ES8203906A1 - Procedimiento para la obtencion de cefalosporinas - Google Patents

Procedimiento para la obtencion de cefalosporinas

Info

Publication number
ES8203906A1
ES8203906A1 ES491689A ES491689A ES8203906A1 ES 8203906 A1 ES8203906 A1 ES 8203906A1 ES 491689 A ES491689 A ES 491689A ES 491689 A ES491689 A ES 491689A ES 8203906 A1 ES8203906 A1 ES 8203906A1
Authority
ES
Spain
Prior art keywords
radical
hydrogen
protective
cephalosporins
vinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491689A
Other languages
English (en)
Other versions
ES491689A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of ES491689A0 publication Critical patent/ES491689A0/es
Publication of ES8203906A1 publication Critical patent/ES8203906A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CEFALOSPORINAS Y DE MEZCLAS DE SUS ISOMEROS, DE FORMULA (I), EN LA QUE N VALE 0 O 1 Y R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. CUANDO N VALE 0, CONSISTE EN LA REACCION DE HIDROLISIS DE UNA ENAMINA DE FORMULA (II), EN LA QUE R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), Y R10 Y R11 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN MEDIO ACUOSO O ACUO-ORGANICO, EN PRESENCIA DE UN ACIDO MINERAL U ORGANICO Y A UNA TEMPERATURA COMPRENDIDA ENTRE -20 GRADOS C Y LA DE REFLUJO DE LA MEZCLA DE REACCION. CUANDO N VALE 1 EL PRODUCTO RESULTANTE DE LA HIDROLISIS ANTERIOR SE OXIDA SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA Y COMO INTERMEDIOS PARA OBTENCION DE SUSTANCIAS ANTIBIOTICAS.
ES491689A 1979-05-23 1980-05-21 Procedimiento para la obtencion de cefalosporinas Expired ES8203906A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7913097A FR2457297A1 (fr) 1979-05-23 1979-05-23 Nouvelles vinyl-3 cephalosporines, et leur preparation

Publications (2)

Publication Number Publication Date
ES491689A0 ES491689A0 (es) 1982-04-16
ES8203906A1 true ES8203906A1 (es) 1982-04-16

Family

ID=9225763

Family Applications (4)

Application Number Title Priority Date Filing Date
ES491689A Expired ES8203906A1 (es) 1979-05-23 1980-05-21 Procedimiento para la obtencion de cefalosporinas
ES491688A Granted ES491688A0 (es) 1979-05-23 1980-05-21 Procedimiento para la obtencion de vinil-3 cefalosporinas
ES495237A Granted ES495237A0 (es) 1979-05-23 1980-09-22 Procedimiento para la obtencion de vinil-3 cefalosporinas
ES495236A Expired ES8106533A1 (es) 1979-05-23 1980-09-22 Procedimiento para la obtencion de vinil-3 cefalosporinas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES491688A Granted ES491688A0 (es) 1979-05-23 1980-05-21 Procedimiento para la obtencion de vinil-3 cefalosporinas
ES495237A Granted ES495237A0 (es) 1979-05-23 1980-09-22 Procedimiento para la obtencion de vinil-3 cefalosporinas
ES495236A Expired ES8106533A1 (es) 1979-05-23 1980-09-22 Procedimiento para la obtencion de vinil-3 cefalosporinas

Country Status (32)

Country Link
US (2) US4365062A (es)
JP (2) JPS55154978A (es)
AT (2) AT368509B (es)
AU (2) AU537785B2 (es)
BE (2) BE883417A (es)
CA (2) CA1149375A (es)
CH (2) CH650000A5 (es)
CS (1) CS235508B2 (es)
DD (2) DD151169A5 (es)
DE (2) DE3019445A1 (es)
DK (2) DK222280A (es)
ES (4) ES8203906A1 (es)
FI (2) FI801643A (es)
FR (1) FR2457297A1 (es)
GB (2) GB2051061B (es)
GR (2) GR68436B (es)
HU (2) HU183143B (es)
IE (2) IE49812B1 (es)
IL (2) IL60141A (es)
IT (2) IT1140972B (es)
LU (2) LU82476A1 (es)
NL (2) NL8003010A (es)
NO (2) NO801503L (es)
NZ (2) NZ193800A (es)
PH (2) PH17310A (es)
PL (3) PL126491B1 (es)
PT (2) PT71278A (es)
SE (2) SE8003822L (es)
SU (4) SU965358A3 (es)
YU (3) YU137080A (es)
ZA (2) ZA803036B (es)
ZW (1) ZW12380A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
FR2511376A1 (fr) * 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur prepration
FR2511372A1 (fr) * 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur preparation
FR2531712A1 (fr) * 1982-08-13 1984-02-17 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur preparation
US4609730A (en) * 1982-11-22 1986-09-02 Fujisawa Pharmaceutical Co., Ltd. 7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
ZM884A1 (en) * 1983-01-28 1984-10-22 Bristol Myers Co Substituted vinyl cephalosporins
JPS604883U (ja) * 1983-06-24 1985-01-14 松下冷機株式会社 冷蔵庫等の冷却装置
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4874856A (en) * 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
MY127641A (en) * 1995-10-12 2006-12-29 Essential Therapeutics Inc Cephalosporin antibiotics
US6025352A (en) * 1997-09-29 2000-02-15 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US6030965A (en) * 1997-09-30 2000-02-29 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US20050267092A1 (en) * 2002-02-28 2005-12-01 Chang-Seok Lee Novel cephalosporin compounds and process for preparing the same
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
JP6403289B2 (ja) 2013-03-12 2018-10-10 グラディウス ファーマシューティカルズ コーポレーションＧｌａｄｉｕｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 誘導体化３−スチリル−セファロスポリン

