DE3571648C5 - Monoklonale Antikörper gegen menschlichen Brustkrebs, ihre Produktion und Verwendung, Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen. - Google Patents

Monoklonale Antikörper gegen menschlichen Brustkrebs, ihre Produktion und Verwendung, Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen. Download PDF

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Publication number
DE3571648C5
DE3571648C5 DE3571648T DE3571648T DE3571648C5 DE 3571648 C5 DE3571648 C5 DE 3571648C5 DE 3571648 T DE3571648 T DE 3571648T DE 3571648 T DE3571648 T DE 3571648T DE 3571648 C5 DE3571648 C5 DE 3571648C5
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Prior art keywords
breast cancer
antibody
cells
human breast
mouse
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Expired - Lifetime
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DE3571648T
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DE3571648D1 (en
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Arthur Edward Frankel
Michael Jon Bjorn
David Baratt Ring
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Novartis Vaccines and Diagnostics Inc
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Chiron Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/804—Drug, bio-affecting and body treating compositions involving IgG3, IgG4, IgA, or IgY
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/861—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgG3, IgG4, IgA, or IgY
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
    • Y10S530/864—Monoclonal

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Monoklonaler Maus-Antikörper, der
(a) ein menschliches Brustkrebs-Antigen bindet, das von einem Vergleichsantikörper ebenfalls gebunden wird, der von einem der unter ATCC HB8484 und HB8696 erhältlichen Hybridome gebildet wird;
(b) einen G- oder M-Isotyp aufweist; und
(c) nach Konjugation mit der Ricin-A-Kette zumindest gegen eine der Zellen MCF-7, CAmA-1, SKBR-3 oder BT-20 einen TCID 50%-Wert von weniger als etwa 10 nM aufweist;
(d) der an ein im Brustkrebs-Gewebe gefundenes Protein von annähernd 210 000 Dalton bindet; und
(e) menschliche Brustkrebszellen selektiv bindet.

Description

  • Das europäische Patent 0 153 114 wird mit Wirkung für das Hoheitsgebiet der Bundesrepublik Deutschland dadurch teilweise für nichtig erklärt, dass die Patentansprüche folgende Fassung erhalten.

Claims (10)

