DE3789536D1 - Pyridin-Derivate, deren pharmazeutische Zusammenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung. - Google Patents
Pyridin-Derivate, deren pharmazeutische Zusammenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung.Info
- Publication number
- DE3789536D1 DE3789536D1 DE87116797T DE3789536T DE3789536D1 DE 3789536 D1 DE3789536 D1 DE 3789536D1 DE 87116797 T DE87116797 T DE 87116797T DE 3789536 T DE3789536 T DE 3789536T DE 3789536 D1 DE3789536 D1 DE 3789536D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- stands
- manufacture
- alkoxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27053686 | 1986-11-13 | ||
JP2198987 | 1987-02-02 | ||
JP7778487 | 1987-03-31 |
Publications (3)
Publication Number | Publication Date |
---|---|
DE3789536D1 true DE3789536D1 (de) | 1994-05-11 |
DE3789536T2 DE3789536T2 (de) | 1994-08-18 |
DE3789536T3 DE3789536T3 (de) | 1998-08-20 |
Family
ID=27283658
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3789536T Expired - Lifetime DE3789536T3 (de) | 1986-11-13 | 1987-11-13 | Pyridin-Derivate, deren pharmazeutische Zusammenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung. |
DE1999175035 Active DE19975035I2 (de) | 1986-11-13 | 1987-11-13 | Pyridin-Derivate, deren pharmazeutische Zusammenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung. |
DE3752167T Expired - Lifetime DE3752167T2 (de) | 1986-11-13 | 1987-11-13 | Pyridin-Derivate, deren pharmazeutische Zusammmenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung |
DE3752201T Expired - Lifetime DE3752201T2 (de) | 1986-11-13 | 1987-11-13 | Pyridin-Derivate, deren pharmazeutische Zusammenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1999175035 Active DE19975035I2 (de) | 1986-11-13 | 1987-11-13 | Pyridin-Derivate, deren pharmazeutische Zusammenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung. |
DE3752167T Expired - Lifetime DE3752167T2 (de) | 1986-11-13 | 1987-11-13 | Pyridin-Derivate, deren pharmazeutische Zusammmenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung |
DE3752201T Expired - Lifetime DE3752201T2 (de) | 1986-11-13 | 1987-11-13 | Pyridin-Derivate, deren pharmazeutische Zusammenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung |
Country Status (18)
Country | Link |
---|---|
US (3) | US5045552A (de) |
EP (3) | EP0475456B1 (de) |
JP (1) | JP2544567B2 (de) |
KR (1) | KR910003330B1 (de) |
CN (1) | CN1018923B (de) |
AT (2) | ATE168111T1 (de) |
AU (1) | AU594836B2 (de) |
CA (1) | CA1265138A (de) |
DE (4) | DE3789536T3 (de) |
DK (2) | DK171024B1 (de) |
ES (3) | ES2118457T3 (de) |
FI (1) | FI90544C (de) |
HK (1) | HK194296A (de) |
HU (1) | HU198475B (de) |
LU (1) | LU90396I2 (de) |
NL (1) | NL990015I2 (de) |
NO (2) | NO170932C (de) |
NZ (1) | NZ222488A (de) |
Families Citing this family (152)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62201884A (ja) * | 1986-02-28 | 1987-09-05 | Tokyo Tanabe Co Ltd | ベンズイミダゾール誘導体及びその製造法 |
JPH0768125B2 (ja) * | 1988-05-18 | 1995-07-26 | エーザイ株式会社 | 酸不安定化合物の内服用製剤 |
AT391693B (de) * | 1988-11-15 | 1990-11-12 | Cl Pharma | Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer |
US5294629A (en) * | 1988-11-22 | 1994-03-15 | Meiji Seika Kaisha, Ltd. | Benzothiazole and benzimidazole derivatives and antiulcer agent containing the same |
