ES485938A1 - Un procedimiento para la preparacion de antibioticos de ce- falosporina - Google Patents
Un procedimiento para la preparacion de antibioticos de ce- falosporinaInfo
- Publication number
- ES485938A1 ES485938A1 ES485938A ES485938A ES485938A1 ES 485938 A1 ES485938 A1 ES 485938A1 ES 485938 A ES485938 A ES 485938A ES 485938 A ES485938 A ES 485938A ES 485938 A1 ES485938 A1 ES 485938A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- formula
- methylpyrazolium
- ceph
- aminothiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 3
- 229940088710 antibiotic agent Drugs 0.000 title abstract 3
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- -1 1-carboxycyclobut-1-oxyimin o Chemical class 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Un procedimiento para la preparación de antibióticos de cefalosporina de fórmula **(Fórmula)** (en la que Ra y Rb, que pueden ser iguales o diferentes, representan cada uno un grupo alcohilo C1-4, o junto con el átomo de carbono al que están unidos forman un grupo cicloalcohilideno C3-7 y R1 representa un grupo alcohilo C 1-4) o sales no tóxicas o ésteres metabólicamente lábiles de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7844595 | 1978-11-15 | ||
| GB7844597 | 1978-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES485938A1 true ES485938A1 (es) | 1980-07-01 |
Family
ID=26269583
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485939A Expired ES485939A1 (es) | 1978-11-15 | 1979-11-14 | Un procedimiento para la preparacion de antibioticos de ce- falosporina |
| ES485937A Expired ES485937A1 (es) | 1978-11-15 | 1979-11-14 | Un procedimiento para la preparacion de antibioticos de ce- falosporina |
| ES485938A Expired ES485938A1 (es) | 1978-11-15 | 1979-11-14 | Un procedimiento para la preparacion de antibioticos de ce- falosporina |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485939A Expired ES485939A1 (es) | 1978-11-15 | 1979-11-14 | Un procedimiento para la preparacion de antibioticos de ce- falosporina |
| ES485937A Expired ES485937A1 (es) | 1978-11-15 | 1979-11-14 | Un procedimiento para la preparacion de antibioticos de ce- falosporina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4464368A (es) |
| AT (1) | AT366387B (es) |
| AU (1) | AU529825B2 (es) |
| CA (1) | CA1136616A (es) |
| CH (1) | CH647784A5 (es) |
| DE (1) | DE2946038A1 (es) |
| DK (1) | DK480679A (es) |
| ES (3) | ES485939A1 (es) |
| FI (1) | FI793566A (es) |
| FR (1) | FR2441630A1 (es) |
| IE (1) | IE49207B1 (es) |
| IL (1) | IL58717A (es) |
| LU (1) | LU81884A1 (es) |
| NL (1) | NL7908318A (es) |
| NO (1) | NO793688L (es) |
| NZ (1) | NZ192127A (es) |
| SE (1) | SE7909401L (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78245B (es) * | 1980-09-12 | 1984-09-26 | Ciba Geigy Ag | |
| NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
| EP0062321B1 (en) * | 1981-04-03 | 1989-03-01 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
| DE3336757A1 (de) * | 1983-10-08 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| CN86107947A (zh) * | 1985-11-22 | 1987-05-27 | 藤沢药品工业株式会社 | 新的头孢烯化合物及其制备方法 |
| US5373000A (en) * | 1985-12-26 | 1994-12-13 | Eisai Co., Ltd. | 7Beta-(thiadiazolyl)-2-iminoacetamido-3cephem compounds |
| EP0346465B1 (en) * | 1986-04-14 | 1993-08-11 | Banyu Pharmaceutical Co., Ltd. | 1-carboxy-1-vyniloxyiminoaminothiazole cephalosporing derivatives and process for their preparation |
| GB8611823D0 (en) * | 1986-05-15 | 1986-06-25 | Ici Plc | Process |
| CA1293719C (en) * | 1986-09-22 | 1991-12-31 | Takao Takaya | Cephem compounds and processes for preparation thereof |
| US5162520A (en) * | 1986-09-22 | 1992-11-10 | Fujisawa Pharmaceutical Co., Ltd. | Intermediates for cephem compounds |
| US5624898A (en) * | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
| US6407061B1 (en) | 1989-12-05 | 2002-06-18 | Chiron Corporation | Method for administering insulin-like growth factor to the brain |
| US10000510B2 (en) | 2014-08-18 | 2018-06-19 | Merck Sharp & Dohme Corp. | Salt forms of ceftolozane |
| WO2016109259A2 (en) | 2014-12-30 | 2016-07-07 | Merck Sharp & Dohme Corp. | Synthesis of cephalosporin compounds |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4079178A (en) * | 1971-05-14 | 1978-03-14 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position |
