DE602004032524D1 - Verfahren zur herstellung von amorphem rabeprazole-natrium-salz - Google Patents
Verfahren zur herstellung von amorphem rabeprazole-natrium-salzInfo
- Publication number
- DE602004032524D1 DE602004032524D1 DE602004032524T DE602004032524T DE602004032524D1 DE 602004032524 D1 DE602004032524 D1 DE 602004032524D1 DE 602004032524 T DE602004032524 T DE 602004032524T DE 602004032524 T DE602004032524 T DE 602004032524T DE 602004032524 D1 DE602004032524 D1 DE 602004032524D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- hydrogen atom
- amorphic
- preparation
- methoxy group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229960004157 rabeprazole Drugs 0.000 title 1
- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 title 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000003462 sulfoxides Chemical class 0.000 abstract 2
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 abstract 1
- -1 3-methoxypropoxy group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003081261 | 2003-03-24 | ||
| PCT/JP2004/003525 WO2004085424A1 (ja) | 2003-03-24 | 2004-03-17 | スルホキシド誘導体またはその塩のアモルファスの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004032524D1 true DE602004032524D1 (de) | 2011-06-16 |
Family
ID=33094891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004032524T Expired - Lifetime DE602004032524D1 (de) | 2003-03-24 | 2004-03-17 | Verfahren zur herstellung von amorphem rabeprazole-natrium-salz |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20060178406A1 (de) |
| EP (1) | EP1607395B1 (de) |
| JP (1) | JP4787017B2 (de) |
| KR (1) | KR100714375B1 (de) |
| CN (1) | CN100364987C (de) |
| AT (1) | ATE508124T1 (de) |
| AU (1) | AU2004224042B2 (de) |
| CA (1) | CA2516600C (de) |
| DE (1) | DE602004032524D1 (de) |
| IL (1) | IL169791A (de) |
| WO (1) | WO2004085424A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI289557B (en) * | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| MXPA05013316A (es) | 2003-06-10 | 2006-03-17 | Teva Pharma | Proceso para preparar bencimidazoles 2[-(piridinil)metil]sulfinil-sustituidos y derivados clorados novedosos de pantoprazol. |
| US7829718B2 (en) | 2004-08-06 | 2010-11-09 | Eisai R&D Management Co., Ltd. | Salts of benzimidazole derivative with amines and process for manufacturing the same |
| AR058440A1 (es) * | 2005-08-02 | 2008-02-06 | Medichem Sa | Procesos para la produccion de rabeprazol sodico amorfo |
| IT1392813B1 (it) * | 2009-02-06 | 2012-03-23 | Dipharma Francis Srl | Forme cristalline di dexlansoprazolo |
| EP2552903A1 (de) * | 2010-03-31 | 2013-02-06 | Ranbaxy Laboratories Limited | Dexlansoprazolsalze und ihre zubereitung |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| FI90544C (fi) * | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
| JPH0674272B2 (ja) * | 1986-11-13 | 1994-09-21 | エーザイ株式会社 | ピリジン誘導体及びそれを含有する潰瘍治療剤 |
| JPH08176113A (ja) * | 1993-11-12 | 1996-07-09 | Dainippon Pharmaceut Co Ltd | ２−スルフィニルニコチンアミド誘導体及びその中間体並びにそれを有効成分とする消化性潰瘍治療薬 |
| SE510666C2 (sv) * | 1996-12-20 | 1999-06-14 | Astra Ab | Nya Kristallmodifikationer |
| JP3926936B2 (ja) * | 1998-11-16 | 2007-06-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホキシド誘導体・アセトン錯体およびその製造法 |
| JP4536905B2 (ja) * | 1999-06-17 | 2010-09-01 | 武田薬品工業株式会社 | ベンズイミダゾール化合物の結晶 |
| TWI289557B (en) * | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| CA2290893C (en) * | 1999-11-16 | 2007-05-01 | Bernard Charles Sherman | Magnesium omeprazole |
| BR0110926A (pt) | 2000-05-15 | 2004-02-17 | Ranbaxy Lab Ltd | Novas formas amorfas de sais de omeprazol e processo de preparação dos mesmos |
| JP5412023B2 (ja) * | 2000-08-04 | 2014-02-12 | 武田薬品工業株式会社 | ベンズイミダゾール化合物の塩およびその用途 |
| US7169793B2 (en) * | 2002-06-27 | 2007-01-30 | Dr. Reddy's Laboratories Limited | Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof |
| WO2004035052A1 (ja) * | 2002-10-16 | 2004-04-29 | Takeda Pharmaceutical Company Limited | 安定な固形製剤 |
| CA2510849A1 (en) * | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
-
2004
- 2004-03-17 DE DE602004032524T patent/DE602004032524D1/de not_active Expired - Lifetime