EG19302A (en) * | 1988-12-22 | 1994-11-30 | Haessle Ab | Compound with gastric acid inhibitory effect and process for its preparation |
SE8804629D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New therapeutically active compounds |
US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
US5049674A (en) * | 1989-12-20 | 1991-09-17 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
ES2024357A6 (es) * | 1990-12-05 | 1992-02-16 | Genesis Para La Investigacion | Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. |
NZ244301A (en) * | 1991-09-20 | 1994-08-26 | Merck & Co Inc | Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds |
US5504082A (en) * | 1992-06-01 | 1996-04-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridine compound and pharmaceutical compostions |
DE69302646T2 (de) * | 1992-08-21 | 1996-10-31 | Eisai Co Ltd | Benzimidazolverbindungen als Antibiotika gegen Campylobacter pylon |
EP0683776B1 (de) * | 1993-02-17 | 1999-04-07 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituierte heteroarylalkylthiopyridine zur bekämpfung von helicobacter bakterien |
CA2166327A1 (en) * | 1993-06-29 | 1995-01-12 | Bernhard Kohl | Substituted arylthioalkylthiopyridines |
TW280770B (de) | 1993-10-15 | 1996-07-11 | Takeda Pharm Industry Co Ltd | |
CA2175235A1 (en) * | 1993-10-29 | 1995-05-04 | Takeshi Kawakita | Pyridine compound and medicinal use thereof |
KR0142815B1 (ko) * | 1994-12-02 | 1998-07-15 | 정도언 | 신규한 5-피롤릴-6-할로게노-2피리딜메틸설피닐벤즈이미다졸 유도체 |
KR0179401B1 (ko) * | 1994-02-28 | 1999-03-20 | 송택선 | 신규한 5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸 유도체 |
HRP960232A2 (en) * | 1995-07-03 | 1998-02-28 | Astra Ab | A process for the optical purification of compounds |
US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
KR970032861A (ko) * | 1995-12-29 | 1997-07-22 | 김준웅 | 헬리코박터 피로리 제거용 약제 투여방법 |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6051570A (en) * | 1997-05-30 | 2000-04-18 | Dr. Reddy's Research Foundation | Benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them |
DE69827392T2 (de) | 1997-07-25 | 2005-10-27 | Altana Pharma Ag | Protonenpumpenhemmer als kombinationstherapeutika mit antibakteriell wirkenden substanzen |
US7230014B1 (en) * | 1997-10-14 | 2007-06-12 | Eisai Co., Ltd. | Pharmaceutical formulation comprising glycine as a stabilizer |
EP1039905B1 (de) * | 1997-10-14 | 2006-07-05 | Eisai Co., Ltd. | Pharmazeutische zusammensetzung enthaltend glyzin als stabilisator |
ATE271555T1 (de) | 1998-01-14 | 2004-08-15 | Uab Research Foundation | Verfahren zur herstellung und screening von inhibitoren des bakteriellen nad synthetase enzyms, verbindungen daraus und methoden zur behandlung bakterieller und mikrobieller infektionen mit diesen inhibitoren |
US6861448B2 (en) | 1998-01-14 | 2005-03-01 | Virtual Drug Development, Inc. | NAD synthetase inhibitors and uses thereof |
DE19815634A1 (de) * | 1998-04-07 | 1999-10-14 | Bayer Ag | Verfahren zur Herstellung von 3-Methoxy-1-propanol |
AU3967399A (en) * | 1998-04-30 | 1999-11-16 | Sepracor, Inc. | S-rabeprazole compositions and methods |
EP1073332A4 (de) * | 1998-04-30 | 2005-06-15 | Sepracor Inc | R-rabeprazol enthaltende zusammensetzungen und verfahren |
