DD224593A5 - Verfahren zur herstellung von 1-heteroaryl-4-[-2,5-pyrrolidindion-1-yl]alkyl]piperazinderivaten - Google Patents

Verfahren zur herstellung von 1-heteroaryl-4-[-2,5-pyrrolidindion-1-yl]alkyl]piperazinderivaten Download PDF

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Publication number
DD224593A5
DD224593A5 DD84267233A DD26723384A DD224593A5 DD 224593 A5 DD224593 A5 DD 224593A5 DD 84267233 A DD84267233 A DD 84267233A DD 26723384 A DD26723384 A DD 26723384A DD 224593 A5 DD224593 A5 DD 224593A5
Authority
DD
German Democratic Republic
Prior art keywords
general formula
pyrimidinyl
compound
compounds
preparation
Prior art date
Application number
DD84267233A
Other languages
German (de)
English (en)
Inventor
James St New
Joseph P Yevich
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DD224593A5 publication Critical patent/DD224593A5/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/54—Preparation of carboxylic acid anhydrides
    • C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DD84267233A 1983-09-12 1984-09-12 Verfahren zur herstellung von 1-heteroaryl-4-[-2,5-pyrrolidindion-1-yl]alkyl]piperazinderivaten DD224593A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/531,519 US4524206A (en) 1983-09-12 1983-09-12 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Publications (1)

Publication Number Publication Date
DD224593A5 true DD224593A5 (de) 1985-07-10

Family

ID=24117966

Family Applications (1)

Application Number Title Priority Date Filing Date
DD84267233A DD224593A5 (de) 1983-09-12 1984-09-12 Verfahren zur herstellung von 1-heteroaryl-4-[-2,5-pyrrolidindion-1-yl]alkyl]piperazinderivaten

Country Status (33)

Country Link
US (1) US4524206A (fr)
JP (1) JPH0647586B2 (fr)
KR (1) KR890000566B1 (fr)
AR (1) AR241910A1 (fr)
AU (1) AU581858B2 (fr)
BE (1) BE900555A (fr)
CA (1) CA1285564C (fr)
CH (1) CH660484A5 (fr)
CS (1) CS258119B2 (fr)
CY (1) CY1538A (fr)
DD (1) DD224593A5 (fr)
DE (1) DE3433327C2 (fr)
DK (1) DK171990B1 (fr)
ES (1) ES8605797A1 (fr)
FI (1) FI83515C (fr)
FR (1) FR2555585B1 (fr)
GB (1) GB2146333B (fr)
GR (1) GR80320B (fr)
HK (1) HK84590A (fr)
HU (1) HU192439B (fr)
IE (1) IE58020B1 (fr)
IL (1) IL72854A (fr)
IT (1) IT1196250B (fr)
LU (1) LU85537A1 (fr)
NL (1) NL8402769A (fr)
NO (1) NO162384B (fr)
NZ (1) NZ209480A (fr)
OA (1) OA07809A (fr)
PT (1) PT79187B (fr)
SE (1) SE463368B (fr)
SU (1) SU1384199A3 (fr)
YU (2) YU45655B (fr)
ZA (1) ZA847065B (fr)

