ES2171116A1 - Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. - Google Patents
Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.Info
- Publication number
- ES2171116A1 ES2171116A1 ES200000989A ES200000989A ES2171116A1 ES 2171116 A1 ES2171116 A1 ES 2171116A1 ES 200000989 A ES200000989 A ES 200000989A ES 200000989 A ES200000989 A ES 200000989A ES 2171116 A1 ES2171116 A1 ES 2171116A1
- Authority
- ES
- Spain
- Prior art keywords
- benzimidazol
- thio
- methyl
- alkoxy
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol. El procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol (I), donde cada uno de R1, R3 y R4, independientemente entre sí, es hidrógeno, un grupo alquilo o un grupo alquiloxi de 1 a 6 átomos de carbono, y R2 es un grupo nitro, un grupo alquiloxi o un grupo alquiloxi fluorado de 1 a 6 átomos de carbono, comprende (a) hacer reaccionar un N-óxido de una metilpiridina con un anhídrido de ácido carboxílico activado o de ácido sulfónico, y (b) hacer reaccionar el intermedio formado en la etapa (a) con un mercaptobencimidazol correspondiente. Los compuestos (I) son útiles para la síntesis de derivados de [[(piridil sustituido)metil]sulfinil]bencimidazol, por ejemplo, omeprazol o lansopazol.
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200000989A ES2171116B1 (es) | 2000-04-14 | 2000-04-14 | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
JP2001576794A JP2003531144A (ja) | 2000-04-14 | 2001-04-10 | [[(ピリジル置換)メチル]チオ]ベンズイミダゾールの誘導体を得る方法 |
KR1020027013675A KR100757346B1 (ko) | 2000-04-14 | 2001-04-10 | [[(피리딜 치환)메틸]티오]벤지미다졸 유도체의 제조 방법 |
CNB018088791A CN1214027C (zh) | 2000-04-14 | 2001-04-10 | [[(取代的吡啶基)甲基]硫基]苯并咪唑衍生物的制备方法 |
US10/204,604 US6723852B2 (en) | 2000-04-14 | 2001-04-10 | Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzomidazol |
CA2405304A CA2405304C (en) | 2000-04-14 | 2001-04-10 | Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzimidazole |
PT01919463T PT1411053E (pt) | 2000-04-14 | 2001-04-10 | Processo para obter derivados de [[ (piridil substituído) metil] tio] benzimidazolo |
EP01919463A EP1411053B1 (en) | 2000-04-14 | 2001-04-10 | Method for obtaining derivatives of (pyridil substituted)methyl|thio|benzimidazol |
PCT/ES2001/000143 WO2001079194A1 (es) | 2000-04-14 | 2001-04-10 | Procedimiento para la obtención de derivados de [[(piridil sustituido)metil]tio]bencimidazol |
DK01919463T DK1411053T3 (da) | 2000-04-14 | 2001-04-10 | Fremgangsmåde til opnåelse af derivater af [[(pyridilsubstitueret)methyl]thio]benzimidazol |
NZ521930A NZ521930A (en) | 2000-04-14 | 2001-04-10 | Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzimidazol |
AT01919463T ATE363479T1 (de) | 2000-04-14 | 2001-04-10 | Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivat n |
HU0300583A HUP0300583A2 (hu) | 2000-04-14 | 2001-04-10 | Eljárás piridilcsoporttal helyettesített metiltiobenzimidazol-származékok előállítására |
AU46551/01A AU780314B2 (en) | 2000-04-14 | 2001-04-10 | Method for obtaining derivatives of (((pyridil substituted) methyl)thio)benzimidazol |
DE60128736T DE60128736T2 (de) | 2000-04-14 | 2001-04-10 | Methode zur darstellung von (pyridyl substituierten)methyl-thio-benzimidazol-derivaten |
SI200130741T SI1411053T1 (sl) | 2000-04-14 | 2001-04-10 | Postopek pridobivanja derivatov (s piridilom substituiranega) metiltiobenzimidazola |
ES01919463T ES2284629T3 (es) | 2000-04-14 | 2001-04-10 | Procredimiento para la obtencion de derivados de (((piridil sustituido ) metil) tio) bencimidazol. |
MXPA02010039A MXPA02010039A (es) | 2000-04-14 | 2001-04-10 | Procedimiento para la obtencion de derivados de 1[[piridil sustituido)metil]tio]bencimidazol. |
