DE2230383C3 - Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben - Google Patents

Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben

Info

Publication number
DE2230383C3
DE2230383C3 DE2230383A DE2230383A DE2230383C3 DE 2230383 C3 DE2230383 C3 DE 2230383C3 DE 2230383 A DE2230383 A DE 2230383A DE 2230383 A DE2230383 A DE 2230383A DE 2230383 C3 DE2230383 C3 DE 2230383C3
Authority
DE
Germany
Prior art keywords
acid
acid derivatives
processes
making
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2230383A
Other languages
German (de)
English (en)
Other versions
DE2230383A1 (de
DE2230383B2 (de
Inventor
Felix Helmut Dr.Rer.Nat. Schmidt
Kurt Dr.-Ing. Stach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19712149070 external-priority patent/DE2149070C3/de
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE2230383A priority Critical patent/DE2230383C3/de
Priority to US00287114A priority patent/US3781328A/en
Priority to NL727212931A priority patent/NL146793B/xx
Priority to FI2626/72A priority patent/FI55493C/fi
Priority to AR244285A priority patent/AR193131A1/es
Priority to SE7212397A priority patent/SE393800B/xx
Priority to CH1416772A priority patent/CH576427A5/xx
Priority to GB4461172A priority patent/GB1359264A/en
Priority to YU2455/72A priority patent/YU36291B/xx
Priority to AU47233/72A priority patent/AU439063B2/en
Priority to CA152,967A priority patent/CA1010892A/en
Priority to FR7234605A priority patent/FR2154739B1/fr
Priority to AT840872A priority patent/AT319209B/de
Priority to HUBO1396A priority patent/HU164572B/hu
Priority to ES407208A priority patent/ES407208A1/es
Priority to JP47098866A priority patent/JPS5112618B2/ja
Publication of DE2230383A1 publication Critical patent/DE2230383A1/de
Priority to BE179642A priority patent/BE857160Q/xx
Priority to KE2755A priority patent/KE2755A/xx
Priority to HK418/77A priority patent/HK41877A/xx
Publication of DE2230383B2 publication Critical patent/DE2230383B2/de
Publication of DE2230383C3 publication Critical patent/DE2230383C3/de
Application granted granted Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2230383A 1971-10-01 1972-06-22 Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben Expired DE2230383C3 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DE2230383A DE2230383C3 (de) 1971-10-01 1972-06-22 Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben
US00287114A US3781328A (en) 1971-10-01 1972-09-07 Phenoxy-alkyl-carboxylic acid compounds
NL727212931A NL146793B (nl) 1971-10-01 1972-09-25 Werkwijze voor het bereiden van een geneesmiddel met lipide-verlagende werking, het volgens die werkwijze verkregen gevormde geneesmiddel en een werkwijze voor het bereiden van een fenoxyalkaancarbonzuurderivaat, geschikt voor de toepassing in het geneesmiddel.
FI2626/72A FI55493C (fi) 1971-10-01 1972-09-25 Foerfarande foer framstaellning av lipidsaenkande verksamma fenoxialkylkarbonsyraderivat
AR244285A AR193131A1 (es) 1971-10-01 1972-09-26 Un procedimiento para la obtencion de derivados de acido fenoxialquilcarboxilico
SE7212397A SE393800B (sv) 1971-10-01 1972-09-26 Forfarande for framstellning av bensoylamino-alkyl-fenoxi-alkylkarbonsyraderivat med lipidsenkande effekt
CH1416772A CH576427A5 (cg-RX-API-DMAC10.html) 1971-10-01 1972-09-27
GB4461172A GB1359264A (en) 1971-10-01 1972-09-27 Phenoxy-alkyl-carboxylic acid derivatives ant the preparation thereof
YU2455/72A YU36291B (en) 1971-10-01 1972-09-28 Process for preparing derivatives of phenoxyalkyl-carboxylic acid
AU47233/72A AU439063B2 (en) 1972-09-28 New phenoxy-alkyl-carboxylic acid derivatives and the preparation thereof
CA152,967A CA1010892A (en) 1971-10-01 1972-09-29 Phenoxy-alkyl-carboxylic acid derivatives and process for their preparation
HUBO1396A HU164572B (cg-RX-API-DMAC10.html) 1971-10-01 1972-09-29
FR7234605A FR2154739B1 (cg-RX-API-DMAC10.html) 1971-10-01 1972-09-29
AT840872A AT319209B (de) 1971-10-01 1972-09-29 Verfahren zur Herstellung von neuen 4-Benzamidoalkylphenoxyalkansäuren und ihren Alkylestern oder Salzen
ES407208A ES407208A1 (es) 1971-10-01 1972-09-30 Procedimiento para la preparacion de derivados de acidos fenoxialcohilcarboxilicos.
JP47098866A JPS5112618B2 (cg-RX-API-DMAC10.html) 1971-10-01 1972-10-02
BE179642A BE857160Q (fr) 1971-10-01 1977-07-26 Derives d'acide phenoxyalcoylcarboxylique et leur procede de fabrication
KE2755A KE2755A (en) 1971-10-01 1977-08-02 New phenoxy-alkyl-carboxylic acid derivatives and the preparation thereof
HK418/77A HK41877A (en) 1971-10-01 1977-08-11 New phenoxy-alkyl-carboxylic acid derivates and the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19712149070 DE2149070C3 (de) 1971-10-01 1971-10-01 Phenoxyalkylcarbonsäurederivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel
DE2230383A DE2230383C3 (de) 1971-10-01 1972-06-22 Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben

Publications (3)

Publication Number Publication Date
DE2230383A1 DE2230383A1 (de) 1974-01-17
DE2230383B2 DE2230383B2 (de) 1980-10-09
DE2230383C3 true DE2230383C3 (de) 1981-12-03

Family

ID=25761810

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2230383A Expired DE2230383C3 (de) 1971-10-01 1972-06-22 Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben

Country Status (18)

Country Link
US (1) US3781328A (cg-RX-API-DMAC10.html)
JP (1) JPS5112618B2 (cg-RX-API-DMAC10.html)
AR (1) AR193131A1 (cg-RX-API-DMAC10.html)
AT (1) AT319209B (cg-RX-API-DMAC10.html)
BE (1) BE857160Q (cg-RX-API-DMAC10.html)
CA (1) CA1010892A (cg-RX-API-DMAC10.html)
CH (1) CH576427A5 (cg-RX-API-DMAC10.html)
DE (1) DE2230383C3 (cg-RX-API-DMAC10.html)
ES (1) ES407208A1 (cg-RX-API-DMAC10.html)
FI (1) FI55493C (cg-RX-API-DMAC10.html)
FR (1) FR2154739B1 (cg-RX-API-DMAC10.html)
GB (1) GB1359264A (cg-RX-API-DMAC10.html)
HK (1) HK41877A (cg-RX-API-DMAC10.html)
HU (1) HU164572B (cg-RX-API-DMAC10.html)
KE (1) KE2755A (cg-RX-API-DMAC10.html)
NL (1) NL146793B (cg-RX-API-DMAC10.html)
SE (1) SE393800B (cg-RX-API-DMAC10.html)
YU (1) YU36291B (cg-RX-API-DMAC10.html)

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KR20220016146A (ko) 2019-05-30 2022-02-08 인터셉트 파마슈티컬즈, 인크. 담즙정체성 간 질환의 치료에서 사용하기 위한 fxr 효능제 및 피브레이트를 포함하는 제약 조성물

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GB1080503A (en) * 1965-07-02 1967-08-23 Smith & Nephew Substituted acetic acids and a process for their preparation

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Publication number Publication date
AR193131A1 (es) 1973-03-30
FR2154739B1 (cg-RX-API-DMAC10.html) 1975-10-31
YU36291B (en) 1982-06-18
DE2230383A1 (de) 1974-01-17
CA1010892A (en) 1977-05-24
YU245572A (en) 1980-10-31
SE393800B (sv) 1977-05-23
ES407208A1 (es) 1975-11-01
NL146793B (nl) 1975-08-15
NL7212931A (cg-RX-API-DMAC10.html) 1973-04-03
US3781328A (en) 1973-12-25
FI55493C (fi) 1979-08-10
KE2755A (en) 1977-10-14
HU164572B (cg-RX-API-DMAC10.html) 1974-03-28
DE2230383B2 (de) 1980-10-09
AU4723372A (en) 1973-08-23
GB1359264A (en) 1974-07-10
HK41877A (en) 1977-08-19
CH576427A5 (cg-RX-API-DMAC10.html) 1976-06-15
FI55493B (fi) 1979-04-30
FR2154739A1 (cg-RX-API-DMAC10.html) 1973-05-11
AT319209B (de) 1974-12-10
BE857160Q (fr) 1978-01-26
JPS4840741A (cg-RX-API-DMAC10.html) 1973-06-15
JPS5112618B2 (cg-RX-API-DMAC10.html) 1976-04-21

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