PL1618114T3 - Sposoby otrzymywania cefepimy - Google Patents
Sposoby otrzymywania cefepimyInfo
- Publication number
- PL1618114T3 PL1618114T3 PL04727526T PL04727526T PL1618114T3 PL 1618114 T3 PL1618114 T3 PL 1618114T3 PL 04727526 T PL04727526 T PL 04727526T PL 04727526 T PL04727526 T PL 04727526T PL 1618114 T3 PL1618114 T3 PL 1618114T3
- Authority
- PL
- Poland
- Prior art keywords
- cefepime
- processes
- preparations
- amino
- methyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- HVFLCNVBZFFHBT-ZKDACBOMSA-N cefepime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-N 0.000 title 1
- 229960002100 cefepime Drugs 0.000 title 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- LRAJHPGSGBRUJN-OMIVUECESA-N cefepime hydrochloride Chemical compound O.Cl.[Cl-].S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 LRAJHPGSGBRUJN-OMIVUECESA-N 0.000 abstract 1
- QMEZUZOCLYUADC-UHFFFAOYSA-N hydrate;dihydrochloride Chemical compound O.Cl.Cl QMEZUZOCLYUADC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT5842003 | 2003-04-16 | ||
| AT5852003 | 2003-04-16 | ||
| AT5862003 | 2003-04-16 | ||
| PCT/EP2004/003988 WO2004092183A2 (en) | 2003-04-16 | 2004-04-15 | Processes for the preparations of cefepime |
| EP04727526A EP1618114B1 (en) | 2003-04-16 | 2004-04-15 | Processes for the preparations of cefepime |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1618114T3 true PL1618114T3 (pl) | 2010-12-31 |
Family
ID=33303376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04727526T PL1618114T3 (pl) | 2003-04-16 | 2004-04-15 | Sposoby otrzymywania cefepimy |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1618114B1 (pl) |
| AT (1) | ATE473986T1 (pl) |
| DE (1) | DE602004028111D1 (pl) |
| ES (1) | ES2348299T3 (pl) |
| PL (1) | PL1618114T3 (pl) |
| WO (1) | WO2004092183A2 (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005019227A1 (en) | 2003-08-22 | 2005-03-03 | Orchid Chemicals & Pharmaceuticals Ltd | Process for the preparation of cephalosporin antibiotic |
| WO2006008749A1 (en) | 2004-07-16 | 2006-01-26 | Hetero Drugs Limited | Process for preparing pure cephalosporine intermediates |
| ITMI20042139A1 (it) * | 2004-11-08 | 2005-02-08 | Acs Dobfar Spa | Procedimento per la produzione di cefepime e cefaposporine analoghe |
| WO2006067803A1 (en) * | 2004-12-21 | 2006-06-29 | Lupin Limited | A novel intermediate for the preparation of cefepime |
| CN101935325B (zh) * | 2010-09-19 | 2012-02-08 | 海南新中正制药有限公司 | 盐酸头孢吡肟的制备方法 |
| RU2469040C1 (ru) * | 2011-12-07 | 2012-12-10 | Общество с ограниченной ответственностью "КОМПАНИЯ "ДЕКО" | Способ получения 7-[2-(2-аминотиазол-4-ил)-2(z)-метоксииминоацетамидо]-3-[(1-метил-1-пирролидино)метил]-цеф-3-ем-4-карбоксилата дигидрохлорида моногидрата (цефепима дигидрохлорида моногидрата) |
| CN102408440A (zh) * | 2011-12-27 | 2012-04-11 | 山东鑫泉医药有限公司 | 盐酸头孢吡肟的合成方法 |
| CN102675345A (zh) * | 2012-06-01 | 2012-09-19 | 苏州中联化学制药有限公司 | 一种盐酸头孢吡肟的制备方法 |
| MX361984B (es) * | 2013-03-13 | 2018-12-19 | Theravance Biopharma Antibiotics Ip Llc | Sales clorhidrato de un compuesto antibiótico. |
| CN105859747B (zh) * | 2016-05-13 | 2018-07-24 | 齐鲁安替制药有限公司 | 一种适于工业化生产的盐酸头孢吡肟的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154939C (da) | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
