FI870153A - Foerfarande foer framstaellning av 7-(substituerad eller osubstituerad amino) -3-substituerad metyl-/3-cefem-4-karboxylsyror. - Google Patents

Foerfarande foer framstaellning av 7-(substituerad eller osubstituerad amino) -3-substituerad metyl-/3-cefem-4-karboxylsyror. Download PDF

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Publication number
FI870153A
FI870153A FI870153A FI870153A FI870153A FI 870153 A FI870153 A FI 870153A FI 870153 A FI870153 A FI 870153A FI 870153 A FI870153 A FI 870153A FI 870153 A FI870153 A FI 870153A
Authority
FI
Finland
Prior art keywords
osubstituerad
karboxylsyror
substituerad
cefem
metyl
Prior art date
Application number
FI870153A
Other languages
English (en)
Other versions
FI870153A0 (fi
FI80041C (fi
FI80041B (fi
Inventor
Hiroshi Sadaki
Hirokazu Narita
Hiroyuki Imaizumi
Yoshinori Konishi
Takihiro Inaba
Tatsuo Hirakawa
Hideo Taki
Masaru Tai
Yasuo Watanabe
Isaru Saikawa
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55132253A external-priority patent/JPS5758689A/ja
Priority claimed from JP55158184A external-priority patent/JPS5782393A/ja
Priority claimed from JP55175263A external-priority patent/JPS6052755B2/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of FI870153A0 publication Critical patent/FI870153A0/fi
Publication of FI870153A publication Critical patent/FI870153A/fi
Application granted granted Critical
Publication of FI80041B publication Critical patent/FI80041B/fi
Publication of FI80041C publication Critical patent/FI80041C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI870153A 1980-09-25 1987-01-15 Foerfarande foer framstaellning av 7-amino-3-(substituerad metyl)- 3 -cefem-4-karboxylsyror. FI80041C (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP13225380 1980-09-25
JP55132253A JPS5758689A (en) 1980-09-25 1980-09-25 Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids
JP15818480 1980-11-12
JP55158184A JPS5782393A (en) 1980-11-12 1980-11-12 7-amino-3-(2-(1,2,3,4-tetrazolyl)methyl)cephem-4-carboxylic acid
JP17526380 1980-12-13
JP55175263A JPS6052755B2 (ja) 1980-12-13 1980-12-13 新規セファロスポリン類
FI812980 1981-09-24
FI812980A FI75575C (fi) 1980-09-25 1981-09-24 Foerfarande foer framstaellning av nya cefalosporiner.

Publications (4)

Publication Number Publication Date
FI870153A0 FI870153A0 (fi) 1987-01-15
FI870153A true FI870153A (fi) 1987-01-15
FI80041B FI80041B (fi) 1989-12-29
FI80041C FI80041C (fi) 1990-04-10

Family

ID=27316463

Family Applications (2)

Application Number Title Priority Date Filing Date
FI812980A FI75575C (fi) 1980-09-25 1981-09-24 Foerfarande foer framstaellning av nya cefalosporiner.
FI870153A FI80041C (fi) 1980-09-25 1987-01-15 Foerfarande foer framstaellning av 7-amino-3-(substituerad metyl)- 3 -cefem-4-karboxylsyror.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI812980A FI75575C (fi) 1980-09-25 1981-09-24 Foerfarande foer framstaellning av nya cefalosporiner.

Country Status (27)

Country Link
US (4) US4489072A (fi)
KR (1) KR860000932B1 (fi)
AR (1) AR240645A1 (fi)
AT (4) AT375082B (fi)
AU (3) AU550330B2 (fi)
CA (2) CA1204735A (fi)
CH (4) CH652128A5 (fi)
DD (2) DD208351A5 (fi)
DE (5) DE3137854A1 (fi)
DK (1) DK163877C (fi)
EG (1) EG17373A (fi)
ES (4) ES8301998A1 (fi)
FI (2) FI75575C (fi)
FR (2) FR2509310B1 (fi)
GB (3) GB2089339B (fi)
HU (1) HU185850B (fi)
IN (4) IN155375B (fi)
IT (1) IT1172201B (fi)
LU (1) LU83650A1 (fi)
MX (1) MX155025A (fi)
NL (1) NL8104386A (fi)
NO (1) NO161117C (fi)
NZ (1) NZ198350A (fi)
PH (5) PH18072A (fi)
PT (1) PT73727B (fi)
RO (4) RO86823B (fi)
SE (5) SE453090B (fi)

