SE8603308D0 - CEPHALOSPORIN SALTS AND INJECTABLE COMPOSITIONS - Google Patents

CEPHALOSPORIN SALTS AND INJECTABLE COMPOSITIONS

Info

Publication number
SE8603308D0
SE8603308D0 SE8603308A SE8603308A SE8603308D0 SE 8603308 D0 SE8603308 D0 SE 8603308D0 SE 8603308 A SE8603308 A SE 8603308A SE 8603308 A SE8603308 A SE 8603308A SE 8603308 D0 SE8603308 D0 SE 8603308D0
Authority
SE
Sweden
Prior art keywords
alpha
methyl
salts
crystalline
dilution
Prior art date
Application number
SE8603308A
Other languages
Swedish (sv)
Other versions
SE8603308L (en
SE469633B (en
Inventor
M A Kaplan
T W Hudyma
R A Lipper
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8603308D0 publication Critical patent/SE8603308D0/en
Publication of SE8603308L publication Critical patent/SE8603308L/en
Publication of SE469633B publication Critical patent/SE469633B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Cephalosporin Salts and Injectable Compositions Crystalline sulfuric, di-nitric, mono-hydrochloric, dihydrochloric, and di- and sesqui-orthosphosphoric acid addition salts of 7-¢.alpha.-(2-aminothiazol-4-yl)-.alpha.-(Z)-methoxyimino-acetamido!-3-¢(1-methyl-1-pyrrolidinio)-methyl!-3-cephem-4-carboxylate are stable even at elevated temperatures. The crystalline sulfuric acid addition salt is made by forming an admixture of (a) at least one molar equivalent of sulfuric acid with (b) zwitterion in an amount so as to be present in the admixture at a concentration of greater than 25 milligrams/ml, causing crystallization, separating the crystals, washing and drying. The crystalline monohydrochloride, dihydrochloride, and orthophosphate salts are prepared by dissolving the zwitterion in the appropriate amount of acid, causing crystallization by adding acetone and isolating the crystal. Physical admixtures of the salts with certain bases in proportions to give a pH ranging from about 3 5 to about 7 on dilution with water provide injectable compositions on dilution. Brief Description of the Drawing Figure 1 is a graphical representation of the infra red absorption spectrum of crystalline 7-¢.alpha.-(2-aminothiazol-4-yl)-.alpha.- (Z)-methoxyiminoacetamido!-3-¢(1-methyl-1-pyrrolidinio)methyl!-3-cephem-4-carboxylate sulfate salt measured on a KBr dilution thereof. BMY-28142.H2SO4 - IR Spectrum.
SE8603308A 1985-08-05 1986-08-04 PHYSICAL MIXTURES OF CEPHALOSPORINE SALTS, CRYSTALLINE SULPHATE SALTS, AND A PROCEDURE FOR THE PREPARATION OF THESE SE469633B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05

Publications (3)

Publication Number Publication Date
SE8603308D0 true SE8603308D0 (en) 1986-08-04
SE8603308L SE8603308L (en) 1987-02-06
SE469633B SE469633B (en) 1993-08-09

Family

ID=25064475

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8603308A SE469633B (en) 1985-08-05 1986-08-04 PHYSICAL MIXTURES OF CEPHALOSPORINE SALTS, CRYSTALLINE SULPHATE SALTS, AND A PROCEDURE FOR THE PREPARATION OF THESE

Country Status (34)

Country Link
JP (1) JPH0615548B2 (en)
KR (1) KR930003121B1 (en)
AR (1) AR243894A1 (en)
AT (1) AT390957B (en)
AU (1) AU597262B2 (en)
BE (1) BE905219A (en)
CA (1) CA1284994C (en)
CH (1) CH675581A5 (en)
CS (2) CS276717B6 (en)
CY (1) CY1614A (en)
DD (2) DD254941A5 (en)
DE (1) DE3626375A1 (en)
DK (1) DK162053C (en)
EG (1) EG18003A (en)
ES (1) ES2002112A6 (en)
FI (1) FI84484C (en)
FR (1) FR2585705B1 (en)
GB (1) GB2179936B (en)
GR (1) GR862055B (en)
HK (1) HK99691A (en)
HU (1) HU196602B (en)
IE (1) IE59222B1 (en)
IL (1) IL79608A (en)
IT (1) IT1197067B (en)
LU (2) LU86540A1 (en)
MY (1) MY102212A (en)
NL (1) NL8601991A (en)
OA (1) OA08672A (en)
PT (1) PT83134B (en)
SE (1) SE469633B (en)
SG (1) SG79791G (en)
SU (1) SU1516013A3 (en)
YU (1) YU45793B (en)
ZA (1) ZA865842B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
WO1988010263A1 (en) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
JPH02101081A (en) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd Crystalline dihydrochloride of cephalosporin derivative and production thereof
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
JP4616844B2 (en) 2003-12-23 2011-01-19 サンド・ゲーエムベーハー Production process of intermediates for use in the synthesis of cephalosporin
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (en) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmaceutical preparation containing an antiviral dihydroquinazoline derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (en) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING CEPHALOSPORINES
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
OA08672A (en) 1989-03-31
CA1284994C (en) 1991-06-18
MY102212A (en) 1992-05-15
JPS62103090A (en) 1987-05-13
PT83134A (en) 1986-09-01
IE59222B1 (en) 1994-01-26
DK162053C (en) 1992-02-10
SG79791G (en) 1991-11-15
IT1197067B (en) 1988-11-25
IT8621409A1 (en) 1988-02-04
LU88574I2 (en) 1995-03-01
IL79608A (en) 1991-07-18
FI84484B (en) 1991-08-30
JPH0615548B2 (en) 1994-03-02
KR880002530A (en) 1988-05-09
AT390957B (en) 1990-07-25
LU86540A1 (en) 1987-03-06
AU597262B2 (en) 1990-05-31
DK371886D0 (en) 1986-08-04
FI863155A0 (en) 1986-08-01
KR930003121B1 (en) 1993-04-19
SE8603308L (en) 1987-02-06
DK162053B (en) 1991-09-09
SU1516013A3 (en) 1989-10-15
GB2179936B (en) 1989-04-26
YU45793B (en) 1992-07-20
FI863155A (en) 1987-02-06
CY1614A (en) 1992-07-10
PT83134B (en) 1989-07-31
SE469633B (en) 1993-08-09
GB8618989D0 (en) 1986-09-17
HK99691A (en) 1991-12-13
DD268395A5 (en) 1989-05-31
AR243894A1 (en) 1993-09-30
AU6069486A (en) 1987-02-12
NL8601991A (en) 1987-03-02
CS276849B6 (en) 1992-08-12
ES2002112A6 (en) 1988-07-16
CH675581A5 (en) 1990-10-15
DD254941A5 (en) 1988-03-16
HUT41802A (en) 1987-05-28
FR2585705A1 (en) 1987-02-06
GB2179936A (en) 1987-03-18
EG18003A (en) 1991-08-30
DK371886A (en) 1987-02-06
YU137186A (en) 1987-12-31
FI84484C (en) 1991-12-10
GR862055B (en) 1986-12-24
BE905219A (en) 1987-02-04
IL79608A0 (en) 1986-11-30
IE862078L (en) 1987-02-05
ATA211086A (en) 1990-01-15
DE3626375A1 (en) 1987-02-12
FR2585705B1 (en) 1989-01-13
CS276717B6 (en) 1992-08-12
HU196602B (en) 1988-12-28
ZA865842B (en) 1987-04-29
IT8621409A0 (en) 1986-08-04

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