DE3120460A1 - Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE3120460A1
DE3120460A1 DE19813120460 DE3120460A DE3120460A1 DE 3120460 A1 DE3120460 A1 DE 3120460A1 DE 19813120460 DE19813120460 DE 19813120460 DE 3120460 A DE3120460 A DE 3120460A DE 3120460 A1 DE3120460 A1 DE 3120460A1
Authority
DE
Germany
Prior art keywords
general formula
pyridoimidazolorifamycin
derivatives
radicals
meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19813120460
Other languages
German (de)
English (en)
Other versions
DE3120460C2 (forum.php
Inventor
Egidio Marchi
Lauretta 40033 Casalecchio di Reno Bologna Montecchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Farmaceutici SpA
Original Assignee
Alfa Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici SpA filed Critical Alfa Farmaceutici SpA
Publication of DE3120460A1 publication Critical patent/DE3120460A1/de
Application granted granted Critical
Publication of DE3120460C2 publication Critical patent/DE3120460C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE19813120460 1980-05-22 1981-05-22 Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Granted DE3120460A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Publications (2)

Publication Number Publication Date
DE3120460A1 true DE3120460A1 (de) 1982-03-11
DE3120460C2 DE3120460C2 (forum.php) 1990-12-13

Family

ID=11107198

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813120460 Granted DE3120460A1 (de) 1980-05-22 1981-05-22 Pyridoimidazolorifamycinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Country Status (25)

Country Link
US (1) US4341785A (forum.php)
JP (1) JPS5711987A (forum.php)
AR (1) AR226212A1 (forum.php)
AT (1) AT373599B (forum.php)
AU (1) AU537093B2 (forum.php)
BE (1) BE888895A (forum.php)
CA (1) CA1142518A (forum.php)
CH (1) CH648037A5 (forum.php)
DE (1) DE3120460A1 (forum.php)
DK (1) DK157876C (forum.php)
EG (1) EG14891A (forum.php)
ES (1) ES502906A0 (forum.php)
FI (1) FI69467C (forum.php)
FR (1) FR2482967A1 (forum.php)
GB (1) GB2079270B (forum.php)
GR (1) GR75640B (forum.php)
IE (1) IE51204B1 (forum.php)
IT (1) IT1154655B (forum.php)
LU (1) LU83376A1 (forum.php)
NL (1) NL187022C (forum.php)
NO (1) NO155622C (forum.php)
PH (2) PH17207A (forum.php)
PT (1) PT73064B (forum.php)
SE (1) SE453089B (forum.php)
ZA (1) ZA813430B (forum.php)