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US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
EP0061234A3 (en) * 1981-03-05 1983-11-16 Beecham Group Plc Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them
US4576938A (en) * 1981-12-08 1986-03-18 Tanabe Seiyaku Co., Ltd. Cephalosporin compound and process for preparing the same
DK521883A (da) * 1982-11-17 1984-05-18 Toyama Chemical Co Ltd Cephalosporinderivater, fremgangsmaade til fremstilling heraf og fremgangsmaade til fremstilling af mellemprodukter herfor
US4618606A (en) * 1982-11-17 1986-10-21 Toyama Chemical Co., Ltd. Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins
JPS6064986A (ja) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd セファロスポリン類の製造法
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
GB8406231D0 (en) * 1984-03-09 1984-04-11 Fujisawa Pharmaceutical Co Cephem compounds
GB2161476B (en) * 1984-05-25 1988-01-27 Toyama Chemical Co Ltd 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
AT397086B (de) * 1984-05-25 1994-01-25 Toyama Chemical Co Ltd Verfahren zur herstellung von neuen 2-(2-aminothiazol-4-4yl)-2-(syn)-alkoxyimino- acetamiden
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
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JPH064643B2 (ja) * 1985-12-20 1994-01-19 ファイザー製薬株式会社 セフアロスポリン化合物
US4692517A (en) * 1986-03-20 1987-09-08 American Home Products Corporation C-3' acylaminooxy-7-[(2-aminothiazol-4-yl)-α-(substituted-oximino)acetyl]cephalosporin derivatives
EP0265185A3 (en) * 1986-10-21 1990-03-28 Beecham Group Plc Cephalosporins, processes for their preparation and pharmaceutical compositions containing them
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JPH0699443B2 (ja) * 1989-09-29 1994-12-07 ファイザー製薬株式会社 セファロスポリン化合物
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
EP1618114B1 (en) * 2003-04-16 2010-07-14 Sandoz AG Processes for the preparations of cefepime
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
JP2007530589A (ja) * 2004-03-26 2007-11-01 アンフォラ ディスカバリー コーポレーション 特定のトリアゾールを基礎とする化合物、組成物、およびそれらの使用
US8198434B2 (en) 2008-05-07 2012-06-12 Idexx Laboratories, Inc. Process for preparing cefsulodin sodium
US20120329770A1 (en) * 2010-02-26 2012-12-27 Gary Igor Dmitrienko Cephalosporin derivatives useful as beta-lactamase inhibitors and compositions and methods of use thereof
CN102351886B (zh) * 2011-09-07 2013-10-16 山东罗欣药业股份有限公司 头孢特仑新戊酯晶体、其制备方法及含有该晶体的组合物片剂
MY184572A (en) * 2013-07-17 2021-04-05 Otsuka Pharma Co Ltd Cyanotriazole compounds
CN106046026B (zh) * 2016-06-30 2018-07-06 济南康和医药科技有限公司 一种头孢特仑新戊酯的制备方法
CN112645842B (zh) * 2020-12-25 2022-08-19 复旦大学 一种氰乙酸叔丁酯的连续流制备方法

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CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof

Also Published As

Publication number Publication date
DE3152935C2 (fi) 1992-07-16
AU4986185A (en) 1986-03-20
FR2509310B1 (fr) 1985-08-02
PT73727B (en) 1982-12-30
AU568033B2 (en) 1987-12-10
US5144027A (en) 1992-09-01
FR2511377A1 (fr) 1983-02-18
DK163877B (da) 1992-04-13
FI75575B (fi) 1988-03-31
IT8149348A0 (it) 1981-09-23
CH652130A5 (de) 1985-10-31
AT378961B (de) 1985-10-25
AT378193B (de) 1985-06-25
GB2136420B (en) 1985-05-01
DE3152934C2 (fi) 1990-01-18
US4879381A (en) 1989-11-07
PH18484A (en) 1985-08-02
CA1204735A (en) 1986-05-20
GB8402250D0 (en) 1984-02-29
RO86823A (ro) 1985-05-20
IN155375B (fi) 1985-01-19
RO86825A (ro) 1985-05-20
RO82689B (ro) 1983-10-30
SE8600192L (sv) 1986-01-16
SE8600194D0 (sv) 1986-01-16
RO86824A (ro) 1985-05-20
GB2136420A (en) 1984-09-19
ATA410981A (de) 1983-11-15
AT375082B (de) 1984-06-25
RO86825B (ro) 1985-05-31
FR2511377B1 (fr) 1985-12-13
IN158589B (fi) 1986-12-13
NO161117C (no) 1989-07-05
NO161117B (no) 1989-03-28
HU185850B (en) 1985-04-28
US4673738A (en) 1987-06-16
FR2509310A1 (fr) 1983-01-14
FI75575C (fi) 1988-07-11
FI870153A0 (fi) 1987-01-15
FI812980L (fi) 1982-03-26
AU550330B2 (en) 1986-03-20
ATA55583A (de) 1985-03-15
SE468476B (sv) 1993-01-25
EG17373A (en) 1990-12-30
US4489072A (en) 1984-12-18
KR860000932B1 (ko) 1986-07-19
NZ198350A (en) 1985-02-28
MX155025A (es) 1988-01-20
SE468477B (sv) 1993-01-25
RO82689A (ro) 1983-11-01
PH20221A (en) 1986-10-23
NO813252L (no) 1982-03-26
CH652129A5 (de) 1985-10-31
DD208351A5 (de) 1984-05-02
IT1172201B (it) 1987-06-18
ES505760A0 (es) 1983-01-01
GB2089339A (en) 1982-06-23
ATA55483A (de) 1985-03-15
PH19147A (en) 1986-01-15
RO86823B (ro) 1985-05-31
SE8105658L (sv) 1982-05-05
ES514669A0 (es) 1983-05-01
SE8600195D0 (sv) 1986-01-16
AU558649B2 (en) 1987-02-05
DE3152931C2 (fi) 1989-10-05
ES8301998A1 (es) 1983-01-01
GB2089339B (en) 1985-04-24
ES514670A0 (es) 1983-05-01
DE3152932C2 (fi) 1990-02-08
ES8306155A1 (es) 1983-05-01
DE3137854C2 (fi) 1987-06-19
GB2135304A (en) 1984-08-30
AR240645A1 (es) 1990-07-31
SE8600193D0 (sv) 1986-01-16
FI80041C (fi) 1990-04-10
AU4986285A (en) 1986-04-24
PH18072A (en) 1985-03-18
SE8600195L (sv) 1986-01-16
IN159126B (fi) 1987-03-28
DK163877C (da) 1992-09-14
IN158590B (fi) 1986-12-13
SE8600192D0 (sv) 1986-01-16
SE8600193L (sv) 1986-01-16
SE468478B (sv) 1993-01-25
ES514671A0 (es) 1983-05-01
ES8306157A1 (es) 1983-05-01
FI80041B (fi) 1989-12-29
SE453090B (sv) 1988-01-11
ES8306156A1 (es) 1983-05-01
DD202436A5 (de) 1983-09-14
DK421881A (da) 1982-04-15
CH651837A5 (de) 1985-10-15
SE8600194L (sv) 1986-01-16
LU83650A1 (fr) 1982-01-21
PH19251A (en) 1986-02-17
DE3137854A1 (de) 1982-04-15
RO86824B (ro) 1985-05-31
NL8104386A (nl) 1982-04-16
PT73727A (en) 1981-10-01
CH652128A5 (de) 1985-10-31
GB2135304B (en) 1985-03-27
AU7543881A (en) 1982-04-01
SE468479B (sv) 1993-01-25
ATA55683A (de) 1984-11-15
AT378962B (de) 1985-10-25
GB8402249D0 (en) 1984-02-29
CA1200541A (en) 1986-02-11

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