- 2004-03-17 CA CA2516600A patent/CA2516600C/en not_active Expired - Fee Related
- 2004-03-17 WO PCT/JP2004/003525 patent/WO2004085424A1/ja active Application Filing
- 2004-03-17 US US10/546,994 patent/US20060178406A1/en not_active Abandoned
- 2004-03-17 AT AT04721289T patent/ATE508124T1/de not_active IP Right Cessation
- 2004-03-17 KR KR1020057015526A patent/KR100714375B1/ko not_active IP Right Cessation
- 2004-03-17 JP JP2005504007A patent/JP4787017B2/ja not_active Expired - Fee Related
- 2004-03-17 AU AU2004224042A patent/AU2004224042B2/en not_active Ceased
- 2004-03-17 CN CNB2004800055704A patent/CN100364987C/zh not_active Expired - Fee Related
- 2004-03-17 EP EP04721289A patent/EP1607395B1/de not_active Expired - Lifetime
-
2005
- 2005-07-20 IL IL169791A patent/IL169791A/en not_active IP Right Cessation
-
2007
- 2007-11-13 US US11/939,418 patent/US7754887B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL169791A (en) | 2012-04-30 |
| US20080214828A1 (en) | 2008-09-04 |
| IL169791A0 (en) | 2007-07-04 |
| ATE508124T1 (de) | 2011-05-15 |
| US20060178406A1 (en) | 2006-08-10 |
| AU2004224042B2 (en) | 2010-03-25 |
| CN100364987C (zh) | 2008-01-30 |
| KR20050108360A (ko) | 2005-11-16 |
| EP1607395B1 (de) | 2011-05-04 |
| EP1607395A1 (de) | 2005-12-21 |
| CN1756751A (zh) | 2006-04-05 |
| WO2004085424A1 (ja) | 2004-10-07 |
| JP4787017B2 (ja) | 2011-10-05 |
| EP1607395A4 (de) | 2009-06-03 |
| CA2516600A1 (en) | 2004-10-07 |
| US7754887B2 (en) | 2010-07-13 |
| KR100714375B1 (ko) | 2007-05-02 |
| AU2004224042A1 (en) | 2004-10-07 |
| CA2516600C (en) | 2011-04-05 |
| JPWO2004085424A1 (ja) | 2006-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG106622A (en) | Process for preparing 4-trifluoromethylsulphinylpyrazole derivative | |
| TW200616994A (en) | Novel thiophene derivatives | |
| NZ536734A (en) | Spiroindolinepiperidine derivatives | |
| HK1038227A1 (en) | Crystalline form of (r)-2-ÄÄÄ3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinylÜmethylÜsulfinylÜ-1h-benzimidazole | |
| TW200745077A (en) | Thiophene compound having sulfonyl group and process for producing the same | |
| GEP20105071B (en) | Processes for preparing 4-(phenoxy-5-methyl-pyrimidin-4-yloxy) piperidine-1-carboxylic acid derivatives and related compounds | |
| ATE420875T1 (de) | Verfahren zur herstellung von 5-(4-ä4-(5-cyano-3- indolyl)-butylü-1-piperazinyl)-benzofuran-2- carboxamid | |
| ATE260275T1 (de) | Substituierte thien-3-yl- sulfonylamino(thio)carbonyl-triazolin(thi)one | |
| IL169791A0 (en) | Process for producing sulfoxide derivatives or salts thereof in the amorphous state | |
| NO20071008L (no) | Fremgangsmate for fremstilling av N-piperidino-1,5-difenylpyrazol-3-karboksamidderivater | |
| WO2009095792A3 (en) | Substituted heteroarylamide diazepinopyrimidone derivatives | |
| WO2008155668A3 (en) | Heteroarylamide pyrimidone compounds | |
| TW200738667A (en) | Preparation method for dioxan-2-ylalkylcarbamate derivatives and intermediate thereof | |
| ATE429429T1 (de) | Pharmazeutisches verfahren und damit hergestellte verbindungen | |
| NO20071319L (no) | Fremgangsmate for fremstilling av isotiazolderivater. | |
| WO2007000505A3 (fr) | Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique | |
| AU9025601A (en) | Cephem compounds and esbl-detecting reagents containing the same | |
| TW200745038A (en) | Improved process for the production of nitroguanidine derivative | |
| ATE315568T1 (de) | Verfahren zur herstellung antibakterieller verbindungen vom carbapenem-typ | |
| DK1565441T3 (da) | Fremgangsmåde til fremstilling af 2-aminomethylpyridinderivater | |
| ATE312867T1 (de) | Substituierter polyaryletherformk rper, verfahren zu seiner herstellung und seine verwendung | |
| HUP0300381A2 (hu) | Új kapcsolási eljárás | |
| ATE264314T1 (de) | Benzoxazol-derivate, verfahren zu ihrer herstellung und herbizide | |
| AU2002214266A1 (en) | Carbamate derivatives, process for producing the same and use thereof | |
| PT1602650E (pt) | Processo para a preparação de quetiapina por n-alquilação redutiva de 11-piperazinodibenzo(b,f)(1,4)-tioazepina com um aldeído |