AU4387799A (en) * | 1998-06-26 | 2000-01-17 | Russinsky Limited | Pyridine building blocks as intermediates in the synthesis of pharmaceutically active compounds |
US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
CN100396675C (zh) | 1998-08-10 | 2008-06-25 | 加利福尼亚州大学董事会 | 质子泵抑制剂的前药 |
AU772726B2 (en) | 1998-08-12 | 2004-05-06 | Takeda Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles |
DE19843413C1 (de) * | 1998-08-18 | 2000-03-30 | Byk Gulden Lomberg Chem Fab | Neue Salzform von Pantoprazol |
JP3926936B2 (ja) * | 1998-11-16 | 2007-06-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホキシド誘導体・アセトン錯体およびその製造法 |
US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
US6362202B1 (en) | 1999-03-02 | 2002-03-26 | Sepracor Inc. | Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists |
US6353005B1 (en) | 1999-03-02 | 2002-03-05 | Sepracor, Inc. | Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist |
US6174902B1 (en) | 1999-04-28 | 2001-01-16 | Sepracor Inc. | R-rabeprazole compositions and methods |
ATE300285T1 (de) | 1999-06-07 | 2005-08-15 | Altana Pharma Ag | Neue zubereitung und darreichungsform enthaltend einen säurelabilen protonenpumpeninhibitor |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
WO2001074810A2 (en) * | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists |
WO2001097753A2 (en) | 2000-06-19 | 2001-12-27 | Eisai Co. Ltd. | Novel methods using pyridine derivatives |
US6544556B1 (en) * | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
US20020064555A1 (en) * | 2000-09-29 | 2002-05-30 | Dan Cullen | Proton pump inhibitor formulation |
BR0115989A (pt) | 2000-12-07 | 2004-01-13 | Altana Pharma Ag | Preparação farmacêutica na forma de uma suspensão compreendendo um ingrediente ativo instável a ácido |
CA2430816C (en) | 2000-12-07 | 2012-05-15 | Altana Pharma Ag | Pharmaceutical preparation in the form of a paste comprising an acid-labile active ingredient |
SI1341528T1 (sl) | 2000-12-07 | 2012-05-31 | Nycomed Gmbh | Hitro razpadljiva tableta ki obsega kislinsko labilno aktivno sestavino |
NL1018295C2 (nl) * | 2001-06-15 | 2002-12-17 | Dsm Nv | Werkwijze voor de bereiding van 4-chloor-pyridine-n-oxiden. |
EP1428825A4 (de) | 2001-09-18 | 2005-03-23 | Zeria Pharm Co Ltd | Benzimidazolderivate |
WO2003063927A2 (en) * | 2001-11-16 | 2003-08-07 | Eisai Co. Ltd | Compositions and methods to treat gastrointestinal disorders |
SE0104295D0 (sv) * | 2001-12-18 | 2001-12-18 | Astrazeneca Ab | New process |
AU2003224781A1 (en) * | 2002-03-26 | 2003-10-13 | Dr. Reddy's Laboratories Limited | Crystalline forms of rabeprazole sodium |
WO2003097011A1 (en) * | 2002-05-17 | 2003-11-27 | Eisai Co., Ltd. | Compositions and methods using proton pump inhibitors |
US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
TW200410955A (en) | 2002-07-29 | 2004-07-01 | Altana Pharma Ag | Novel salt of (S)-PANTOPRAZOLE |
JP4634144B2 (ja) * | 2002-08-01 | 2011-02-16 | ニコックス エスエー | ニトロソ化プロトンポンプ阻害剤、組成物および使用方法 |
AT413538B (de) * | 2002-10-01 | 2006-03-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten pyridin-n-oxid-verbindungen |
