DD208351A5 - Verfahren zur herstellung eines 7-(subst.-oder unsubst.-amiono)-3-(subst.-methyl)-delta hoch 3-cephem-4-carbonsaeure - Google Patents

Verfahren zur herstellung eines 7-(subst.-oder unsubst.-amiono)-3-(subst.-methyl)-delta hoch 3-cephem-4-carbonsaeure Download PDF

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Publication number
DD208351A5
DD208351A5 DD81247292A DD24729281A DD208351A5 DD 208351 A5 DD208351 A5 DD 208351A5 DD 81247292 A DD81247292 A DD 81247292A DD 24729281 A DD24729281 A DD 24729281A DD 208351 A5 DD208351 A5 DD 208351A5
Authority
DD
German Democratic Republic
Prior art keywords
acid
group
substituted
groups
methyl
Prior art date
Application number
DD81247292A
Other languages
German (de)
English (en)
Inventor
Hiroshi Sadaki
Hirokazu Narha
Hiroyuki Imaizumi
Yoshinori Konishi
Iakihiro Inaba
Iaisuo Hirakawa
Hideo Taki
Masaru Tai
Yasuo Watanabe
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55132253A external-priority patent/JPS5758689A/ja
Priority claimed from JP55158184A external-priority patent/JPS5782393A/ja
Priority claimed from JP55175263A external-priority patent/JPS6052755B2/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of DD208351A5 publication Critical patent/DD208351A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD81247292A 1980-09-25 1981-09-25 Verfahren zur herstellung eines 7-(subst.-oder unsubst.-amiono)-3-(subst.-methyl)-delta hoch 3-cephem-4-carbonsaeure DD208351A5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP55132253A JPS5758689A (en) 1980-09-25 1980-09-25 Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids
JP55158184A JPS5782393A (en) 1980-11-12 1980-11-12 7-amino-3-(2-(1,2,3,4-tetrazolyl)methyl)cephem-4-carboxylic acid
JP55175263A JPS6052755B2 (ja) 1980-12-13 1980-12-13 新規セファロスポリン類

Publications (1)

Publication Number Publication Date
DD208351A5 true DD208351A5 (de) 1984-05-02

Family

ID=27316463

Family Applications (2)

Application Number Title Priority Date Filing Date
DD81233599A DD202436A5 (de) 1980-09-25 1981-09-25 Verfahren zur herstellung von neuen cephalosporinen
DD81247292A DD208351A5 (de) 1980-09-25 1981-09-25 Verfahren zur herstellung eines 7-(subst.-oder unsubst.-amiono)-3-(subst.-methyl)-delta hoch 3-cephem-4-carbonsaeure

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DD81233599A DD202436A5 (de) 1980-09-25 1981-09-25 Verfahren zur herstellung von neuen cephalosporinen

Country Status (27)

Country Link
US (4) US4489072A (es)
KR (1) KR860000932B1 (es)
AR (1) AR240645A1 (es)
AT (4) AT375082B (es)
AU (3) AU550330B2 (es)
CA (2) CA1204735A (es)
CH (4) CH652129A5 (es)
DD (2) DD202436A5 (es)
DE (5) DE3152932C2 (es)
DK (1) DK163877C (es)
EG (1) EG17373A (es)
ES (4) ES8301998A1 (es)
FI (2) FI75575C (es)
FR (2) FR2509310B1 (es)
GB (3) GB2089339B (es)
HU (1) HU185850B (es)
IN (4) IN155375B (es)
IT (1) IT1172201B (es)
LU (1) LU83650A1 (es)
MX (1) MX155025A (es)
NL (1) NL8104386A (es)
NO (1) NO161117C (es)
NZ (1) NZ198350A (es)
PH (5) PH18072A (es)
PT (1) PT73727B (es)
RO (4) RO86823B (es)
SE (5) SE453090B (es)

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EP0081971A3 (en) * 1981-12-08 1984-09-26 Tanabe Seiyaku Co., Ltd. Novel cephalosporin compound and process for preparing the same
FI75827C (fi) * 1982-11-17 1988-08-08 Toyama Chemical Co Ltd Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart 7-tiazolyl-3-pyrazinylmetylcefalosporin samt en i foerfarandet anvaendbar mellanprodukt.
US4618606A (en) * 1982-11-17 1986-10-21 Toyama Chemical Co., Ltd. Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins
JPS6064986A (ja) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd セファロスポリン類の製造法
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
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AT397086B (de) * 1984-05-25 1994-01-25 Toyama Chemical Co Ltd Verfahren zur herstellung von neuen 2-(2-aminothiazol-4-4yl)-2-(syn)-alkoxyimino- acetamiden
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US4692517A (en) * 1986-03-20 1987-09-08 American Home Products Corporation C-3' acylaminooxy-7-[(2-aminothiazol-4-yl)-α-(substituted-oximino)acetyl]cephalosporin derivatives
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US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
PL1618114T3 (pl) * 2003-04-16 2010-12-31 Sandoz Ag Sposoby otrzymywania cefepimy
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
US20050288347A1 (en) * 2004-03-26 2005-12-29 Hodge Carl N Certain triazole-based compounds, compositions, and uses thereof
US8198434B2 (en) * 2008-05-07 2012-06-12 Idexx Laboratories, Inc. Process for preparing cefsulodin sodium
CA2828114A1 (en) * 2010-02-26 2011-09-01 Gary Igor DMITRIENKO Cephalosporin derivatives useful as .beta.-lactamase inhibitors and compositions and methods of use thereof
CN102351886B (zh) * 2011-09-07 2013-10-16 山东罗欣药业股份有限公司 头孢特仑新戊酯晶体、其制备方法及含有该晶体的组合物片剂
EP4219477A1 (en) 2013-07-17 2023-08-02 Otsuka Pharmaceutical Co., Ltd. Cyanotriazole compounds
CN106046026B (zh) * 2016-06-30 2018-07-06 济南康和医药科技有限公司 一种头孢特仑新戊酯的制备方法
CN112645842B (zh) * 2020-12-25 2022-08-19 复旦大学 一种氰乙酸叔丁酯的连续流制备方法

