DD151169A5 - Verfahren zur herstellung neuer cephalosporine - Google Patents

Verfahren zur herstellung neuer cephalosporine Download PDF

Info

Publication number
DD151169A5
DD151169A5 DD80221268A DD22126880A DD151169A5 DD 151169 A5 DD151169 A5 DD 151169A5 DD 80221268 A DD80221268 A DD 80221268A DD 22126880 A DD22126880 A DD 22126880A DD 151169 A5 DD151169 A5 DD 151169A5
Authority
DD
German Democratic Republic
Prior art keywords
radical
general formula
ecm
ene
thia
Prior art date
Application number
DD80221268A
Other languages
German (de)
English (en)
Inventor
Daniel Farge
Roy Pierre Le
Claude Moutonnier
Jean-Francois Peyronel
Original Assignee
Rhone Poulenc Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Ind filed Critical Rhone Poulenc Ind
Publication of DD151169A5 publication Critical patent/DD151169A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD80221268A 1979-05-23 1980-05-21 Verfahren zur herstellung neuer cephalosporine DD151169A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7913097A FR2457297A1 (fr) 1979-05-23 1979-05-23 Nouvelles vinyl-3 cephalosporines, et leur preparation

Publications (1)

Publication Number Publication Date
DD151169A5 true DD151169A5 (de) 1981-10-08

Family

ID=9225763

Family Applications (2)

Application Number Title Priority Date Filing Date
DD80221268A DD151169A5 (de) 1979-05-23 1980-05-21 Verfahren zur herstellung neuer cephalosporine
DD80221267A DD151064A5 (de) 1979-05-23 1980-05-21 Verfahren zur herstellung neuer 3-vinyl-cephalosporine

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD80221267A DD151064A5 (de) 1979-05-23 1980-05-21 Verfahren zur herstellung neuer 3-vinyl-cephalosporine

Country Status (32)

Country Link
US (2) US4365062A (fi)
JP (2) JPS55154978A (fi)
AT (2) AT368509B (fi)
AU (2) AU532884B2 (fi)
BE (2) BE883417A (fi)
CA (2) CA1148141A (fi)
CH (2) CH645380A5 (fi)
CS (1) CS235508B2 (fi)
DD (2) DD151169A5 (fi)
DE (2) DE3019430A1 (fi)
DK (2) DK222280A (fi)
ES (4) ES8203906A1 (fi)
FI (2) FI801642A (fi)
FR (1) FR2457297A1 (fi)
GB (2) GB2052488B (fi)
GR (2) GR68428B (fi)
HU (2) HU184759B (fi)
IE (2) IE49813B1 (fi)
IL (2) IL60140A (fi)
IT (2) IT1140972B (fi)
LU (2) LU82476A1 (fi)
NL (2) NL8003024A (fi)
NO (2) NO801504L (fi)
NZ (2) NZ193801A (fi)
PH (2) PH17310A (fi)
PL (3) PL126491B1 (fi)
PT (2) PT71278A (fi)
SE (2) SE8003823L (fi)
SU (4) SU927118A3 (fi)
YU (3) YU137080A (fi)
ZA (2) ZA803036B (fi)
ZW (1) ZW12380A1 (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
FR2511376A1 (fr) * 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur prepration
FR2511372A1 (fr) * 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur preparation
FR2531712A1 (fr) * 1982-08-13 1984-02-17 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur preparation
US4609730A (en) * 1982-11-22 1986-09-02 Fujisawa Pharmaceutical Co., Ltd. 7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities
ZA84584B (en) * 1983-01-28 1984-09-26 Bristol Myers Co Substituted vinyl cephalosporins
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
JPS604883U (ja) * 1983-06-24 1985-01-14 松下冷機株式会社 冷蔵庫等の冷却装置
US4874856A (en) * 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
MY127641A (en) * 1995-10-12 2006-12-29 Essential Therapeutics Inc Cephalosporin antibiotics
US6025352A (en) * 1997-09-29 2000-02-15 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US6030965A (en) * 1997-09-30 2000-02-29 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
AU2002239076A1 (en) * 2002-02-28 2003-09-09 Lg Life Sciences Ltd. Novel cephalosporin compounds and process for preparing the same
JP5733856B2 (ja) 2007-10-09 2015-06-10 ソファーミア，インコーポレイテッド 広帯域β−ラクタマーゼ阻害薬
ES2700575T3 (es) 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
US3823139A (en) * 1970-03-26 1974-07-09 Glaxo Lab Ltd Cephalosporins having a ypsilon-carbonyl group at position-3
US3674784A (en) * 1970-07-27 1972-07-04 Lilly Co Eli 3-formyl cephalosporin sulfoxides
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
US4095021A (en) * 1973-12-21 1978-06-13 Glaxo Laboratories Limited 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof
DE2637176A1 (de) 1975-08-22 1977-03-03 Ciba Geigy Ag Carbonylmethylderivate
JPS5285185A (en) * 1976-01-05 1977-07-15 Teijin Ltd Preparation of 7-acylaminocephalosporanic acids
JPS5289694A (en) * 1976-01-23 1977-07-27 Asahi Chem Ind Co Ltd Novel cephalosporins
US4094978A (en) * 1976-07-29 1978-06-13 Syntex (U.S.A.) Inc. 3-propenyl derivatives of cephalosporin, compositions and their use
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
EP0015240A1 (de) * 1979-02-16 1980-09-03 Ciba-Geigy Ag Azacyclyl (thio) ureidoacetyl-Verbindungen und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
AU5859380A (en) 1980-11-27
PL224390A1 (fi) 1981-02-13
NO801503L (no) 1980-11-24
PL126671B1 (en) 1983-08-31
CH650000A5 (fr) 1985-06-28
DE3019430A1 (de) 1980-12-04
JPS55154979A (en) 1980-12-02
DD151064A5 (de) 1981-09-30
IT1140973B (it) 1986-10-10
IL60140A (en) 1984-04-30
ES491688A0 (es) 1980-12-16
ES8102137A1 (es) 1980-12-16
IE49813B1 (en) 1985-12-25
US4307230A (en) 1981-12-22
NZ193800A (en) 1983-05-10
LU82476A1 (fr) 1980-12-16
GB2051061B (en) 1983-09-28
GR68428B (fi) 1981-12-30
ES491689A0 (es) 1982-04-16
FI801643A (fi) 1980-11-24
AU537785B2 (en) 1984-07-12
CS235508B2 (en) 1985-05-15
IL60141A (en) 1984-04-30
NL8003024A (nl) 1980-11-25
NL8003010A (nl) 1980-11-25
SU927118A3 (ru) 1982-05-07
FR2457297A1 (fr) 1980-12-19
FR2457297B1 (fi) 1982-10-22
BE883418A (fr) 1980-11-21
YU137080A (en) 1983-04-30
ZW12380A1 (en) 1980-11-26
NO801504L (no) 1980-11-24
IL60140A0 (en) 1980-07-31
AU532884B2 (en) 1983-10-20
HU183143B (en) 1984-04-28
FI801642A (fi) 1980-11-24
AT370737B (de) 1983-04-25
ES8106533A1 (es) 1981-08-16
PL126491B1 (en) 1983-08-31
GB2052488B (en) 1983-09-21
SU984411A3 (ru) 1982-12-23
ES8106734A1 (es) 1981-09-01
ES495236A0 (es) 1981-08-16
IE801060L (en) 1980-11-23
YU56183A (en) 1984-02-29
IE49812B1 (en) 1985-12-25
GB2052488A (en) 1981-01-28
DK222280A (da) 1980-11-24
AT368509B (de) 1982-10-25
GR68436B (fi) 1981-12-30
IT8022242A0 (it) 1980-05-21
PT71277A (fr) 1980-06-01
LU82478A1 (fr) 1980-12-16
CH645380A5 (fr) 1984-09-28
PT71278A (fr) 1980-06-01
ES8203906A1 (es) 1982-04-16
CA1148141A (fr) 1983-06-14
ATA271180A (de) 1982-09-15
NZ193801A (en) 1983-03-15
AU5859480A (en) 1980-11-27
DE3019445A1 (de) 1980-12-04
SU965358A3 (ru) 1982-10-07
SE8003822L (sv) 1980-11-24
SE8003823L (sv) 1980-11-24
SU988193A3 (ru) 1983-01-07
BE883417A (fr) 1980-11-21
ATA271080A (de) 1982-02-15
HU184759B (en) 1984-10-29
JPS55154978A (en) 1980-12-02
IE801059L (en) 1980-11-23
DK223180A (da) 1980-11-24
YU136980A (en) 1983-10-31
IT8022241A0 (it) 1980-05-21
IT1140972B (it) 1986-10-10
IL60141A0 (en) 1980-07-31
ZA803035B (en) 1981-05-27
PH17310A (en) 1984-07-18
GB2051061A (en) 1981-01-14
CA1149375A (fr) 1983-07-05
PH15916A (en) 1983-04-22
US4365062A (en) 1982-12-21
PL122638B1 (en) 1982-08-31
PL224392A1 (fi) 1981-02-13
ZA803036B (en) 1981-05-27
ES495237A0 (es) 1981-09-01