DE10254167A1 (de) | 2002-11-20 | 2004-06-09 | Icon Genetics Ag | Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen |
BRPI0310118B1 (pt) | 2002-12-06 | 2015-10-20 | Altana Pharma Ag | processo para a preparação de inibidores de bomba de próton (ppi) opticamente puro possuindo uma estrutura de sulfinila |
US7301030B2 (en) | 2002-12-06 | 2007-11-27 | Nycomed Gmbh | Process for preparing (S)-pantoprazole |
WO2004055001A2 (en) * | 2002-12-16 | 2004-07-01 | Ranbaxy Laboratories Limited | Rabeprazole calcium |
WO2004056804A2 (en) * | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
CN1723208A (zh) * | 2003-01-07 | 2006-01-18 | 兰贝克赛实验室有限公司 | 咪唑衍生物的镁盐 |
US20040180935A1 (en) * | 2003-02-28 | 2004-09-16 | Dr. Reddy's Laboratories Limited Dr. Reddy's Laboratories Inc. | Crystalline form Z of rabeprazole sodium and process for preparation thereof |
WO2004080961A2 (en) * | 2003-03-12 | 2004-09-23 | Teva Pharmaceutical Industries Ltd. | Crystalline and amorphous solids of pantoprazole and processes for their preparation |
WO2004080487A1 (ja) * | 2003-03-13 | 2004-09-23 | Eisai Co. Ltd. | 歯ぎしりの予防剤または治療剤 |
ATE508124T1 (de) | 2003-03-24 | 2011-05-15 | Eisai R&D Man Co Ltd | Verfahren zur herstellung von amorphem rabeprazole-natrium-salz |
CL2004000983A1 (es) | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
PE20050150A1 (es) | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
WO2004101533A1 (en) * | 2003-05-12 | 2004-11-25 | Janssen Pharmaceutica, N.V. | 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands |
CA2528993A1 (en) * | 2003-06-10 | 2004-12-23 | Teva Pharmaceutical Industries Ltd. | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
CA2529984C (en) | 2003-06-26 | 2012-09-25 | Isa Odidi | Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors |
NZ544173A (en) * | 2003-07-15 | 2009-04-30 | Alevium Pharmaceuticals Inc | Process for preparing isomerically pure prodrugs of benzimidazole derivative proton pump inhibitors |
US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
EP1660052A2 (de) * | 2003-09-03 | 2006-05-31 | Agi Therapeutics Limited | Protonenpumpenhemmer-formulierungen und verfahren zur herstellung und verwendung dieser formulierungen |
TWI372066B (en) | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
WO2005039640A1 (en) * | 2003-10-03 | 2005-05-06 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs |
WO2005077936A1 (en) | 2004-02-11 | 2005-08-25 | Ulkar Kimya Sanayii Ve Ticaret A.S. | Pyridine benzimidazole sulfoxides with high purity |
JP2007523164A (ja) * | 2004-02-18 | 2007-08-16 | アラーガン、インコーポレイテッド | プロトンポンプインヒビターに関連する化合物の静脈内投与のための方法および組成物 |
US20070060621A1 (en) * | 2004-02-18 | 2007-03-15 | Hughes Patrick M | Methods and compositions for the administration of prodrugs of proton pump inhibitors |
JP2007532677A (ja) * | 2004-04-16 | 2007-11-15 | サンタラス インコーポレイティッド | プロトンポンプ阻害剤、緩衝剤、および運動促進薬の組み合わせ |
RS52233B (en) * | 2004-05-07 | 2012-10-31 | Nycomed Gmbh | THE PHARMACEUTICAL DOSAGE FORM CONTAINING GRANULES AND ITS PRODUCTION PROCEDURE |
US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
WO2006003946A1 (ja) * | 2004-06-30 | 2006-01-12 | Eisai R & D Management Co., Ltd. | ベンズイミダゾール誘導体塩沈殿物の製造方法 |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