| US4064346A (en) * | 1971-05-14 | 1977-12-20 | Glaxo Laboratories Limited | 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
| US4093803A (en) * | 1971-05-14 | 1978-06-06 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins |
| US4017515A (en) * | 1971-05-14 | 1977-04-12 | Glaxo Laboratories Limited | α-(Etherified oximino) carboxylic acids and acid chlorides |
| GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
| US4024133A (en) * | 1971-05-14 | 1977-05-17 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins |
| US4092477A (en) * | 1971-05-14 | 1978-05-30 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins |
| US4024137A (en) * | 1971-05-14 | 1977-05-17 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins |
| US3971778A (en) * | 1972-05-12 | 1976-07-27 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position |
| US4060686A (en) * | 1973-12-21 | 1977-11-29 | Janice Bradshaw | Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group |
| GB1496757A (en) * | 1973-12-21 | 1978-01-05 | Glaxo Lab Ltd | Cephalosporin derivatives |
| US4144392A (en) * | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile |
| US4162360A (en) * | 1973-12-21 | 1979-07-24 | Glaxo Laboratories Limited | 3-Carbamoyloxymethyl-7-substituted oximino acetamido cephalosporanic acid derivatives |
| US4144393A (en) * | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group |
| US4032950A (en) * | 1974-12-06 | 1977-06-28 | Hughes Aircraft Company | Liquid phase epitaxial process for growing semi-insulating gaas layers |
| DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
| DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| US4165430A (en) * | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
| US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
| FR2457296A1 (fr) * | 1979-05-23 | 1980-12-19 | Rhone Poulenc Ind | Nouveaux derives de vinyl-3 cephalosporines et leur preparation |
| IL61458A0 (en) * | 1979-12-07 | 1980-12-31 | Erba Farmitalia | N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them |
| US4382932A (en) * | 1981-09-08 | 1983-05-10 | Eli Lilly And Company | Isoquinolinium substituted cephalosporins |
-
1979
- 1979-11-14 ES ES485939A patent/ES485939A1/es not_active Expired
- 1979-11-14 CH CH10175/79A patent/CH647784A5/de not_active IP Right Cessation
- 1979-11-14 IL IL58717A patent/IL58717A/xx unknown
- 1979-11-14 IE IE2186/79A patent/IE49207B1/en unknown
- 1979-11-14 ES ES485937A patent/ES485937A1/es not_active Expired
- 1979-11-14 NO NO793688A patent/NO793688L/no unknown
- 1979-11-14 LU LU81884A patent/LU81884A1/fr unknown
- 1979-11-14 FR FR7928103A patent/FR2441630A1/fr active Granted
- 1979-11-14 NL NL7908318A patent/NL7908318A/xx not_active Application Discontinuation
- 1979-11-14 NZ NZ192127A patent/NZ192127A/xx unknown
- 1979-11-14 FI FI793566A patent/FI793566A/fi not_active Application Discontinuation
- 1979-11-14 DE DE19792946038 patent/DE2946038A1/de not_active Withdrawn
- 1979-11-14 DK DK480679A patent/DK480679A/da not_active Application Discontinuation
- 1979-11-14 AU AU52815/79A patent/AU529825B2/en not_active Ceased
- 1979-11-14 SE SE7909401A patent/SE7909401L/xx not_active Application Discontinuation
- 1979-11-14 ES ES485938A patent/ES485938A1/es not_active Expired
- 1979-11-14 CA CA000339879A patent/CA1136616A/en not_active Expired
- 1979-11-14 AT AT0727279A patent/AT366387B/de not_active IP Right Cessation
-
1981
- 1981-07-23 US US06/285,966 patent/US4464368A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NL7908318A (nl) | 1980-05-19 |
| CH647784A5 (de) | 1985-02-15 |
| FR2441630B1 (es) | 1983-06-03 |
| SE7909401L (sv) | 1980-05-16 |
| ES485939A1 (es) | 1980-07-01 |
| DE2946038A1 (de) | 1980-05-29 |
| AU5281579A (en) | 1980-05-22 |
| LU81884A1 (fr) | 1980-06-05 |
| NZ192127A (en) | 1982-12-21 |
| IE792186L (en) | 1980-05-15 |
| FI793566A (fi) | 1980-05-16 |
| AU529825B2 (en) | 1983-06-23 |
| CA1136616A (en) | 1982-11-30 |
| NO793688L (no) | 1980-05-19 |
| DK480679A (da) | 1980-05-16 |
| IL58717A0 (en) | 1980-02-29 |
| ATA727279A (de) | 1981-08-15 |
| IL58717A (en) | 1983-05-15 |
| AT366387B (de) | 1982-04-13 |
| FR2441630A1 (fr) | 1980-06-13 |
| ES485937A1 (es) | 1980-07-01 |
| IE49207B1 (en) | 1985-08-21 |
| US4464368A (en) | 1984-08-07 |
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