NO20024858A NO323468B1 (no) | 2000-04-14 | 2002-10-08 | Fremgangsmate for fremstilling av derivater av [[(substituert pyridyl)metyl]tio]benzimidazol, et mellomprodukt samt en fremgangsmate for oppnaelse av mellomproduktet |
CY20071100725T CY1106632T1 (el) | 2000-04-14 | 2007-05-31 | Μεθοδος ληψης παραγωγων [[(πυριδιλ υποκατεστημενου) μεθυλ] θειο] βενζιμιδαζολιου |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200000989A ES2171116B1 (es) | 2000-04-14 | 2000-04-14 | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2171116A1 true ES2171116A1 (es) | 2002-08-16 |
ES2171116B1 ES2171116B1 (es) | 2003-08-01 |
Family
ID=8493207
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200000989A Expired - Fee Related ES2171116B1 (es) | 2000-04-14 | 2000-04-14 | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
ES01919463T Expired - Lifetime ES2284629T3 (es) | 2000-04-14 | 2001-04-10 | Procredimiento para la obtencion de derivados de (((piridil sustituido ) metil) tio) bencimidazol. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01919463T Expired - Lifetime ES2284629T3 (es) | 2000-04-14 | 2001-04-10 | Procredimiento para la obtencion de derivados de (((piridil sustituido ) metil) tio) bencimidazol. |
Country Status (18)
Country | Link |
---|---|
US (1) | US6723852B2 (es) |
EP (1) | EP1411053B1 (es) |
JP (1) | JP2003531144A (es) |
KR (1) | KR100757346B1 (es) |
CN (1) | CN1214027C (es) |
AT (1) | ATE363479T1 (es) |
AU (1) | AU780314B2 (es) |
CA (1) | CA2405304C (es) |
CY (1) | CY1106632T1 (es) |
DE (1) | DE60128736T2 (es) |
DK (1) | DK1411053T3 (es) |
ES (2) | ES2171116B1 (es) |
HU (1) | HUP0300583A2 (es) |
MX (1) | MXPA02010039A (es) |
NO (1) | NO323468B1 (es) |
NZ (1) | NZ521930A (es) |
PT (1) | PT1411053E (es) |
WO (1) | WO2001079194A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2185459B1 (es) * | 2000-10-02 | 2003-12-16 | Dinamite Dipharma Spa | Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo. |
EP1572680A2 (en) * | 2002-12-19 | 2005-09-14 | Eva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation. |
EP1601667A2 (en) * | 2003-03-12 | 2005-12-07 | Teva Pharmaceutical Industries Limited | Crystalline and amorphous solids of pantoprazole and processes for their preparation |
EP1615913A2 (en) * | 2003-06-10 | 2006-01-18 | Teva Pharmaceutical Industries Limited | Process for preparing 2-(pyridinyl)methyl sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
ITMI20031813A1 (it) * | 2003-09-23 | 2005-03-24 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Procedimento per la preparazione di pantoprazolo e suoi sali. |
KR100771659B1 (ko) * | 2005-03-23 | 2007-10-30 | 주식회사 카이로제닉스 | 판토프라졸 및 그 중간체의 제조방법 |
EP1893602A2 (en) * | 2005-05-06 | 2008-03-05 | Medichem, S.A. | Pantoprazole free acid form iii |
WO2007105551A1 (ja) * | 2006-03-10 | 2007-09-20 | Arigen Pharmaceuticals, Inc. | 抗ヘリコバクター・ピロリ作用を有する新規ピリジン誘導体 |
WO2008001392A2 (en) * | 2006-06-30 | 2008-01-03 | Msn Laboratories Limited | An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts |
US8778975B2 (en) * | 2006-12-18 | 2014-07-15 | Link Geonomics, Inc. | Helicobacter pylori eradicating agent having inhibitory activity on gastric acid secretion |
US20100210847A1 (en) * | 2007-07-17 | 2010-08-19 | Ranbaxy Laboratories Limited | Process for the preparation of pantoprazole sodium and pantoprazole sodium sesquihydrate |
US20090076089A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched pantoprazole |
CN102020637B (zh) * | 2010-12-13 | 2014-09-10 | 浙江华义医药有限公司 | 5-二氟甲氧基-2-[[(3,4-二甲氧基-2-吡啶基)甲基]硫基]-1h-苯并咪唑制备法 |
CN103242297A (zh) * | 2013-05-20 | 2013-08-14 | 湖北宜恒茶油产业科技有限责任公司 | 一种5-二氟甲氧基-2-[[(4-氯-3-甲氧基-2-吡啶基)甲基]硫代]-1h-苯并咪唑一水合物的制备方法 |
CN103664886A (zh) * | 2013-12-06 | 2014-03-26 | 威海迪素制药有限公司 | 2-[[[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基]硫代]-1h-苯并咪唑的制备方法 |