JP3921497B2 (ja) * | 2004-08-06 | 2007-05-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ベンズイミダゾール誘導体とアミンとの塩およびその製造方法 |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
WO2006024890A1 (en) * | 2004-08-30 | 2006-03-09 | Apollo International Limited | Improved process for rabeprazole sodium in amorphous form |
CA2603290A1 (en) * | 2004-09-30 | 2006-04-06 | Jiangsu Hansen Pharmaceutical Co., Ltd. | Prazole derivatives and salts thereof and use of same |
CN100364989C (zh) * | 2004-09-30 | 2008-01-30 | 江苏豪森药业股份有限公司 | 拉唑类衍生物及其盐和用途 |
US20090169566A1 (en) | 2004-11-22 | 2009-07-02 | Anadis Ltd. | Bioactive compositions |
NZ561008A (en) | 2005-02-21 | 2009-09-25 | Cipla Ltd | New process for synthesis of proton pump inhibitors, namely Rabeprazole sodium |
AU2006245298A1 (en) * | 2005-03-30 | 2006-11-16 | Lupin Limited | An improved process for the manufacture of rabeprazole sodium |
US7601737B2 (en) | 2005-07-26 | 2009-10-13 | Nycomed Gmbh | Isotopically substituted proton pump inhibitors |
GB0525710D0 (en) * | 2005-12-17 | 2006-01-25 | Pliva Hrvatska D O O | An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
EP1818331A1 (de) | 2006-02-14 | 2007-08-15 | EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. | Verfahren zur Herstellung von 2-[{4-(3-Methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazol wesentlich frei von Sulfonverunreinigung |
ES2374730T3 (es) | 2006-03-10 | 2012-02-21 | Arigen Pharmaceuticals, Inc. | Nuevo derivado de piridina que tiene actividad contra helicobacter pylori. |
JP5457830B2 (ja) | 2006-04-03 | 2014-04-02 | オディディ,イサ | オルガノゾル被膜を含む制御放出送達デバイス |
KR100771655B1 (ko) * | 2006-04-24 | 2007-10-30 | 주식회사 카이로제닉스 | 라베프라졸 및 그 중간체의 제조방법 |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
US7786309B2 (en) | 2006-06-09 | 2010-08-31 | Apotex Pharmachem Inc. | Process for the preparation of esomeprazole and salts thereof |
US7863330B2 (en) | 2006-06-14 | 2011-01-04 | Rottapharm S.P.A. | Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders |
WO2008017020A2 (en) * | 2006-08-03 | 2008-02-07 | Dr. Reddy's Laboratories Limited | Process for preparing proton pump inhibitors |
US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
EP2068841B1 (de) | 2006-10-05 | 2018-09-26 | Santarus, Inc. | Neuartige formulierungen von protonenpumpenhemmern und verfahren zu ihrer verwendung |
JP5492417B2 (ja) * | 2006-10-13 | 2014-05-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 胃酸分泌抑制作用を有するベンズイミダゾール化合物 |
US20080103169A1 (en) | 2006-10-27 | 2008-05-01 | The Curators Of The University Of Missouri | Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same |
PL2103608T3 (pl) | 2006-12-18 | 2013-02-28 | Link Genomics Inc | Środek do eradykacji Helicobacter pylori mający działanie hamujące na sekrecję kwasu żołądkowego |
ITMI20062449A1 (it) | 2006-12-19 | 2008-06-20 | Dipharma Spa | Forma cristallina di rabeprazolo sodico |
RU2491075C2 (ru) | 2006-12-22 | 2013-08-27 | Айронвуд Фармасьютикалз, Инк. | Способы и композиции для лечения расстройств пищевода |
US20100145057A1 (en) * | 2007-03-15 | 2010-06-10 | Sun Pharma Advanced Research Company Ltd. | Novel prodrugs |
US20100204478A1 (en) * | 2007-05-25 | 2010-08-12 | Hetero Drugs Limited | Improved process for amophous rabeprazole sodium |
