AT366387B - Verfahren zur herstellung von neuen cephalosporin-antibiotika - Google Patents
Verfahren zur herstellung von neuen cephalosporin-antibiotikaInfo
- Publication number
- AT366387B AT366387B AT0727279A AT727279A AT366387B AT 366387 B AT366387 B AT 366387B AT 0727279 A AT0727279 A AT 0727279A AT 727279 A AT727279 A AT 727279A AT 366387 B AT366387 B AT 366387B
- Authority
- AT
- Austria
- Prior art keywords
- producing new
- antibiotics
- new cephalosporine
- cephalosporine antibiotics
- producing
- Prior art date
Links
- HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0200281A AT371124B (de) | 1978-11-15 | 1981-05-06 | Verfahren zur herstellung von neuen cephalosporin-antibiotika |
AT0200381A AT373894B (de) | 1978-11-15 | 1981-05-06 | Verfahren zur herstellung von neuen cephalosporin-antibiotika sowie von deren salzen und estern |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7844597 | 1978-11-15 | ||
GB7844595 | 1978-11-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA727279A ATA727279A (de) | 1981-08-15 |
AT366387B true AT366387B (de) | 1982-04-13 |
Family
ID=26269583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0727279A AT366387B (de) | 1978-11-15 | 1979-11-14 | Verfahren zur herstellung von neuen cephalosporin-antibiotika |
Country Status (17)
Country | Link |
---|---|
US (1) | US4464368A (de) |
AT (1) | AT366387B (de) |
AU (1) | AU529825B2 (de) |
CA (1) | CA1136616A (de) |
CH (1) | CH647784A5 (de) |
DE (1) | DE2946038A1 (de) |
DK (1) | DK480679A (de) |
ES (3) | ES485938A1 (de) |
FI (1) | FI793566A (de) |
FR (1) | FR2441630A1 (de) |
IE (1) | IE49207B1 (de) |
IL (1) | IL58717A (de) |
LU (1) | LU81884A1 (de) |
NL (1) | NL7908318A (de) |
NO (1) | NO793688L (de) |
NZ (1) | NZ192127A (de) |
SE (1) | SE7909401L (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR78245B (de) * | 1980-09-12 | 1984-09-26 | Ciba Geigy Ag | |
NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
DE3279470D1 (en) * | 1981-04-03 | 1989-04-06 | Fujisawa Pharmaceutical Co | New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
DE3336757A1 (de) * | 1983-10-08 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
CN86107947A (zh) * | 1985-11-22 | 1987-05-27 | 藤沢药品工业株式会社 | 新的头孢烯化合物及其制备方法 |
US5373000A (en) * | 1985-12-26 | 1994-12-13 | Eisai Co., Ltd. | 7Beta-(thiadiazolyl)-2-iminoacetamido-3cephem compounds |
DE3787030T2 (de) * | 1986-04-14 | 1994-04-07 | Banyu Pharma Co Ltd | 1-carboxy-1-vinyloxyiminoaminothiazol-cephalosporin-derivate und deren herstellung. |
GB8611823D0 (en) * | 1986-05-15 | 1986-06-25 | Ici Plc | Process |
CA1293719C (en) * | 1986-09-22 | 1991-12-31 | Takao Takaya | Cephem compounds and processes for preparation thereof |
US5162520A (en) * | 1986-09-22 | 1992-11-10 | Fujisawa Pharmaceutical Co., Ltd. | Intermediates for cephem compounds |
US5624898A (en) * | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
US6407061B1 (en) | 1989-12-05 | 2002-06-18 | Chiron Corporation | Method for administering insulin-like growth factor to the brain |
US10000510B2 (en) | 2014-08-18 | 2018-06-19 | Merck Sharp & Dohme Corp. | Salt forms of ceftolozane |
US10214543B2 (en) | 2014-12-30 | 2019-02-26 | Merck Sharp & Dohme Corp. | Synthesis of cephalosporin compounds |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4024133A (en) * | 1971-05-14 | 1977-05-17 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins |
US4093803A (en) * | 1971-05-14 | 1978-06-06 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins |
US3971778A (en) * | 1972-05-12 | 1976-07-27 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position |
US4024137A (en) * | 1971-05-14 | 1977-05-17 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins |
US4091209A (en) * | 1971-05-14 | 1978-05-23 | Glaxo Laboratories Limited | 7β-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]cephalosporins having a 2-haloalkylcarbamoyloxymethyl group at the 3-position |
