DE3626375A1 - Cephalosporinsalze und diese enthaltende injizierbare mittel - Google Patents

Cephalosporinsalze und diese enthaltende injizierbare mittel

Info

Publication number
DE3626375A1
DE3626375A1 DE19863626375 DE3626375A DE3626375A1 DE 3626375 A1 DE3626375 A1 DE 3626375A1 DE 19863626375 DE19863626375 DE 19863626375 DE 3626375 A DE3626375 A DE 3626375A DE 3626375 A1 DE3626375 A1 DE 3626375A1
Authority
DE
Germany
Prior art keywords
acid addition
salts
crystalline
zwitterion
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19863626375
Other languages
German (de)
English (en)
Inventor
Murray A Kaplan
Thomas W Hudyma
Robert A Lipper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DE3626375A1 publication Critical patent/DE3626375A1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
DE19863626375 1985-08-05 1986-08-04 Cephalosporinsalze und diese enthaltende injizierbare mittel Ceased DE3626375A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05

Publications (1)

Publication Number Publication Date
DE3626375A1 true DE3626375A1 (de) 1987-02-12

Family

ID=25064475

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19863626375 Ceased DE3626375A1 (de) 1985-08-05 1986-08-04 Cephalosporinsalze und diese enthaltende injizierbare mittel

Country Status (34)

Country Link
JP (1) JPH0615548B2 (fr)
KR (1) KR930003121B1 (fr)
AR (1) AR243894A1 (fr)
AT (1) AT390957B (fr)
AU (1) AU597262B2 (fr)
BE (1) BE905219A (fr)
CA (1) CA1284994C (fr)
CH (1) CH675581A5 (fr)
CS (2) CS276849B6 (fr)
CY (1) CY1614A (fr)
DD (2) DD254941A5 (fr)
DE (1) DE3626375A1 (fr)
DK (1) DK162053C (fr)
EG (1) EG18003A (fr)
ES (1) ES2002112A6 (fr)
FI (1) FI84484C (fr)
FR (1) FR2585705B1 (fr)
GB (1) GB2179936B (fr)
GR (1) GR862055B (fr)
HK (1) HK99691A (fr)
HU (1) HU196602B (fr)
IE (1) IE59222B1 (fr)
IL (1) IL79608A (fr)
IT (1) IT1197067B (fr)
LU (2) LU86540A1 (fr)
MY (1) MY102212A (fr)
NL (1) NL8601991A (fr)
OA (1) OA08672A (fr)
PT (1) PT83134B (fr)
SE (1) SE469633B (fr)
SG (1) SG79791G (fr)
SU (1) SU1516013A3 (fr)
YU (1) YU45793B (fr)
ZA (1) ZA865842B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901359A1 (de) * 1988-01-19 1989-10-05 Bristol Myers Co Cephalosporinsalze und injizierbare mittel
WO2008056221A2 (fr) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Sel de sulfate cristallin d'antibiotique céphalosporine
US7592447B2 (en) 2003-12-23 2009-09-22 Sandoz Ag Process for production of intermediates for use in cefalosporin synthesis

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988010263A1 (fr) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Composes cristallins de cephalosporine, procede de preparation et produits intermediaires pour la preparation de ces composes
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (fr) * 1989-03-06 1999-11-16 Murray A. Kaplan Dihydrochlorure de bmy-28142 lyophilise pour usage parenteral
CA2101571A1 (fr) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Dihydrate cristallise d'un sel de cephalosporine dihydrate; compositions injectables a base de ce compose
EP0638573A1 (fr) * 1993-08-10 1995-02-15 Lucky Ltd. Hydrates crystallins d'une céphalosporine et procédé pour leur préparation
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3307550A1 (de) * 1982-03-04 1983-09-15 Bristol-Myers Co., 10154 New York, N.Y. Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten
EP0121244A2 (fr) * 1983-03-30 1984-10-10 Bristol-Myers Company Dérivés de céphalosporine
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
DE3534857A1 (de) * 1984-10-01 1986-04-10 Glaxo Group Ltd., London Cephalosporinsulfoxide, verfahren zu deren herstellung und deren verwendung bei der herstellung von cephalosporinen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3307550A1 (de) * 1982-03-04 1983-09-15 Bristol-Myers Co., 10154 New York, N.Y. Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten
DE3307550C2 (fr) * 1982-03-04 1988-11-24 Bristol-Myers Co., New York, N.Y., Us
EP0121244A2 (fr) * 1983-03-30 1984-10-10 Bristol-Myers Company Dérivés de céphalosporine
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
DE3534857A1 (de) * 1984-10-01 1986-04-10 Glaxo Group Ltd., London Cephalosporinsulfoxide, verfahren zu deren herstellung und deren verwendung bei der herstellung von cephalosporinen