CN105399729B (zh) * | 2015-12-21 | 2018-04-17 | 山东金城医药化工有限公司 | 奥美拉唑的合成方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103553A1 (en) * | 1982-08-26 | 1984-03-21 | Aktiebolaget Hässle | Intermediates for the preparation of omeprazole |
US4628098A (en) * | 1984-08-16 | 1986-12-09 | Takeda Chemical Industries, Ltd. | 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles |
ES2003658A6 (es) * | 1986-01-20 | 1988-11-01 | Esteve Labor Dr | Procedimiento de preparar derivaods de 2-alquilbenzimidazol. |
ES2024357A6 (es) * | 1990-12-05 | 1992-02-16 | Genesis Para La Investigacion | Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. |
ES2026761A6 (es) * | 1990-10-31 | 1992-05-01 | Genesis Para La Investigacion | Procedimiento de obtencion del omeprazol. |
EP0729957A1 (en) * | 1993-10-29 | 1996-09-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridine compound and medicinal use thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL71664A (en) * | 1983-05-03 | 1987-11-30 | Byk Gulden Lomberg Chem Fab | Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same |
ZA854287B (en) * | 1984-06-16 | 1986-02-26 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridines,process for their preparation,their use and medicaments containing them |
JPH0674272B2 (ja) * | 1986-11-13 | 1994-09-21 | エーザイ株式会社 | ピリジン誘導体及びそれを含有する潰瘍治療剤 |
ES2036948B1 (es) * | 1991-11-21 | 1994-09-01 | Genesis Para La Investigacion | Procedimiento de obtencion de compuestos derivados de piridina. |
JP3828648B2 (ja) * | 1996-11-14 | 2006-10-04 | 武田薬品工業株式会社 | 2−(2−ピリジルメチルスルフィニル)ベンズイミダゾール系化合物の結晶およびその製造法 |
ID18983A (id) * | 1996-12-04 | 1998-05-28 | Lilly Co Eli | Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia |
GB9921578D0 (en) * | 1999-09-13 | 1999-11-17 | Cipla Limited | Omeprazole synthesis |
-
2000
- 2000-04-14 ES ES200000989A patent/ES2171116B1/es not_active Expired - Fee Related
-
2001
- 2001-04-10 DE DE60128736T patent/DE60128736T2/de not_active Expired - Lifetime
- 2001-04-10 US US10/204,604 patent/US6723852B2/en not_active Expired - Fee Related
- 2001-04-10 CA CA2405304A patent/CA2405304C/en not_active Expired - Fee Related
- 2001-04-10 HU HU0300583A patent/HUP0300583A2/hu unknown
- 2001-04-10 EP EP01919463A patent/EP1411053B1/en not_active Expired - Lifetime
- 2001-04-10 JP JP2001576794A patent/JP2003531144A/ja active Pending
- 2001-04-10 NZ NZ521930A patent/NZ521930A/en unknown
- 2001-04-10 DK DK01919463T patent/DK1411053T3/da active
- 2001-04-10 AU AU46551/01A patent/AU780314B2/en not_active Ceased
- 2001-04-10 PT PT01919463T patent/PT1411053E/pt unknown
- 2001-04-10 ES ES01919463T patent/ES2284629T3/es not_active Expired - Lifetime
- 2001-04-10 CN CNB018088791A patent/CN1214027C/zh not_active Expired - Fee Related
- 2001-04-10 MX MXPA02010039A patent/MXPA02010039A/es active IP Right Grant
- 2001-04-10 AT AT01919463T patent/ATE363479T1/de not_active IP Right Cessation
- 2001-04-10 KR KR1020027013675A patent/KR100757346B1/ko not_active IP Right Cessation
- 2001-04-10 WO PCT/ES2001/000143 patent/WO2001079194A1/es active IP Right Grant
-
2002
- 2002-10-08 NO NO20024858A patent/NO323468B1/no not_active IP Right Cessation
-
2007
- 2007-05-31 CY CY20071100725T patent/CY1106632T1/el unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103553A1 (en) * | 1982-08-26 | 1984-03-21 | Aktiebolaget Hässle | Intermediates for the preparation of omeprazole |
US4628098A (en) * | 1984-08-16 | 1986-12-09 | Takeda Chemical Industries, Ltd. | 2-[2-pyridylmethylthio-(sulfinyl)]benzimidazoles |
ES2003658A6 (es) * | 1986-01-20 | 1988-11-01 | Esteve Labor Dr | Procedimiento de preparar derivaods de 2-alquilbenzimidazol. |
ES2026761A6 (es) * | 1990-10-31 | 1992-05-01 | Genesis Para La Investigacion | Procedimiento de obtencion del omeprazol. |