| FI67385C (fi) | 1979-11-21 | 1985-03-11 | Hoffmann La Roche | Foerfarande foer framstaellning av (6r 7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat |
| US4266049A (en) | 1980-02-20 | 1981-05-05 | Eli Lilly And Company | Process for 3-iodomethyl cephalosporins |
| DE3165922D1 (en) | 1980-03-28 | 1984-10-18 | Biochemie Gmbh | New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production |
| NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
| US4336253A (en) | 1981-03-11 | 1982-06-22 | Eli Lilly And Company | Cephalosporin antibiotics |
| PL238158A1 (en) | 1981-09-08 | 1984-11-19 | Lilly Co Eli | Method of obtaining new cephalosporin derivatives |
| US4406899A (en) | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
| DE3316797A1 (de) | 1983-05-07 | 1984-11-08 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von cephemverbindungen |
| DE3409431A1 (de) * | 1983-10-08 | 1985-04-18 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| CN86107947A (zh) | 1985-11-22 | 1987-05-27 | 藤沢药品工业株式会社 | 新的头孢烯化合物及其制备方法 |
| US4959495A (en) | 1986-07-28 | 1990-09-25 | American Cyanamid Company | Process for the preparation of intermediates used to produce aminothiazoloximino cephalosporins |
| JPH01230547A (ja) | 1988-01-14 | 1989-09-14 | Takeda Chem Ind Ltd | ３−オキソ酪酸第三ブチルの製造法及びその用途 |
| IT1234385B (it) | 1989-05-23 | 1992-05-18 | Sbd Synthetic And Biolog Devel | Procedimento migliorato per la produzione di una sostanza antibiotica appartenente al gruppo delle cefalosporine |
| YU81692A (sh) * | 1991-09-10 | 1995-03-27 | Bristol-Myers Co. | Postupak za proizvodnju cefalosporinskog antibiotika |
| AT399877B (de) | 1992-02-20 | 1995-08-25 | Biochemie Gmbh | Neues verfahren zur herstellung von ceftriaxon |
| US5574154A (en) * | 1994-09-29 | 1996-11-12 | Alnejma Bulk Pharmaceutical Co. A.B.P.C. | Process for the preparation of cephalosporanic compounds |
| IT1286494B1 (it) | 1996-11-19 | 1998-07-15 | Hichem Pharma S P A | Procedimento per la preparazione di derivati cefalosporanici |
| EP1169324A1 (en) * | 1999-04-15 | 2002-01-09 | BIOCHEMIE Gesellschaft m.b.H. | Beta-lactam production |
| US6458949B1 (en) | 2000-08-14 | 2002-10-01 | Aurobindo Pharma Limited | Ceftiofur, its intermediate and a process for the preparation of the same |
| US6384215B1 (en) * | 2001-06-07 | 2002-05-07 | Orchid Chemicals & Pharmaceuticals Ltd. | Preparation of new intermediates and their use in manufacturing of cephalosporin compounds |
-
2004
- 2004-04-15 WO PCT/EP2004/003988 patent/WO2004092183A2/en not_active Ceased
- 2004-04-15 EP EP04727526A patent/EP1618114B1/en not_active Expired - Lifetime
- 2004-04-15 EP EP10005006A patent/EP2218723A3/en not_active Withdrawn
- 2004-04-15 PL PL04727526T patent/PL1618114T3/pl unknown
- 2004-04-15 AT AT04727526T patent/ATE473986T1/de active
- 2004-04-15 DE DE602004028111T patent/DE602004028111D1/de not_active Expired - Lifetime
- 2004-04-15 ES ES04727526T patent/ES2348299T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE473986T1 (de) | 2010-07-15 |
| EP2218723A3 (en) | 2010-11-17 |
| WO2004092183A2 (en) | 2004-10-28 |
| WO2004092183A3 (en) | 2004-12-09 |
| ES2348299T3 (es) | 2010-12-02 |
| EP1618114B1 (en) | 2010-07-14 |
| EP1618114A2 (en) | 2006-01-25 |
| EP2218723A2 (en) | 2010-08-18 |
| DE602004028111D1 (de) | 2010-08-26 |
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