US4064346A (en) * | 1971-05-14 | 1977-12-20 | Glaxo Laboratories Limited | 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
US4017515A (en) * | 1971-05-14 | 1977-04-12 | Glaxo Laboratories Limited | α-(Etherified oximino) carboxylic acids and acid chlorides |
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
US4079178A (en) * | 1971-05-14 | 1978-03-14 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position |
US4162360A (en) * | 1973-12-21 | 1979-07-24 | Glaxo Laboratories Limited | 3-Carbamoyloxymethyl-7-substituted oximino acetamido cephalosporanic acid derivatives |
US4144392A (en) * | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile |
GB1496757A (en) * | 1973-12-21 | 1978-01-05 | Glaxo Lab Ltd | Cephalosporin derivatives |
US4144393A (en) * | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group |
US4060686A (en) * | 1973-12-21 | 1977-11-29 | Janice Bradshaw | Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group |
US4032950A (en) * | 1974-12-06 | 1977-06-28 | Hughes Aircraft Company | Liquid phase epitaxial process for growing semi-insulating gaas layers |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
US4165430A (en) * | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
FR2457296A1 (fr) * | 1979-05-23 | 1980-12-19 | Rhone Poulenc Ind | Nouveaux derives de vinyl-3 cephalosporines et leur preparation |
IL61458A0 (en) * | 1979-12-07 | 1980-12-31 | Erba Farmitalia | N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them |
US4382932A (en) * | 1981-09-08 | 1983-05-10 | Eli Lilly And Company | Isoquinolinium substituted cephalosporins |
-
1979
- 1979-11-14 AT AT0727279A patent/AT366387B/de not_active IP Right Cessation
- 1979-11-14 CA CA000339879A patent/CA1136616A/en not_active Expired
- 1979-11-14 NZ NZ192127A patent/NZ192127A/xx unknown
- 1979-11-14 DE DE19792946038 patent/DE2946038A1/de not_active Withdrawn
- 1979-11-14 LU LU81884A patent/LU81884A1/fr unknown
- 1979-11-14 FR FR7928103A patent/FR2441630A1/fr active Granted
- 1979-11-14 DK DK480679A patent/DK480679A/da not_active Application Discontinuation
- 1979-11-14 IL IL58717A patent/IL58717A/xx unknown
- 1979-11-14 AU AU52815/79A patent/AU529825B2/en not_active Ceased
- 1979-11-14 FI FI793566A patent/FI793566A/fi not_active Application Discontinuation
- 1979-11-14 CH CH10175/79A patent/CH647784A5/de not_active IP Right Cessation
- 1979-11-14 IE IE2186/79A patent/IE49207B1/en unknown
- 1979-11-14 ES ES485938A patent/ES485938A1/es not_active Expired
- 1979-11-14 ES ES485937A patent/ES485937A1/es not_active Expired
- 1979-11-14 NL NL7908318A patent/NL7908318A/xx not_active Application Discontinuation
- 1979-11-14 NO NO793688A patent/NO793688L/no unknown
- 1979-11-14 ES ES485939A patent/ES485939A1/es not_active Expired
- 1979-11-14 SE SE7909401A patent/SE7909401L/xx not_active Application Discontinuation
-
1981
- 1981-07-23 US US06/285,966 patent/US4464368A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NL7908318A (nl) | 1980-05-19 |
FI793566A (fi) | 1980-05-16 |
US4464368A (en) | 1984-08-07 |
ES485937A1 (es) | 1980-07-01 |
AU529825B2 (en) | 1983-06-23 |
ES485939A1 (es) | 1980-07-01 |
IE49207B1 (en) | 1985-08-21 |
FR2441630B1 (de) | 1983-06-03 |
ATA727279A (de) | 1981-08-15 |
IE792186L (en) | 1980-05-15 |
DE2946038A1 (de) | 1980-05-29 |
SE7909401L (sv) | 1980-05-16 |
IL58717A (en) | 1983-05-15 |
IL58717A0 (en) | 1980-02-29 |
CA1136616A (en) | 1982-11-30 |
ES485938A1 (es) | 1980-07-01 |
NZ192127A (en) | 1982-12-21 |
CH647784A5 (de) | 1985-02-15 |
NO793688L (no) | 1980-05-19 |
AU5281579A (en) | 1980-05-22 |
FR2441630A1 (fr) | 1980-06-13 |
DK480679A (da) | 1980-05-16 |
LU81884A1 (fr) | 1980-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELJ | Ceased due to non-payment of the annual fee |