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DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4585773A (en) * 1984-07-11 1986-04-29 Bristol-Myers Company Isoindolinyl-alkyl-piperazines
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
JPS61238784A (ja) * 1985-04-17 1986-10-24 Sumitomo Seiyaku Kk コハク酸イミド誘導体及びその酸付加塩
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
NZ216720A (en) * 1985-07-08 1990-09-26 Bristol Myers Co Diazinylpiperidine derivatives and pharmaceutical compositions
US4826843A (en) * 1985-07-08 1989-05-02 Bristol-Myers Cerebral function enhancing diazinylpiperidine derivatives
US4925841A (en) * 1985-07-22 1990-05-15 Temple University Of The Commonwealth System Of Higher Education Mannich bases of spirosuccinimides
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
US4757073A (en) * 1986-09-30 1988-07-12 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1-yl) pyridines, compositions and use
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US4777254A (en) * 1986-12-02 1988-10-11 American Home Products Corp. Cyclic imides as H1 -antagonists
CA1335289C (fr) * 1987-10-26 1995-04-18 Fujio Antoku Derives piperidinylbenzisoxazole, leur production et leur utilisation pharmaceutique
US4855430A (en) * 1987-11-12 1989-08-08 American Home Products Corporation Polycyclicamine with psychotropic activity
WO1989004311A1 (fr) * 1987-11-12 1989-05-18 American Home Products Corporation Amines polycycliques a activite psychotrope
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
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US5015740A (en) * 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
KR0179063B1 (ko) * 1993-02-04 1999-03-20 사사이 아키라 항정신병 작용을 갖는 화합물
US5338738A (en) * 1993-04-19 1994-08-16 Bristol-Myers Squibb Company Cerebral function enhancers: acyclic amide derivatives of pyrimidinylpiperidines
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
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JP2009527568A (ja) 2006-02-22 2009-07-30 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
US7858790B2 (en) 2006-06-29 2010-12-28 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
WO2008121019A1 (fr) * 2007-03-29 2008-10-09 Obschestvo S Ogranishennoi Otvetstvennostu 'farmving' Produit à activité anti-allergique anti-histaminique et procédé de fabrication correspondant
BR112013008063A2 (pt) 2010-10-05 2016-06-14 Syngenta Participations Ag pirrolidin-il-aril-carboxamidas inseticidas
TW201311677A (zh) 2011-05-31 2013-03-16 Syngenta Participations Ag 殺蟲化合物
BR112014007460A2 (pt) 2011-10-03 2017-04-04 Syngenta Participations Ag processos enanciosseletivos para pirrolidinas 3-aril-3-trifluorometil-substituídas inseticidas
EP3896058A3 (fr) 2011-10-03 2022-01-12 Syngenta Participations Ag Procédés énantiosélectifs pour des insecticides de pyrrolidines 3-aryl-3-trifluorométhyl-substituées
EP3601280A1 (fr) 2017-03-23 2020-02-05 Syngenta Participations AG Composés insecticides
WO2018172477A1 (fr) 2017-03-23 2018-09-27 Syngenta Participations Ag Composés insecticides
WO2019243263A1 (fr) 2018-06-19 2019-12-26 Syngenta Participations Ag Composés insecticides
EP3856715A1 (fr) 2018-09-26 2021-08-04 Syngenta Participations Ag Composés insecticides

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DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
IL72854A (en) 1988-03-31
DK433884A (da) 1985-03-13
CY1538A (en) 1990-11-16
FI843522L (fi) 1985-03-13
DK171990B1 (da) 1997-09-08
NO843579L (no) 1985-03-13
PT79187A (en) 1984-10-01
NL8402769A (nl) 1985-04-01
YU45655B (sh) 1992-07-20
PT79187B (en) 1986-11-24
AU3287084A (en) 1985-05-30
NZ209480A (en) 1988-01-08
US4524206A (en) 1985-06-18
ZA847065B (en) 1985-04-24
CS258119B2 (en) 1988-07-15
HK84590A (en) 1990-10-25
SE8404552D0 (sv) 1984-09-11
SE8404552L (sv) 1985-03-13
SU1384199A3 (ru) 1988-03-23
FI83515C (fi) 1991-07-25
IE842311L (en) 1985-03-12
OA07809A (fr) 1986-11-20
IL72854A0 (en) 1984-12-31
ES8605797A1 (es) 1986-04-01
GB2146333A (en) 1985-04-17
ES535780A0 (es) 1986-04-01
FI83515B (fi) 1991-04-15
SE463368B (sv) 1990-11-12
GB8422860D0 (en) 1984-10-17
CS672184A2 (en) 1987-12-17
BE900555A (fr) 1985-03-11
CH660484A5 (de) 1987-04-30
IE58020B1 (en) 1993-06-30
LU85537A1 (fr) 1985-04-29
JPH0647586B2 (ja) 1994-06-22
KR850002483A (ko) 1985-05-13
KR890000566B1 (ko) 1989-03-21
FR2555585A1 (fr) 1985-05-31
YU156384A (en) 1987-02-28
CA1285564C (fr) 1991-07-02
FR2555585B1 (fr) 1989-01-06
HUT36116A (en) 1985-08-28
GB2146333B (en) 1987-04-01
JPS6084282A (ja) 1985-05-13
AR241910A1 (es) 1993-01-29
AU581858B2 (en) 1989-03-09
GR80320B (en) 1985-01-14
IT8422621A0 (it) 1984-09-11
HU192439B (en) 1987-06-29
YU210386A (en) 1987-12-31
DE3433327C2 (de) 1998-07-16
DE3433327A1 (de) 1985-03-28
DK433884D0 (da) 1984-09-12
NO162384B (no) 1989-09-11
YU45809B (sh) 1992-07-20
IT1196250B (it) 1988-11-16
FI843522A0 (fi) 1984-09-07

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