Similar Documents

Publication Publication Date Title
CA1316171C (en) Cephalosporin derivatives
CA1204735A (en) Cephalosporins, processes for producing the same, intermediates thereof and process for producing the intermediates
DD151169A5 (de) Verfahren zur herstellung neuer cephalosporine
DE3019400A1 (de) Neue 3-thiovinyl-cephalosporine, verfahren zu deren herstellung und diese enthaltende zusammensetzungen
CA1144919A (fr) Derives de vinyl-3 cephalosporines, et leur preparation
DE3105136A1 (de) "neue thioloester, ihre herstellung und ihre verwendung zur synthese"
CH625245A5 (fi)
US4018921A (en) Substituted phenylglycylcephalosporins
US3953439A (en) Substituted phenylglycylcephalosporins
NO810144L (no) Nye tioler og fremgangsmaate for fremstilling derav
DE3043865A1 (de) N-substituierte thiazolylderivate von oxy-imino-substituierten cephalosporinen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische und veterinaermedizinische mittel
JPS6217592B2 (fi)
CA1276139C (en) Cephalosporins, processes for producing the same, antibacterial agent containing the same, intermediates thereof and process for producing the intermediates
US4107440A (en) Intermediates for preparing substituted phenylglycylcephalosporins
KR840001021B1 (ko) 3-비닐-세팔로스포린유도체의 제조방법
JPH09506100A (ja) 抗炎症剤および抗変性剤としての２−スピロ（２’−スピロシクロアルキル）シクロプロピルセファロスポリンスルホン類
US4044047A (en) Intermediates for preparing substituted phenylglycylcephalosporins
DD151170A5 (de) Verfahren zur herstellung von neuen 3-thiovinyl-cephalosporinen
US4022895A (en) Substituted phenylglycylcephalosporins
US4013764A (en) Pharmaceutical compositions comprising substituted phenylglycylcephalosporins and methods of treating bacterial infections
CH640535A5 (de) Halogen- bzw. trifluormethylarylmalonamido-1-dethia-1-oxacephalosporine sowie verfahren zu ihrer herstellung.
FR2475545A1 (fr) Nouveaux thioloesters, leur preparation et leur utilisation en synthese
JPS604191A (ja) 新規セフアロスポリン類