YU45793B - PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEM - Google Patents
PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEMInfo
- Publication number
- YU45793B YU45793B YU137186A YU137186A YU45793B YU 45793 B YU45793 B YU 45793B YU 137186 A YU137186 A YU 137186A YU 137186 A YU137186 A YU 137186A YU 45793 B YU45793 B YU 45793B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alpha
- methyl
- aminothiazola
- pyrolidino
- cefem
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 4
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
POSTUPAK ZA DOBIJANJE STABILNIH KRISTALNIH ADICIONIH SOLI 7-/ALFA-(2-AMINOTIAZOLA-4-IL)-ALFA-(Z)-METOKSIIMINO ACETAMIDO/-3-/(1-METIL-1-PIROLIDINO)-METIL/-3-CEFEM-KARBOKSILATA SA KISELINAMA, KAO I PREPARATA KOJI IH SADRŽE , naznačen time, što se gradi smeša bar dva molska ekvivalenta azotne kiseline i amfoternog jona koji odgovara navedenoj adicionoj soli sa kiselinom, tako da njegova koncentracija u smeši bude veća od 100 mg/ml; što se kristalizacija navedene adicione soli sa kiselinom izaziva zasejavanjem ili trljanjem sa staklenim štapićem,, nakon čega sledi razblaživanje sa 2-propanolom i hladjenje; i što se vrši izolovanje stabilne kristalne dinitratne adicione soli sa kiselinom, poželjno filtriranjem, ispiranjem i sušenjem pod vakuumom. Prijava sadrži još 4 patentna zahteva.PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEM, characterized in that a mixture of at least two molar equivalents of nitric acid and an amphoteric ion corresponding to said acid addition salt is formed so that its concentration in the mixture is greater than 100 mg / ml ; wherein the crystallization of said acid addition salt is induced by seeding or rubbing with a glass rod, followed by dilution with 2-propanol and cooling; and isolating the stable crystalline dinitrate addition salt with an acid, preferably by filtration, washing and drying under vacuum. The application contains 4 more patent claims.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76223585A | 1985-08-05 | 1985-08-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU137186A YU137186A (en) | 1987-12-31 |
| YU45793B true YU45793B (en) | 1992-07-20 |
Family
ID=25064475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU137186A YU45793B (en) | 1985-08-05 | 1986-07-31 | PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEM |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPH0615548B2 (en) |
| KR (1) | KR930003121B1 (en) |
| AR (1) | AR243894A1 (en) |
| AT (1) | AT390957B (en) |
| AU (1) | AU597262B2 (en) |
| BE (1) | BE905219A (en) |
| CA (1) | CA1284994C (en) |
| CH (1) | CH675581A5 (en) |
| CS (2) | CS276717B6 (en) |
| CY (1) | CY1614A (en) |
| DD (2) | DD254941A5 (en) |
| DE (1) | DE3626375A1 (en) |
| DK (1) | DK162053C (en) |
| EG (1) | EG18003A (en) |
| ES (1) | ES2002112A6 (en) |
| FI (1) | FI84484C (en) |
| FR (1) | FR2585705B1 (en) |
| GB (1) | GB2179936B (en) |
| GR (1) | GR862055B (en) |
| HK (1) | HK99691A (en) |
| HU (1) | HU196602B (en) |
| IE (1) | IE59222B1 (en) |
| IL (1) | IL79608A (en) |
| IT (1) | IT1197067B (en) |
| LU (2) | LU88574I2 (en) |
| MY (1) | MY102212A (en) |
| NL (1) | NL8601991A (en) |
| OA (1) | OA08672A (en) |
| PT (1) | PT83134B (en) |
| SE (1) | SE469633B (en) |
| SG (1) | SG79791G (en) |
| SU (1) | SU1516013A3 (en) |
| YU (1) | YU45793B (en) |
| ZA (1) | ZA865842B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4883868A (en) * | 1984-12-27 | 1989-11-28 | Banyu Pharmaceutical Co., Ltd. | 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives |
| US4959469A (en) * | 1984-12-27 | 1990-09-25 | Banyu Pharmaceutical Company, Ltd. | Crystalline cephalosporin compounds |
| US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
| US5244891A (en) * | 1985-08-05 | 1993-09-14 | Bristol-Myers Squibb Company | Injectable compositions of cefepime dihydrochloride hydrate |
| US4808617A (en) * | 1985-12-18 | 1989-02-28 | Bristol-Myers Company | Lyophilized or precipitated cephalosporin zwitterion and salt combination |
| KR950010084B1 (en) * | 1987-06-25 | 1995-09-06 | 반유세이야꾸 가부시끼가이샤 | Crystalline Cephalosporin Compounds, Preparations thereof and Intermediates thereof |