ES2024357A6 (es) * | 1990-12-05 | 1992-02-16 | Genesis Para La Investigacion | Procedimiento de obtencion de halohidrato de 2-halometil-3,5-dimetil-4-metoxipiri-dina. |
EP0729957A1 (en) * | 1993-10-29 | 1996-09-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridine compound and medicinal use thereof |
Non-Patent Citations (1)
Title |
---|
C. FONTENAS, E. BEJAN, H. AIET HADDOU, G.G.A. GALAVOINE, "The Boekelheide reaction: trifluoroacetic anhydride a convenient acylating agent". Synth. Commun., 1995, Vol. 25, No 5, paginas 629-633. * |
Also Published As
Publication number | Publication date |
---|---|
CY1106632T1 (el) | 2012-01-25 |
DE60128736D1 (de) | 2007-07-12 |
KR20030030990A (ko) | 2003-04-18 |
NO20024858L (no) | 2002-12-06 |
JP2003531144A (ja) | 2003-10-21 |
MXPA02010039A (es) | 2004-08-19 |
US6723852B2 (en) | 2004-04-20 |
DE60128736T2 (de) | 2008-02-07 |
EP1411053B1 (en) | 2007-05-30 |
CN1214027C (zh) | 2005-08-10 |
NO20024858D0 (no) | 2002-10-08 |
NO323468B1 (no) | 2007-05-21 |
AU4655101A (en) | 2001-10-30 |
US20030036656A1 (en) | 2003-02-20 |
HUP0300583A2 (hu) | 2003-07-28 |
CA2405304A1 (en) | 2002-10-07 |
PT1411053E (pt) | 2007-07-12 |
EP1411053A1 (en) | 2004-04-21 |
DK1411053T3 (da) | 2007-09-24 |
KR100757346B1 (ko) | 2007-09-11 |
NZ521930A (en) | 2004-07-30 |
ATE363479T1 (de) | 2007-06-15 |
WO2001079194A1 (es) | 2001-10-25 |
CN1427836A (zh) | 2003-07-02 |
AU780314B2 (en) | 2005-03-17 |
ES2284629T3 (es) | 2007-11-16 |
WO2001079194A9 (es) | 2003-05-08 |
ES2171116B1 (es) | 2003-08-01 |
CA2405304C (en) | 2011-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1106632T1 (el) | Μεθοδος ληψης παραγωγων [[(πυριδιλ υποκατεστημενου) μεθυλ] θειο] βενζιμιδαζολιου | |
NO20016087D0 (no) | Benzimidazolforbindelsekrystall | |
EE200400052A (et) | Meetod bensimidasooli-tüüpi ühendite valmistamiseks ning kõrvalsaadusena moodustunud sulfoonide eemaldamiseks | |
ATE105285T1 (de) | Salicylaldehyd- und salicylsaeurederivate sowie deren schwefelanaloge, verfahren zu ihrer herstellung und ihre verwendung als herbizide und bioregulatoren. | |
HUP9603014A2 (hu) | Savas közegben bomlékony benzimidazolszármazékot tartalmazó új, stabilizált galenusi gyógyszerkészítmények és előállításuk | |
CA2387746A1 (en) | Methods for stabilizing benzimidazole-based compounds | |
IS3832A (is) | Hliðstæð aðferð til að framleiða ný antihistamín,sem ekki hafa róandi áhrif, leidd af benzimidazole efnum | |
WO2000047584A3 (de) | Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung | |
ATE216382T1 (de) | Verfahren zur herstellung von 5-methoxy-2-((4- methoxy-3,5-dimethyl-2-pyrydyl)methyl)sulfinyl- h-benzimidazol | |
JP2003531144A5 (es) | ||
ES2023609A6 (es) | Procedimiento para la obtencion del 2-(((3-metil -4-(2,2,2-trifluoroetoxi) -2-piridinil) metilisulfinil) -1h-bemzimidazol. | |
WO1998050361A3 (en) | Synthesis of pharmaceutically useful pyridine derivatives | |
YU59401A (sh) | Postupak za proizvodnju alendronske kiseline | |
YU74601A (sh) | POSTUPAK ZA DOBIJANJE (S-(R*,S*)]-p-[[[1-OkSO-3-(4-PIPERIDINIL)PROPIL]-3-PIPERIDINIL]KARBONIL]AMINO]-3-PIPERIDINPROPIONSKE KISELINE I NJENIH DERIVATA | |
DE60104719D1 (de) | Verfahren zur herstellung von triphendioxazinpigmenten | |
KR100573705B1 (ko) | 설파이드 유도체의 제조 방법 | |
DE60029493D1 (de) | Neues verfahren zur herstellung von 1-phenyl-2-(2-pyridyl)ethanamin | |
AU2003213386A1 (en) | Process for production of optically active compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20020816 Kind code of ref document: A1 Effective date: 20020816 |
|
FG2A | Definitive protection |
Ref document number: 2171116B1 Country of ref document: ES |
|
FD2A | Announcement of lapse in spain |
Effective date: 20180807 |