KR930003121B1 - 세팔로스포린염의 제조방법 - Google Patents

세팔로스포린염의 제조방법 Download PDF

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Publication number
KR930003121B1
KR930003121B1 KR1019860006445A KR860006445A KR930003121B1 KR 930003121 B1 KR930003121 B1 KR 930003121B1 KR 1019860006445 A KR1019860006445 A KR 1019860006445A KR 860006445 A KR860006445 A KR 860006445A KR 930003121 B1 KR930003121 B1 KR 930003121B1
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KR
South Korea
Prior art keywords
methyl
aminothiazol
pyrrolidinio
carboxylate
methoxyiminoacetamido
Prior art date
Application number
KR1019860006445A
Other languages
English (en)
Korean (ko)
Other versions
KR880002530A (ko
Inventor
에이. 카플렌 머레이
더블유. 휴디마 토마스
에이. 립퍼 로버트
Original Assignee
브리스톨-마이어즈 스퀴브 캄파니
이삭 쟈코브스키
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 브리스톨-마이어즈 스퀴브 캄파니, 이삭 쟈코브스키 filed Critical 브리스톨-마이어즈 스퀴브 캄파니
Publication of KR880002530A publication Critical patent/KR880002530A/ko
Application granted granted Critical
Publication of KR930003121B1 publication Critical patent/KR930003121B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019860006445A 1985-08-05 1986-08-05 세팔로스포린염의 제조방법 KR930003121B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05
US762235 1985-08-05
US762,235 1985-08-05

Publications (2)

Publication Number Publication Date
KR880002530A KR880002530A (ko) 1988-05-09
KR930003121B1 true KR930003121B1 (ko) 1993-04-19

Family

ID=25064475

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860006445A KR930003121B1 (ko) 1985-08-05 1986-08-05 세팔로스포린염의 제조방법

Country Status (34)

Country Link
JP (1) JPH0615548B2 (fr)
KR (1) KR930003121B1 (fr)
AR (1) AR243894A1 (fr)
AT (1) AT390957B (fr)
AU (1) AU597262B2 (fr)
BE (1) BE905219A (fr)
CA (1) CA1284994C (fr)
CH (1) CH675581A5 (fr)
CS (2) CS276849B6 (fr)
CY (1) CY1614A (fr)
DD (2) DD254941A5 (fr)
DE (1) DE3626375A1 (fr)
DK (1) DK162053C (fr)
EG (1) EG18003A (fr)
ES (1) ES2002112A6 (fr)
FI (1) FI84484C (fr)
FR (1) FR2585705B1 (fr)
GB (1) GB2179936B (fr)
GR (1) GR862055B (fr)
HK (1) HK99691A (fr)
HU (1) HU196602B (fr)
IE (1) IE59222B1 (fr)
IL (1) IL79608A (fr)
IT (1) IT1197067B (fr)
LU (2) LU86540A1 (fr)
MY (1) MY102212A (fr)
NL (1) NL8601991A (fr)
OA (1) OA08672A (fr)
PT (1) PT83134B (fr)
SE (1) SE469633B (fr)
SG (1) SG79791G (fr)
SU (1) SU1516013A3 (fr)
YU (1) YU45793B (fr)
ZA (1) ZA865842B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988010263A1 (fr) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Composes cristallins de cephalosporine, procede de preparation et produits intermediaires pour la preparation de ces composes
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (fr) * 1989-03-06 1999-11-16 Murray A. Kaplan Dihydrochlorure de bmy-28142 lyophilise pour usage parenteral
CA2101571A1 (fr) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Dihydrate cristallise d'un sel de cephalosporine dihydrate; compositions injectables a base de ce compose
EP0638573A1 (fr) * 1993-08-10 1995-02-15 Lucky Ltd. Hydrates crystallins d'une céphalosporine et procédé pour leur préparation
CN100543027C (zh) 2003-12-23 2009-09-23 桑多斯有限公司 制备用于合成头孢菌素的中间体的方法
WO2008056221A2 (fr) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Sel de sulfate cristallin d'antibiotique céphalosporine
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
CA1213882A (fr) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporines
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
ES2002112A6 (es) 1988-07-16
OA08672A (en) 1989-03-31
SE469633B (sv) 1993-08-09
GB8618989D0 (en) 1986-09-17
CA1284994C (fr) 1991-06-18
AR243894A1 (es) 1993-09-30
FI863155A0 (fi) 1986-08-01
CS276849B6 (en) 1992-08-12
DK371886D0 (da) 1986-08-04
SG79791G (en) 1991-11-15
HUT41802A (en) 1987-05-28
DK162053C (da) 1992-02-10
JPS62103090A (ja) 1987-05-13
IL79608A0 (en) 1986-11-30
YU137186A (en) 1987-12-31
CH675581A5 (fr) 1990-10-15
AT390957B (de) 1990-07-25
EG18003A (en) 1991-08-30
DD268395A5 (de) 1989-05-31
GB2179936A (en) 1987-03-18
JPH0615548B2 (ja) 1994-03-02
KR880002530A (ko) 1988-05-09
CY1614A (en) 1992-07-10
AU6069486A (en) 1987-02-12
NL8601991A (nl) 1987-03-02
AU597262B2 (en) 1990-05-31
SU1516013A3 (ru) 1989-10-15
IT1197067B (it) 1988-11-25
YU45793B (sh) 1992-07-20
IL79608A (en) 1991-07-18
CS276717B6 (en) 1992-08-12
DK162053B (da) 1991-09-09
MY102212A (en) 1992-05-15
FR2585705A1 (fr) 1987-02-06
SE8603308D0 (sv) 1986-08-04
IT8621409A1 (it) 1988-02-04
PT83134B (pt) 1989-07-31
IT8621409A0 (it) 1986-08-04
FI84484B (fi) 1991-08-30
BE905219A (fr) 1987-02-04
IE862078L (en) 1987-02-05
IE59222B1 (en) 1994-01-26
HK99691A (en) 1991-12-13
DD254941A5 (de) 1988-03-16
ATA211086A (de) 1990-01-15
GR862055B (en) 1986-12-24
SE8603308L (sv) 1987-02-06
LU86540A1 (fr) 1987-03-06
FR2585705B1 (fr) 1989-01-13
FI84484C (fi) 1991-12-10
PT83134A (en) 1986-09-01
ZA865842B (en) 1987-04-29
HU196602B (en) 1988-12-28
GB2179936B (en) 1989-04-26
DK371886A (da) 1987-02-06
LU88574I2 (fr) 1995-03-01
FI863155A (fi) 1987-02-06
DE3626375A1 (de) 1987-02-12

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