US8247568B2 (en) * | 2007-06-21 | 2012-08-21 | Matrix Laboratories Ltd | Process for the preparation of pure rabeprazole |
WO2009010937A1 (en) * | 2007-07-17 | 2009-01-22 | Ranbaxy Laboratories Limited | Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate |
CN101497604B (zh) * | 2008-01-30 | 2012-09-26 | 山东轩竹医药科技有限公司 | 含有被烷氧乙酰胺基氧基取代的吡啶的苯并咪唑衍生物 |
CN101497603B (zh) * | 2008-01-30 | 2012-11-07 | 山东轩竹医药科技有限公司 | 含有被烷氧烷胺氧基取代的吡啶的苯并咪唑衍生物 |
SI22806A (sl) * | 2008-06-23 | 2009-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove kristalinične oblike natrijevega rabeprazola |
RU2484089C1 (ru) * | 2009-04-09 | 2013-06-10 | Ариджен Фармасьютикалз, Инк. | Тиопроизводное пиридина и фармацевтическая композиция, которая его содержит и имеет способность действовать против helicobacter pylori |
WO2010134099A1 (en) | 2009-05-21 | 2010-11-25 | Cadila Healthcare Limited | One pot process for preparing omeprazole and related compounds |
WO2011004281A1 (en) | 2009-07-09 | 2011-01-13 | Alembic Limited | A process for the preparation of amorphous form of rabeprazole sodium |
CN102140099A (zh) | 2010-02-02 | 2011-08-03 | 山东轩竹医药科技有限公司 | 新的吡啶衍生物 |
CA2795056C (en) * | 2010-03-31 | 2015-03-24 | Ranbaxy Laboratories Limited | Salts of dexlansoprazole and their preparation |
CN102219777B (zh) * | 2010-04-19 | 2013-06-05 | 江苏豪森药业股份有限公司 | 制备雷贝拉唑钠的方法 |
CN101805327B (zh) * | 2010-04-29 | 2012-11-21 | 郝志艳 | 一种雷贝拉唑钠化合物及其制法 |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
EP2790696A1 (de) | 2011-12-16 | 2014-10-22 | Atopix Therapeutics Limited | Kombination von crth2-antagonisten und einem protonenpumpenhemmer zur behandlung von eosinophiler ösophagitis |
WO2013108068A1 (en) | 2012-01-21 | 2013-07-25 | Jubilant Life Sciences Limited | Process for the preparation of 2-pyridinylmethylsulfinyl benzimidazoles, their analogs and optically active enantiomers |
WO2014091450A1 (en) | 2012-12-12 | 2014-06-19 | Ranbaxy Laboratories Limited | Process for the preparation of rabeprazole |
AU2014207680B2 (en) | 2013-01-15 | 2018-09-06 | Ironwood Pharmaceuticals, Inc. | Gastro-retentive sustained-release oral dosage form of a bile acid sequestrant |
CN103073536B (zh) * | 2013-01-17 | 2015-06-24 | 丽珠医药集团股份有限公司 | 一种艾普拉唑的制备方法 |
CN103709141A (zh) * | 2013-10-14 | 2014-04-09 | 寿光富康制药有限公司 | 雷贝拉唑钠的晶型及无定形形式 |
CN104119315B (zh) * | 2014-05-21 | 2016-03-02 | 丽珠医药集团股份有限公司 | 一种雷贝拉唑钠的制备方法 |
RU2554735C1 (ru) * | 2014-08-20 | 2015-06-27 | Открытое Акционерное Общество "Татхимфармпрепараты" | Фармацевтическая композиция, содержащая рабепразол натрия, и способ ее получения |
US20180015118A1 (en) | 2015-02-03 | 2018-01-18 | Ironwood Pharmaceuticals, Inc. | Methods of treating upper gastrointestinal disorders in ppi refractory gerd |
EP3288556A4 (de) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Oral zerfallende zusammensetzungen |
WO2017145146A1 (en) | 2016-02-25 | 2017-08-31 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
CN106083705A (zh) * | 2016-06-14 | 2016-11-09 | 上药康丽(常州)药业有限公司 | 2‑羟甲基‑4‑(甲氧基丙氧基)‑3‑甲基吡啶盐酸盐的制备方法 |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
CN106349220A (zh) * | 2016-08-25 | 2017-01-25 | 岳阳正昊化学科技有限公司 | 一种右旋雷贝拉唑钠的纯化方法 |
JP7044789B2 (ja) | 2016-09-24 | 2022-03-30 | ワシントン・ユニバーシティ | Sarm1 nadアーゼ活性の阻害剤およびその使用 |
MX2022002949A (es) | 2019-09-24 | 2022-04-06 | Prolacta Bioscience Inc | Composiciones y metodos para el tratamiento de enfermedades inflamatorias e inmunes. |
WO2024075017A1 (en) | 2022-10-04 | 2024-04-11 | Zabirnyk Arsenii | Inhibition of aortic valve calcification |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
IL66340A (en) * | 1981-08-13 | 1986-08-31 | Haessle Ab | Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation |
SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
GB8417171D0 (en) * | 1984-07-05 | 1984-08-08 | Beecham Group Plc | Compounds |
SE8404065D0 (sv) * | 1984-08-10 | 1984-08-10 | Haessle Ab | Novel biologically active compounds |
DE3509333A1 (de) * | 1985-03-15 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Substituierte benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer |
JPH0674272B2 (ja) * | 1986-11-13 | 1994-09-21 | エーザイ株式会社 | ピリジン誘導体及びそれを含有する潰瘍治療剤 |
DE4036908A1 (de) * | 1990-11-20 | 1992-05-21 | Ruetgers Pagid Ag | Nutausbildung |
-
1987
- 1987-10-26 FI FI874709A patent/FI90544C/fi not_active IP Right Cessation
- 1987-10-27 NO NO874477A patent/NO170932C/no not_active IP Right Cessation
- 1987-11-03 DK DK575887A patent/DK171024B1/da not_active IP Right Cessation
- 1987-11-09 NZ NZ222488A patent/NZ222488A/en unknown
- 1987-11-12 HU HU875044A patent/HU198475B/hu unknown
- 1987-11-12 CA CA000551684A patent/CA1265138A/en not_active Expired - Lifetime
- 1987-11-12 AU AU81138/87A patent/AU594836B2/en not_active Expired
- 1987-11-13 EP EP91117132A patent/EP0475456B1/de not_active Expired - Lifetime
- 1987-11-13 CN CN87107777A patent/CN1018923B/zh not_active Expired
- 1987-11-13 ES ES95102165T patent/ES2118457T3/es not_active Expired - Lifetime
- 1987-11-13 ES ES91117132T patent/ES2112260T3/es not_active Expired - Lifetime
- 1987-11-13 DE DE3789536T patent/DE3789536T3/de not_active Expired - Lifetime
- 1987-11-13 DE DE1999175035 patent/DE19975035I2/de active Active
- 1987-11-13 ES ES87116797T patent/ES2061471T5/es not_active Expired - Lifetime
- 1987-11-13 EP EP95102165A patent/EP0654471B1/de not_active Expired - Lifetime
- 1987-11-13 AT AT95102165T patent/ATE168111T1/de not_active IP Right Cessation
- 1987-11-13 AT AT91117132T patent/ATE163011T1/de not_active IP Right Cessation
- 1987-11-13 DE DE3752167T patent/DE3752167T2/de not_active Expired - Lifetime
- 1987-11-13 DE DE3752201T patent/DE3752201T2/de not_active Expired - Lifetime
- 1987-11-13 KR KR1019870012813A patent/KR910003330B1/ko not_active IP Right Cessation
- 1987-11-13 EP EP87116797A patent/EP0268956B2/de not_active Expired - Lifetime
-
1989
- 1989-12-28 US US07/462,328 patent/US5045552A/en not_active Expired - Lifetime
-
1993
- 1993-01-07 JP JP5001119A patent/JP2544567B2/ja not_active Expired - Lifetime
- 1993-11-24 DK DK131893A patent/DK131893A/da not_active Application Discontinuation
-
1994
- 1994-12-06 US US08/354,726 patent/US5840910A/en not_active Expired - Lifetime
-
1996
- 1996-07-09 US US08/679,473 patent/US5998445A/en not_active Expired - Fee Related
- 1996-10-24 HK HK194296A patent/HK194296A/xx not_active IP Right Cessation
-
1999
- 1999-05-07 LU LU90396C patent/LU90396I2/fr unknown
- 1999-05-26 NL NL990015C patent/NL990015I2/nl unknown
-
2000
- 2000-08-18 NO NO2000006C patent/NO2000006I1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3789536T3 (de) | Pyridin-Derivate, deren pharmazeutische Zusammenstellungen, deren Anwendung für die Herstellung von Arzneimitteln mit therapeutischem oder vorbeugendem Wert und Verfahren zu deren Herstellung. | |
YU69991A (sh) | Derivati piridina | |
NO933200D0 (no) | Substituerte cykloheksanderivater, fremgangsm}te til fremstilling derav og anvendelsen av forbindelsene til behandling av sykdommer | |
ES483661A1 (es) | Procedimiento para la obtencion de derivados de 1,4-dihidro-piridina sila-sustituidos | |
HUT46664A (en) | Process for producing new dihydropyridineamide derivatives and pharmaceutical compositions comprising these compounds | |
BR8400549A (pt) | Derivados e sais inertes de hidroxido de aminopiridinios e processos de preparacao;e composicao farmaceutica | |
FR2321294A1 (fr) | Derives d'acides 7b-amino-3-cephem-3-carbonylmethyl-4-carboxyliques utiles comme medicaments | |
ES462387A1 (es) | Procedimiento para la obtencion de derivados de 1,4-dihidro-piridin-azucar. | |
ATE103912T1 (de) | Pyridin-derivate, deren pharmazeutische zusammenstellungen, deren anwendung fuer die herstellung von arzneimitteln mit therapeutischem oder vorbeugendem wert und verfahren zu deren herstellung. | |
DE68917049T2 (de) | Furylthiazol-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten. | |
EP0360130A3 (de) | Elaiophylinderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und sie enthaltende Arzneimittel | |
FR2655042B1 (fr) | Nouvelles benzothiazolinones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
IT7926945A0 (it) | Derivati eterociclici azotati adattivita'terapeutica ,processi per la loro preparazione e composizioni farmaceutiche contenenti detti derivati | |
RU92004439A (ru) | Азотсодержащие тетрациклические соединения, способ их получения, применение и фармацевтическая композиция | |
DE59105961D1 (de) | 2,13-disubstituierte ergoline, deren herstellung und verwendung in arzneimitteln. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8366 | Restricted maintained after opposition proceedings | ||
V448 | Application of spc |
Free format text: PRODUCT NAME: RABEPRAZOL UND SEINE PHARMAZEUTISCH GEEIGNETEN SALZE, INSBESONDERE RABEPRAZOL-NATRIUM; REGISTRATION NO/DATE: 44258.00.00, 44258.01.00, 44260.00.00, 44260.01.00; 19981111 Spc suppl protection certif: 199 75 035 Filing date: 19990510 |
|
V457 | Spc granted |
Free format text: PRODUCT NAME: RABEPRAZOL UND SEINE PHARMAZEUTISCH GEEIGNETEN SALZE, INSBESONDERE RABEPRAZOL-NATRIUM; REGISTRATION NO/DATE: 44258.00.00, 44258.01.00, 44260.00.00, 44260.01.00; 19981111 Spc suppl protection certif: 199 75 035 Filing date: 19990510 |
|
R071 | Expiry of right |
Free format text: PRODUCT NAME: RABEPRAZOL UND SEINE PHARMAZEUTISCH GEEIGNETEN SALZE, INSBESONDERE RABEPRAZOL-NATRIUM; NAT. REGISTRATION NO/DATE: 44258.00.00 44258.01.00 44260.00.00 44260.01.00 19981111 FIRST REGISTRATION: GROSSBRITANNIEN 10555/0008 10555/0010 19980508 Spc suppl protection certif: 19975035 Filing date: 19990510 Expiry date: 20071114 Extension date: 20121113 Effective date: 20121114 |