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
US3823139A (en) * 1970-03-26 1974-07-09 Glaxo Lab Ltd Cephalosporins having a ypsilon-carbonyl group at position-3
US3674784A (en) * 1970-07-27 1972-07-04 Lilly Co Eli 3-formyl cephalosporin sulfoxides
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
US4095021A (en) * 1973-12-21 1978-06-13 Glaxo Laboratories Limited 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof
DE2637176A1 (de) 1975-08-22 1977-03-03 Ciba Geigy Ag Carbonylmethylderivate
JPS5285185A (en) * 1976-01-05 1977-07-15 Teijin Ltd Preparation of 7-acylaminocephalosporanic acids
JPS5289694A (en) * 1976-01-23 1977-07-27 Asahi Chem Ind Co Ltd Novel cephalosporins
US4094978A (en) * 1976-07-29 1978-06-13 Syntex (U.S.A.) Inc. 3-propenyl derivatives of cephalosporin, compositions and their use
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
EP0015240A1 (de) * 1979-02-16 1980-09-03 Ciba-Geigy Ag Azacyclyl (thio) ureidoacetyl-Verbindungen und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
CS235508B2 (en) 1985-05-15
GR68428B (es) 1981-12-30
DE3019445A1 (de) 1980-12-04
SU927118A3 (ru) 1982-05-07
GB2051061B (en) 1983-09-28
HU184759B (en) 1984-10-29
IT8022242A0 (it) 1980-05-21
YU137080A (en) 1983-04-30
ES495236A0 (es) 1981-08-16
ES8106734A1 (es) 1981-09-01
IT1140972B (it) 1986-10-10
ZA803035B (en) 1981-05-27
YU56183A (en) 1984-02-29
FR2457297A1 (fr) 1980-12-19
YU136980A (en) 1983-10-31
ZA803036B (en) 1981-05-27
IE49812B1 (en) 1985-12-25
IL60141A0 (en) 1980-07-31
IE801060L (en) 1980-11-23
PH17310A (en) 1984-07-18
CA1148141A (fr) 1983-06-14
IT8022241A0 (it) 1980-05-21
GB2051061A (en) 1981-01-14
AU532884B2 (en) 1983-10-20
DD151169A5 (de) 1981-10-08
GR68436B (es) 1981-12-30
FR2457297B1 (es) 1982-10-22
GB2052488A (en) 1981-01-28
AU537785B2 (en) 1984-07-12
NL8003010A (nl) 1980-11-25
BE883417A (fr) 1980-11-21
AT370737B (de) 1983-04-25
JPS55154978A (en) 1980-12-02
ES491689A0 (es) 1982-04-16
JPS55154979A (en) 1980-12-02
CA1149375A (fr) 1983-07-05
PT71277A (fr) 1980-06-01
DK223180A (da) 1980-11-24
US4365062A (en) 1982-12-21
ES8106533A1 (es) 1981-08-16
LU82478A1 (fr) 1980-12-16
NZ193801A (en) 1983-03-15
NO801504L (no) 1980-11-24
ATA271080A (de) 1982-02-15
LU82476A1 (fr) 1980-12-16
ES8102137A1 (es) 1980-12-16
SU988193A3 (ru) 1983-01-07
SE8003823L (sv) 1980-11-24
GB2052488B (en) 1983-09-21
FI801643A (fi) 1980-11-24
SU965358A3 (ru) 1982-10-07
DD151064A5 (de) 1981-09-30
NZ193800A (en) 1983-05-10
PL126671B1 (en) 1983-08-31
PL126491B1 (en) 1983-08-31
PT71278A (fr) 1980-06-01
DK222280A (da) 1980-11-24
ZW12380A1 (en) 1980-11-26
CH645380A5 (fr) 1984-09-28
IL60140A (en) 1984-04-30
IE49813B1 (en) 1985-12-25
NL8003024A (nl) 1980-11-25
DE3019430A1 (de) 1980-12-04
IL60141A (en) 1984-04-30
AT368509B (de) 1982-10-25
BE883418A (fr) 1980-11-21
ES495237A0 (es) 1981-09-01
SU984411A3 (ru) 1982-12-23
HU183143B (en) 1984-04-28
FI801642A (fi) 1980-11-24
IT1140973B (it) 1986-10-10
PH15916A (en) 1983-04-22
SE8003822L (sv) 1980-11-24
US4307230A (en) 1981-12-22
NO801503L (no) 1980-11-24
IL60140A0 (en) 1980-07-31
ATA271180A (de) 1982-09-15
ES491688A0 (es) 1980-12-16
AU5859480A (en) 1980-11-27
PL122638B1 (en) 1982-08-31
PL224392A1 (es) 1981-02-13
AU5859380A (en) 1980-11-27
CH650000A5 (fr) 1985-06-28
IE801059L (en) 1980-11-23
PL224390A1 (es) 1981-02-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990601