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US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
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US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
US7902206B2 (en) * 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
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US7265107B2 (en) * 2004-03-10 2007-09-04 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
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US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
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US8404664B2 (en) 2005-08-11 2013-03-26 Targanta Therapeutics, Inc. Phosphonated Rifamycins and uses thereof for the prevention and treatment of bone and joint infections
DK1996710T3 (da) 2006-03-09 2019-10-07 Salix Pharmaceuticals Inc Rifaximin-præparat mod rektal dysfunktion
JP5844961B2 (ja) 2006-08-02 2016-01-20 サリックス ファーマシューティカルズ， インコーポレイテッド 放射線直腸ｓ状結腸炎を処置するための組成物および方法
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
AU2007298733B2 (en) * 2006-09-22 2012-11-08 Cipla Limited Rifaximin
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
AU2008273699A1 (en) 2007-07-06 2009-01-15 Lupin Limited Pharmaceutical compositions of rifaximin
SI2011486T1 (sl) 2007-07-06 2012-10-30 Lupin Ltd Farmacevtski sestavki rifaksimina
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CN104650114A (zh) 2008-02-25 2015-05-27 萨利克斯药品有限公司 利福昔明的多种形式及其用途
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
PT2252148T (pt) 2008-02-26 2020-01-23 Salix Pharmaceuticals Ltd Métodos de tratamento da síndrome do intestino irritável
EP2294012B1 (en) 2008-05-07 2014-07-09 Salix Pharmaceuticals, Ltd. Administration of a bowel cleanser and an antibiotic for the treatment of bowel disease
WO2010019511A2 (en) 2008-08-13 2010-02-18 Targanta Therapeutics Corp. Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
KR20110071096A (ko) 2008-09-26 2011-06-28 아스카 세이야쿠 가부시키가이샤 기능성 소화관 장해의 예방 및/또는 치료제
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
PT3628319T (pt) 2008-10-02 2024-03-22 Salix Pharmaceuticals Ltd Tratamento da encefalopatia hepática com rifaximina
EP2355805B1 (en) 2008-12-10 2019-02-13 Cipla Limited Rifaximin complexes
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
RU2540513C2 (ru) 2009-06-02 2015-02-10 Саликс Фармасьютикалз, Лтд. Способы лечения печеночной энцефалопатии
RU2582940C2 (ru) 2009-09-13 2016-04-27 Саликс Фармасьютикалз, Лтд. Способы лечения синдрома раздраженного кишечника (срк)
JP6211768B2 (ja) 2009-10-27 2017-10-11 ルピン・リミテッド リファキシミンの固溶体
RU2012126084A (ru) 2009-11-23 2013-12-27 Сипла Лимитед Пенная композиция для местного применения
EP2401282B2 (en) 2009-12-28 2017-01-04 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
JP5896380B2 (ja) 2010-02-18 2016-03-30 サリックス ファーマスーティカルズ，リミテッド 感染症を治療するための方法
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JP6092629B2 (ja) 2010-03-10 2017-03-08 ルピン・リミテッドＬｕｐｉｎ Ｌｉｍｉｔｅｄ リファキシミン使用準備済懸濁液
SMT202000390T1 (it) 2010-07-12 2020-09-10 Salix Pharmaceuticals Inc Formulazioni di rifaximina e loro usi
US8759513B2 (en) 2010-09-13 2014-06-24 Sequent Scientific Limited Polymorphic form of rifaximin and process for its preparation
AU2012214239B2 (en) 2011-02-11 2016-06-30 Salix Pharmaceuticals, Ltd. Forms of Rifaximin and uses thereof
EP2705042A1 (en) 2011-05-02 2014-03-12 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
ITMI20110890A1 (it) 2011-05-19 2012-11-20 A M S A Anonima Materie Sint & Affini S P A Polimorfo di rifaximina e processo per la sua preparazione
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
CA2854380A1 (en) 2011-11-02 2013-05-10 Salix Pharmaceuticals, Ltd. Methods for treating irritable bowel syndrome (ibs) and infections
JP2015509105A (ja) * 2012-01-25 2015-03-26 サリックス ファーマスーティカルズ，リミテッド リファキシミン誘導体及びその使用
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
WO2014091432A1 (en) 2012-12-12 2014-06-19 Ranbaxy Laboratories Limited Pharmaceutical compositions of rifaximin
JP2016516988A (ja) 2013-03-15 2016-06-09 アルファ ワッセルマン ソシエタ ペル アチオニＡｌｆａ Ｗａｓｓｅｒｍａｎｎ Ｓ．Ｐ．Ａ． 膣感染症を診断するための方法
EP2968283A1 (en) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Rifaximin for use in the treating of vaginal infections.
EP2983647B1 (en) 2013-04-12 2020-09-09 Alfasigma S.p.A. Nsaid administration and related compositions, methods and systems
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
EP2927235B1 (en) 2014-03-31 2017-02-08 Euticals S.P.A. Polymorphic mixture of rifaximin and its use for the preparation of solid formulations
US9765088B2 (en) * 2014-04-19 2017-09-19 Granules India Limited Process for the preparation of rifamycin derivatives
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SI3143027T1 (sl) * 2014-05-12 2019-10-30 Alfasigma Spa Nova solvatirana kristalna oblika rifaksimina, proizvodnja, sestavki in uporaba le-teh
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
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IT201700091912A1 (it) * 2017-08-08 2019-02-08 Biofer Spa Nuove pirido-imidazo rifamicine
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Citations (3)

