YU45793B - PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEM - Google Patents

PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEM

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Publication number
YU45793B
YU45793B YU137186A YU137186A YU45793B YU 45793 B YU45793 B YU 45793B YU 137186 A YU137186 A YU 137186A YU 137186 A YU137186 A YU 137186A YU 45793 B YU45793 B YU 45793B
Authority
YU
Yugoslavia
Prior art keywords
alpha
methyl
aminothiazola
pyrolidino
cefem
Prior art date
Application number
YU137186A
Other languages
Serbo-Croatian (sh)
Other versions
YU137186A (en
Inventor
M.A. Kaplan
T.W. Hudyma
R.A. Lipper
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of YU137186A publication Critical patent/YU137186A/en
Publication of YU45793B publication Critical patent/YU45793B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

POSTUPAK ZA DOBIJANJE STABILNIH KRISTALNIH ADICIONIH SOLI 7-/ALFA-(2-AMINOTIAZOLA-4-IL)-ALFA-(Z)-METOKSIIMINO ACETAMIDO/-3-/(1-METIL-1-PIROLIDINO)-METIL/-3-CEFEM-KARBOKSILATA SA KISELINAMA, KAO I PREPARATA KOJI IH SADRŽE , naznačen time, što se gradi smeša bar dva molska ekvivalenta azotne kiseline i amfoternog jona koji odgovara navedenoj adicionoj soli sa kiselinom, tako da njegova koncentracija u smeši bude veća od 100 mg/ml; što se kristalizacija navedene adicione soli sa kiselinom izaziva zasejavanjem ili trljanjem sa staklenim štapićem,, nakon čega sledi razblaživanje sa 2-propanolom i hladjenje; i što se vrši izolovanje stabilne kristalne dinitratne adicione soli sa kiselinom, poželjno filtriranjem, ispiranjem i sušenjem pod vakuumom. Prijava sadrži još 4 patentna zahteva.PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEM, characterized in that a mixture of at least two molar equivalents of nitric acid and an amphoteric ion corresponding to said acid addition salt is formed so that its concentration in the mixture is greater than 100 mg / ml ; wherein the crystallization of said acid addition salt is induced by seeding or rubbing with a glass rod, followed by dilution with 2-propanol and cooling; and isolating the stable crystalline dinitrate addition salt with an acid, preferably by filtration, washing and drying under vacuum. The application contains 4 more patent claims.

YU137186A 1985-08-05 1986-07-31 PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEM YU45793B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05

Publications (2)

Publication Number Publication Date
YU137186A YU137186A (en) 1987-12-31
YU45793B true YU45793B (en) 1992-07-20

Family

ID=25064475

Family Applications (1)

Application Number Title Priority Date Filing Date
YU137186A YU45793B (en) 1985-08-05 1986-07-31 PROCESS FOR PREPARATION OF STABLE CRYSTAL ADDITIONAL SALTS OF 7- (ALPHA- (2-AMINOTHIAZOLA-4-YL) -ALPHA- (Z) -METHOXYIMINO ACETAMIDO / -3- / (1-METHYL-1-PYROLIDINO) -METHYL / -3- CEFEM-CARBOXYLATES WITH ACIDS, AS WELL AS PREPARATIONS CONTAINING THEM

Country Status (34)

Country Link
JP (1) JPH0615548B2 (en)
KR (1) KR930003121B1 (en)
AR (1) AR243894A1 (en)
AT (1) AT390957B (en)
AU (1) AU597262B2 (en)
BE (1) BE905219A (en)
CA (1) CA1284994C (en)
CH (1) CH675581A5 (en)
CS (2) CS276717B6 (en)
CY (1) CY1614A (en)
DD (2) DD254941A5 (en)
DE (1) DE3626375A1 (en)
DK (1) DK162053C (en)
EG (1) EG18003A (en)
ES (1) ES2002112A6 (en)
FI (1) FI84484C (en)
FR (1) FR2585705B1 (en)
GB (1) GB2179936B (en)
GR (1) GR862055B (en)
HK (1) HK99691A (en)
HU (1) HU196602B (en)
IE (1) IE59222B1 (en)
IL (1) IL79608A (en)
IT (1) IT1197067B (en)
LU (2) LU86540A1 (en)
MY (1) MY102212A (en)
NL (1) NL8601991A (en)
OA (1) OA08672A (en)
PT (1) PT83134B (en)
SE (1) SE469633B (en)
SG (1) SG79791G (en)
SU (1) SU1516013A3 (en)
YU (1) YU45793B (en)
ZA (1) ZA865842B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
WO1988010263A1 (en) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
JPH02101081A (en) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd Crystalline dihydrochloride of cephalosporin derivative and production thereof
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
JP4616844B2 (en) 2003-12-23 2011-01-19 サンド・ゲーエムベーハー Production process of intermediates for use in the synthesis of cephalosporin
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (en) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (en) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING CEPHALOSPORINES
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
OA08672A (en) 1989-03-31
CA1284994C (en) 1991-06-18
MY102212A (en) 1992-05-15
JPS62103090A (en) 1987-05-13
PT83134A (en) 1986-09-01
IE59222B1 (en) 1994-01-26
DK162053C (en) 1992-02-10
SG79791G (en) 1991-11-15
SE8603308D0 (en) 1986-08-04
IT1197067B (en) 1988-11-25
IT8621409A1 (en) 1988-02-04
LU88574I2 (en) 1995-03-01
IL79608A (en) 1991-07-18
FI84484B (en) 1991-08-30
JPH0615548B2 (en) 1994-03-02
KR880002530A (en) 1988-05-09
AT390957B (en) 1990-07-25
LU86540A1 (en) 1987-03-06
AU597262B2 (en) 1990-05-31
DK371886D0 (en) 1986-08-04
FI863155A0 (en) 1986-08-01
KR930003121B1 (en) 1993-04-19
SE8603308L (en) 1987-02-06
DK162053B (en) 1991-09-09
SU1516013A3 (en) 1989-10-15
GB2179936B (en) 1989-04-26
FI863155A (en) 1987-02-06
CY1614A (en) 1992-07-10
PT83134B (en) 1989-07-31
SE469633B (en) 1993-08-09
GB8618989D0 (en) 1986-09-17
HK99691A (en) 1991-12-13
DD268395A5 (en) 1989-05-31
AR243894A1 (en) 1993-09-30
AU6069486A (en) 1987-02-12
NL8601991A (en) 1987-03-02
CS276849B6 (en) 1992-08-12
ES2002112A6 (en) 1988-07-16
CH675581A5 (en) 1990-10-15
DD254941A5 (en) 1988-03-16
HUT41802A (en) 1987-05-28
FR2585705A1 (en) 1987-02-06
GB2179936A (en) 1987-03-18
EG18003A (en) 1991-08-30
DK371886A (en) 1987-02-06
YU137186A (en) 1987-12-31
FI84484C (en) 1991-12-10
GR862055B (en) 1986-12-24
BE905219A (en) 1987-02-04
IL79608A0 (en) 1986-11-30
IE862078L (en) 1987-02-05
ATA211086A (en) 1990-01-15
DE3626375A1 (en) 1987-02-12
FR2585705B1 (en) 1989-01-13
CS276717B6 (en) 1992-08-12
HU196602B (en) 1988-12-28
ZA865842B (en) 1987-04-29
IT8621409A0 (en) 1986-08-04

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