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Also Published As

Publication number Publication date
US4879381A (en) 1989-11-07
RO86824B (ro) 1985-05-31
SE468476B (sv) 1993-01-25
IN158589B (es) 1986-12-13
AU4986185A (en) 1986-03-20
RO86825B (ro) 1985-05-31
CA1200541A (en) 1986-02-11
US4489072A (en) 1984-12-18
FI80041C (fi) 1990-04-10
IN155375B (es) 1985-01-19
GB2135304B (en) 1985-03-27
FI812980L (fi) 1982-03-26
CH652128A5 (de) 1985-10-31
RO82689A (ro) 1983-11-01
AU550330B2 (en) 1986-03-20
NZ198350A (en) 1985-02-28
RO82689B (ro) 1983-10-30
AU558649B2 (en) 1987-02-05
US4673738A (en) 1987-06-16
IN159126B (es) 1987-03-28
DE3152934C2 (es) 1990-01-18
AU4986285A (en) 1986-04-24
US5144027A (en) 1992-09-01
SE468479B (sv) 1993-01-25
LU83650A1 (fr) 1982-01-21
ATA410981A (de) 1983-11-15
RO86825A (ro) 1985-05-20
IT1172201B (it) 1987-06-18
PH19147A (en) 1986-01-15
RO86823B (ro) 1985-05-31
ATA55483A (de) 1985-03-15
MX155025A (es) 1988-01-20
SE468477B (sv) 1993-01-25
DD202436A5 (de) 1983-09-14
SE8105658L (sv) 1982-05-05
HU185850B (en) 1985-04-28
DE3152935C2 (es) 1992-07-16
SE8600195D0 (sv) 1986-01-16
ATA55683A (de) 1984-11-15
FR2509310A1 (fr) 1983-01-14
ES514671A0 (es) 1983-05-01
AT378193B (de) 1985-06-25
SE453090B (sv) 1988-01-11
CH652130A5 (de) 1985-10-31
FI870153A0 (fi) 1987-01-15
FR2511377A1 (fr) 1983-02-18
PH20221A (en) 1986-10-23
FR2511377B1 (fr) 1985-12-13
SE468478B (sv) 1993-01-25
ES8306157A1 (es) 1983-05-01
FR2509310B1 (fr) 1985-08-02
DE3137854A1 (de) 1982-04-15
DK163877B (da) 1992-04-13
KR860000932B1 (ko) 1986-07-19
SE8600194D0 (sv) 1986-01-16
EG17373A (en) 1990-12-30
FI75575C (fi) 1988-07-11
DE3152932C2 (es) 1990-02-08
DE3152931C2 (es) 1989-10-05
PH18072A (en) 1985-03-18
SE8600195L (sv) 1986-01-16
AR240645A1 (es) 1990-07-31
CA1204735A (en) 1986-05-20
ES8306155A1 (es) 1983-05-01
RO86824A (ro) 1985-05-20
RO86823A (ro) 1985-05-20
AU7543881A (en) 1982-04-01
AU568033B2 (en) 1987-12-10
FI870153A (fi) 1987-01-15
SE8600193D0 (sv) 1986-01-16
PT73727A (en) 1981-10-01
ATA55583A (de) 1985-03-15
AT378962B (de) 1985-10-25
ES505760A0 (es) 1983-01-01
CH652129A5 (de) 1985-10-31
GB8402249D0 (en) 1984-02-29
SE8600192L (sv) 1986-01-16
NO813252L (no) 1982-03-26
SE8600192D0 (sv) 1986-01-16
SE8600193L (sv) 1986-01-16
ES8306156A1 (es) 1983-05-01
PH18484A (en) 1985-08-02
ES514669A0 (es) 1983-05-01
IT8149348A0 (it) 1981-09-23
GB2089339B (en) 1985-04-24
AT375082B (de) 1984-06-25
DE3137854C2 (es) 1987-06-19
GB8402250D0 (en) 1984-02-29
FI75575B (fi) 1988-03-31
PT73727B (en) 1982-12-30
ES8301998A1 (es) 1983-01-01
GB2136420B (en) 1985-05-01
GB2136420A (en) 1984-09-19
IN158590B (es) 1986-12-13
DK163877C (da) 1992-09-14
NL8104386A (nl) 1982-04-16
CH651837A5 (de) 1985-10-15
GB2089339A (en) 1982-06-23
ES514670A0 (es) 1983-05-01
DK421881A (da) 1982-04-15
FI80041B (fi) 1989-12-29
GB2135304A (en) 1984-08-30
PH19251A (en) 1986-02-17
SE8600194L (sv) 1986-01-16
AT378961B (de) 1985-10-25
NO161117B (no) 1989-03-28
NO161117C (no) 1989-07-05

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