  1. Monoklonaler Maus-Antikörper, der (a) ein menschliches Brustkrebs-Antigen bindet, das von einem Vergleichsantikörper ebenfalls gebunden wird, der von einem der unter ATCC HB8484 und HB8696 erhältlichen Hybridome gebildet wird; (b) einen G- oder M-Isotyp aufweist; und (c) nach Konjugation mit der Ricin-A-Kette zumindest gegen eine der Zellen MCF-7, CAmA-1, SKBR-3 oder BT-20 einen TCID 50%-Wert von weniger als etwa 10 nM aufweist; (d) der an ein im Brustkrebs-Gewebe gefundenes Protein von annähernd 210 000 Dalton bindet; und (e) menschliche Brustkrebszellen selektiv bindet.
  2. Monoklonaler Maus-Antikörper, der (a) ein menschliches Brustkrebs-Antigen bindet, das von dem unter ATCC HB8484 erhältlichen Hybridom gebildeten Antikörper gebunden wird; (b) einen G-Isotyp aufweist; und (c) nach Konjugation mit der Ricin-A-Kette gegen MCF-7 Zellen einen TCID 50%-Wert von weniger als etwa 10 nM aufweist; (d) menschliche Brustkrebszellen selektiv bindet; und (e) der durch das Hybridom ATCC HB8484 gebildet wird.
  3. Monoklonaler Antikörper nach Anspruch 1, der durch das Hybridom HB8696 gebildet wird, oder ein monoklonaler Antikörper, der mit dem vorstehend genannten Antikörper oder mit dem Antikörper gemäß Anspruch 2 funktionell äquivalent ist.
  4. Maus × Maus-Hybridom, das einen monoklonalen Antikörper nach Anspruch 1 oder 2 bildet, und seine zur Herstellung des gegen menschlichen Brustkrebs gerichteten monoklonalen Antikörpers der Eltern-Zellen fähigen Nachkommen.
  5. Hybridom, nämlich HB8484 und HB8696; oder seine zur Herstellung des gegen menschlichen Brustkrebs gerichteten monoklonalen Antikörpers der Eltern-Zellen fähiger Nachkommen.
  6. Immuntoxin, das ein Konjugat aus einem monoklonalen Antikörper nach einem der Ansprüche 1 bis 3 und einer cytotoxischen Gruppe darstellt.
  7. Verfahren zur in vitro-Abtötung von menschlichen Brustkrebs-Zellen, umfassend, dass man die Zellen mit einer cytotoxisch-wirksamen Menge eines Immuntoxins nach Anspruch 6 in Kontakt bringt.
  8. Monoklonaler Antikörper nach einem der Ansprüche 1 bis 3, der mit einem nachweisbaren Marker markiert ist.
  9. Verfahren zur in vitro-Diagnose, ob eine menschliche Zelle eine Brustkrebszelle ist, bei dem man (a) eine menschliche Zelle mit einem Antikörper nach Anspruch 8 inkubiert; und (b) das Vorliegen von markierten binären Immun-Komplexen auf der menschlichen Zelle bestimmt.
  10. Verfahren zur Herstellung eines Hybridoms nach Anspruch 4, umfassend, dass man Maus-Tumorzellen mit Maus-Milzzellen aus einer mit menschlichen Brustkrebs-Antigen immunisierten Maus fusioniert und auf Hybridome selektiert, die Antikörper nach Anspruch 1 bilden.
DE3571648T 1984-02-08 1985-02-08 Monoklonale Antikörper gegen menschlichen Brustkrebs, ihre Produktion und Verwendung, Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen. Expired - Lifetime DE3571648C5 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57797684A 1984-02-08 1984-02-08
US06/690,750 US4753894A (en) 1984-02-08 1985-01-11 Monoclonal anti-human breast cancer antibodies
US577976 1985-01-11
US690750 1985-01-11

Publications (2)

Publication Number Publication Date
DE3571648D1 DE3571648D1 (en) 1989-08-24
DE3571648C5 true DE3571648C5 (de) 2006-05-11

Family

ID=27077394

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2001199017 Pending DE10199017I1 (de) 1984-02-08 1985-02-08 Monoklonale Antikoerper gegen menschlichen Brustkrebs ihre Produktion und Verwendung Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen
DE3571648T Expired - Lifetime DE3571648C5 (de) 1984-02-08 1985-02-08 Monoklonale Antikörper gegen menschlichen Brustkrebs, ihre Produktion und Verwendung, Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE2001199017 Pending DE10199017I1 (de) 1984-02-08 1985-02-08 Monoklonale Antikoerper gegen menschlichen Brustkrebs ihre Produktion und Verwendung Hybridomen zu ihrer Herstellung und Herstellung dieser Hybridomen

Country Status (14)

Country Link
US (1) US4753894A (de)
EP (1) EP0153114B1 (de)
JP (4) JPH0646958B2 (de)
AT (1) ATE44769T1 (de)
DE (2) DE10199017I1 (de)
DK (1) DK167194B1 (de)
FI (1) FI853884L (de)
IE (1) IE58974B1 (de)
IL (1) IL74271A (de)
LU (1) LU90734I2 (de)
NL (1) NL300040I2 (de)
NO (2) NO164306C (de)
NZ (1) NZ211070A (de)
WO (1) WO1985003523A1 (de)

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NO164306B (no) 1990-06-11
LU90734I2 (en) 2001-04-30
EP0153114A2 (de) 1985-08-28
ATE44769T1 (de) 1989-08-15
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JP2769311B2 (ja) 1998-06-25
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IL74271A0 (en) 1985-05-31
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US4753894A (en) 1988-06-28
DE10199017I1 (de) 2001-05-23
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