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Publication number Priority date Publication date Assignee Title
DE273377C (forum.php) *
AT273377B (de) * 1967-03-01 1969-08-11 Lepetit Spa Verfahren zur Herstellung von neuen Rifamycinen
AT358171B (de) * 1975-06-13 1980-08-25 Archifar Lab Chim Farm Verfahren zur herstellung von neuen rifamycin- -verbindungen

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
DK345977A (da) * 1976-09-30 1978-03-31 Archifar Ind Chim Trentino G rifamycinforbindelser og fremgangsmaade til deres fremstillin
CH629212A5 (it) * 1976-10-18 1982-04-15 Erba Farmitalia Procedimento per la preparazione di composti di rifamicina.
CH633014A5 (en) * 1978-06-09 1982-11-15 Erba Farmitalia Rifamycin compounds

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
DE273377C (forum.php) *
AT273377B (de) * 1967-03-01 1969-08-11 Lepetit Spa Verfahren zur Herstellung von neuen Rifamycinen
AT358171B (de) * 1975-06-13 1980-08-25 Archifar Lab Chim Farm Verfahren zur herstellung von neuen rifamycin- -verbindungen

Non-Patent Citations (6)

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Title
FORTH, W., HENSCHLER, D., REUMMEL, W.: Pharmakologie und Toxikologie, 4. Aufl., S. 322 *
FÜLGRAFT, G., PALM, D.:Pharmacotherapie, 3. Aufl.,1979, S. 145 *
GB-Appl. 20 84 575 A *
Journal of Antibiotics, Vol. XXXVII, 1984, S. 178-181 *
Rote Liste 77/78, 59147 B *
WALTER, A.M., HEILMEYER, L.: Antibiotica- Fibel, 4. Aufl., 1975, S. 549 *

Also Published As

Publication number Publication date
JPS5711987A (en) 1982-01-21
DE3120460C2 (forum.php) 1990-12-13
FI811565L (fi) 1981-11-23
CH648037A5 (de) 1985-02-28
IE811139L (en) 1981-11-22
LU83376A1 (fr) 1981-09-11
EG14891A (en) 1985-12-31
DK224781A (da) 1981-11-23
ZA813430B (en) 1982-06-30
IT8003429A0 (it) 1980-05-22
FR2482967A1 (fr) 1981-11-27
GB2079270A (en) 1982-01-20
NO155622C (no) 1987-04-29
ATA222781A (de) 1983-06-15
FI69467B (fi) 1985-10-31
AU7065581A (en) 1981-11-26
US4341785A (en) 1982-07-27
IT1154655B (it) 1987-01-21
JPS6123192B2 (forum.php) 1986-06-04
FI69467C (fi) 1986-02-10
AR226212A1 (es) 1982-06-15
CA1142518A (en) 1983-03-08
ES8203388A1 (es) 1982-04-01
AU537093B2 (en) 1984-06-07
DK157876B (da) 1990-02-26
GR75640B (forum.php) 1984-08-02
PH18704A (en) 1985-09-05
PT73064A (en) 1981-06-01
NL187022B (nl) 1990-12-03
IE51204B1 (en) 1986-10-29
PT73064B (en) 1982-07-05
SE8103216L (sv) 1981-11-23
NL187022C (nl) 1991-05-01
SE453089B (sv) 1988-01-11
NL8102290A (nl) 1981-12-16
NO811731L (no) 1981-11-23
GB2079270B (en) 1984-01-18
DK157876C (da) 1990-07-30
ES502906A0 (es) 1982-04-01
FR2482967B1 (forum.php) 1985-03-29
AT373599B (de) 1984-02-10
PH17207A (en) 1984-06-19
BE888895A (fr) 1981-09-16
NO155622B (no) 1987-01-19

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