GB2179936B - Cephalosporin salts and injectable compositions - Google Patents

Cephalosporin salts and injectable compositions

Info

Publication number
GB2179936B
GB2179936B GB8618989A GB8618989A GB2179936B GB 2179936 B GB2179936 B GB 2179936B GB 8618989 A GB8618989 A GB 8618989A GB 8618989 A GB8618989 A GB 8618989A GB 2179936 B GB2179936 B GB 2179936B
Authority
GB
United Kingdom
Prior art keywords
injectable compositions
cephalosporin salts
cephalosporin
salts
injectable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8618989A
Other versions
GB8618989D0 (en
GB2179936A (en
Inventor
Murray Arthur Kaplan
Thomas W Hudyma
Robert Alan Lipper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB8618989D0 publication Critical patent/GB8618989D0/en
Publication of GB2179936A publication Critical patent/GB2179936A/en
Priority to MYPI87002279A priority Critical patent/MY102212A/en
Application granted granted Critical
Publication of GB2179936B publication Critical patent/GB2179936B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
GB8618989A 1985-08-05 1986-08-04 Cephalosporin salts and injectable compositions Expired GB2179936B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MYPI87002279A MY102212A (en) 1985-08-05 1987-09-29 Cephalosporin salts and injectable compositions.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05

Publications (3)

Publication Number Publication Date
GB8618989D0 GB8618989D0 (en) 1986-09-17
GB2179936A GB2179936A (en) 1987-03-18
GB2179936B true GB2179936B (en) 1989-04-26

Family

ID=25064475

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8618989A Expired GB2179936B (en) 1985-08-05 1986-08-04 Cephalosporin salts and injectable compositions

Country Status (34)

Country Link
JP (1) JPH0615548B2 (en)
KR (1) KR930003121B1 (en)
AR (1) AR243894A1 (en)
AT (1) AT390957B (en)
AU (1) AU597262B2 (en)
BE (1) BE905219A (en)
CA (1) CA1284994C (en)
CH (1) CH675581A5 (en)
CS (2) CS276849B6 (en)
CY (1) CY1614A (en)
DD (2) DD254941A5 (en)
DE (1) DE3626375A1 (en)
DK (1) DK162053C (en)
EG (1) EG18003A (en)
ES (1) ES2002112A6 (en)
FI (1) FI84484C (en)
FR (1) FR2585705B1 (en)
GB (1) GB2179936B (en)
GR (1) GR862055B (en)
HK (1) HK99691A (en)
HU (1) HU196602B (en)
IE (1) IE59222B1 (en)
IL (1) IL79608A (en)
IT (1) IT1197067B (en)
LU (2) LU88574I2 (en)
MY (1) MY102212A (en)
NL (1) NL8601991A (en)
OA (1) OA08672A (en)
PT (1) PT83134B (en)
SE (1) SE469633B (en)
SG (1) SG79791G (en)
SU (1) SU1516013A3 (en)
YU (1) YU45793B (en)
ZA (1) ZA865842B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988010263A1 (en) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
JPH02101081A (en) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd Crystalline dihydrochloride of cephalosporin derivative and production thereof
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
DE602004011685T2 (en) 2003-12-23 2009-02-05 Sandoz Gmbh PROCESS FOR PREPARING INTERMEDIATE PRODUCTS FOR USE IN THE CEFALOSPORIN SYNTHESIS
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (en) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2116180A (en) * 1982-03-04 1983-09-21 Bristol Myers Co Cephalosporin derivatives
GB2165245A (en) * 1984-10-01 1986-04-09 Glaxo Group Ltd Chemical compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (en) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING CEPHALOSPORINES
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2116180A (en) * 1982-03-04 1983-09-21 Bristol Myers Co Cephalosporin derivatives
GB2165245A (en) * 1984-10-01 1986-04-09 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
FI84484B (en) 1991-08-30
SU1516013A3 (en) 1989-10-15
SG79791G (en) 1991-11-15
ZA865842B (en) 1987-04-29
CS276717B6 (en) 1992-08-12
DK162053B (en) 1991-09-09
AR243894A1 (en) 1993-09-30
HUT41802A (en) 1987-05-28
YU45793B (en) 1992-07-20
PT83134B (en) 1989-07-31
DK371886D0 (en) 1986-08-04
EG18003A (en) 1991-08-30
DK371886A (en) 1987-02-06
IL79608A0 (en) 1986-11-30
DD254941A5 (en) 1988-03-16
FI84484C (en) 1991-12-10
BE905219A (en) 1987-02-04
IE862078L (en) 1987-02-05
AU6069486A (en) 1987-02-12
AT390957B (en) 1990-07-25
CH675581A5 (en) 1990-10-15
LU88574I2 (en) 1995-03-01
DE3626375A1 (en) 1987-02-12
ATA211086A (en) 1990-01-15
FR2585705B1 (en) 1989-01-13
GB8618989D0 (en) 1986-09-17
IT1197067B (en) 1988-11-25
MY102212A (en) 1992-05-15
CY1614A (en) 1992-07-10
IT8621409A1 (en) 1988-02-04
KR930003121B1 (en) 1993-04-19
SE8603308L (en) 1987-02-06
FR2585705A1 (en) 1987-02-06
GB2179936A (en) 1987-03-18
ES2002112A6 (en) 1988-07-16
OA08672A (en) 1989-03-31
CA1284994C (en) 1991-06-18
JPS62103090A (en) 1987-05-13
YU137186A (en) 1987-12-31
HK99691A (en) 1991-12-13
SE469633B (en) 1993-08-09
JPH0615548B2 (en) 1994-03-02
KR880002530A (en) 1988-05-09
DD268395A5 (en) 1989-05-31
DK162053C (en) 1992-02-10
IE59222B1 (en) 1994-01-26
FI863155A (en) 1987-02-06
NL8601991A (en) 1987-03-02
CS276849B6 (en) 1992-08-12
IL79608A (en) 1991-07-18
PT83134A (en) 1986-09-01
FI863155A0 (en) 1986-08-01
HU196602B (en) 1988-12-28
LU86540A1 (en) 1987-03-06
GR862055B (en) 1986-12-24
IT8621409A0 (en) 1986-08-04
AU597262B2 (en) 1990-05-31
SE8603308D0 (en) 1986-08-04

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
CTFF Supplementary protection certificate filed

Free format text: SPC/GB95/017, 950620

CTFG Supplementary protection certificate granted

Free format text: SPC/GB94/011, 951101, EXPIRES:20080628

CTFG Supplementary protection certificate granted

Free format text: SPC/GB95/017, 951101, EXPIRES:20080628

PE20 Patent expired after termination of 20 years

Effective date: 20060803

CTFE Supplementary protection certificate entered into force

Free format text: SPC/GB95/017: 20060804, EXPIRES: 20080628

Spc suppl protection certif: SPC/GB95/017

Filing date: 20060804

Expiry date: 20080628

SPCE Supplementary protection certificate expired

Spc suppl protection certif: SPC/GB95/017

Filing date: 19950620

Expiry date: 20060804

Extension date: 20080628