| JPH02101081A (en) * | 1988-10-08 | 1990-04-12 | Meiji Seika Kaisha Ltd | Crystalline dihydrochloride of cephalosporin derivative and production thereof |
| CA2011116C (en) * | 1989-03-06 | 1999-11-16 | Murray A. Kaplan | Lyophilized bmy-28142 dihydrochloride for parenteral use |
| CA2101571A1 (en) * | 1992-09-08 | 1994-03-09 | Elizabeth A. Garofalo | Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof |
| DE69427469T2 (en) * | 1993-03-12 | 2001-10-31 | Pharmacia & Upjohn Co., Kalamazoo | CRYSTALLINE CEFTIOFUR (FREE ACID) |
| EP0638573A1 (en) * | 1993-08-10 | 1995-02-15 | Lucky Ltd. | Crystalline hydrates of cephalosporin and process for preparation thereof |
| WO2005063772A1 (en) | 2003-12-23 | 2005-07-14 | Sandoz Ag | Process for production of intermediates for use in cefalosporin synthesis |
| WO2008056221A2 (en) * | 2006-11-06 | 2008-05-15 | Orchid Chemicals & Pharmaceuticals Limited | Crystalline sulfate salt of cephalosporin antibiotic |
| DE102012101680A1 (en) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55151588A (en) * | 1979-05-14 | 1980-11-26 | Takeda Chem Ind Ltd | Preparation of cephalosporin salt crystal |
| US4406899A (en) * | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
| CA1213882A (en) * | 1982-03-04 | 1986-11-12 | Jun Okumura | Cephalosporins |
| US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
| DE3419015A1 (en) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING CEPHALOSPORINES |
| GB8424692D0 (en) * | 1984-10-01 | 1984-11-07 | Glaxo Group Ltd | Chemical compounds |
| GB2165245B (en) * | 1984-10-01 | 1988-05-25 | Glaxo Group Ltd | Chemical compounds |
-
1986
- 1986-07-28 CA CA000514766A patent/CA1284994C/en not_active Expired - Lifetime
- 1986-07-28 FR FR8610892A patent/FR2585705B1/en not_active Expired
- 1986-07-29 AR AR86304717A patent/AR243894A1/en active
- 1986-07-30 AU AU60694/86A patent/AU597262B2/en not_active Expired
- 1986-07-31 YU YU137186A patent/YU45793B/en unknown
- 1986-08-01 FI FI863155A patent/FI84484C/en not_active IP Right Cessation
- 1986-08-01 IE IE207886A patent/IE59222B1/en not_active IP Right Cessation
- 1986-08-04 ZA ZA865842A patent/ZA865842B/en unknown
- 1986-08-04 GB GB8618989A patent/GB2179936B/en not_active Expired
- 1986-08-04 JP JP61183288A patent/JPH0615548B2/en not_active Expired - Lifetime
- 1986-08-04 LU LU88574C patent/LU88574I2/en unknown
- 1986-08-04 IL IL79608A patent/IL79608A/en not_active IP Right Cessation
- 1986-08-04 CS CS865827A patent/CS276717B6/en unknown
- 1986-08-04 CH CH3117/86A patent/CH675581A5/de not_active IP Right Cessation
- 1986-08-04 NL NL8601991A patent/NL8601991A/en not_active Application Discontinuation
- 1986-08-04 DE DE19863626375 patent/DE3626375A1/en not_active Ceased
- 1986-08-04 CS CS903570A patent/CS276849B6/en unknown
- 1986-08-04 SE SE8603308A patent/SE469633B/en not_active IP Right Cessation
- 1986-08-04 LU LU86540A patent/LU86540A1/en unknown
- 1986-08-04 SU SU864027914A patent/SU1516013A3/en active
- 1986-08-04 PT PT83134A patent/PT83134B/en unknown
- 1986-08-04 IT IT21409/86A patent/IT1197067B/en active Protection Beyond IP Right Term
- 1986-08-04 GR GR862055A patent/GR862055B/en unknown
- 1986-08-04 BE BE07217010A patent/BE905219A/en not_active IP Right Cessation
- 1986-08-04 DK DK371886A patent/DK162053C/en not_active IP Right Cessation
- 1986-08-05 DD DD86293433A patent/DD254941A5/en unknown
- 1986-08-05 HU HU863376A patent/HU196602B/en unknown
- 1986-08-05 AT AT0211086A patent/AT390957B/en not_active IP Right Cessation
- 1986-08-05 OA OA58918A patent/OA08672A/en unknown
- 1986-08-05 KR KR1019860006445A patent/KR930003121B1/en not_active Expired - Lifetime
- 1986-08-05 ES ES8600872A patent/ES2002112A6/en not_active Expired
-
1987
- 1987-09-29 MY MYPI87002279A patent/MY102212A/en unknown
-
1988
- 1988-03-30 DD DD88314213A patent/DD268395A5/en unknown
-
1989
- 1989-08-04 EG EG489/86A patent/EG18003A/en active
-
1991
- 1991-10-02 SG SG797/91A patent/SG79791G/en unknown
- 1991-12-05 HK HK996/91A patent/HK99691A/en not_active IP Right Cessation
-
1992
- 1992-07-10 CY CY1614A patent/CY1614A/en unknown
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