DD254941A5 - Verfahren zur herstellung temperaturstabiler kristalline salze von 7-(delta-(2-aminothiazol-4-yl)-2-(z)methoxyiminoacetamido)-3-((1-methyl-1-pyrrolidinio)-methyl)-3-cephem-4-carboxylat (zwitterion) - Google Patents

Verfahren zur herstellung temperaturstabiler kristalline salze von 7-(delta-(2-aminothiazol-4-yl)-2-(z)methoxyiminoacetamido)-3-((1-methyl-1-pyrrolidinio)-methyl)-3-cephem-4-carboxylat (zwitterion) Download PDF

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Publication number
DD254941A5
DD254941A5 DD86293433A DD29343386A DD254941A5 DD 254941 A5 DD254941 A5 DD 254941A5 DD 86293433 A DD86293433 A DD 86293433A DD 29343386 A DD29343386 A DD 29343386A DD 254941 A5 DD254941 A5 DD 254941A5
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DD
German Democratic Republic
Prior art keywords
zwitterion
acid addition
crystalline
methyl
salts
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DD86293433A
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German (de)
English (en)
Inventor
Kaplan
Hudyma
Lipper
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Publication of DD254941A5 publication Critical patent/DD254941A5/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
DD86293433A 1985-08-05 1986-08-05 Verfahren zur herstellung temperaturstabiler kristalline salze von 7-(delta-(2-aminothiazol-4-yl)-2-(z)methoxyiminoacetamido)-3-((1-methyl-1-pyrrolidinio)-methyl)-3-cephem-4-carboxylat (zwitterion) DD254941A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05

Publications (1)

Publication Number Publication Date
DD254941A5 true DD254941A5 (de) 1988-03-16

Family

ID=25064475

Family Applications (2)

Application Number Title Priority Date Filing Date
DD86293433A DD254941A5 (de) 1985-08-05 1986-08-05 Verfahren zur herstellung temperaturstabiler kristalline salze von 7-(delta-(2-aminothiazol-4-yl)-2-(z)methoxyiminoacetamido)-3-((1-methyl-1-pyrrolidinio)-methyl)-3-cephem-4-carboxylat (zwitterion)
DD88314213A DD268395A5 (de) 1985-08-05 1988-03-30 Verfahren zur herstellung eines physikalischen gemisches aus einem cepalosporin-saeureadditionssalz und einer organischen oder anorganischen base

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD88314213A DD268395A5 (de) 1985-08-05 1988-03-30 Verfahren zur herstellung eines physikalischen gemisches aus einem cepalosporin-saeureadditionssalz und einer organischen oder anorganischen base

Country Status (34)

Country Link
JP (1) JPH0615548B2 (fr)
KR (1) KR930003121B1 (fr)
AR (1) AR243894A1 (fr)
AT (1) AT390957B (fr)
AU (1) AU597262B2 (fr)
BE (1) BE905219A (fr)
CA (1) CA1284994C (fr)
CH (1) CH675581A5 (fr)
CS (2) CS276849B6 (fr)
CY (1) CY1614A (fr)
DD (2) DD254941A5 (fr)
DE (1) DE3626375A1 (fr)
DK (1) DK162053C (fr)
EG (1) EG18003A (fr)
ES (1) ES2002112A6 (fr)
FI (1) FI84484C (fr)
FR (1) FR2585705B1 (fr)
GB (1) GB2179936B (fr)
GR (1) GR862055B (fr)
HK (1) HK99691A (fr)
HU (1) HU196602B (fr)
IE (1) IE59222B1 (fr)
IL (1) IL79608A (fr)
IT (1) IT1197067B (fr)
LU (2) LU86540A1 (fr)
MY (1) MY102212A (fr)
NL (1) NL8601991A (fr)
OA (1) OA08672A (fr)
PT (1) PT83134B (fr)
SE (1) SE469633B (fr)
SG (1) SG79791G (fr)
SU (1) SU1516013A3 (fr)
YU (1) YU45793B (fr)
ZA (1) ZA865842B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988010263A1 (fr) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Composes cristallins de cephalosporine, procede de preparation et produits intermediaires pour la preparation de ces composes
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (fr) * 1989-03-06 1999-11-16 Murray A. Kaplan Dihydrochlorure de bmy-28142 lyophilise pour usage parenteral
CA2101571A1 (fr) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Dihydrate cristallise d'un sel de cephalosporine dihydrate; compositions injectables a base de ce compose
EP0638573A1 (fr) * 1993-08-10 1995-02-15 Lucky Ltd. Hydrates crystallins d'une céphalosporine et procédé pour leur préparation
CN100543027C (zh) 2003-12-23 2009-09-23 桑多斯有限公司 制备用于合成头孢菌素的中间体的方法
WO2008056221A2 (fr) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Sel de sulfate cristallin d'antibiotique céphalosporine
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
CA1213882A (fr) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporines
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
ES2002112A6 (es) 1988-07-16
OA08672A (en) 1989-03-31
SE469633B (sv) 1993-08-09
GB8618989D0 (en) 1986-09-17
CA1284994C (fr) 1991-06-18
AR243894A1 (es) 1993-09-30
FI863155A0 (fi) 1986-08-01
CS276849B6 (en) 1992-08-12
DK371886D0 (da) 1986-08-04
SG79791G (en) 1991-11-15
HUT41802A (en) 1987-05-28
DK162053C (da) 1992-02-10
JPS62103090A (ja) 1987-05-13
IL79608A0 (en) 1986-11-30
YU137186A (en) 1987-12-31
CH675581A5 (fr) 1990-10-15
AT390957B (de) 1990-07-25
EG18003A (en) 1991-08-30
DD268395A5 (de) 1989-05-31
GB2179936A (en) 1987-03-18
JPH0615548B2 (ja) 1994-03-02
KR880002530A (ko) 1988-05-09
CY1614A (en) 1992-07-10
AU6069486A (en) 1987-02-12
NL8601991A (nl) 1987-03-02
AU597262B2 (en) 1990-05-31
SU1516013A3 (ru) 1989-10-15
IT1197067B (it) 1988-11-25
YU45793B (sh) 1992-07-20
IL79608A (en) 1991-07-18
CS276717B6 (en) 1992-08-12
DK162053B (da) 1991-09-09
MY102212A (en) 1992-05-15
FR2585705A1 (fr) 1987-02-06
SE8603308D0 (sv) 1986-08-04
IT8621409A1 (it) 1988-02-04
PT83134B (pt) 1989-07-31
IT8621409A0 (it) 1986-08-04
FI84484B (fi) 1991-08-30
BE905219A (fr) 1987-02-04
IE862078L (en) 1987-02-05
IE59222B1 (en) 1994-01-26
HK99691A (en) 1991-12-13
ATA211086A (de) 1990-01-15
GR862055B (en) 1986-12-24
KR930003121B1 (ko) 1993-04-19
SE8603308L (sv) 1987-02-06
LU86540A1 (fr) 1987-03-06
FR2585705B1 (fr) 1989-01-13
FI84484C (fi) 1991-12-10
PT83134A (en) 1986-09-01
ZA865842B (en) 1987-04-29
HU196602B (en) 1988-12-28
GB2179936B (en) 1989-04-26
DK371886A (da) 1987-02-06
LU88574I2 (fr) 1995-03-01
FI863155A (fi) 1987-02-06
DE3626375A1 (de) 1987-02-12

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Expiry date: 20060806