melanomas |
US4695449A (en) * | 1983-03-30 | 1987-09-22 | Yale University | Composition and method for treatment of melanomas |
IT1213182B (it) * | 1984-06-25 | 1989-12-14 | Simes | Derivati di composti a struttura catecolamminica. |
IT1200427B (it) * | 1985-03-22 | 1989-01-18 | Afros Spa | Procedimento ed impianto per lo stampaggio di pezzi in materiale plastico espanso,con parti o inserti preformati a spruzzo nello stesso stampo di formatura |
US4663349A (en) * | 1985-12-30 | 1987-05-05 | Merck & Co., Inc. | Rectally absorbable form of L-dopa |
-
1990
- 1990-04-17 EP EP90200937A patent/EP0393781B1/de not_active Expired - Lifetime
- 1990-04-17 AT AT90200937T patent/ATE118216T1/de not_active IP Right Cessation
- 1990-04-17 ES ES90200937T patent/ES2070994T3/es not_active Expired - Lifetime
- 1990-04-17 DE DE69016688T patent/DE69016688T2/de not_active Expired - Fee Related
- 1990-04-20 US US07/512,211 patent/US5073547A/en not_active Expired - Lifetime
- 1990-04-20 JP JP2103274A patent/JPH02292290A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2070994T3 (es) | 1995-06-16 |
EP0393781B1 (de) | 1995-02-08 |
EP0393781A3 (de) | 1991-01-09 |
DE69016688D1 (de) | 1995-03-23 |
EP0393781A2 (de) | 1990-10-24 |
JPH02292290A (ja) | 1990-12-03 |
US5073547A (en) | 1991-12-17 |
DE69016688T2 (de) | 1995-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |