ES2024357A6 - Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. - Google Patents
Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina.Info
- Publication number
- ES2024357A6 ES2024357A6 ES9003113A ES9003113A ES2024357A6 ES 2024357 A6 ES2024357 A6 ES 2024357A6 ES 9003113 A ES9003113 A ES 9003113A ES 9003113 A ES9003113 A ES 9003113A ES 2024357 A6 ES2024357 A6 ES 2024357A6
- Authority
- ES
- Spain
- Prior art keywords
- methoxypyridine
- halomethyl
- halohydrate
- dimethyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE HALOHIDRATO DE 2-HALOMETIL-3,5-DIMETIL-4-METOXIPIRIDINA, DE FORMULA FIGURA 1 (X Y X'' SON HALOGENOS, IGUALES O NO), QUE COMPRENDE UNA PRIMERA ETAPA DE 0-ACILACION Y SUBSIGUIENTE ACILOXILACION DEL GRUPO METILO EN POSICION 2 DEL N-OXIDO DE 2,3,5-TRIMETIL-4-METOXIPIRIDINA, OBTENIENDO UN COMPUESTO DE FORMULA FIGURA 2 (R ES METILO, TRICLOROMETILO O TRIFLUOROMETILO Y N ES 0 O 1) Y UNA ULTIMA ETPA DE HALOGENACION, EN LA QUE EL SUSTITUYENTE EN POSICION 2 DEVIENE HALOMETIL. EL COMPUESTO ES UN ANTECEDENTE DE SINTESIS DEL OMEPRAZOL, QUE ES UN MEDICAMENTO MUY EFICAZ PARA EL TRATAMIENTO DE ULCERAS GASTRICAS.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9003113A ES2024357A6 (es) | 1990-12-05 | 1990-12-05 | Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. |
US07/796,070 US5292886A (en) | 1990-12-05 | 1991-11-20 | Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9003113A ES2024357A6 (es) | 1990-12-05 | 1990-12-05 | Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2024357A6 true ES2024357A6 (es) | 1992-02-16 |
Family
ID=8269936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9003113A Expired - Lifetime ES2024357A6 (es) | 1990-12-05 | 1990-12-05 | Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. |
Country Status (2)
Country | Link |
---|---|
US (1) | US5292886A (es) |
ES (1) | ES2024357A6 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2066701A1 (es) * | 1991-11-21 | 1995-03-01 | Genesis Para La Investigacion | Perfeccionamientos en el objeto de la patente 9102594 por procedimiento de obtencion de compuestos derivados de piridina. |
WO2001079194A1 (es) * | 2000-04-14 | 2001-10-25 | Esteve Quimica, S.A. | Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103664750A (zh) * | 2013-12-09 | 2014-03-26 | 惠州市莱佛士制药技术有限公司 | 一种拉唑氯代物的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103353A3 (en) * | 1982-09-13 | 1986-03-05 | Genrad, Inc. | Method of and apparatus for multiplexed automatic testing of electronic circuits and the like |
SE8404065D0 (sv) * | 1984-08-10 | 1984-08-10 | Haessle Ab | Novel biologically active compounds |
FI90544C (fi) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
AT391693B (de) * | 1988-11-15 | 1990-11-12 | Cl Pharma | Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer |
-
1990
- 1990-12-05 ES ES9003113A patent/ES2024357A6/es not_active Expired - Lifetime
-
1991
- 1991-11-20 US US07/796,070 patent/US5292886A/en not_active Expired - Lifetime
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2066701A1 (es) * | 1991-11-21 | 1995-03-01 | Genesis Para La Investigacion | Perfeccionamientos en el objeto de la patente 9102594 por procedimiento de obtencion de compuestos derivados de piridina. |
ES2067407A1 (es) * | 1991-11-21 | 1995-03-16 | Genesis Para La Investigacion | Perfeccionamientos en el objeto de la patente 9102594 por procedimiento de obtencion de derivados de piridina. |
WO2001079194A1 (es) * | 2000-04-14 | 2001-10-25 | Esteve Quimica, S.A. | Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol |
ES2171116A1 (es) * | 2000-04-14 | 2002-08-16 | Esteve Quimica Sa | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
US6723852B2 (en) * | 2000-04-14 | 2004-04-20 | Esteve Quimica, S.A. | Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzomidazol |
Also Published As
Publication number | Publication date |
---|---|
US5292886A (en) | 1994-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted |
Owner name: ESTEVE QUIMICA, S.A. |
|
FD2A | Announcement of lapse in spain |
Effective date: 20110214 |