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901359A1 (de) * 1988-01-19 1989-10-05 Bristol Myers Co Cephalosporinsalze und injizierbare mittel
US7592447B2 (en) 2003-12-23 2009-09-22 Sandoz Ag Process for production of intermediates for use in cefalosporin synthesis
WO2008056221A2 (fr) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Sel de sulfate cristallin d'antibiotique céphalosporine
WO2008056221A3 (fr) * 2006-11-06 2008-07-17 Orchid Chemicals & Pharm Ltd Sel de sulfate cristallin d'antibiotique céphalosporine

Also Published As

Publication number Publication date
ES2002112A6 (es) 1988-07-16
OA08672A (en) 1989-03-31
SE469633B (sv) 1993-08-09
GB8618989D0 (en) 1986-09-17
CA1284994C (fr) 1991-06-18
AR243894A1 (es) 1993-09-30
FI863155A0 (fi) 1986-08-01
CS276849B6 (en) 1992-08-12
DK371886D0 (da) 1986-08-04
SG79791G (en) 1991-11-15
HUT41802A (en) 1987-05-28
DK162053C (da) 1992-02-10
JPS62103090A (ja) 1987-05-13
IL79608A0 (en) 1986-11-30
YU137186A (en) 1987-12-31
CH675581A5 (fr) 1990-10-15
AT390957B (de) 1990-07-25
EG18003A (en) 1991-08-30
DD268395A5 (de) 1989-05-31
GB2179936A (en) 1987-03-18
JPH0615548B2 (ja) 1994-03-02
KR880002530A (ko) 1988-05-09
CY1614A (en) 1992-07-10
AU6069486A (en) 1987-02-12
NL8601991A (nl) 1987-03-02
AU597262B2 (en) 1990-05-31
SU1516013A3 (ru) 1989-10-15
IT1197067B (it) 1988-11-25
YU45793B (sh) 1992-07-20
IL79608A (en) 1991-07-18
CS276717B6 (en) 1992-08-12
DK162053B (da) 1991-09-09
MY102212A (en) 1992-05-15
FR2585705A1 (fr) 1987-02-06
SE8603308D0 (sv) 1986-08-04
IT8621409A1 (it) 1988-02-04
PT83134B (pt) 1989-07-31
IT8621409A0 (it) 1986-08-04
FI84484B (fi) 1991-08-30
BE905219A (fr) 1987-02-04
IE862078L (en) 1987-02-05
IE59222B1 (en) 1994-01-26
HK99691A (en) 1991-12-13
DD254941A5 (de) 1988-03-16
ATA211086A (de) 1990-01-15
GR862055B (en) 1986-12-24
KR930003121B1 (ko) 1993-04-19
SE8603308L (sv) 1987-02-06
LU86540A1 (fr) 1987-03-06
FR2585705B1 (fr) 1989-01-13
FI84484C (fi) 1991-12-10
PT83134A (en) 1986-09-01
ZA865842B (en) 1987-04-29
HU196602B (en) 1988-12-28
GB2179936B (en) 1989-04-26
DK371886A (da) 1987-02-06
LU88574I2 (fr) 1995-03-01
FI863155A (fi) 1987-02-06

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: BRISTOL-MYERS SQUIBB CO. (N.D.GES.D.STAATES DELAWA

8128 New person/name/address of the agent

Representative=s name: KINZEBACH, W., DIPL.-CHEM. DR.PHIL. RIEDL, P., DIP

8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D501/46

8131 Rejection