DE69114546T2 - Neue Verwendung für einen monoklonalen Antikörper. - Google Patents

Neue Verwendung für einen monoklonalen Antikörper.

Info

Publication number
DE69114546T2
DE69114546T2 DE69114546T DE69114546T DE69114546T2 DE 69114546 T2 DE69114546 T2 DE 69114546T2 DE 69114546 T DE69114546 T DE 69114546T DE 69114546 T DE69114546 T DE 69114546T DE 69114546 T2 DE69114546 T2 DE 69114546T2
Authority
DE
Germany
Prior art keywords
monoclonal antibody
new use
specificity
fragments
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69114546T
Other languages
English (en)
Other versions
DE69114546D1 (de
Inventor
Hans Loibner
Dierter Scholz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Priority to DE69114546T priority Critical patent/DE69114546T2/de
Application granted granted Critical
Publication of DE69114546D1 publication Critical patent/DE69114546D1/de
Publication of DE69114546T2 publication Critical patent/DE69114546T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69114546T 1990-02-28 1991-02-26 Neue Verwendung für einen monoklonalen Antikörper. Expired - Lifetime DE69114546T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69114546T DE69114546T2 (de) 1990-02-28 1991-02-26 Neue Verwendung für einen monoklonalen Antikörper.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4006308A DE4006308A1 (de) 1990-02-28 1990-02-28 Verwendung des monoklonalen antikoerpers br 55.2 gegen kleinzelliges lungenkarzinom
DE69114546T DE69114546T2 (de) 1990-02-28 1991-02-26 Neue Verwendung für einen monoklonalen Antikörper.

Publications (2)

Publication Number Publication Date
DE69114546D1 DE69114546D1 (de) 1995-12-21
DE69114546T2 true DE69114546T2 (de) 1996-04-04

Family

ID=6401132

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4006308A Withdrawn DE4006308A1 (de) 1990-02-28 1990-02-28 Verwendung des monoklonalen antikoerpers br 55.2 gegen kleinzelliges lungenkarzinom
DE69114546T Expired - Lifetime DE69114546T2 (de) 1990-02-28 1991-02-26 Neue Verwendung für einen monoklonalen Antikörper.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4006308A Withdrawn DE4006308A1 (de) 1990-02-28 1990-02-28 Verwendung des monoklonalen antikoerpers br 55.2 gegen kleinzelliges lungenkarzinom

Country Status (5)

Country Link
US (1) US5523085A (de)
EP (1) EP0445078B1 (de)
JP (1) JP2996526B2 (de)
AT (1) ATE130200T1 (de)
DE (2) DE4006308A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2145004T3 (es) * 1991-08-21 2000-07-01 Novartis Ag Derivados de anticuerpos.
RU2208642C2 (ru) * 1992-05-22 2003-07-20 Новартис Аг МОНОКЛОНАЛЬНОЕ АНТИИДИОТИПИЧЕСКОЕ АНТИТЕЛО Ab2, СПОСОБ ЕГО ПОЛУЧЕНИЯ, ИСПОЛЬЗОВАНИЯ ПРОТИВ БОЛЕЗНЕЙ, СОПРОВОЖДАЮЩИХСЯ ЭКСПРЕССИЕЙ Lewis Y6 АНТИГЕНА, И ДЛЯ ОЧИСТКИ ВАРИАНТА BR55-2 АНТИТЕЛА, ЛЕЧЕБНО-ПРОФИЛАКТИЧЕСКИЙ СОСТАВ
AT413486B (de) * 2002-07-03 2006-03-15 Igeneon Krebs Immuntherapie Verwendung eines antikörpers gerichtet gegen lewis-antigene
TWI618669B (zh) * 2016-05-09 2018-03-21 力山工業股份有限公司 可收折的文具

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468231B (sv) * 1984-05-18 1992-11-23 Kabi Pharmacia Ab Foerfarande foer att paavisa smaacelligt lungcarcinomantigen och anvaendning av antikroppar mot fukosylsialosylgangliotetraos foer framstaellning av komposition foer behandling eller in vivo/ diagnos
US4971792A (en) * 1987-03-27 1990-11-20 The Wistar Institute Monoclonal antibodies against glycolipid antigens
EP0323802A3 (de) * 1987-12-24 1989-07-26 Sandoz Ag Gegen Lungenkrebs gerichtete monoklonale Antikörper und Zelloberflächenantigen davon

Also Published As

Publication number Publication date
EP0445078A1 (de) 1991-09-04
JPH04211612A (ja) 1992-08-03
EP0445078B1 (de) 1995-11-15
ATE130200T1 (de) 1995-12-15
DE4006308A1 (de) 1991-08-29
US5523085A (en) 1996-06-04
JP2996526B2 (ja) 2000-01-11
DE69114546D1 (de) 1995-12-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8339 Ceased/non-payment of the annual fee
8370 Indication related to discontinuation of the patent is to be deleted