ATE508124T1 - Verfahren zur herstellung von amorphem rabeprazole-natrium-salz - Google Patents
Verfahren zur herstellung von amorphem rabeprazole-natrium-salzInfo
- Publication number
- ATE508124T1 ATE508124T1 AT04721289T AT04721289T ATE508124T1 AT E508124 T1 ATE508124 T1 AT E508124T1 AT 04721289 T AT04721289 T AT 04721289T AT 04721289 T AT04721289 T AT 04721289T AT E508124 T1 ATE508124 T1 AT E508124T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen atom
- sodium salt
- methoxy group
- rabeprazole sodium
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960004157 rabeprazole Drugs 0.000 title 1
- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 title 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000003462 sulfoxides Chemical class 0.000 abstract 2
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 abstract 1
- -1 3-methoxypropoxy group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003081261 | 2003-03-24 | ||
| PCT/JP2004/003525 WO2004085424A1 (ja) | 2003-03-24 | 2004-03-17 | スルホキシド誘導体またはその塩のアモルファスの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE508124T1 true ATE508124T1 (de) | 2011-05-15 |
Family
ID=33094891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04721289T ATE508124T1 (de) | 2003-03-24 | 2004-03-17 | Verfahren zur herstellung von amorphem rabeprazole-natrium-salz |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20060178406A1 (de) |
| EP (1) | EP1607395B1 (de) |
| JP (1) | JP4787017B2 (de) |
| KR (1) | KR100714375B1 (de) |
| CN (1) | CN100364987C (de) |
| AT (1) | ATE508124T1 (de) |
| AU (1) | AU2004224042B2 (de) |
| CA (1) | CA2516600C (de) |
| DE (1) | DE602004032524D1 (de) |
| IL (1) | IL169791A (de) |
| WO (1) | WO2004085424A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI275587B (en) * | 1999-06-17 | 2007-03-11 | Takeda Chemical Industries Ltd | A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| CA2528993A1 (en) | 2003-06-10 | 2004-12-23 | Teva Pharmaceutical Industries Ltd. | Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
| US7829718B2 (en) | 2004-08-06 | 2010-11-09 | Eisai R&D Management Co., Ltd. | Salts of benzimidazole derivative with amines and process for manufacturing the same |
| AR058440A1 (es) * | 2005-08-02 | 2008-02-06 | Medichem Sa | Procesos para la produccion de rabeprazol sodico amorfo |
| IT1392813B1 (it) * | 2009-02-06 | 2012-03-23 | Dipharma Francis Srl | Forme cristalline di dexlansoprazolo |
| AU2011234001B2 (en) * | 2010-03-31 | 2014-08-28 | Sun Pharmaceutical Industries Limited | Salts of dexlansoprazole and their preparation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| JPH0674272B2 (ja) * | 1986-11-13 | 1994-09-21 | エーザイ株式会社 | ピリジン誘導体及びそれを含有する潰瘍治療剤 |
| FI90544C (fi) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
| JPH08176113A (ja) * | 1993-11-12 | 1996-07-09 | Dainippon Pharmaceut Co Ltd | ２−スルフィニルニコチンアミド誘導体及びその中間体並びにそれを有効成分とする消化性潰瘍治療薬 |
| SE510666C2 (sv) * | 1996-12-20 | 1999-06-14 | Astra Ab | Nya Kristallmodifikationer |
| JP3926936B2 (ja) * | 1998-11-16 | 2007-06-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホキシド誘導体・アセトン錯体およびその製造法 |
| JP4536905B2 (ja) * | 1999-06-17 | 2010-09-01 | 武田薬品工業株式会社 | ベンズイミダゾール化合物の結晶 |
| TWI275587B (en) * | 1999-06-17 | 2007-03-11 | Takeda Chemical Industries Ltd | A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| CA2290893C (en) * | 1999-11-16 | 2007-05-01 | Bernard Charles Sherman | Magnesium omeprazole |
| CA2409258A1 (en) | 2000-05-15 | 2001-11-22 | Ranbaxy Laboratories Limited | Novel amorphous form of omeprazole salts |
| ATE342263T1 (de) * | 2000-08-04 | 2006-11-15 | Takeda Pharmaceutical | Salze von benzimidazol-derivaten und deren verwendung |
| WO2004002982A2 (en) * | 2002-06-27 | 2004-01-08 | Dr. Reddy's Laboratories Limited | A process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof |
| CA2771725C (en) * | 2002-10-16 | 2015-08-18 | Takeda Pharmaceutical Company Limited | Solid preparation comprising a non-toxic base and a proton pump inhibitor |
| WO2004056804A2 (en) * | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
-
2004
- 2004-03-17 AT AT04721289T patent/ATE508124T1/de not_active IP Right Cessation
- 2004-03-17 EP EP04721289A patent/EP1607395B1/de not_active Expired - Lifetime
- 2004-03-17 KR KR1020057015526A patent/KR100714375B1/ko not_active Expired - Fee Related
- 2004-03-17 CN CNB2004800055704A patent/CN100364987C/zh not_active Expired - Fee Related
- 2004-03-17 US US10/546,994 patent/US20060178406A1/en not_active Abandoned
- 2004-03-17 CA CA2516600A patent/CA2516600C/en not_active Expired - Fee Related
- 2004-03-17 DE DE602004032524T patent/DE602004032524D1/de not_active Expired - Lifetime
- 2004-03-17 JP JP2005504007A patent/JP4787017B2/ja not_active Expired - Fee Related
- 2004-03-17 WO PCT/JP2004/003525 patent/WO2004085424A1/ja not_active Ceased
- 2004-03-17 AU AU2004224042A patent/AU2004224042B2/en not_active Ceased
-
2005
- 2005-07-20 IL IL169791A patent/IL169791A/en not_active IP Right Cessation
-
2007
- 2007-11-13 US US11/939,418 patent/US7754887B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7754887B2 (en) | 2010-07-13 |
| US20060178406A1 (en) | 2006-08-10 |
| JP4787017B2 (ja) | 2011-10-05 |
| KR100714375B1 (ko) | 2007-05-02 |
| AU2004224042B2 (en) | 2010-03-25 |
| IL169791A (en) | 2012-04-30 |
| CA2516600C (en) | 2011-04-05 |
| CN1756751A (zh) | 2006-04-05 |
| WO2004085424A1 (ja) | 2004-10-07 |
| JPWO2004085424A1 (ja) | 2006-06-29 |
| AU2004224042A1 (en) | 2004-10-07 |
| EP1607395A4 (de) | 2009-06-03 |
| IL169791A0 (en) | 2007-07-04 |
| EP1607395B1 (de) | 2011-05-04 |
| US20080214828A1 (en) | 2008-09-04 |
| CN100364987C (zh) | 2008-01-30 |
| EP1607395A1 (de) | 2005-12-21 |
| DE602004032524D1 (de) | 2011-06-16 |
| KR20050108360A (ko) | 2005-11-16 |
| CA2516600A1 (en) | 2004-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |