SE8603308D0 - CEPHALOSPORIN SALTS AND INJECTABLE COMPOSITIONS - Google Patents
CEPHALOSPORIN SALTS AND INJECTABLE COMPOSITIONSInfo
- Publication number
- SE8603308D0 SE8603308D0 SE8603308A SE8603308A SE8603308D0 SE 8603308 D0 SE8603308 D0 SE 8603308D0 SE 8603308 A SE8603308 A SE 8603308A SE 8603308 A SE8603308 A SE 8603308A SE 8603308 D0 SE8603308 D0 SE 8603308D0
- Authority
- SE
- Sweden
- Prior art keywords
- alpha
- methyl
- salts
- crystalline
- dilution
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Cephalosporin Salts and Injectable Compositions Crystalline sulfuric, di-nitric, mono-hydrochloric, dihydrochloric, and di- and sesqui-orthosphosphoric acid addition salts of 7-¢.alpha.-(2-aminothiazol-4-yl)-.alpha.-(Z)-methoxyimino-acetamido!-3-¢(1-methyl-1-pyrrolidinio)-methyl!-3-cephem-4-carboxylate are stable even at elevated temperatures. The crystalline sulfuric acid addition salt is made by forming an admixture of (a) at least one molar equivalent of sulfuric acid with (b) zwitterion in an amount so as to be present in the admixture at a concentration of greater than 25 milligrams/ml, causing crystallization, separating the crystals, washing and drying. The crystalline monohydrochloride, dihydrochloride, and orthophosphate salts are prepared by dissolving the zwitterion in the appropriate amount of acid, causing crystallization by adding acetone and isolating the crystal. Physical admixtures of the salts with certain bases in proportions to give a pH ranging from about 3 5 to about 7 on dilution with water provide injectable compositions on dilution. Brief Description of the Drawing Figure 1 is a graphical representation of the infra red absorption spectrum of crystalline 7-¢.alpha.-(2-aminothiazol-4-yl)-.alpha.- (Z)-methoxyiminoacetamido!-3-¢(1-methyl-1-pyrrolidinio)methyl!-3-cephem-4-carboxylate sulfate salt measured on a KBr dilution thereof. BMY-28142.H2SO4 - IR Spectrum.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76223585A | 1985-08-05 | 1985-08-05 |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8603308D0 true SE8603308D0 (en) | 1986-08-04 |
SE8603308L SE8603308L (en) | 1987-02-06 |
SE469633B SE469633B (en) | 1993-08-09 |
Family
ID=25064475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8603308A SE469633B (en) | 1985-08-05 | 1986-08-04 | PHYSICAL MIXTURES OF CEPHALOSPORINE SALTS, CRYSTALLINE SULPHATE SALTS, AND A PROCEDURE FOR THE PREPARATION OF THESE |
Country Status (34)
Country | Link |
---|---|
JP (1) | JPH0615548B2 (en) |
KR (1) | KR930003121B1 (en) |
AR (1) | AR243894A1 (en) |
AT (1) | AT390957B (en) |
AU (1) | AU597262B2 (en) |
BE (1) | BE905219A (en) |
CA (1) | CA1284994C (en) |
CH (1) | CH675581A5 (en) |
CS (2) | CS276849B6 (en) |
CY (1) | CY1614A (en) |
DD (2) | DD254941A5 (en) |
DE (1) | DE3626375A1 (en) |
DK (1) | DK162053C (en) |
EG (1) | EG18003A (en) |
ES (1) | ES2002112A6 (en) |
FI (1) | FI84484C (en) |
FR (1) | FR2585705B1 (en) |
GB (1) | GB2179936B (en) |
GR (1) | GR862055B (en) |
HK (1) | HK99691A (en) |
HU (1) | HU196602B (en) |
IE (1) | IE59222B1 (en) |
IL (1) | IL79608A (en) |
IT (1) | IT1197067B (en) |
LU (2) | LU88574I2 (en) |
MY (1) | MY102212A (en) |
NL (1) | NL8601991A (en) |
OA (1) | OA08672A (en) |
PT (1) | PT83134B (en) |
SE (1) | SE469633B (en) |
SG (1) | SG79791G (en) |
SU (1) | SU1516013A3 (en) |
YU (1) | YU45793B (en) |
ZA (1) | ZA865842B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959469A (en) * | 1984-12-27 | 1990-09-25 | Banyu Pharmaceutical Company, Ltd. | Crystalline cephalosporin compounds |
US4883868A (en) * | 1984-12-27 | 1989-11-28 | Banyu Pharmaceutical Co., Ltd. | 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives |
US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
US5244891A (en) * | 1985-08-05 | 1993-09-14 | Bristol-Myers Squibb Company | Injectable compositions of cefepime dihydrochloride hydrate |
US4808617A (en) * | 1985-12-18 | 1989-02-28 | Bristol-Myers Company | Lyophilized or precipitated cephalosporin zwitterion and salt combination |
DE3788279T2 (en) * | 1987-06-25 | 1994-06-16 | Banyu Pharma Co Ltd | CRYSTALLINE CEPHALOSPORINE COMPOSITIONS, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION. |
JPH02101081A (en) * | 1988-10-08 | 1990-04-12 | Meiji Seika Kaisha Ltd | Crystalline dihydrochloride of cephalosporin derivative and production thereof |
CA2011116C (en) * | 1989-03-06 | 1999-11-16 | Murray A. Kaplan | Lyophilized bmy-28142 dihydrochloride for parenteral use |
CA2101571A1 (en) * | 1992-09-08 | 1994-03-09 | Elizabeth A. Garofalo | Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof |
EP0638573A1 (en) * | 1993-08-10 | 1995-02-15 | Lucky Ltd. | Crystalline hydrates of cephalosporin and process for preparation thereof |
ES2298850T3 (en) | 2003-12-23 | 2008-05-16 | Sandoz Gmbh | PROCESS FOR THE PRODUCTION OF INTERMEDIATES TO USE IN THE SYNTHESIS OF CEPHALOSPORINE. |
WO2008056221A2 (en) * | 2006-11-06 | 2008-05-15 | Orchid Chemicals & Pharmaceuticals Limited | Crystalline sulfate salt of cephalosporin antibiotic |
DE102012101680A1 (en) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55151588A (en) * | 1979-05-14 | 1980-11-26 | Takeda Chem Ind Ltd | Preparation of cephalosporin salt crystal |
CA1213882A (en) * | 1982-03-04 | 1986-11-12 | Jun Okumura | Cephalosporins |
US4406899A (en) * | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
DE3419015A1 (en) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING CEPHALOSPORINES |
GB8424692D0 (en) * | 1984-10-01 | 1984-11-07 | Glaxo Group Ltd | Chemical compounds |
GB2165245B (en) * | 1984-10-01 | 1988-05-25 | Glaxo Group Ltd | Chemical compounds |
-
1986
- 1986-07-28 FR FR8610892A patent/FR2585705B1/en not_active Expired
- 1986-07-28 CA CA000514766A patent/CA1284994C/en not_active Expired - Lifetime
- 1986-07-29 AR AR86304717A patent/AR243894A1/en active
- 1986-07-30 AU AU60694/86A patent/AU597262B2/en not_active Expired
- 1986-07-31 YU YU137186A patent/YU45793B/en unknown
- 1986-08-01 IE IE207886A patent/IE59222B1/en not_active IP Right Cessation
- 1986-08-01 FI FI863155A patent/FI84484C/en not_active IP Right Cessation
- 1986-08-04 JP JP61183288A patent/JPH0615548B2/en not_active Expired - Lifetime
- 1986-08-04 PT PT83134A patent/PT83134B/en unknown
- 1986-08-04 DK DK371886A patent/DK162053C/en not_active IP Right Cessation
- 1986-08-04 GB GB8618989A patent/GB2179936B/en not_active Expired
- 1986-08-04 CH CH3117/86A patent/CH675581A5/de not_active IP Right Cessation
- 1986-08-04 DE DE19863626375 patent/DE3626375A1/en not_active Ceased
- 1986-08-04 CS CS903570A patent/CS276849B6/en unknown
- 1986-08-04 CS CS865827A patent/CS276717B6/en unknown
- 1986-08-04 NL NL8601991A patent/NL8601991A/en not_active Application Discontinuation
- 1986-08-04 IT IT21409/86A patent/IT1197067B/en active Protection Beyond IP Right Term
- 1986-08-04 LU LU88574C patent/LU88574I2/en unknown
- 1986-08-04 BE BE07217010A patent/BE905219A/en not_active IP Right Cessation
- 1986-08-04 LU LU86540A patent/LU86540A1/en unknown
- 1986-08-04 GR GR862055A patent/GR862055B/en unknown
- 1986-08-04 IL IL79608A patent/IL79608A/en not_active IP Right Cessation
- 1986-08-04 ZA ZA865842A patent/ZA865842B/en unknown
- 1986-08-04 SE SE8603308A patent/SE469633B/en not_active IP Right Cessation
- 1986-08-04 SU SU864027914A patent/SU1516013A3/en active
- 1986-08-05 ES ES8600872A patent/ES2002112A6/en not_active Expired
- 1986-08-05 OA OA58918A patent/OA08672A/en unknown
- 1986-08-05 KR KR1019860006445A patent/KR930003121B1/en not_active IP Right Cessation
- 1986-08-05 DD DD86293433A patent/DD254941A5/en unknown
- 1986-08-05 HU HU863376A patent/HU196602B/en unknown
- 1986-08-05 AT AT0211086A patent/AT390957B/en not_active IP Right Cessation
-
1987
- 1987-09-29 MY MYPI87002279A patent/MY102212A/en unknown
-
1988
- 1988-03-30 DD DD88314213A patent/DD268395A5/en unknown
-
1989
- 1989-08-04 EG EG489/86A patent/EG18003A/en active
-
1991
- 1991-10-02 SG SG797/91A patent/SG79791G/en unknown
- 1991-12-05 HK HK996/91A patent/HK99691A/en not_active IP Right Cessation
-
1992
- 1992-07-10 CY CY1614A patent/CY1614A/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SPCF | Application for supplementary protection certificate filed |
Free format text: 8603308 |
|
SPCG | Supplementary protection certificate granted |
Free format text: 8603308, EXPIRES: 20080628 |
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NAL | Patent in force |
Ref document number: 8603308-1 Format of ref document f/p: F |
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